Amino acid dipepetide frequency for Thauera sp. 27

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.528AlaAla: 18.528 ± 0.19	1.438AlaCys: 1.438 ± 0.041	7.244AlaAsp: 7.244 ± 0.077	7.985AlaGlu: 7.985 ± 0.083	4.196AlaPhe: 4.196 ± 0.06	11.356AlaGly: 11.356 ± 0.147	2.855AlaHis: 2.855 ± 0.047	5.403AlaIle: 5.403 ± 0.072	3.098AlaLys: 3.098 ± 0.057	15.556AlaLeu: 15.556 ± 0.153	3.308AlaMet: 3.308 ± 0.052	2.858AlaAsn: 2.858 ± 0.046	5.762AlaPro: 5.762 ± 0.092	4.805AlaGln: 4.805 ± 0.066	10.296AlaArg: 10.296 ± 0.116	6.416AlaSer: 6.416 ± 0.092	5.672AlaThr: 5.672 ± 0.065	9.19AlaVal: 9.19 ± 0.085	1.909AlaTrp: 1.909 ± 0.044	2.486AlaTyr: 2.486 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	1.235CysAla: 1.235 ± 0.032	0.133CysCys: 0.133 ± 0.011	0.583CysAsp: 0.583 ± 0.021	0.552CysGlu: 0.552 ± 0.023	0.322CysPhe: 0.322 ± 0.014	1.039CysGly: 1.039 ± 0.032	0.291CysHis: 0.291 ± 0.017	0.419CysIle: 0.419 ± 0.019	0.234CysLys: 0.234 ± 0.014	0.86CysLeu: 0.86 ± 0.026	0.184CysMet: 0.184 ± 0.01	0.24CysAsn: 0.24 ± 0.012	0.505CysPro: 0.505 ± 0.022	0.242CysGln: 0.242 ± 0.014	0.72CysArg: 0.72 ± 0.026	0.49CysSer: 0.49 ± 0.022	0.474CysThr: 0.474 ± 0.021	0.694CysVal: 0.694 ± 0.026	0.132CysTrp: 0.132 ± 0.01	0.228CysTyr: 0.228 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.362AspAla: 7.362 ± 0.08	0.507AspCys: 0.507 ± 0.02	3.095AspAsp: 3.095 ± 0.058	3.757AspGlu: 3.757 ± 0.057	2.169AspPhe: 2.169 ± 0.041	5.018AspGly: 5.018 ± 0.08	1.201AspHis: 1.201 ± 0.031	2.725AspIle: 2.725 ± 0.048	1.685AspLys: 1.685 ± 0.037	5.367AspLeu: 5.367 ± 0.062	1.201AspMet: 1.201 ± 0.031	1.302AspAsn: 1.302 ± 0.032	3.021AspPro: 3.021 ± 0.053	1.556AspGln: 1.556 ± 0.033	3.711AspArg: 3.711 ± 0.055	2.459AspSer: 2.459 ± 0.053	2.83AspThr: 2.83 ± 0.044	3.939AspVal: 3.939 ± 0.068	1.023AspTrp: 1.023 ± 0.027	1.518AspTyr: 1.518 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	8.043GluAla: 8.043 ± 0.079	0.444GluCys: 0.444 ± 0.019	2.759GluAsp: 2.759 ± 0.049	2.818GluGlu: 2.818 ± 0.053	1.802GluPhe: 1.802 ± 0.036	4.406GluGly: 4.406 ± 0.059	1.616GluHis: 1.616 ± 0.034	3.132GluIle: 3.132 ± 0.049	1.651GluLys: 1.651 ± 0.042	6.751GluLeu: 6.751 ± 0.086	1.311GluMet: 1.311 ± 0.03	1.232GluAsn: 1.232 ± 0.028	2.573GluPro: 2.573 ± 0.051	2.595GluGln: 2.595 ± 0.049	5.808GluArg: 5.808 ± 0.078	2.598GluSer: 2.598 ± 0.043	2.742GluThr: 2.742 ± 0.043	4.529GluVal: 4.529 ± 0.053	0.78GluTrp: 0.78 ± 0.025	1.121GluTyr: 1.121 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.395PheAla: 4.395 ± 0.058	0.392PheCys: 0.392 ± 0.019	2.534PheAsp: 2.534 ± 0.052	2.389PheGlu: 2.389 ± 0.05	1.342PhePhe: 1.342 ± 0.037	3.421PheGly: 3.421 ± 0.06	0.775PheHis: 0.775 ± 0.026	1.631PheIle: 1.631 ± 0.035	0.958PheLys: 0.958 ± 0.028	3.001PheLeu: 3.001 ± 0.051	0.76PheMet: 0.76 ± 0.025	1.079PheAsn: 1.079 ± 0.03	1.447PhePro: 1.447 ± 0.029	0.943PheGln: 0.943 ± 0.028	2.147PheArg: 2.147 ± 0.041	2.089PheSer: 2.089 ± 0.044	1.661PheThr: 1.661 ± 0.041	2.931PheVal: 2.931 ± 0.054	0.501PheTrp: 0.501 ± 0.021	0.816PheTyr: 0.816 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	9.266GlyAla: 9.266 ± 0.102	0.977GlyCys: 0.977 ± 0.028	4.269GlyAsp: 4.269 ± 0.071	5.405GlyGlu: 5.405 ± 0.07	3.379GlyPhe: 3.379 ± 0.055	7.009GlyGly: 7.009 ± 0.09	1.917GlyHis: 1.917 ± 0.038	4.034GlyIle: 4.034 ± 0.06	3.008GlyLys: 3.008 ± 0.057	9.402GlyLeu: 9.402 ± 0.1	2.368GlyMet: 2.368 ± 0.041	2.116GlyAsn: 2.116 ± 0.06	2.732GlyPro: 2.732 ± 0.049	2.911GlyGln: 2.911 ± 0.056	6.449GlyArg: 6.449 ± 0.071	4.421GlySer: 4.421 ± 0.095	4.166GlyThr: 4.166 ± 0.068	6.717GlyVal: 6.717 ± 0.085	1.419GlyTrp: 1.419 ± 0.036	2.138GlyTyr: 2.138 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.964HisAla: 2.964 ± 0.046	0.292HisCys: 0.292 ± 0.018	1.337HisAsp: 1.337 ± 0.032	1.198HisGlu: 1.198 ± 0.025	0.888HisPhe: 0.888 ± 0.027	2.206HisGly: 2.206 ± 0.04	0.664HisHis: 0.664 ± 0.024	0.948HisIle: 0.948 ± 0.023	0.547HisLys: 0.547 ± 0.019	2.37HisLeu: 2.37 ± 0.043	0.501HisMet: 0.501 ± 0.019	0.533HisAsn: 0.533 ± 0.021	1.497HisPro: 1.497 ± 0.037	0.695HisGln: 0.695 ± 0.023	1.63HisArg: 1.63 ± 0.04	0.985HisSer: 0.985 ± 0.026	1.097HisThr: 1.097 ± 0.028	1.593HisVal: 1.593 ± 0.036	0.394HisTrp: 0.394 ± 0.015	0.687HisTyr: 0.687 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.343IleAla: 6.343 ± 0.067	0.404IleCys: 0.404 ± 0.018	3.458IleAsp: 3.458 ± 0.042	3.586IleGlu: 3.586 ± 0.052	1.364IlePhe: 1.364 ± 0.036	4.435IleGly: 4.435 ± 0.061	1.01IleHis: 1.01 ± 0.03	1.761IleIle: 1.761 ± 0.044	1.281IleLys: 1.281 ± 0.03	3.693IleLeu: 3.693 ± 0.058	0.792IleMet: 0.792 ± 0.026	1.48IleAsn: 1.48 ± 0.035	2.101IlePro: 2.101 ± 0.045	1.21IleGln: 1.21 ± 0.029	3.015IleArg: 3.015 ± 0.047	2.334IleSer: 2.334 ± 0.044	2.485IleThr: 2.485 ± 0.046	3.711IleVal: 3.711 ± 0.057	0.439IleTrp: 0.439 ± 0.019	0.935IleTyr: 0.935 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.552LysAla: 3.552 ± 0.063	0.168LysCys: 0.168 ± 0.012	1.482LysAsp: 1.482 ± 0.037	1.386LysGlu: 1.386 ± 0.04	0.769LysPhe: 0.769 ± 0.029	2.159LysGly: 2.159 ± 0.047	0.623LysHis: 0.623 ± 0.024	1.3LysIle: 1.3 ± 0.032	1.027LysLys: 1.027 ± 0.035	3.116LysLeu: 3.116 ± 0.057	0.655LysMet: 0.655 ± 0.023	0.749LysAsn: 0.749 ± 0.026	1.681LysPro: 1.681 ± 0.037	1.026LysGln: 1.026 ± 0.025	2.162LysArg: 2.162 ± 0.046	1.348LysSer: 1.348 ± 0.035	1.46LysThr: 1.46 ± 0.035	2.377LysVal: 2.377 ± 0.045	0.327LysTrp: 0.327 ± 0.016	0.64LysTyr: 0.64 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	15.803LeuAla: 15.803 ± 0.149	1.02LeuCys: 1.02 ± 0.029	6.537LeuAsp: 6.537 ± 0.076	6.193LeuGlu: 6.193 ± 0.082	3.581LeuPhe: 3.581 ± 0.057	8.977LeuGly: 8.977 ± 0.096	2.372LeuHis: 2.372 ± 0.044	4.732LeuIle: 4.732 ± 0.064	3.151LeuLys: 3.151 ± 0.05	11.456LeuLeu: 11.456 ± 0.139	2.326LeuMet: 2.326 ± 0.043	2.685LeuAsn: 2.685 ± 0.049	6.2LeuPro: 6.2 ± 0.063	3.663LeuGln: 3.663 ± 0.06	8.395LeuArg: 8.395 ± 0.107	6.036LeuSer: 6.036 ± 0.075	4.983LeuThr: 4.983 ± 0.065	7.915LeuVal: 7.915 ± 0.087	1.235LeuTrp: 1.235 ± 0.034	2.123LeuTyr: 2.123 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	2.706MetAla: 2.706 ± 0.045	0.18MetCys: 0.18 ± 0.012	1.132MetAsp: 1.132 ± 0.031	1.047MetGlu: 1.047 ± 0.025	0.705MetPhe: 0.705 ± 0.023	1.705MetGly: 1.705 ± 0.037	0.537MetHis: 0.537 ± 0.021	1.082MetIle: 1.082 ± 0.031	0.956MetLys: 0.956 ± 0.029	2.653MetLeu: 2.653 ± 0.044	0.608MetMet: 0.608 ± 0.024	0.85MetAsn: 0.85 ± 0.024	1.386MetPro: 1.386 ± 0.034	0.999MetGln: 0.999 ± 0.023	1.842MetArg: 1.842 ± 0.04	1.63MetSer: 1.63 ± 0.036	1.357MetThr: 1.357 ± 0.032	1.673MetVal: 1.673 ± 0.033	0.203MetTrp: 0.203 ± 0.012	0.36MetTyr: 0.36 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.201AsnAla: 3.201 ± 0.052	0.267AsnCys: 0.267 ± 0.015	1.306AsnAsp: 1.306 ± 0.03	1.215AsnGlu: 1.215 ± 0.029	0.86AsnPhe: 0.86 ± 0.026	2.084AsnGly: 2.084 ± 0.053	0.511AsnHis: 0.511 ± 0.019	1.201AsnIle: 1.201 ± 0.032	0.72AsnLys: 0.72 ± 0.026	2.725AsnLeu: 2.725 ± 0.051	0.585AsnMet: 0.585 ± 0.019	0.663AsnAsn: 0.663 ± 0.03	1.767AsnPro: 1.767 ± 0.038	0.761AsnGln: 0.761 ± 0.026	1.785AsnArg: 1.785 ± 0.035	1.02AsnSer: 1.02 ± 0.027	1.359AsnThr: 1.359 ± 0.03	1.881AsnVal: 1.881 ± 0.051	0.372AsnTrp: 0.372 ± 0.017	0.646AsnTyr: 0.646 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	7.056ProAla: 7.056 ± 0.083	0.379ProCys: 0.379 ± 0.019	3.074ProAsp: 3.074 ± 0.049	3.479ProGlu: 3.479 ± 0.052	1.731ProPhe: 1.731 ± 0.038	4.497ProGly: 4.497 ± 0.062	1.066ProHis: 1.066 ± 0.029	1.921ProIle: 1.921 ± 0.039	1.211ProLys: 1.211 ± 0.037	5.085ProLeu: 5.085 ± 0.054	1.168ProMet: 1.168 ± 0.032	1.174ProAsn: 1.174 ± 0.028	2.484ProPro: 2.484 ± 0.061	1.768ProGln: 1.768 ± 0.037	3.067ProArg: 3.067 ± 0.051	2.443ProSer: 2.443 ± 0.042	2.333ProThr: 2.333 ± 0.056	4.05ProVal: 4.05 ± 0.064	0.739ProTrp: 0.739 ± 0.025	1.049ProTyr: 1.049 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	5.064GlnAla: 5.064 ± 0.073	0.27GlnCys: 0.27 ± 0.015	1.552GlnAsp: 1.552 ± 0.038	1.462GlnGlu: 1.462 ± 0.035	1.11GlnPhe: 1.11 ± 0.027	2.762GlnGly: 2.762 ± 0.043	0.833GlnHis: 0.833 ± 0.025	1.651GlnIle: 1.651 ± 0.032	0.928GlnLys: 0.928 ± 0.03	3.679GlnLeu: 3.679 ± 0.052	0.838GlnMet: 0.838 ± 0.025	0.662GlnAsn: 0.662 ± 0.022	2.003GlnPro: 2.003 ± 0.041	1.521GlnGln: 1.521 ± 0.037	3.058GlnArg: 3.058 ± 0.05	1.67GlnSer: 1.67 ± 0.038	1.554GlnThr: 1.554 ± 0.039	2.72GlnVal: 2.72 ± 0.053	0.534GlnTrp: 0.534 ± 0.018	0.681GlnTyr: 0.681 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	8.829ArgAla: 8.829 ± 0.115	0.704ArgCys: 0.704 ± 0.024	4.005ArgAsp: 4.005 ± 0.058	4.705ArgGlu: 4.705 ± 0.063	3.126ArgPhe: 3.126 ± 0.045	4.959ArgGly: 4.959 ± 0.06	2.078ArgHis: 2.078 ± 0.042	4.225ArgIle: 4.225 ± 0.051	2.142ArgLys: 2.142 ± 0.044	9.068ArgLeu: 9.068 ± 0.106	2.093ArgMet: 2.093 ± 0.038	2.025ArgAsn: 2.025 ± 0.042	3.427ArgPro: 3.427 ± 0.054	2.878ArgGln: 2.878 ± 0.045	5.945ArgArg: 5.945 ± 0.099	3.77ArgSer: 3.77 ± 0.058	3.344ArgThr: 3.344 ± 0.055	5.446ArgVal: 5.446 ± 0.068	1.193ArgTrp: 1.193 ± 0.034	2.003ArgTyr: 2.003 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	6.673SerAla: 6.673 ± 0.092	0.456SerCys: 0.456 ± 0.02	2.404SerAsp: 2.404 ± 0.046	2.586SerGlu: 2.586 ± 0.054	2.032SerPhe: 2.032 ± 0.042	5.101SerGly: 5.101 ± 0.087	1.132SerHis: 1.132 ± 0.03	2.462SerIle: 2.462 ± 0.046	1.266SerLys: 1.266 ± 0.038	5.497SerLeu: 5.497 ± 0.083	1.221SerMet: 1.221 ± 0.031	1.293SerAsn: 1.293 ± 0.036	2.627SerPro: 2.627 ± 0.048	1.524SerGln: 1.524 ± 0.034	3.633SerArg: 3.633 ± 0.058	2.724SerSer: 2.724 ± 0.057	2.667SerThr: 2.667 ± 0.047	3.761SerVal: 3.761 ± 0.059	0.726SerTrp: 0.726 ± 0.025	1.12SerTyr: 1.12 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	5.847ThrAla: 5.847 ± 0.075	0.383ThrCys: 0.383 ± 0.016	2.512ThrAsp: 2.512 ± 0.059	2.549ThrGlu: 2.549 ± 0.043	1.511ThrPhe: 1.511 ± 0.035	4.336ThrGly: 4.336 ± 0.053	1.112ThrHis: 1.112 ± 0.029	2.11ThrIle: 2.11 ± 0.043	1.003ThrLys: 1.003 ± 0.032	6.175ThrLeu: 6.175 ± 0.077	0.998ThrMet: 0.998 ± 0.03	1.151ThrAsn: 1.151 ± 0.04	3.206ThrPro: 3.206 ± 0.051	1.56ThrGln: 1.56 ± 0.035	3.547ThrArg: 3.547 ± 0.05	2.184ThrSer: 2.184 ± 0.044	2.469ThrThr: 2.469 ± 0.05	4.033ThrVal: 4.033 ± 0.088	0.634ThrTrp: 0.634 ± 0.019	0.983ThrTyr: 0.983 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	9.623ValAla: 9.623 ± 0.095	0.757ValCys: 0.757 ± 0.027	4.337ValAsp: 4.337 ± 0.062	4.673ValGlu: 4.673 ± 0.053	2.938ValPhe: 2.938 ± 0.049	5.818ValGly: 5.818 ± 0.068	1.558ValHis: 1.558 ± 0.037	3.671ValIle: 3.671 ± 0.054	2.114ValLys: 2.114 ± 0.05	8.427ValLeu: 8.427 ± 0.101	1.904ValMet: 1.904 ± 0.045	1.851ValAsn: 1.851 ± 0.045	3.641ValPro: 3.641 ± 0.055	2.394ValGln: 2.394 ± 0.043	5.617ValArg: 5.617 ± 0.064	4.412ValSer: 4.412 ± 0.073	3.847ValThr: 3.847 ± 0.081	6.615ValVal: 6.615 ± 0.077	0.912ValTrp: 0.912 ± 0.027	1.363ValTyr: 1.363 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.301TrpAla: 1.301 ± 0.036	0.162TrpCys: 0.162 ± 0.011	0.618TrpAsp: 0.618 ± 0.023	0.625TrpGlu: 0.625 ± 0.023	0.499TrpPhe: 0.499 ± 0.02	0.895TrpGly: 0.895 ± 0.026	0.366TrpHis: 0.366 ± 0.015	0.65TrpIle: 0.65 ± 0.022	0.433TrpLys: 0.433 ± 0.018	2.062TrpLeu: 2.062 ± 0.041	0.379TrpMet: 0.379 ± 0.017	0.427TrpAsn: 0.427 ± 0.017	0.642TrpPro: 0.642 ± 0.022	0.701TrpGln: 0.701 ± 0.022	1.236TrpArg: 1.236 ± 0.035	0.752TrpSer: 0.752 ± 0.022	0.669TrpThr: 0.669 ± 0.032	1.088TrpVal: 1.088 ± 0.029	0.228TrpTrp: 0.228 ± 0.014	0.305TrpTyr: 0.305 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.571TyrAla: 2.571 ± 0.047	0.242TyrCys: 0.242 ± 0.014	1.211TyrAsp: 1.211 ± 0.038	1.1TyrGlu: 1.1 ± 0.031	0.887TyrPhe: 0.887 ± 0.024	1.919TyrGly: 1.919 ± 0.039	0.511TyrHis: 0.511 ± 0.019	0.779TyrIle: 0.779 ± 0.027	0.592TyrLys: 0.592 ± 0.02	2.436TyrLeu: 2.436 ± 0.046	0.41TyrMet: 0.41 ± 0.017	0.562TyrAsn: 0.562 ± 0.02	1.071TyrPro: 1.071 ± 0.033	0.799TyrGln: 0.799 ± 0.026	1.904TyrArg: 1.904 ± 0.037	1.124TyrSer: 1.124 ± 0.027	1.134TyrThr: 1.134 ± 0.031	1.61TyrVal: 1.61 ± 0.034	0.336TyrTrp: 0.336 ± 0.015	0.59TyrTyr: 0.59 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4268 proteins (1408651 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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