Amino acid dipepetide frequency for Candidatus Bathyarchaeota archaeon

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.633AlaAla: 5.633 ± 0.121	0.895AlaCys: 0.895 ± 0.039	3.755AlaAsp: 3.755 ± 0.083	4.516AlaGlu: 4.516 ± 0.108	2.943AlaPhe: 2.943 ± 0.083	4.995AlaGly: 4.995 ± 0.101	1.107AlaHis: 1.107 ± 0.038	5.529AlaIle: 5.529 ± 0.1	5.211AlaLys: 5.211 ± 0.109	7.259AlaLeu: 7.259 ± 0.126	1.652AlaMet: 1.652 ± 0.044	2.668AlaAsn: 2.668 ± 0.06	2.496AlaPro: 2.496 ± 0.081	2.264AlaGln: 2.264 ± 0.056	2.665AlaArg: 2.665 ± 0.06	4.409AlaSer: 4.409 ± 0.085	4.485AlaThr: 4.485 ± 0.087	6.374AlaVal: 6.374 ± 0.111	0.734AlaTrp: 0.734 ± 0.036	2.461AlaTyr: 2.461 ± 0.066	0.0AlaXaa: 0.0 ± 0.0
Cys	0.755CysAla: 0.755 ± 0.035	0.199CysCys: 0.199 ± 0.019	0.698CysAsp: 0.698 ± 0.031	0.724CysGlu: 0.724 ± 0.041	0.506CysPhe: 0.506 ± 0.029	1.33CysGly: 1.33 ± 0.055	0.246CysHis: 0.246 ± 0.022	0.766CysIle: 0.766 ± 0.039	0.738CysLys: 0.738 ± 0.038	1.085CysLeu: 1.085 ± 0.046	0.282CysMet: 0.282 ± 0.02	0.635CysAsn: 0.635 ± 0.038	0.886CysPro: 0.886 ± 0.046	0.324CysGln: 0.324 ± 0.023	0.503CysArg: 0.503 ± 0.029	0.889CysSer: 0.889 ± 0.046	0.642CysThr: 0.642 ± 0.029	0.917CysVal: 0.917 ± 0.04	0.178CysTrp: 0.178 ± 0.017	0.547CysTyr: 0.547 ± 0.03	0.0CysXaa: 0.0 ± 0.0
Asp	4.116AspAla: 4.116 ± 0.08	0.69AspCys: 0.69 ± 0.037	2.436AspAsp: 2.436 ± 0.078	3.478AspGlu: 3.478 ± 0.074	2.387AspPhe: 2.387 ± 0.072	3.992AspGly: 3.992 ± 0.13	0.788AspHis: 0.788 ± 0.035	3.722AspIle: 3.722 ± 0.07	2.912AspLys: 2.912 ± 0.077	4.814AspLeu: 4.814 ± 0.083	1.227AspMet: 1.227 ± 0.038	2.106AspAsn: 2.106 ± 0.067	2.437AspPro: 2.437 ± 0.065	1.282AspGln: 1.282 ± 0.041	1.774AspArg: 1.774 ± 0.053	3.275AspSer: 3.275 ± 0.092	2.713AspThr: 2.713 ± 0.078	4.577AspVal: 4.577 ± 0.099	0.783AspTrp: 0.783 ± 0.034	2.411AspTyr: 2.411 ± 0.067	0.0AspXaa: 0.0 ± 0.0
Glu	5.167GluAla: 5.167 ± 0.114	0.642GluCys: 0.642 ± 0.032	3.116GluAsp: 3.116 ± 0.077	4.826GluGlu: 4.826 ± 0.116	2.352GluPhe: 2.352 ± 0.054	3.682GluGly: 3.682 ± 0.093	1.227GluHis: 1.227 ± 0.043	4.92GluIle: 4.92 ± 0.1	5.607GluLys: 5.607 ± 0.155	6.406GluLeu: 6.406 ± 0.12	1.603GluMet: 1.603 ± 0.05	3.429GluAsn: 3.429 ± 0.087	2.221GluPro: 2.221 ± 0.066	2.585GluGln: 2.585 ± 0.062	2.676GluArg: 2.676 ± 0.073	3.361GluSer: 3.361 ± 0.08	4.722GluThr: 4.722 ± 0.1	4.403GluVal: 4.403 ± 0.085	0.808GluTrp: 0.808 ± 0.035	2.127GluTyr: 2.127 ± 0.063	0.0GluXaa: 0.0 ± 0.0
Phe	2.827PheAla: 2.827 ± 0.066	0.582PheCys: 0.582 ± 0.032	2.456PheAsp: 2.456 ± 0.06	2.638PheGlu: 2.638 ± 0.066	1.975PhePhe: 1.975 ± 0.062	3.476PheGly: 3.476 ± 0.085	0.696PheHis: 0.696 ± 0.03	2.518PheIle: 2.518 ± 0.065	2.205PheLys: 2.205 ± 0.062	4.082PheLeu: 4.082 ± 0.095	0.983PheMet: 0.983 ± 0.037	1.668PheAsn: 1.668 ± 0.043	1.705PhePro: 1.705 ± 0.052	1.093PheGln: 1.093 ± 0.047	1.726PheArg: 1.726 ± 0.059	3.362PheSer: 3.362 ± 0.074	2.526PheThr: 2.526 ± 0.071	3.412PheVal: 3.412 ± 0.083	0.614PheTrp: 0.614 ± 0.032	1.366PheTyr: 1.366 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	4.94GlyAla: 4.94 ± 0.114	0.984GlyCys: 0.984 ± 0.05	3.369GlyAsp: 3.369 ± 0.077	4.115GlyGlu: 4.115 ± 0.09	3.196GlyPhe: 3.196 ± 0.072	4.99GlyGly: 4.99 ± 0.129	1.16GlyHis: 1.16 ± 0.044	5.315GlyIle: 5.315 ± 0.099	5.118GlyLys: 5.118 ± 0.11	6.03GlyLeu: 6.03 ± 0.105	1.564GlyMet: 1.564 ± 0.048	3.129GlyAsn: 3.129 ± 0.088	2.046GlyPro: 2.046 ± 0.055	1.649GlyGln: 1.649 ± 0.051	2.71GlyArg: 2.71 ± 0.063	4.635GlySer: 4.635 ± 0.115	4.806GlyThr: 4.806 ± 0.126	5.663GlyVal: 5.663 ± 0.103	1.076GlyTrp: 1.076 ± 0.041	3.048GlyTyr: 3.048 ± 0.086	0.0GlyXaa: 0.0 ± 0.0
His	1.079HisAla: 1.079 ± 0.039	0.269HisCys: 0.269 ± 0.022	0.925HisAsp: 0.925 ± 0.038	1.045HisGlu: 1.045 ± 0.037	0.758HisPhe: 0.758 ± 0.034	1.342HisGly: 1.342 ± 0.047	0.34HisHis: 0.34 ± 0.024	1.174HisIle: 1.174 ± 0.044	1.109HisLys: 1.109 ± 0.043	1.554HisLeu: 1.554 ± 0.049	0.414HisMet: 0.414 ± 0.023	0.702HisAsn: 0.702 ± 0.033	0.911HisPro: 0.911 ± 0.039	0.455HisGln: 0.455 ± 0.024	0.705HisArg: 0.705 ± 0.031	1.143HisSer: 1.143 ± 0.041	0.92HisThr: 0.92 ± 0.041	1.269HisVal: 1.269 ± 0.048	0.206HisTrp: 0.206 ± 0.02	0.592HisTyr: 0.592 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.392IleAla: 5.392 ± 0.102	0.846IleCys: 0.846 ± 0.035	3.967IleAsp: 3.967 ± 0.087	4.73IleGlu: 4.73 ± 0.096	2.922IlePhe: 2.922 ± 0.066	4.976IleGly: 4.976 ± 0.101	1.271IleHis: 1.271 ± 0.05	5.398IleIle: 5.398 ± 0.116	4.382IleLys: 4.382 ± 0.096	6.848IleLeu: 6.848 ± 0.113	1.534IleMet: 1.534 ± 0.044	2.892IleAsn: 2.892 ± 0.069	3.157IlePro: 3.157 ± 0.072	2.3IleGln: 2.3 ± 0.062	2.979IleArg: 2.979 ± 0.067	4.962IleSer: 4.962 ± 0.095	4.47IleThr: 4.47 ± 0.09	5.755IleVal: 5.755 ± 0.102	0.76IleTrp: 0.76 ± 0.042	2.264IleTyr: 2.264 ± 0.07	0.0IleXaa: 0.0 ± 0.0
Lys	4.792LysAla: 4.792 ± 0.095	0.824LysCys: 0.824 ± 0.048	3.283LysAsp: 3.283 ± 0.089	5.138LysGlu: 5.138 ± 0.124	2.127LysPhe: 2.127 ± 0.06	3.809LysGly: 3.809 ± 0.091	1.26LysHis: 1.26 ± 0.048	5.322LysIle: 5.322 ± 0.111	6.231LysLys: 6.231 ± 0.131	6.42LysLeu: 6.42 ± 0.115	2.046LysMet: 2.046 ± 0.058	3.367LysAsn: 3.367 ± 0.076	2.722LysPro: 2.722 ± 0.073	2.715LysGln: 2.715 ± 0.07	3.596LysArg: 3.596 ± 0.084	3.453LysSer: 3.453 ± 0.083	4.917LysThr: 4.917 ± 0.095	4.635LysVal: 4.635 ± 0.108	0.642LysTrp: 0.642 ± 0.03	1.948LysTyr: 1.948 ± 0.056	0.0LysXaa: 0.0 ± 0.0
Leu	7.081LeuAla: 7.081 ± 0.129	1.118LeuCys: 1.118 ± 0.054	5.055LeuAsp: 5.055 ± 0.086	6.536LeuGlu: 6.536 ± 0.101	3.96LeuPhe: 3.96 ± 0.098	6.544LeuGly: 6.544 ± 0.115	1.536LeuHis: 1.536 ± 0.051	6.105LeuIle: 6.105 ± 0.117	6.614LeuLys: 6.614 ± 0.122	8.651LeuLeu: 8.651 ± 0.166	1.997LeuMet: 1.997 ± 0.058	3.982LeuAsn: 3.982 ± 0.087	3.599LeuPro: 3.599 ± 0.073	2.923LeuGln: 2.923 ± 0.078	4.18LeuArg: 4.18 ± 0.081	6.335LeuSer: 6.335 ± 0.105	5.915LeuThr: 5.915 ± 0.115	7.131LeuVal: 7.131 ± 0.12	1.177LeuTrp: 1.177 ± 0.056	2.591LeuTyr: 2.591 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	1.638MetAla: 1.638 ± 0.054	0.252MetCys: 0.252 ± 0.022	1.268MetAsp: 1.268 ± 0.046	1.411MetGlu: 1.411 ± 0.048	0.914MetPhe: 0.914 ± 0.037	1.722MetGly: 1.722 ± 0.045	0.417MetHis: 0.417 ± 0.021	1.492MetIle: 1.492 ± 0.049	1.941MetLys: 1.941 ± 0.059	2.23MetLeu: 2.23 ± 0.055	0.607MetMet: 0.607 ± 0.029	1.14MetAsn: 1.14 ± 0.048	1.1MetPro: 1.1 ± 0.039	0.796MetGln: 0.796 ± 0.036	0.976MetArg: 0.976 ± 0.042	1.617MetSer: 1.617 ± 0.054	1.478MetThr: 1.478 ± 0.048	1.73MetVal: 1.73 ± 0.055	0.274MetTrp: 0.274 ± 0.02	0.582MetTyr: 0.582 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	2.774AsnAla: 2.774 ± 0.068	0.66AsnCys: 0.66 ± 0.035	1.775AsnAsp: 1.775 ± 0.07	2.718AsnGlu: 2.718 ± 0.071	1.816AsnPhe: 1.816 ± 0.059	3.066AsnGly: 3.066 ± 0.075	0.676AsnHis: 0.676 ± 0.03	3.39AsnIle: 3.39 ± 0.084	2.886AsnLys: 2.886 ± 0.082	4.199AsnLeu: 4.199 ± 0.087	1.146AsnMet: 1.146 ± 0.044	2.367AsnAsn: 2.367 ± 0.114	2.336AsnPro: 2.336 ± 0.06	1.54AsnGln: 1.54 ± 0.055	1.819AsnArg: 1.819 ± 0.05	2.81AsnSer: 2.81 ± 0.07	2.554AsnThr: 2.554 ± 0.083	3.666AsnVal: 3.666 ± 0.083	0.671AsnTrp: 0.671 ± 0.034	1.749AsnTyr: 1.749 ± 0.059	0.0AsnXaa: 0.0 ± 0.0
Pro	2.701ProAla: 2.701 ± 0.072	0.458ProCys: 0.458 ± 0.027	2.403ProAsp: 2.403 ± 0.069	3.735ProGlu: 3.735 ± 0.089	1.814ProPhe: 1.814 ± 0.054	1.984ProGly: 1.984 ± 0.066	0.754ProHis: 0.754 ± 0.037	2.805ProIle: 2.805 ± 0.066	2.73ProLys: 2.73 ± 0.065	3.498ProLeu: 3.498 ± 0.077	0.883ProMet: 0.883 ± 0.039	1.786ProAsn: 1.786 ± 0.054	1.536ProPro: 1.536 ± 0.065	1.322ProGln: 1.322 ± 0.056	1.484ProArg: 1.484 ± 0.049	2.643ProSer: 2.643 ± 0.065	2.668ProThr: 2.668 ± 0.065	3.295ProVal: 3.295 ± 0.071	0.455ProTrp: 0.455 ± 0.032	1.35ProTyr: 1.35 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	2.096GlnAla: 2.096 ± 0.061	0.385GlnCys: 0.385 ± 0.027	1.31GlnAsp: 1.31 ± 0.051	1.969GlnGlu: 1.969 ± 0.056	1.154GlnPhe: 1.154 ± 0.043	1.659GlnGly: 1.659 ± 0.054	0.525GlnHis: 0.525 ± 0.029	2.444GlnIle: 2.444 ± 0.058	2.576GlnLys: 2.576 ± 0.069	2.887GlnLeu: 2.887 ± 0.071	0.796GlnMet: 0.796 ± 0.034	1.64GlnAsn: 1.64 ± 0.055	1.057GlnPro: 1.057 ± 0.042	1.216GlnGln: 1.216 ± 0.049	1.439GlnArg: 1.439 ± 0.05	1.777GlnSer: 1.777 ± 0.052	2.302GlnThr: 2.302 ± 0.065	2.207GlnVal: 2.207 ± 0.062	0.357GlnTrp: 0.357 ± 0.029	0.916GlnTyr: 0.916 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.686ArgAla: 2.686 ± 0.069	0.575ArgCys: 0.575 ± 0.033	1.995ArgAsp: 1.995 ± 0.067	2.637ArgGlu: 2.637 ± 0.082	1.93ArgPhe: 1.93 ± 0.054	2.68ArgGly: 2.68 ± 0.071	0.783ArgHis: 0.783 ± 0.037	3.034ArgIle: 3.034 ± 0.065	3.456ArgLys: 3.456 ± 0.073	4.031ArgLeu: 4.031 ± 0.089	1.064ArgMet: 1.064 ± 0.04	1.861ArgAsn: 1.861 ± 0.062	1.469ArgPro: 1.469 ± 0.047	1.275ArgGln: 1.275 ± 0.049	2.188ArgArg: 2.188 ± 0.067	2.141ArgSer: 2.141 ± 0.057	2.179ArgThr: 2.179 ± 0.063	3.023ArgVal: 3.023 ± 0.067	0.531ArgTrp: 0.531 ± 0.026	1.395ArgTyr: 1.395 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	4.314SerAla: 4.314 ± 0.089	0.813SerCys: 0.813 ± 0.037	3.333SerAsp: 3.333 ± 0.075	3.981SerGlu: 3.981 ± 0.083	3.062SerPhe: 3.062 ± 0.071	5.297SerGly: 5.297 ± 0.119	1.087SerHis: 1.087 ± 0.036	4.35SerIle: 4.35 ± 0.09	4.007SerLys: 4.007 ± 0.093	6.066SerLeu: 6.066 ± 0.106	1.515SerMet: 1.515 ± 0.048	2.701SerAsn: 2.701 ± 0.084	2.634SerPro: 2.634 ± 0.07	1.821SerGln: 1.821 ± 0.053	2.509SerArg: 2.509 ± 0.068	4.914SerSer: 4.914 ± 0.12	4.002SerThr: 4.002 ± 0.092	5.065SerVal: 5.065 ± 0.097	0.925SerTrp: 0.925 ± 0.039	2.355SerTyr: 2.355 ± 0.078	0.0SerXaa: 0.0 ± 0.0
Thr	4.509ThrAla: 4.509 ± 0.1	0.673ThrCys: 0.673 ± 0.034	3.218ThrAsp: 3.218 ± 0.086	4.171ThrGlu: 4.171 ± 0.104	2.599ThrPhe: 2.599 ± 0.069	5.009ThrGly: 5.009 ± 0.098	1.015ThrHis: 1.015 ± 0.043	5.138ThrIle: 5.138 ± 0.111	4.216ThrLys: 4.216 ± 0.083	5.857ThrLeu: 5.857 ± 0.107	1.395ThrMet: 1.395 ± 0.043	2.507ThrAsn: 2.507 ± 0.071	2.853ThrPro: 2.853 ± 0.091	1.948ThrGln: 1.948 ± 0.055	2.299ThrArg: 2.299 ± 0.066	3.76ThrSer: 3.76 ± 0.084	4.059ThrThr: 4.059 ± 0.102	5.744ThrVal: 5.744 ± 0.133	0.716ThrTrp: 0.716 ± 0.035	2.182ThrTyr: 2.182 ± 0.071	0.0ThrXaa: 0.0 ± 0.0
Val	6.34ValAla: 6.34 ± 0.092	1.209ValCys: 1.209 ± 0.052	4.666ValAsp: 4.666 ± 0.095	4.842ValGlu: 4.842 ± 0.108	3.425ValPhe: 3.425 ± 0.076	5.376ValGly: 5.376 ± 0.099	1.227ValHis: 1.227 ± 0.046	5.484ValIle: 5.484 ± 0.096	4.82ValLys: 4.82 ± 0.096	6.977ValLeu: 6.977 ± 0.12	1.718ValMet: 1.718 ± 0.06	3.543ValAsn: 3.543 ± 0.066	3.188ValPro: 3.188 ± 0.076	1.955ValGln: 1.955 ± 0.058	2.613ValArg: 2.613 ± 0.068	5.692ValSer: 5.692 ± 0.105	5.396ValThr: 5.396 ± 0.119	6.395ValVal: 6.395 ± 0.113	0.914ValTrp: 0.914 ± 0.043	2.996ValTyr: 2.996 ± 0.078	0.0ValXaa: 0.0 ± 0.0
Trp	0.766TrpAla: 0.766 ± 0.039	0.164TrpCys: 0.164 ± 0.017	0.744TrpAsp: 0.744 ± 0.039	0.699TrpGlu: 0.699 ± 0.034	0.562TrpPhe: 0.562 ± 0.032	0.93TrpGly: 0.93 ± 0.044	0.204TrpHis: 0.204 ± 0.02	0.843TrpIle: 0.843 ± 0.045	0.819TrpLys: 0.819 ± 0.033	1.02TrpLeu: 1.02 ± 0.039	0.396TrpMet: 0.396 ± 0.025	0.832TrpAsn: 0.832 ± 0.044	0.368TrpPro: 0.368 ± 0.029	0.378TrpGln: 0.378 ± 0.024	0.604TrpArg: 0.604 ± 0.029	0.93TrpSer: 0.93 ± 0.048	1.028TrpThr: 1.028 ± 0.051	0.804TrpVal: 0.804 ± 0.04	0.201TrpTrp: 0.201 ± 0.018	0.392TrpTyr: 0.392 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.445TyrAla: 2.445 ± 0.082	0.614TyrCys: 0.614 ± 0.029	2.149TyrAsp: 2.149 ± 0.059	1.972TyrGlu: 1.972 ± 0.058	1.508TyrPhe: 1.508 ± 0.048	2.683TyrGly: 2.683 ± 0.076	0.595TyrHis: 0.595 ± 0.03	2.056TyrIle: 2.056 ± 0.06	1.668TyrLys: 1.668 ± 0.051	3.119TyrLeu: 3.119 ± 0.067	0.763TyrMet: 0.763 ± 0.035	1.663TyrAsn: 1.663 ± 0.056	1.582TyrPro: 1.582 ± 0.049	0.867TyrGln: 0.867 ± 0.036	1.487TyrArg: 1.487 ± 0.055	2.643TyrSer: 2.643 ± 0.069	2.085TyrThr: 2.085 ± 0.077	2.711TyrVal: 2.711 ± 0.067	0.662TyrTrp: 0.662 ± 0.036	1.347TyrTyr: 1.347 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2329 proteins (642103 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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