Amino acid dipepetide frequency for Trichoderma harzianum (Hypocrea lixii)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.81AlaAla: 9.81 ± 0.064
1.059AlaCys: 1.059 ± 0.016
4.421AlaAsp: 4.421 ± 0.029
5.211AlaGlu: 5.211 ± 0.042
3.208AlaPhe: 3.208 ± 0.024
5.737AlaGly: 5.737 ± 0.047
1.75AlaHis: 1.75 ± 0.017
4.675AlaIle: 4.675 ± 0.035
4.324AlaLys: 4.324 ± 0.036
7.763AlaLeu: 7.763 ± 0.05
2.061AlaMet: 2.061 ± 0.021
3.182AlaAsn: 3.182 ± 0.027
4.737AlaPro: 4.737 ± 0.034
3.51AlaGln: 3.51 ± 0.031
4.633AlaArg: 4.633 ± 0.033
7.564AlaSer: 7.564 ± 0.046
5.376AlaThr: 5.376 ± 0.035
5.537AlaVal: 5.537 ± 0.034
1.204AlaTrp: 1.204 ± 0.018
2.182AlaTyr: 2.182 ± 0.023
0.0AlaXaa: 0.0 ± 0.0
Cys
0.912CysAla: 0.912 ± 0.014
0.242CysCys: 0.242 ± 0.009
0.664CysAsp: 0.664 ± 0.013
0.578CysGlu: 0.578 ± 0.012
0.546CysPhe: 0.546 ± 0.013
0.927CysGly: 0.927 ± 0.015
0.319CysHis: 0.319 ± 0.007
0.731CysIle: 0.731 ± 0.014
0.494CysLys: 0.494 ± 0.01
1.21CysLeu: 1.21 ± 0.015
0.25CysMet: 0.25 ± 0.007
0.437CysAsn: 0.437 ± 0.009
0.628CysPro: 0.628 ± 0.014
0.456CysGln: 0.456 ± 0.01
0.694CysArg: 0.694 ± 0.012
0.883CysSer: 0.883 ± 0.015
0.656CysThr: 0.656 ± 0.012
0.769CysVal: 0.769 ± 0.015
0.204CysTrp: 0.204 ± 0.006
0.364CysTyr: 0.364 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
5.016AspAla: 5.016 ± 0.031
0.644AspCys: 0.644 ± 0.01
4.564AspAsp: 4.564 ± 0.041
4.72AspGlu: 4.72 ± 0.039
2.266AspPhe: 2.266 ± 0.022
4.294AspGly: 4.294 ± 0.034
1.214AspHis: 1.214 ± 0.016
3.329AspIle: 3.329 ± 0.025
2.655AspLys: 2.655 ± 0.026
4.971AspLeu: 4.971 ± 0.032
1.329AspMet: 1.329 ± 0.015
2.017AspAsn: 2.017 ± 0.022
3.14AspPro: 3.14 ± 0.026
1.882AspGln: 1.882 ± 0.019
2.873AspArg: 2.873 ± 0.03
4.198AspSer: 4.198 ± 0.036
2.917AspThr: 2.917 ± 0.024
3.845AspVal: 3.845 ± 0.03
0.896AspTrp: 0.896 ± 0.015
1.63AspTyr: 1.63 ± 0.019
0.0AspXaa: 0.0 ± 0.0
Glu
5.757GluAla: 5.757 ± 0.042
0.613GluCys: 0.613 ± 0.011
4.25GluAsp: 4.25 ± 0.04
5.522GluGlu: 5.522 ± 0.068
2.025GluPhe: 2.025 ± 0.019
3.539GluGly: 3.539 ± 0.028
1.364GluHis: 1.364 ± 0.018
3.154GluIle: 3.154 ± 0.027
3.7GluLys: 3.7 ± 0.035
5.284GluLeu: 5.284 ± 0.03
1.535GluMet: 1.535 ± 0.016
2.27GluAsn: 2.27 ± 0.021
2.768GluPro: 2.768 ± 0.03
2.504GluGln: 2.504 ± 0.023
3.663GluArg: 3.663 ± 0.035
4.267GluSer: 4.267 ± 0.031
3.526GluThr: 3.526 ± 0.029
3.449GluVal: 3.449 ± 0.031
0.901GluTrp: 0.901 ± 0.012
1.688GluTyr: 1.688 ± 0.018
0.0GluXaa: 0.0 ± 0.0
Phe
3.122PheAla: 3.122 ± 0.026
0.555PheCys: 0.555 ± 0.009
2.369PheAsp: 2.369 ± 0.021
2.15PheGlu: 2.15 ± 0.023
1.68PhePhe: 1.68 ± 0.019
2.909PheGly: 2.909 ± 0.029
0.897PheHis: 0.897 ± 0.014
1.982PheIle: 1.982 ± 0.022
1.551PheLys: 1.551 ± 0.017
3.435PheLeu: 3.435 ± 0.024
0.821PheMet: 0.821 ± 0.013
1.516PheAsn: 1.516 ± 0.015
1.921PhePro: 1.921 ± 0.022
1.448PheGln: 1.448 ± 0.017
1.908PheArg: 1.908 ± 0.018
3.044PheSer: 3.044 ± 0.024
2.187PheThr: 2.187 ± 0.02
2.414PheVal: 2.414 ± 0.022
0.65PheTrp: 0.65 ± 0.012
1.129PheTyr: 1.129 ± 0.013
0.0PheXaa: 0.0 ± 0.0
Gly
5.327GlyAla: 5.327 ± 0.038
0.843GlyCys: 0.843 ± 0.014
3.759GlyAsp: 3.759 ± 0.03
3.62GlyGlu: 3.62 ± 0.028
2.823GlyPhe: 2.823 ± 0.026
5.682GlyGly: 5.682 ± 0.059
1.721GlyHis: 1.721 ± 0.017
3.727GlyIle: 3.727 ± 0.032
3.468GlyLys: 3.468 ± 0.031
6.024GlyLeu: 6.024 ± 0.04
1.571GlyMet: 1.571 ± 0.019
2.635GlyAsn: 2.635 ± 0.028
3.242GlyPro: 3.242 ± 0.029
2.577GlyGln: 2.577 ± 0.022
3.961GlyArg: 3.961 ± 0.034
5.778GlySer: 5.778 ± 0.039
3.883GlyThr: 3.883 ± 0.028
4.283GlyVal: 4.283 ± 0.036
1.166GlyTrp: 1.166 ± 0.015
2.15GlyTyr: 2.15 ± 0.023
0.0GlyXaa: 0.0 ± 0.0
His
1.74HisAla: 1.74 ± 0.018
0.315HisCys: 0.315 ± 0.008
1.351HisAsp: 1.351 ± 0.017
1.331HisGlu: 1.331 ± 0.017
0.919HisPhe: 0.919 ± 0.014
1.72HisGly: 1.72 ± 0.019
0.878HisHis: 0.878 ± 0.018
1.254HisIle: 1.254 ± 0.014
0.953HisLys: 0.953 ± 0.015
2.202HisLeu: 2.202 ± 0.024
0.518HisMet: 0.518 ± 0.01
0.856HisAsn: 0.856 ± 0.012
1.526HisPro: 1.526 ± 0.02
1.036HisGln: 1.036 ± 0.016
1.45HisArg: 1.45 ± 0.019
1.763HisSer: 1.763 ± 0.021
1.171HisThr: 1.171 ± 0.016
1.424HisVal: 1.424 ± 0.018
0.351HisTrp: 0.351 ± 0.009
0.689HisTyr: 0.689 ± 0.014
0.0HisXaa: 0.0 ± 0.0
Ile
4.412IleAla: 4.412 ± 0.031
0.753IleCys: 0.753 ± 0.014
3.054IleAsp: 3.054 ± 0.024
3.034IleGlu: 3.034 ± 0.025
2.11IlePhe: 2.11 ± 0.023
3.37IleGly: 3.37 ± 0.029
1.27IleHis: 1.27 ± 0.016
2.763IleIle: 2.763 ± 0.026
2.365IleLys: 2.365 ± 0.022
4.694IleLeu: 4.694 ± 0.035
1.077IleMet: 1.077 ± 0.012
1.988IleAsn: 1.988 ± 0.023
3.122IlePro: 3.122 ± 0.023
2.066IleGln: 2.066 ± 0.023
2.884IleArg: 2.884 ± 0.021
4.053IleSer: 4.053 ± 0.031
2.96IleThr: 2.96 ± 0.024
3.309IleVal: 3.309 ± 0.026
0.777IleTrp: 0.777 ± 0.013
1.451IleTyr: 1.451 ± 0.016
0.0IleXaa: 0.0 ± 0.0
Lys
4.482LysAla: 4.482 ± 0.038
0.484LysCys: 0.484 ± 0.011
2.895LysAsp: 2.895 ± 0.026
3.417LysGlu: 3.417 ± 0.033
1.567LysPhe: 1.567 ± 0.018
2.991LysGly: 2.991 ± 0.028
1.118LysHis: 1.118 ± 0.016
2.372LysIle: 2.372 ± 0.022
3.358LysLys: 3.358 ± 0.045
4.272LysLeu: 4.272 ± 0.029
1.077LysMet: 1.077 ± 0.013
1.771LysAsn: 1.771 ± 0.017
2.708LysPro: 2.708 ± 0.025
1.905LysGln: 1.905 ± 0.018
3.273LysArg: 3.273 ± 0.031
3.567LysSer: 3.567 ± 0.028
2.908LysThr: 2.908 ± 0.024
2.809LysVal: 2.809 ± 0.023
0.699LysTrp: 0.699 ± 0.013
1.399LysTyr: 1.399 ± 0.015
0.0LysXaa: 0.0 ± 0.0
Leu
7.972LeuAla: 7.972 ± 0.042
1.169LeuCys: 1.169 ± 0.017
5.361LeuAsp: 5.361 ± 0.03
5.519LeuGlu: 5.519 ± 0.041
3.367LeuPhe: 3.367 ± 0.027
5.93LeuGly: 5.93 ± 0.035
2.164LeuHis: 2.164 ± 0.02
4.151LeuIle: 4.151 ± 0.029
4.261LeuLys: 4.261 ± 0.031
8.426LeuLeu: 8.426 ± 0.056
1.822LeuMet: 1.822 ± 0.02
3.231LeuAsn: 3.231 ± 0.025
5.333LeuPro: 5.333 ± 0.032
3.931LeuGln: 3.931 ± 0.031
5.536LeuArg: 5.536 ± 0.034
7.279LeuSer: 7.279 ± 0.041
4.714LeuThr: 4.714 ± 0.03
5.41LeuVal: 5.41 ± 0.035
1.237LeuTrp: 1.237 ± 0.017
2.339LeuTyr: 2.339 ± 0.024
0.0LeuXaa: 0.0 ± 0.0
Met
2.415MetAla: 2.415 ± 0.021
0.24MetCys: 0.24 ± 0.006
1.312MetAsp: 1.312 ± 0.014
1.334MetGlu: 1.334 ± 0.015
0.738MetPhe: 0.738 ± 0.012
1.486MetGly: 1.486 ± 0.018
0.467MetHis: 0.467 ± 0.009
1.031MetIle: 1.031 ± 0.012
1.04MetLys: 1.04 ± 0.015
1.9MetLeu: 1.9 ± 0.017
0.621MetMet: 0.621 ± 0.011
0.828MetAsn: 0.828 ± 0.014
1.314MetPro: 1.314 ± 0.016
0.879MetGln: 0.879 ± 0.015
1.258MetArg: 1.258 ± 0.016
1.874MetSer: 1.874 ± 0.019
1.302MetThr: 1.302 ± 0.015
1.314MetVal: 1.314 ± 0.015
0.272MetTrp: 0.272 ± 0.006
0.526MetTyr: 0.526 ± 0.009
0.0MetXaa: 0.0 ± 0.0
Asn
3.211AsnAla: 3.211 ± 0.025
0.456AsnCys: 0.456 ± 0.01
2.065AsnAsp: 2.065 ± 0.02
2.014AsnGlu: 2.014 ± 0.021
1.416AsnPhe: 1.416 ± 0.016
3.124AsnGly: 3.124 ± 0.032
0.874AsnHis: 0.874 ± 0.013
2.183AsnIle: 2.183 ± 0.02
1.673AsnLys: 1.673 ± 0.019
3.316AsnLeu: 3.316 ± 0.024
0.911AsnMet: 0.911 ± 0.014
1.622AsnAsn: 1.622 ± 0.024
2.418AsnPro: 2.418 ± 0.022
1.379AsnGln: 1.379 ± 0.018
1.913AsnArg: 1.913 ± 0.018
2.831AsnSer: 2.831 ± 0.024
2.189AsnThr: 2.189 ± 0.018
2.324AsnVal: 2.324 ± 0.022
0.593AsnTrp: 0.593 ± 0.011
1.111AsnTyr: 1.111 ± 0.018
0.0AsnXaa: 0.0 ± 0.0
Pro
5.019ProAla: 5.019 ± 0.042
0.506ProCys: 0.506 ± 0.011
3.231ProAsp: 3.231 ± 0.026
3.752ProGlu: 3.752 ± 0.03
2.048ProPhe: 2.048 ± 0.021
3.767ProGly: 3.767 ± 0.03
1.241ProHis: 1.241 ± 0.017
2.577ProIle: 2.577 ± 0.024
2.693ProLys: 2.693 ± 0.024
4.785ProLeu: 4.785 ± 0.031
1.122ProMet: 1.122 ± 0.015
2.234ProAsn: 2.234 ± 0.022
4.951ProPro: 4.951 ± 0.069
2.451ProGln: 2.451 ± 0.029
3.147ProArg: 3.147 ± 0.026
5.697ProSer: 5.697 ± 0.043
3.738ProThr: 3.738 ± 0.027
3.48ProVal: 3.48 ± 0.03
0.741ProTrp: 0.741 ± 0.011
1.462ProTyr: 1.462 ± 0.018
0.0ProXaa: 0.0 ± 0.0
Gln
3.583GlnAla: 3.583 ± 0.03
0.436GlnCys: 0.436 ± 0.01
2.181GlnAsp: 2.181 ± 0.019
2.43GlnGlu: 2.43 ± 0.024
1.377GlnPhe: 1.377 ± 0.015
2.468GlnGly: 2.468 ± 0.022
1.071GlnHis: 1.071 ± 0.015
1.935GlnIle: 1.935 ± 0.02
1.984GlnLys: 1.984 ± 0.023
3.64GlnLeu: 3.64 ± 0.027
0.912GlnMet: 0.912 ± 0.012
1.546GlnAsn: 1.546 ± 0.017
2.575GlnPro: 2.575 ± 0.029
2.675GlnGln: 2.675 ± 0.063
2.572GlnArg: 2.572 ± 0.026
3.104GlnSer: 3.104 ± 0.025
2.298GlnThr: 2.298 ± 0.02
2.183GlnVal: 2.183 ± 0.019
0.606GlnTrp: 0.606 ± 0.01
1.178GlnTyr: 1.178 ± 0.016
0.0GlnXaa: 0.0 ± 0.0
Arg
4.443ArgAla: 4.443 ± 0.03
0.655ArgCys: 0.655 ± 0.012
3.338ArgAsp: 3.338 ± 0.032
3.62ArgGlu: 3.62 ± 0.035
2.104ArgPhe: 2.104 ± 0.019
3.603ArgGly: 3.603 ± 0.031
1.502ArgHis: 1.502 ± 0.016
2.919ArgIle: 2.919 ± 0.023
3.191ArgLys: 3.191 ± 0.029
5.409ArgLeu: 5.409 ± 0.034
1.258ArgMet: 1.258 ± 0.015
2.187ArgAsn: 2.187 ± 0.019
3.332ArgPro: 3.332 ± 0.033
2.565ArgGln: 2.565 ± 0.023
4.754ArgArg: 4.754 ± 0.041
4.467ArgSer: 4.467 ± 0.037
2.982ArgThr: 2.982 ± 0.024
3.222ArgVal: 3.222 ± 0.024
0.888ArgTrp: 0.888 ± 0.012
1.594ArgTyr: 1.594 ± 0.018
0.0ArgXaa: 0.0 ± 0.0
Ser
6.61SerAla: 6.61 ± 0.042
0.87SerCys: 0.87 ± 0.012
4.252SerAsp: 4.252 ± 0.034
4.126SerGlu: 4.126 ± 0.034
3.079SerPhe: 3.079 ± 0.024
5.585SerGly: 5.585 ± 0.035
1.948SerHis: 1.948 ± 0.022
4.174SerIle: 4.174 ± 0.033
3.775SerLys: 3.775 ± 0.034
7.215SerLeu: 7.215 ± 0.04
1.746SerMet: 1.746 ± 0.018
3.039SerAsn: 3.039 ± 0.027
5.254SerPro: 5.254 ± 0.043
3.391SerGln: 3.391 ± 0.027
4.853SerArg: 4.853 ± 0.039
8.747SerSer: 8.747 ± 0.065
5.37SerThr: 5.37 ± 0.046
4.595SerVal: 4.595 ± 0.031
1.191SerTrp: 1.191 ± 0.016
2.074SerTyr: 2.074 ± 0.021
0.0SerXaa: 0.0 ± 0.0
Thr
5.288ThrAla: 5.288 ± 0.036
0.711ThrCys: 0.711 ± 0.013
2.847ThrAsp: 2.847 ± 0.024
3.138ThrGlu: 3.138 ± 0.026
2.224ThrPhe: 2.224 ± 0.019
4.119ThrGly: 4.119 ± 0.032
1.193ThrHis: 1.193 ± 0.013
3.219ThrIle: 3.219 ± 0.024
2.656ThrLys: 2.656 ± 0.021
5.162ThrLeu: 5.162 ± 0.029
1.189ThrMet: 1.189 ± 0.014
2.154ThrAsn: 2.154 ± 0.024
4.042ThrPro: 4.042 ± 0.036
2.051ThrGln: 2.051 ± 0.02
2.941ThrArg: 2.941 ± 0.021
5.129ThrSer: 5.129 ± 0.039
4.122ThrThr: 4.122 ± 0.042
3.711ThrVal: 3.711 ± 0.032
0.853ThrTrp: 0.853 ± 0.012
1.591ThrTyr: 1.591 ± 0.019
0.0ThrXaa: 0.0 ± 0.0
Val
5.436ValAla: 5.436 ± 0.037
0.805ValCys: 0.805 ± 0.017
3.803ValAsp: 3.803 ± 0.028
3.82ValGlu: 3.82 ± 0.032
2.446ValPhe: 2.446 ± 0.023
3.902ValGly: 3.902 ± 0.028
1.336ValHis: 1.336 ± 0.015
3.085ValIle: 3.085 ± 0.026
2.961ValLys: 2.961 ± 0.021
5.477ValLeu: 5.477 ± 0.032
1.321ValMet: 1.321 ± 0.014
2.293ValAsn: 2.293 ± 0.021
3.523ValPro: 3.523 ± 0.031
2.378ValGln: 2.378 ± 0.023
3.244ValArg: 3.244 ± 0.027
4.602ValSer: 4.602 ± 0.032
3.566ValThr: 3.566 ± 0.031
4.34ValVal: 4.34 ± 0.032
0.874ValTrp: 0.874 ± 0.015
1.7ValTyr: 1.7 ± 0.021
0.0ValXaa: 0.0 ± 0.0
Trp
1.218TrpAla: 1.218 ± 0.02
0.191TrpCys: 0.191 ± 0.006
0.975TrpAsp: 0.975 ± 0.015
0.874TrpGlu: 0.874 ± 0.012
0.558TrpPhe: 0.558 ± 0.01
0.942TrpGly: 0.942 ± 0.014
0.371TrpHis: 0.371 ± 0.008
0.821TrpIle: 0.821 ± 0.011
0.805TrpLys: 0.805 ± 0.012
1.358TrpLeu: 1.358 ± 0.015
0.371TrpMet: 0.371 ± 0.007
0.673TrpAsn: 0.673 ± 0.012
0.619TrpPro: 0.619 ± 0.012
0.581TrpGln: 0.581 ± 0.01
0.928TrpArg: 0.928 ± 0.013
1.042TrpSer: 1.042 ± 0.012
0.925TrpThr: 0.925 ± 0.014
0.885TrpVal: 0.885 ± 0.014
0.293TrpTrp: 0.293 ± 0.008
0.424TrpTyr: 0.424 ± 0.008
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.171TyrAla: 2.171 ± 0.018
0.415TyrCys: 0.415 ± 0.01
1.706TyrAsp: 1.706 ± 0.018
1.569TyrGlu: 1.569 ± 0.018
1.189TyrPhe: 1.189 ± 0.016
2.147TyrGly: 2.147 ± 0.023
0.749TyrHis: 0.749 ± 0.014
1.426TyrIle: 1.426 ± 0.016
1.167TyrLys: 1.167 ± 0.014
2.61TyrLeu: 2.61 ± 0.023
0.637TyrMet: 0.637 ± 0.012
1.141TyrAsn: 1.141 ± 0.017
1.491TyrPro: 1.491 ± 0.019
1.089TyrGln: 1.089 ± 0.014
1.548TyrArg: 1.548 ± 0.017
2.007TyrSer: 2.007 ± 0.02
1.551TyrThr: 1.551 ± 0.018
1.611TyrVal: 1.611 ± 0.018
0.455TyrTrp: 0.455 ± 0.009
0.925TyrTyr: 0.925 ± 0.013
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.002XaaXaa: 0.002 ± 0.001
Statistics based on 11497 proteins (5801780 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski