Amino acid dipepetide frequency for Methanonatronarchaeum thermophilum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.88AlaAla: 3.88 ± 0.126
0.541AlaCys: 0.541 ± 0.044
2.862AlaAsp: 2.862 ± 0.082
4.452AlaGlu: 4.452 ± 0.105
1.924AlaPhe: 1.924 ± 0.07
4.496AlaGly: 4.496 ± 0.123
0.894AlaHis: 0.894 ± 0.048
5.376AlaIle: 5.376 ± 0.133
3.725AlaLys: 3.725 ± 0.109
5.381AlaLeu: 5.381 ± 0.126
1.51AlaMet: 1.51 ± 0.057
1.928AlaAsn: 1.928 ± 0.07
1.679AlaPro: 1.679 ± 0.063
1.317AlaGln: 1.317 ± 0.06
2.688AlaArg: 2.688 ± 0.086
3.189AlaSer: 3.189 ± 0.094
2.965AlaThr: 2.965 ± 0.103
4.379AlaVal: 4.379 ± 0.099
0.477AlaTrp: 0.477 ± 0.038
1.761AlaTyr: 1.761 ± 0.067
0.0AlaXaa: 0.0 ± 0.0
Cys
0.452CysAla: 0.452 ± 0.035
0.115CysCys: 0.115 ± 0.017
0.583CysAsp: 0.583 ± 0.041
0.593CysGlu: 0.593 ± 0.036
0.334CysPhe: 0.334 ± 0.03
1.094CysGly: 1.094 ± 0.067
0.226CysHis: 0.226 ± 0.024
0.788CysIle: 0.788 ± 0.045
0.623CysLys: 0.623 ± 0.036
0.762CysLeu: 0.762 ± 0.048
0.209CysMet: 0.209 ± 0.023
0.548CysAsn: 0.548 ± 0.037
0.649CysPro: 0.649 ± 0.046
0.299CysGln: 0.299 ± 0.026
0.527CysArg: 0.527 ± 0.039
0.755CysSer: 0.755 ± 0.044
0.423CysThr: 0.423 ± 0.037
0.55CysVal: 0.55 ± 0.037
0.08CysTrp: 0.08 ± 0.013
0.266CysTyr: 0.266 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
2.893AspAla: 2.893 ± 0.086
0.649AspCys: 0.649 ± 0.044
2.643AspAsp: 2.643 ± 0.116
4.896AspGlu: 4.896 ± 0.16
2.434AspPhe: 2.434 ± 0.089
4.268AspGly: 4.268 ± 0.118
0.922AspHis: 0.922 ± 0.048
6.27AspIle: 6.27 ± 0.131
4.485AspLys: 4.485 ± 0.118
5.853AspLeu: 5.853 ± 0.137
1.366AspMet: 1.366 ± 0.054
2.218AspAsn: 2.218 ± 0.087
2.316AspPro: 2.316 ± 0.078
1.616AspGln: 1.616 ± 0.073
3.194AspArg: 3.194 ± 0.099
3.137AspSer: 3.137 ± 0.097
2.697AspThr: 2.697 ± 0.072
4.588AspVal: 4.588 ± 0.121
0.668AspTrp: 0.668 ± 0.045
2.145AspTyr: 2.145 ± 0.072
0.0AspXaa: 0.0 ± 0.0
Glu
4.285GluAla: 4.285 ± 0.11
0.727GluCys: 0.727 ± 0.051
4.741GluAsp: 4.741 ± 0.139
7.678GluGlu: 7.678 ± 0.18
2.791GluPhe: 2.791 ± 0.084
5.042GluGly: 5.042 ± 0.129
1.291GluHis: 1.291 ± 0.056
9.632GluIle: 9.632 ± 0.166
8.678GluLys: 8.678 ± 0.185
7.624GluLeu: 7.624 ± 0.159
2.152GluMet: 2.152 ± 0.078
4.781GluAsn: 4.781 ± 0.128
2.479GluPro: 2.479 ± 0.077
2.208GluGln: 2.208 ± 0.078
3.593GluArg: 3.593 ± 0.106
3.549GluSer: 3.549 ± 0.108
4.889GluThr: 4.889 ± 0.121
6.265GluVal: 6.265 ± 0.155
0.743GluTrp: 0.743 ± 0.045
2.714GluTyr: 2.714 ± 0.08
0.0GluXaa: 0.0 ± 0.0
Phe
1.761PheAla: 1.761 ± 0.065
0.383PheCys: 0.383 ± 0.032
2.361PheAsp: 2.361 ± 0.094
2.627PheGlu: 2.627 ± 0.085
1.496PhePhe: 1.496 ± 0.069
2.78PheGly: 2.78 ± 0.095
0.576PheHis: 0.576 ± 0.04
2.834PheIle: 2.834 ± 0.082
2.667PheLys: 2.667 ± 0.089
3.415PheLeu: 3.415 ± 0.114
0.661PheMet: 0.661 ± 0.038
1.752PheAsn: 1.752 ± 0.07
1.204PhePro: 1.204 ± 0.055
0.985PheGln: 0.985 ± 0.051
1.298PheArg: 1.298 ± 0.052
2.38PheSer: 2.38 ± 0.081
1.839PheThr: 1.839 ± 0.062
2.319PheVal: 2.319 ± 0.085
0.374PheTrp: 0.374 ± 0.03
1.263PheTyr: 1.263 ± 0.054
0.0PheXaa: 0.0 ± 0.0
Gly
4.198GlyAla: 4.198 ± 0.112
1.023GlyCys: 1.023 ± 0.063
4.273GlyAsp: 4.273 ± 0.11
6.105GlyGlu: 6.105 ± 0.118
3.114GlyPhe: 3.114 ± 0.088
5.331GlyGly: 5.331 ± 0.143
1.275GlyHis: 1.275 ± 0.057
5.74GlyIle: 5.74 ± 0.128
4.419GlyLys: 4.419 ± 0.09
6.545GlyLeu: 6.545 ± 0.136
1.768GlyMet: 1.768 ± 0.07
2.537GlyAsn: 2.537 ± 0.079
1.994GlyPro: 1.994 ± 0.06
1.623GlyGln: 1.623 ± 0.057
3.21GlyArg: 3.21 ± 0.109
4.278GlySer: 4.278 ± 0.116
3.662GlyThr: 3.662 ± 0.106
5.978GlyVal: 5.978 ± 0.156
0.757GlyTrp: 0.757 ± 0.039
2.933GlyTyr: 2.933 ± 0.078
0.0GlyXaa: 0.0 ± 0.0
His
0.915HisAla: 0.915 ± 0.048
0.247HisCys: 0.247 ± 0.021
0.936HisAsp: 0.936 ± 0.039
1.143HisGlu: 1.143 ± 0.058
0.595HisPhe: 0.595 ± 0.035
1.397HisGly: 1.397 ± 0.061
0.496HisHis: 0.496 ± 0.032
1.496HisIle: 1.496 ± 0.06
1.427HisLys: 1.427 ± 0.06
1.637HisLeu: 1.637 ± 0.057
0.386HisMet: 0.386 ± 0.03
0.957HisAsn: 0.957 ± 0.055
1.152HisPro: 1.152 ± 0.054
0.743HisGln: 0.743 ± 0.039
0.887HisArg: 0.887 ± 0.042
0.955HisSer: 0.955 ± 0.047
1.07HisThr: 1.07 ± 0.05
0.957HisVal: 0.957 ± 0.05
0.158HisTrp: 0.158 ± 0.022
0.607HisTyr: 0.607 ± 0.042
0.0HisXaa: 0.0 ± 0.0
Ile
5.726IleAla: 5.726 ± 0.139
0.694IleCys: 0.694 ± 0.037
6.234IleAsp: 6.234 ± 0.139
8.579IleGlu: 8.579 ± 0.164
2.655IlePhe: 2.655 ± 0.092
6.218IleGly: 6.218 ± 0.15
1.554IleHis: 1.554 ± 0.064
6.352IleIle: 6.352 ± 0.151
7.944IleLys: 7.944 ± 0.163
7.006IleLeu: 7.006 ± 0.154
1.712IleMet: 1.712 ± 0.061
4.459IleAsn: 4.459 ± 0.109
3.847IlePro: 3.847 ± 0.094
2.975IleGln: 2.975 ± 0.093
2.796IleArg: 2.796 ± 0.087
5.089IleSer: 5.089 ± 0.114
5.526IleThr: 5.526 ± 0.151
4.976IleVal: 4.976 ± 0.118
0.574IleTrp: 0.574 ± 0.041
2.497IleTyr: 2.497 ± 0.091
0.0IleXaa: 0.0 ± 0.0
Lys
4.663LysAla: 4.663 ± 0.125
0.743LysCys: 0.743 ± 0.048
4.398LysAsp: 4.398 ± 0.098
7.603LysGlu: 7.603 ± 0.166
1.973LysPhe: 1.973 ± 0.073
4.595LysGly: 4.595 ± 0.117
1.919LysHis: 1.919 ± 0.078
8.059LysIle: 8.059 ± 0.173
9.931LysLys: 9.931 ± 0.224
6.737LysLeu: 6.737 ± 0.143
1.881LysMet: 1.881 ± 0.065
5.743LysAsn: 5.743 ± 0.153
3.302LysPro: 3.302 ± 0.109
4.188LysGln: 4.188 ± 0.153
3.21LysArg: 3.21 ± 0.076
3.417LysSer: 3.417 ± 0.111
6.937LysThr: 6.937 ± 0.194
4.188LysVal: 4.188 ± 0.107
0.609LysTrp: 0.609 ± 0.046
2.65LysTyr: 2.65 ± 0.089
0.0LysXaa: 0.0 ± 0.0
Leu
4.868LeuAla: 4.868 ± 0.123
0.71LeuCys: 0.71 ± 0.04
6.016LeuAsp: 6.016 ± 0.139
7.238LeuGlu: 7.238 ± 0.126
3.194LeuPhe: 3.194 ± 0.118
6.044LeuGly: 6.044 ± 0.132
1.463LeuHis: 1.463 ± 0.057
7.184LeuIle: 7.184 ± 0.171
7.725LeuLys: 7.725 ± 0.177
7.361LeuLeu: 7.361 ± 0.205
1.987LeuMet: 1.987 ± 0.07
4.562LeuAsn: 4.562 ± 0.121
3.384LeuPro: 3.384 ± 0.094
2.556LeuGln: 2.556 ± 0.088
3.375LeuArg: 3.375 ± 0.099
5.414LeuSer: 5.414 ± 0.123
4.981LeuThr: 4.981 ± 0.135
5.83LeuVal: 5.83 ± 0.15
0.635LeuTrp: 0.635 ± 0.044
2.432LeuTyr: 2.432 ± 0.081
0.0LeuXaa: 0.0 ± 0.0
Met
1.583MetAla: 1.583 ± 0.063
0.165MetCys: 0.165 ± 0.02
1.677MetAsp: 1.677 ± 0.062
1.975MetGlu: 1.975 ± 0.079
0.745MetPhe: 0.745 ± 0.042
1.578MetGly: 1.578 ± 0.07
0.428MetHis: 0.428 ± 0.032
1.493MetIle: 1.493 ± 0.063
1.926MetLys: 1.926 ± 0.067
1.651MetLeu: 1.651 ± 0.061
0.567MetMet: 0.567 ± 0.04
1.098MetAsn: 1.098 ± 0.047
0.807MetPro: 0.807 ± 0.048
0.501MetGln: 0.501 ± 0.029
0.88MetArg: 0.88 ± 0.043
1.453MetSer: 1.453 ± 0.059
1.303MetThr: 1.303 ± 0.053
1.712MetVal: 1.712 ± 0.07
0.181MetTrp: 0.181 ± 0.021
0.607MetTyr: 0.607 ± 0.039
0.0MetXaa: 0.0 ± 0.0
Asn
2.316AsnAla: 2.316 ± 0.076
0.524AsnCys: 0.524 ± 0.037
2.145AsnAsp: 2.145 ± 0.081
3.793AsnGlu: 3.793 ± 0.116
1.298AsnPhe: 1.298 ± 0.054
2.862AsnGly: 2.862 ± 0.08
1.042AsnHis: 1.042 ± 0.043
4.407AsnIle: 4.407 ± 0.121
5.308AsnLys: 5.308 ± 0.142
4.369AsnLeu: 4.369 ± 0.102
1.016AsnMet: 1.016 ± 0.045
2.584AsnAsn: 2.584 ± 0.091
2.843AsnPro: 2.843 ± 0.088
2.664AsnGln: 2.664 ± 0.107
2.135AsnArg: 2.135 ± 0.069
2.269AsnSer: 2.269 ± 0.066
2.707AsnThr: 2.707 ± 0.087
2.58AsnVal: 2.58 ± 0.084
0.477AsnTrp: 0.477 ± 0.032
1.703AsnTyr: 1.703 ± 0.065
0.0AsnXaa: 0.0 ± 0.0
Pro
1.766ProAla: 1.766 ± 0.068
0.317ProCys: 0.317 ± 0.031
2.479ProAsp: 2.479 ± 0.078
4.202ProGlu: 4.202 ± 0.109
1.418ProPhe: 1.418 ± 0.061
2.688ProGly: 2.688 ± 0.092
0.764ProHis: 0.764 ± 0.047
3.182ProIle: 3.182 ± 0.089
3.076ProLys: 3.076 ± 0.089
2.961ProLeu: 2.961 ± 0.086
0.67ProMet: 0.67 ± 0.045
1.954ProAsn: 1.954 ± 0.072
1.43ProPro: 1.43 ± 0.064
1.232ProGln: 1.232 ± 0.06
1.232ProArg: 1.232 ± 0.057
2.135ProSer: 2.135 ± 0.069
2.641ProThr: 2.641 ± 0.079
2.766ProVal: 2.766 ± 0.078
0.343ProTrp: 0.343 ± 0.03
1.253ProTyr: 1.253 ± 0.058
0.0ProXaa: 0.0 ± 0.0
Gln
1.7GlnAla: 1.7 ± 0.07
0.254GlnCys: 0.254 ± 0.025
1.507GlnAsp: 1.507 ± 0.058
2.925GlnGlu: 2.925 ± 0.086
0.842GlnPhe: 0.842 ± 0.052
1.594GlnGly: 1.594 ± 0.062
0.628GlnHis: 0.628 ± 0.04
2.864GlnIle: 2.864 ± 0.085
4.454GlnLys: 4.454 ± 0.158
2.74GlnLeu: 2.74 ± 0.089
0.694GlnMet: 0.694 ± 0.04
2.069GlnAsn: 2.069 ± 0.081
1.058GlnPro: 1.058 ± 0.052
1.303GlnGln: 1.303 ± 0.07
1.176GlnArg: 1.176 ± 0.051
1.242GlnSer: 1.242 ± 0.052
2.323GlnThr: 2.323 ± 0.093
1.531GlnVal: 1.531 ± 0.062
0.193GlnTrp: 0.193 ± 0.019
0.929GlnTyr: 0.929 ± 0.05
0.0GlnXaa: 0.0 ± 0.0
Arg
2.356ArgAla: 2.356 ± 0.081
0.487ArgCys: 0.487 ± 0.04
2.895ArgAsp: 2.895 ± 0.086
4.48ArgGlu: 4.48 ± 0.113
1.674ArgPhe: 1.674 ± 0.073
2.632ArgGly: 2.632 ± 0.093
0.738ArgHis: 0.738 ± 0.041
3.165ArgIle: 3.165 ± 0.096
3.516ArgLys: 3.516 ± 0.095
3.269ArgLeu: 3.269 ± 0.088
1.002ArgMet: 1.002 ± 0.048
1.902ArgAsn: 1.902 ± 0.071
1.338ArgPro: 1.338 ± 0.062
1.244ArgGln: 1.244 ± 0.053
2.051ArgArg: 2.051 ± 0.08
2.211ArgSer: 2.211 ± 0.083
1.865ArgThr: 1.865 ± 0.064
2.836ArgVal: 2.836 ± 0.091
0.442ArgTrp: 0.442 ± 0.036
1.825ArgTyr: 1.825 ± 0.07
0.0ArgXaa: 0.0 ± 0.0
Ser
2.679SerAla: 2.679 ± 0.093
0.586SerCys: 0.586 ± 0.04
3.238SerAsp: 3.238 ± 0.099
4.339SerGlu: 4.339 ± 0.121
2.227SerPhe: 2.227 ± 0.08
4.527SerGly: 4.527 ± 0.115
1.086SerHis: 1.086 ± 0.059
4.802SerIle: 4.802 ± 0.122
4.264SerLys: 4.264 ± 0.117
4.877SerLeu: 4.877 ± 0.107
1.293SerMet: 1.293 ± 0.058
2.406SerAsn: 2.406 ± 0.078
1.992SerPro: 1.992 ± 0.069
1.688SerGln: 1.688 ± 0.062
2.606SerArg: 2.606 ± 0.088
3.306SerSer: 3.306 ± 0.107
2.695SerThr: 2.695 ± 0.093
3.617SerVal: 3.617 ± 0.103
0.527SerTrp: 0.527 ± 0.04
1.754SerTyr: 1.754 ± 0.073
0.0SerXaa: 0.0 ± 0.0
Thr
3.727ThrAla: 3.727 ± 0.094
0.43ThrCys: 0.43 ± 0.032
3.123ThrAsp: 3.123 ± 0.093
4.565ThrGlu: 4.565 ± 0.116
1.698ThrPhe: 1.698 ± 0.075
4.532ThrGly: 4.532 ± 0.108
1.082ThrHis: 1.082 ± 0.052
5.185ThrIle: 5.185 ± 0.13
5.033ThrLys: 5.033 ± 0.162
4.941ThrLeu: 4.941 ± 0.112
1.178ThrMet: 1.178 ± 0.048
2.789ThrAsn: 2.789 ± 0.115
3.027ThrPro: 3.027 ± 0.082
2.022ThrGln: 2.022 ± 0.076
2.004ThrArg: 2.004 ± 0.066
2.857ThrSer: 2.857 ± 0.09
4.16ThrThr: 4.16 ± 0.137
3.603ThrVal: 3.603 ± 0.113
0.409ThrTrp: 0.409 ± 0.031
1.726ThrTyr: 1.726 ± 0.059
0.0ThrXaa: 0.0 ± 0.0
Val
3.716ValAla: 3.716 ± 0.095
0.825ValCys: 0.825 ± 0.049
4.929ValAsp: 4.929 ± 0.153
6.034ValGlu: 6.034 ± 0.134
2.98ValPhe: 2.98 ± 0.101
6.074ValGly: 6.074 ± 0.164
1.148ValHis: 1.148 ± 0.046
4.83ValIle: 4.83 ± 0.13
4.254ValLys: 4.254 ± 0.111
5.867ValLeu: 5.867 ± 0.182
1.406ValMet: 1.406 ± 0.062
2.566ValAsn: 2.566 ± 0.076
2.345ValPro: 2.345 ± 0.085
1.338ValGln: 1.338 ± 0.056
2.817ValArg: 2.817 ± 0.091
4.16ValSer: 4.16 ± 0.099
3.128ValThr: 3.128 ± 0.089
5.931ValVal: 5.931 ± 0.189
0.626ValTrp: 0.626 ± 0.039
1.961ValTyr: 1.961 ± 0.075
0.0ValXaa: 0.0 ± 0.0
Trp
0.433TrpAla: 0.433 ± 0.033
0.068TrpCys: 0.068 ± 0.013
0.529TrpAsp: 0.529 ± 0.035
0.564TrpGlu: 0.564 ± 0.039
0.397TrpPhe: 0.397 ± 0.031
0.564TrpGly: 0.564 ± 0.041
0.134TrpHis: 0.134 ± 0.018
0.917TrpIle: 0.917 ± 0.056
0.689TrpLys: 0.689 ± 0.039
0.825TrpLeu: 0.825 ± 0.047
0.212TrpMet: 0.212 ± 0.025
0.43TrpAsn: 0.43 ± 0.034
0.254TrpPro: 0.254 ± 0.025
0.24TrpGln: 0.24 ± 0.027
0.522TrpArg: 0.522 ± 0.034
0.597TrpSer: 0.597 ± 0.042
0.376TrpThr: 0.376 ± 0.03
0.595TrpVal: 0.595 ± 0.043
0.141TrpTrp: 0.141 ± 0.019
0.256TrpTyr: 0.256 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.507TyrAla: 1.507 ± 0.061
0.386TyrCys: 0.386 ± 0.032
1.688TyrAsp: 1.688 ± 0.066
2.072TyrGlu: 2.072 ± 0.073
1.185TyrPhe: 1.185 ± 0.056
2.446TyrGly: 2.446 ± 0.074
0.494TyrHis: 0.494 ± 0.037
2.836TyrIle: 2.836 ± 0.094
2.606TyrLys: 2.606 ± 0.072
3.137TyrLeu: 3.137 ± 0.101
0.656TyrMet: 0.656 ± 0.041
1.759TyrAsn: 1.759 ± 0.073
1.411TyrPro: 1.411 ± 0.063
1.284TyrGln: 1.284 ± 0.058
1.728TyrArg: 1.728 ± 0.073
2.116TyrSer: 2.116 ± 0.075
1.902TyrThr: 1.902 ± 0.073
1.736TyrVal: 1.736 ± 0.069
0.332TyrTrp: 0.332 ± 0.031
1.169TyrTyr: 1.169 ± 0.054
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1510 proteins (425233 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski