Human papillomavirus 22

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Betapapillomavirus; Betapapillomavirus 2

Average proteome isoelectric point is 6.1

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 7 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>sp|P50788|VL1_HPV22 Major capsid protein L1 OS=Human papillomavirus 22 OX=37954 GN=L1 PE=3 SV=1
MM1 pKa = 7.54IGKK4 pKa = 8.5QATLCDD10 pKa = 3.55IVLEE14 pKa = 4.14EE15 pKa = 4.64LVLPIDD21 pKa = 3.84LHH23 pKa = 6.32CHH25 pKa = 5.61EE26 pKa = 5.67EE27 pKa = 4.29LPEE30 pKa = 4.22LPEE33 pKa = 4.02EE34 pKa = 4.36LEE36 pKa = 3.99EE37 pKa = 4.46SVVEE41 pKa = 4.17EE42 pKa = 4.18EE43 pKa = 5.43PEE45 pKa = 3.87YY46 pKa = 10.33TPYY49 pKa = 10.77KK50 pKa = 9.65IVVYY54 pKa = 10.65CGGCDD59 pKa = 3.31TKK61 pKa = 11.31LKK63 pKa = 10.71LYY65 pKa = 10.38ILATLSGIRR74 pKa = 11.84DD75 pKa = 3.89FQTSLLGPVKK85 pKa = 10.12LLCPTCRR92 pKa = 11.84EE93 pKa = 4.03EE94 pKa = 4.14IRR96 pKa = 11.84NGRR99 pKa = 11.84RR100 pKa = 3.02

Molecular weight: 11.36 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>sp|P50775|VE6_HPV22 Protein E6 OS=Human papillomavirus 22 OX=37954 GN=E6 PE=3 SV=1
MM1 pKa = 7.65EE2 pKa = 5.45KK3 pKa = 10.47LSEE6 pKa = 4.19RR7 pKa = 11.84FSALQEE13 pKa = 4.13KK14 pKa = 10.62LMDD17 pKa = 4.3LYY19 pKa = 11.28EE20 pKa = 5.14SGVEE24 pKa = 3.96DD25 pKa = 5.76LEE27 pKa = 4.52TQIQHH32 pKa = 5.68WKK34 pKa = 10.31LLRR37 pKa = 11.84QEE39 pKa = 4.1QVLFYY44 pKa = 9.06YY45 pKa = 10.58ARR47 pKa = 11.84RR48 pKa = 11.84HH49 pKa = 5.52GILRR53 pKa = 11.84LGYY56 pKa = 10.15QPVPTLATSEE66 pKa = 4.56SKK68 pKa = 11.11AKK70 pKa = 10.43DD71 pKa = 3.81AIAMGLLLEE80 pKa = 4.66SLQKK84 pKa = 10.32SQYY87 pKa = 10.93AEE89 pKa = 4.19EE90 pKa = 4.41PWTLVEE96 pKa = 4.35TSLEE100 pKa = 4.49TVKK103 pKa = 10.9SPPADD108 pKa = 3.66CFKK111 pKa = 10.81KK112 pKa = 10.31GPKK115 pKa = 9.57SVEE118 pKa = 4.01VYY120 pKa = 10.71FDD122 pKa = 3.98GDD124 pKa = 3.74PEE126 pKa = 4.3NVMSYY131 pKa = 7.4TVWSYY136 pKa = 11.33IYY138 pKa = 10.26YY139 pKa = 8.54QTDD142 pKa = 3.26DD143 pKa = 3.88EE144 pKa = 4.49SWEE147 pKa = 4.15KK148 pKa = 11.3VEE150 pKa = 4.39GHH152 pKa = 5.67VDD154 pKa = 3.38YY155 pKa = 11.04TGAYY159 pKa = 8.88YY160 pKa = 9.92IEE162 pKa = 4.73GTFKK166 pKa = 10.02TYY168 pKa = 10.46YY169 pKa = 10.05IKK171 pKa = 10.91FEE173 pKa = 4.25TDD175 pKa = 2.4AKK177 pKa = 10.55RR178 pKa = 11.84YY179 pKa = 6.43GTTGHH184 pKa = 6.66WEE186 pKa = 3.74VHH188 pKa = 4.76VNKK191 pKa = 9.36DD192 pKa = 3.53TVFTPVTSSTPPVGVASQNSAPEE215 pKa = 4.1PASTSDD221 pKa = 3.09SPQRR225 pKa = 11.84SSQVTHH231 pKa = 6.93RR232 pKa = 11.84YY233 pKa = 8.31GRR235 pKa = 11.84KK236 pKa = 9.38ASSPTITTIRR246 pKa = 11.84RR247 pKa = 11.84QKK249 pKa = 9.53RR250 pKa = 11.84RR251 pKa = 11.84EE252 pKa = 3.86RR253 pKa = 11.84QRR255 pKa = 11.84QEE257 pKa = 3.51TPTRR261 pKa = 11.84RR262 pKa = 11.84RR263 pKa = 11.84KK264 pKa = 7.37TRR266 pKa = 11.84SRR268 pKa = 11.84SRR270 pKa = 11.84STEE273 pKa = 3.58QRR275 pKa = 11.84GGRR278 pKa = 11.84ATRR281 pKa = 11.84RR282 pKa = 11.84SLSRR286 pKa = 11.84EE287 pKa = 3.82SAEE290 pKa = 3.94SPRR293 pKa = 11.84RR294 pKa = 11.84GGRR297 pKa = 11.84GGGGPLTRR305 pKa = 11.84SRR307 pKa = 11.84SRR309 pKa = 11.84SRR311 pKa = 11.84SRR313 pKa = 11.84TRR315 pKa = 11.84EE316 pKa = 3.95SVDD319 pKa = 3.22GGGVAPDD326 pKa = 3.43EE327 pKa = 4.5VGATLRR333 pKa = 11.84SIGRR337 pKa = 11.84QHH339 pKa = 7.26SGRR342 pKa = 11.84LAQLLDD348 pKa = 3.62AAKK351 pKa = 9.99DD352 pKa = 3.57PPVILLRR359 pKa = 11.84GAANTLKK366 pKa = 10.45CYY368 pKa = 10.33RR369 pKa = 11.84YY370 pKa = 10.07RR371 pKa = 11.84FRR373 pKa = 11.84KK374 pKa = 8.73KK375 pKa = 9.77HH376 pKa = 5.68AGSFQFISTTWSWVGGHH393 pKa = 4.66TTDD396 pKa = 4.03RR397 pKa = 11.84IGRR400 pKa = 11.84SRR402 pKa = 11.84ILISFHH408 pKa = 5.67TDD410 pKa = 3.06RR411 pKa = 11.84EE412 pKa = 4.27RR413 pKa = 11.84EE414 pKa = 3.92KK415 pKa = 11.0CLQQMKK421 pKa = 10.49LPLGVEE427 pKa = 4.08WSYY430 pKa = 11.91GQFDD434 pKa = 4.19DD435 pKa = 5.18LL436 pKa = 5.54

Molecular weight: 49.73 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

7

0

7

2536

100

608

362.3

40.98

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

5.323 ± 0.456

2.169 ± 0.653

6.23 ± 0.38

6.822 ± 0.592

4.101 ± 0.511

6.388 ± 0.617

2.248 ± 0.228

4.771 ± 0.756

4.968 ± 0.707

8.872 ± 0.717

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.696 ± 0.53

3.352 ± 0.694

6.467 ± 1.15

5.047 ± 0.691

6.782 ± 0.992

7.571 ± 0.649

6.23 ± 0.792

6.191 ± 0.802

1.222 ± 0.336

3.549 ± 0.426
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski