Amino acid dipepetide frequency for Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.54AlaAla: 5.54 ± 0.125
0.471AlaCys: 0.471 ± 0.032
2.338AlaAsp: 2.338 ± 0.061
3.539AlaGlu: 3.539 ± 0.092
2.498AlaPhe: 2.498 ± 0.064
4.671AlaGly: 4.671 ± 0.101
0.992AlaHis: 0.992 ± 0.041
5.33AlaIle: 5.33 ± 0.11
3.926AlaLys: 3.926 ± 0.098
9.953AlaLeu: 9.953 ± 0.174
1.935AlaMet: 1.935 ± 0.054
2.22AlaAsn: 2.22 ± 0.059
2.559AlaPro: 2.559 ± 0.065
1.493AlaGln: 1.493 ± 0.049
3.834AlaArg: 3.834 ± 0.078
5.32AlaSer: 5.32 ± 0.108
3.415AlaThr: 3.415 ± 0.084
7.062AlaVal: 7.062 ± 0.114
1.02AlaTrp: 1.02 ± 0.047
3.508AlaTyr: 3.508 ± 0.075
0.0AlaXaa: 0.0 ± 0.0
Cys
0.29CysAla: 0.29 ± 0.022
0.103CysCys: 0.103 ± 0.014
0.261CysAsp: 0.261 ± 0.022
0.29CysGlu: 0.29 ± 0.024
0.143CysPhe: 0.143 ± 0.016
0.775CysGly: 0.775 ± 0.043
0.107CysHis: 0.107 ± 0.014
0.516CysIle: 0.516 ± 0.029
0.195CysLys: 0.195 ± 0.02
0.559CysLeu: 0.559 ± 0.032
0.171CysMet: 0.171 ± 0.016
0.24CysAsn: 0.24 ± 0.02
0.577CysPro: 0.577 ± 0.039
0.103CysGln: 0.103 ± 0.013
0.458CysArg: 0.458 ± 0.028
0.606CysSer: 0.606 ± 0.031
0.346CysThr: 0.346 ± 0.025
0.491CysVal: 0.491 ± 0.033
0.082CysTrp: 0.082 ± 0.013
0.208CysTyr: 0.208 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
3.613AspAla: 3.613 ± 0.1
0.291AspCys: 0.291 ± 0.021
2.238AspAsp: 2.238 ± 0.075
3.854AspGlu: 3.854 ± 0.089
1.516AspPhe: 1.516 ± 0.044
2.914AspGly: 2.914 ± 0.077
0.577AspHis: 0.577 ± 0.028
2.841AspIle: 2.841 ± 0.068
2.618AspLys: 2.618 ± 0.068
4.841AspLeu: 4.841 ± 0.1
0.839AspMet: 0.839 ± 0.037
1.622AspAsn: 1.622 ± 0.056
2.34AspPro: 2.34 ± 0.065
0.707AspGln: 0.707 ± 0.034
1.762AspArg: 1.762 ± 0.057
2.716AspSer: 2.716 ± 0.073
1.802AspThr: 1.802 ± 0.057
4.601AspVal: 4.601 ± 0.093
0.746AspTrp: 0.746 ± 0.036
2.551AspTyr: 2.551 ± 0.063
0.0AspXaa: 0.0 ± 0.0
Glu
5.615GluAla: 5.615 ± 0.115
0.428GluCys: 0.428 ± 0.028
2.894GluAsp: 2.894 ± 0.072
4.503GluGlu: 4.503 ± 0.129
2.145GluPhe: 2.145 ± 0.059
3.899GluGly: 3.899 ± 0.091
0.852GluHis: 0.852 ± 0.036
3.09GluIle: 3.09 ± 0.087
2.441GluLys: 2.441 ± 0.073
8.216GluLeu: 8.216 ± 0.164
1.068GluMet: 1.068 ± 0.045
1.811GluAsn: 1.811 ± 0.064
2.468GluPro: 2.468 ± 0.061
1.03GluGln: 1.03 ± 0.043
2.962GluArg: 2.962 ± 0.089
3.285GluSer: 3.285 ± 0.072
2.396GluThr: 2.396 ± 0.07
5.961GluVal: 5.961 ± 0.125
0.789GluTrp: 0.789 ± 0.036
2.786GluTyr: 2.786 ± 0.065
0.0GluXaa: 0.0 ± 0.0
Phe
1.974PheAla: 1.974 ± 0.063
0.148PheCys: 0.148 ± 0.016
1.406PheAsp: 1.406 ± 0.057
1.586PheGlu: 1.586 ± 0.05
1.097PhePhe: 1.097 ± 0.044
2.187PheGly: 2.187 ± 0.073
0.554PheHis: 0.554 ± 0.032
3.516PheIle: 3.516 ± 0.088
2.308PheLys: 2.308 ± 0.063
2.881PheLeu: 2.881 ± 0.081
1.067PheMet: 1.067 ± 0.042
2.506PheAsn: 2.506 ± 0.071
1.167PhePro: 1.167 ± 0.044
0.574PheGln: 0.574 ± 0.033
1.82PheArg: 1.82 ± 0.061
2.275PheSer: 2.275 ± 0.063
2.576PheThr: 2.576 ± 0.072
1.664PheVal: 1.664 ± 0.062
0.344PheTrp: 0.344 ± 0.025
1.246PheTyr: 1.246 ± 0.046
0.0PheXaa: 0.0 ± 0.0
Gly
4.541GlyAla: 4.541 ± 0.099
0.489GlyCys: 0.489 ± 0.033
3.594GlyAsp: 3.594 ± 0.083
4.604GlyGlu: 4.604 ± 0.103
3.569GlyPhe: 3.569 ± 0.084
5.615GlyGly: 5.615 ± 0.108
1.135GlyHis: 1.135 ± 0.044
5.937GlyIle: 5.937 ± 0.111
4.317GlyLys: 4.317 ± 0.092
8.798GlyLeu: 8.798 ± 0.139
1.647GlyMet: 1.647 ± 0.053
3.035GlyAsn: 3.035 ± 0.075
2.373GlyPro: 2.373 ± 0.06
1.373GlyGln: 1.373 ± 0.054
4.044GlyArg: 4.044 ± 0.087
5.155GlySer: 5.155 ± 0.101
3.06GlyThr: 3.06 ± 0.089
7.648GlyVal: 7.648 ± 0.106
1.097GlyTrp: 1.097 ± 0.039
3.564GlyTyr: 3.564 ± 0.079
0.0GlyXaa: 0.0 ± 0.0
His
0.965HisAla: 0.965 ± 0.043
0.158HisCys: 0.158 ± 0.015
0.719HisAsp: 0.719 ± 0.035
0.967HisGlu: 0.967 ± 0.04
0.413HisPhe: 0.413 ± 0.028
1.443HisGly: 1.443 ± 0.049
0.31HisHis: 0.31 ± 0.024
0.937HisIle: 0.937 ± 0.041
0.514HisLys: 0.514 ± 0.029
1.331HisLeu: 1.331 ± 0.047
0.458HisMet: 0.458 ± 0.028
0.506HisAsn: 0.506 ± 0.031
0.842HisPro: 0.842 ± 0.036
0.27HisGln: 0.27 ± 0.021
0.899HisArg: 0.899 ± 0.042
0.81HisSer: 0.81 ± 0.042
0.582HisThr: 0.582 ± 0.03
1.469HisVal: 1.469 ± 0.054
0.295HisTrp: 0.295 ± 0.024
0.676HisTyr: 0.676 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
5.751IleAla: 5.751 ± 0.115
0.379IleCys: 0.379 ± 0.029
4.403IleAsp: 4.403 ± 0.092
5.017IleGlu: 5.017 ± 0.117
1.757IlePhe: 1.757 ± 0.052
5.991IleGly: 5.991 ± 0.13
1.338IleHis: 1.338 ± 0.048
7.27IleIle: 7.27 ± 0.145
5.257IleLys: 5.257 ± 0.081
6.928IleLeu: 6.928 ± 0.124
2.295IleMet: 2.295 ± 0.066
5.741IleAsn: 5.741 ± 0.115
4.105IlePro: 4.105 ± 0.09
1.335IleGln: 1.335 ± 0.042
4.756IleArg: 4.756 ± 0.103
4.696IleSer: 4.696 ± 0.098
4.114IleThr: 4.114 ± 0.091
6.052IleVal: 6.052 ± 0.103
0.679IleTrp: 0.679 ± 0.038
2.862IleTyr: 2.862 ± 0.069
0.0IleXaa: 0.0 ± 0.0
Lys
4.927LysAla: 4.927 ± 0.092
0.479LysCys: 0.479 ± 0.031
2.479LysAsp: 2.479 ± 0.072
3.125LysGlu: 3.125 ± 0.09
1.235LysPhe: 1.235 ± 0.051
3.999LysGly: 3.999 ± 0.082
0.78LysHis: 0.78 ± 0.034
2.846LysIle: 2.846 ± 0.093
1.3LysLys: 1.3 ± 0.06
5.683LysLeu: 5.683 ± 0.11
1.053LysMet: 1.053 ± 0.042
1.338LysAsn: 1.338 ± 0.052
3.566LysPro: 3.566 ± 0.076
0.872LysGln: 0.872 ± 0.037
2.531LysArg: 2.531 ± 0.08
2.626LysSer: 2.626 ± 0.068
1.849LysThr: 1.849 ± 0.06
5.465LysVal: 5.465 ± 0.098
0.747LysTrp: 0.747 ± 0.035
2.747LysTyr: 2.747 ± 0.061
0.0LysXaa: 0.0 ± 0.0
Leu
8.269LeuAla: 8.269 ± 0.139
0.546LeuCys: 0.546 ± 0.03
3.962LeuAsp: 3.962 ± 0.094
4.916LeuGlu: 4.916 ± 0.103
3.113LeuPhe: 3.113 ± 0.088
8.295LeuGly: 8.295 ± 0.128
1.261LeuHis: 1.261 ± 0.046
10.354LeuIle: 10.354 ± 0.18
5.528LeuLys: 5.528 ± 0.104
9.86LeuLeu: 9.86 ± 0.172
3.534LeuMet: 3.534 ± 0.092
5.688LeuAsn: 5.688 ± 0.108
4.315LeuPro: 4.315 ± 0.086
1.551LeuGln: 1.551 ± 0.055
6.967LeuArg: 6.967 ± 0.128
8.746LeuSer: 8.746 ± 0.135
6.999LeuThr: 6.999 ± 0.127
7.928LeuVal: 7.928 ± 0.133
1.122LeuTrp: 1.122 ± 0.044
3.802LeuTyr: 3.802 ± 0.081
0.0LeuXaa: 0.0 ± 0.0
Met
2.01MetAla: 2.01 ± 0.067
0.107MetCys: 0.107 ± 0.013
1.245MetAsp: 1.245 ± 0.046
1.391MetGlu: 1.391 ± 0.054
0.722MetPhe: 0.722 ± 0.035
2.498MetGly: 2.498 ± 0.074
0.519MetHis: 0.519 ± 0.031
2.1MetIle: 2.1 ± 0.065
0.884MetLys: 0.884 ± 0.038
2.674MetLeu: 2.674 ± 0.077
0.641MetMet: 0.641 ± 0.037
1.336MetAsn: 1.336 ± 0.048
1.383MetPro: 1.383 ± 0.049
0.547MetGln: 0.547 ± 0.03
1.583MetArg: 1.583 ± 0.054
2.062MetSer: 2.062 ± 0.06
1.01MetThr: 1.01 ± 0.046
2.521MetVal: 2.521 ± 0.062
0.293MetTrp: 0.293 ± 0.021
0.978MetTyr: 0.978 ± 0.041
0.0MetXaa: 0.0 ± 0.0
Asn
3.678AsnAla: 3.678 ± 0.084
0.384AsnCys: 0.384 ± 0.025
2.453AsnAsp: 2.453 ± 0.064
3.36AsnGlu: 3.36 ± 0.082
1.067AsnPhe: 1.067 ± 0.043
4.18AsnGly: 4.18 ± 0.107
0.649AsnHis: 0.649 ± 0.034
3.315AsnIle: 3.315 ± 0.08
1.882AsnLys: 1.882 ± 0.055
4.267AsnLeu: 4.267 ± 0.086
1.193AsnMet: 1.193 ± 0.041
2.132AsnAsn: 2.132 ± 0.076
3.01AsnPro: 3.01 ± 0.078
1.015AsnGln: 1.015 ± 0.04
1.892AsnArg: 1.892 ± 0.07
2.524AsnSer: 2.524 ± 0.083
2.233AsnThr: 2.233 ± 0.069
4.283AsnVal: 4.283 ± 0.093
0.711AsnTrp: 0.711 ± 0.039
2.157AsnTyr: 2.157 ± 0.061
0.0AsnXaa: 0.0 ± 0.0
Pro
2.232ProAla: 2.232 ± 0.062
0.333ProCys: 0.333 ± 0.022
1.96ProAsp: 1.96 ± 0.063
2.681ProGlu: 2.681 ± 0.078
1.631ProPhe: 1.631 ± 0.057
3.39ProGly: 3.39 ± 0.082
0.737ProHis: 0.737 ± 0.037
3.767ProIle: 3.767 ± 0.069
1.832ProLys: 1.832 ± 0.057
4.643ProLeu: 4.643 ± 0.093
1.2ProMet: 1.2 ± 0.042
1.995ProAsn: 1.995 ± 0.063
2.406ProPro: 2.406 ± 0.079
1.273ProGln: 1.273 ± 0.056
2.526ProArg: 2.526 ± 0.069
3.431ProSer: 3.431 ± 0.085
2.311ProThr: 2.311 ± 0.072
3.886ProVal: 3.886 ± 0.082
0.827ProTrp: 0.827 ± 0.045
2.213ProTyr: 2.213 ± 0.071
0.0ProXaa: 0.0 ± 0.0
Gln
1.418GlnAla: 1.418 ± 0.047
0.216GlnCys: 0.216 ± 0.02
0.759GlnAsp: 0.759 ± 0.035
0.99GlnGlu: 0.99 ± 0.046
0.731GlnPhe: 0.731 ± 0.034
1.463GlnGly: 1.463 ± 0.049
0.286GlnHis: 0.286 ± 0.021
1.018GlnIle: 1.018 ± 0.044
0.411GlnLys: 0.411 ± 0.025
2.406GlnLeu: 2.406 ± 0.061
0.547GlnMet: 0.547 ± 0.025
0.559GlnAsn: 0.559 ± 0.036
0.924GlnPro: 0.924 ± 0.044
0.567GlnGln: 0.567 ± 0.042
1.03GlnArg: 1.03 ± 0.043
1.115GlnSer: 1.115 ± 0.049
0.629GlnThr: 0.629 ± 0.034
2.068GlnVal: 2.068 ± 0.067
0.369GlnTrp: 0.369 ± 0.027
1.205GlnTyr: 1.205 ± 0.047
0.0GlnXaa: 0.0 ± 0.0
Arg
3.02ArgAla: 3.02 ± 0.076
0.368ArgCys: 0.368 ± 0.031
2.869ArgAsp: 2.869 ± 0.073
3.982ArgGlu: 3.982 ± 0.1
2.243ArgPhe: 2.243 ± 0.073
4.689ArgGly: 4.689 ± 0.094
0.882ArgHis: 0.882 ± 0.042
4.976ArgIle: 4.976 ± 0.099
2.073ArgLys: 2.073 ± 0.057
6.586ArgLeu: 6.586 ± 0.14
1.38ArgMet: 1.38 ± 0.048
2.202ArgAsn: 2.202 ± 0.059
1.89ArgPro: 1.89 ± 0.069
1.163ArgGln: 1.163 ± 0.045
4.994ArgArg: 4.994 ± 0.105
3.069ArgSer: 3.069 ± 0.074
1.827ArgThr: 1.827 ± 0.063
5.561ArgVal: 5.561 ± 0.106
0.657ArgTrp: 0.657 ± 0.034
2.205ArgTyr: 2.205 ± 0.064
0.0ArgXaa: 0.0 ± 0.0
Ser
3.491SerAla: 3.491 ± 0.084
0.391SerCys: 0.391 ± 0.027
2.776SerAsp: 2.776 ± 0.066
3.864SerGlu: 3.864 ± 0.09
2.217SerPhe: 2.217 ± 0.058
5.122SerGly: 5.122 ± 0.112
0.82SerHis: 0.82 ± 0.04
6.573SerIle: 6.573 ± 0.111
3.265SerLys: 3.265 ± 0.078
7.19SerLeu: 7.19 ± 0.135
2.32SerMet: 2.32 ± 0.069
3.258SerAsn: 3.258 ± 0.088
2.441SerPro: 2.441 ± 0.071
1.308SerGln: 1.308 ± 0.049
4.43SerArg: 4.43 ± 0.101
5.119SerSer: 5.119 ± 0.139
3.949SerThr: 3.949 ± 0.12
5.032SerVal: 5.032 ± 0.093
0.789SerTrp: 0.789 ± 0.041
2.496SerTyr: 2.496 ± 0.076
0.0SerXaa: 0.0 ± 0.0
Thr
3.784ThrAla: 3.784 ± 0.099
0.354ThrCys: 0.354 ± 0.027
1.704ThrAsp: 1.704 ± 0.055
2.273ThrGlu: 2.273 ± 0.059
1.403ThrPhe: 1.403 ± 0.058
4.332ThrGly: 4.332 ± 0.096
0.857ThrHis: 0.857 ± 0.04
4.205ThrIle: 4.205 ± 0.091
1.827ThrLys: 1.827 ± 0.056
5.621ThrLeu: 5.621 ± 0.105
1.468ThrMet: 1.468 ± 0.05
1.789ThrAsn: 1.789 ± 0.066
2.767ThrPro: 2.767 ± 0.079
1.305ThrGln: 1.305 ± 0.051
2.381ThrArg: 2.381 ± 0.075
3.24ThrSer: 3.24 ± 0.096
3.21ThrThr: 3.21 ± 0.166
4.991ThrVal: 4.991 ± 0.115
0.819ThrTrp: 0.819 ± 0.039
2.393ThrTyr: 2.393 ± 0.075
0.0ThrXaa: 0.0 ± 0.0
Val
6.35ValAla: 6.35 ± 0.119
0.431ValCys: 0.431 ± 0.028
4.282ValAsp: 4.282 ± 0.105
4.916ValGlu: 4.916 ± 0.099
3.172ValPhe: 3.172 ± 0.084
5.28ValGly: 5.28 ± 0.098
1.138ValHis: 1.138 ± 0.046
8.061ValIle: 8.061 ± 0.127
7.38ValLys: 7.38 ± 0.125
8.179ValLeu: 8.179 ± 0.137
2.26ValMet: 2.26 ± 0.06
6.134ValAsn: 6.134 ± 0.121
3.4ValPro: 3.4 ± 0.086
1.251ValGln: 1.251 ± 0.05
4.411ValArg: 4.411 ± 0.095
5.904ValSer: 5.904 ± 0.1
5.556ValThr: 5.556 ± 0.124
7.397ValVal: 7.397 ± 0.137
0.752ValTrp: 0.752 ± 0.035
3.561ValTyr: 3.561 ± 0.074
0.0ValXaa: 0.0 ± 0.0
Trp
0.889TrpAla: 0.889 ± 0.045
0.111TrpCys: 0.111 ± 0.014
0.689TrpAsp: 0.689 ± 0.036
0.544TrpGlu: 0.544 ± 0.033
0.684TrpPhe: 0.684 ± 0.031
1.185TrpGly: 1.185 ± 0.048
0.186TrpHis: 0.186 ± 0.019
0.882TrpIle: 0.882 ± 0.043
0.318TrpLys: 0.318 ± 0.024
1.556TrpLeu: 1.556 ± 0.051
0.266TrpMet: 0.266 ± 0.019
0.493TrpAsn: 0.493 ± 0.028
0.567TrpPro: 0.567 ± 0.039
0.251TrpGln: 0.251 ± 0.023
0.957TrpArg: 0.957 ± 0.042
0.99TrpSer: 0.99 ± 0.05
0.526TrpThr: 0.526 ± 0.034
1.298TrpVal: 1.298 ± 0.047
0.25TrpTrp: 0.25 ± 0.02
0.561TrpTyr: 0.561 ± 0.037
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.268TyrAla: 3.268 ± 0.078
0.331TyrCys: 0.331 ± 0.027
1.957TyrAsp: 1.957 ± 0.058
2.235TyrGlu: 2.235 ± 0.059
1.541TyrPhe: 1.541 ± 0.047
3.673TyrGly: 3.673 ± 0.079
0.581TyrHis: 0.581 ± 0.033
3.192TyrIle: 3.192 ± 0.076
1.373TyrLys: 1.373 ± 0.046
4.586TyrLeu: 4.586 ± 0.09
1.16TyrMet: 1.16 ± 0.046
1.781TyrAsn: 1.781 ± 0.075
2.173TyrPro: 2.173 ± 0.063
0.724TyrGln: 0.724 ± 0.037
2.4TyrArg: 2.4 ± 0.073
3.162TyrSer: 3.162 ± 0.073
2.331TyrThr: 2.331 ± 0.064
4.436TyrVal: 4.436 ± 0.086
0.817TyrTrp: 0.817 ± 0.037
2.227TyrTyr: 2.227 ± 0.078
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1962 proteins (600938 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski