Human papillomavirus 44

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Alphapapillomavirus; Alphapapillomavirus 10

Average proteome isoelectric point is 6.76

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 7 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>sp|Q80915|VE1_HPV44 Replication protein E1 OS=Human papillomavirus 44 OX=10592 GN=E1 PE=3 SV=1
MM1 pKa = 7.36HH2 pKa = 7.41GNYY5 pKa = 7.32TTLKK9 pKa = 10.19EE10 pKa = 3.95IVLQLEE16 pKa = 4.4PPDD19 pKa = 4.04PVGLHH24 pKa = 6.71CNEE27 pKa = 4.3QLDD30 pKa = 4.05SSEE33 pKa = 5.23DD34 pKa = 3.83EE35 pKa = 4.19VDD37 pKa = 3.73EE38 pKa = 5.18LATQATQDD46 pKa = 3.28VTQPYY51 pKa = 10.19QIVTTCGTCSRR62 pKa = 11.84KK63 pKa = 9.51VRR65 pKa = 11.84LVVQCTGTDD74 pKa = 2.73IHH76 pKa = 6.77HH77 pKa = 7.08LHH79 pKa = 6.15TLLLGSLDD87 pKa = 3.63ILCPVCAPKK96 pKa = 9.78TT97 pKa = 3.67

Molecular weight: 10.64 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>sp|Q80914|VE7_HPV44 Protein E7 OS=Human papillomavirus 44 OX=10592 GN=E7 PE=3 SV=1
TT1 pKa = 7.22IKK3 pKa = 10.79GCIMYY8 pKa = 9.05MVGIKK13 pKa = 10.01PIIQILKK20 pKa = 9.77RR21 pKa = 11.84RR22 pKa = 11.84PKK24 pKa = 11.19NMGTLYY30 pKa = 10.48NGRR33 pKa = 11.84YY34 pKa = 8.69VLAAVSYY41 pKa = 10.09VLLHH45 pKa = 6.87LYY47 pKa = 10.3LVLCKK52 pKa = 9.93TYY54 pKa = 10.34PLLGLLHH61 pKa = 6.78TPPPPPPPPLHH72 pKa = 6.8RR73 pKa = 11.84PHH75 pKa = 6.9PHH77 pKa = 6.75CPLAPPRR84 pKa = 11.84TAWTRR89 pKa = 11.84RR90 pKa = 11.84HH91 pKa = 5.86VNDD94 pKa = 5.16PEE96 pKa = 5.24DD97 pKa = 4.17PPQTPTTPEE106 pKa = 4.02TPSVSEE112 pKa = 4.16TATPWTVQTTTSSLTVTTVTKK133 pKa = 10.62DD134 pKa = 2.84GTTIIVQLRR143 pKa = 11.84LL144 pKa = 3.31

Molecular weight: 16.01 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

7

0

7

2371

97

643

338.7

37.77

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

6.706 ± 0.575

2.91 ± 0.592

5.146 ± 0.598

4.935 ± 0.568

3.627 ± 0.609

5.483 ± 0.361

2.657 ± 0.398

5.103 ± 0.652

5.23 ± 0.737

8.013 ± 0.707

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

2.024 ± 0.302

4.302 ± 0.719

6.748 ± 1.359

4.808 ± 0.433

4.471 ± 0.331

7.465 ± 1.032

8.309 ± 0.858

6.959 ± 0.289

1.518 ± 0.262

3.585 ± 0.414
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski