Amino acid dipepetide frequency for Novipirellula artificiosorum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.673AlaAla: 10.673 ± 0.088	1.124AlaCys: 1.124 ± 0.023	6.067AlaAsp: 6.067 ± 0.058	6.397AlaGlu: 6.397 ± 0.064	3.274AlaPhe: 3.274 ± 0.036	7.329AlaGly: 7.329 ± 0.071	1.522AlaHis: 1.522 ± 0.024	5.857AlaIle: 5.857 ± 0.053	4.081AlaLys: 4.081 ± 0.046	7.45AlaLeu: 7.45 ± 0.059	2.716AlaMet: 2.716 ± 0.04	3.221AlaAsn: 3.221 ± 0.046	3.674AlaPro: 3.674 ± 0.04	2.974AlaGln: 2.974 ± 0.035	4.939AlaArg: 4.939 ± 0.055	6.534AlaSer: 6.534 ± 0.054	5.929AlaThr: 5.929 ± 0.068	6.708AlaVal: 6.708 ± 0.063	1.347AlaTrp: 1.347 ± 0.027	2.1AlaTyr: 2.1 ± 0.028	0.0AlaXaa: 0.0 ± 0.0
Cys	0.754CysAla: 0.754 ± 0.018	0.285CysCys: 0.285 ± 0.012	0.838CysAsp: 0.838 ± 0.02	0.735CysGlu: 0.735 ± 0.02	0.488CysPhe: 0.488 ± 0.012	1.098CysGly: 1.098 ± 0.027	0.406CysHis: 0.406 ± 0.018	0.534CysIle: 0.534 ± 0.014	0.367CysLys: 0.367 ± 0.012	1.128CysLeu: 1.128 ± 0.023	0.223CysMet: 0.223 ± 0.009	0.355CysAsn: 0.355 ± 0.013	0.589CysPro: 0.589 ± 0.018	0.47CysGln: 0.47 ± 0.015	0.819CysArg: 0.819 ± 0.019	0.788CysSer: 0.788 ± 0.019	0.549CysThr: 0.549 ± 0.017	0.872CysVal: 0.872 ± 0.021	0.206CysTrp: 0.206 ± 0.007	0.348CysTyr: 0.348 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.506AspAla: 6.506 ± 0.073	0.709AspCys: 0.709 ± 0.02	4.098AspAsp: 4.098 ± 0.052	4.098AspGlu: 4.098 ± 0.045	2.481AspPhe: 2.481 ± 0.033	5.614AspGly: 5.614 ± 0.086	1.53AspHis: 1.53 ± 0.023	2.42AspIle: 2.42 ± 0.032	1.803AspLys: 1.803 ± 0.029	5.969AspLeu: 5.969 ± 0.054	1.033AspMet: 1.033 ± 0.02	1.742AspAsn: 1.742 ± 0.03	3.965AspPro: 3.965 ± 0.047	2.781AspGln: 2.781 ± 0.034	4.586AspArg: 4.586 ± 0.041	4.116AspSer: 4.116 ± 0.058	2.828AspThr: 2.828 ± 0.073	4.398AspVal: 4.398 ± 0.046	1.194AspTrp: 1.194 ± 0.023	1.742AspTyr: 1.742 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	5.63GluAla: 5.63 ± 0.058	0.537GluCys: 0.537 ± 0.016	2.932GluAsp: 2.932 ± 0.04	3.14GluGlu: 3.14 ± 0.048	2.182GluPhe: 2.182 ± 0.025	3.901GluGly: 3.901 ± 0.044	1.347GluHis: 1.347 ± 0.02	3.472GluIle: 3.472 ± 0.034	2.642GluLys: 2.642 ± 0.039	6.266GluLeu: 6.266 ± 0.071	1.669GluMet: 1.669 ± 0.028	2.113GluAsn: 2.113 ± 0.028	2.865GluPro: 2.865 ± 0.039	3.034GluGln: 3.034 ± 0.044	3.827GluArg: 3.827 ± 0.049	4.471GluSer: 4.471 ± 0.048	3.837GluThr: 3.837 ± 0.047	4.136GluVal: 4.136 ± 0.045	0.764GluTrp: 0.764 ± 0.017	1.384GluTyr: 1.384 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	3.763PheAla: 3.763 ± 0.038	0.526PheCys: 0.526 ± 0.014	2.994PheAsp: 2.994 ± 0.038	2.346PheGlu: 2.346 ± 0.031	1.553PhePhe: 1.553 ± 0.027	3.276PheGly: 3.276 ± 0.039	0.864PheHis: 0.864 ± 0.019	1.415PheIle: 1.415 ± 0.025	1.051PheLys: 1.051 ± 0.02	3.396PheLeu: 3.396 ± 0.041	0.666PheMet: 0.666 ± 0.017	1.212PheAsn: 1.212 ± 0.023	1.616PhePro: 1.616 ± 0.026	1.262PheGln: 1.262 ± 0.024	2.328PheArg: 2.328 ± 0.031	2.489PheSer: 2.489 ± 0.034	2.038PheThr: 2.038 ± 0.034	2.896PheVal: 2.896 ± 0.034	0.568PheTrp: 0.568 ± 0.014	1.038PheTyr: 1.038 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	5.56GlyAla: 5.56 ± 0.061	1.058GlyCys: 1.058 ± 0.024	4.923GlyAsp: 4.923 ± 0.07	4.538GlyGlu: 4.538 ± 0.05	3.135GlyPhe: 3.135 ± 0.035	6.53GlyGly: 6.53 ± 0.087	1.702GlyHis: 1.702 ± 0.029	4.131GlyIle: 4.131 ± 0.045	3.728GlyLys: 3.728 ± 0.051	6.514GlyLeu: 6.514 ± 0.06	1.995GlyMet: 1.995 ± 0.034	2.903GlyAsn: 2.903 ± 0.066	3.205GlyPro: 3.205 ± 0.037	3.157GlyGln: 3.157 ± 0.036	4.846GlyArg: 4.846 ± 0.05	5.107GlySer: 5.107 ± 0.072	4.538GlyThr: 4.538 ± 0.084	5.423GlyVal: 5.423 ± 0.047	1.392GlyTrp: 1.392 ± 0.029	2.311GlyTyr: 2.311 ± 0.029	0.001GlyXaa: 0.001 ± 0.001
His	2.053HisAla: 2.053 ± 0.032	0.353HisCys: 0.353 ± 0.013	1.382HisAsp: 1.382 ± 0.022	1.183HisGlu: 1.183 ± 0.022	0.998HisPhe: 0.998 ± 0.019	1.789HisGly: 1.789 ± 0.03	0.753HisHis: 0.753 ± 0.018	0.772HisIle: 0.772 ± 0.019	0.521HisLys: 0.521 ± 0.015	2.226HisLeu: 2.226 ± 0.03	0.365HisMet: 0.365 ± 0.014	0.652HisAsn: 0.652 ± 0.017	1.493HisPro: 1.493 ± 0.027	1.005HisGln: 1.005 ± 0.02	1.712HisArg: 1.712 ± 0.032	1.381HisSer: 1.381 ± 0.027	0.956HisThr: 0.956 ± 0.021	1.54HisVal: 1.54 ± 0.025	0.51HisTrp: 0.51 ± 0.015	0.707HisTyr: 0.707 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	5.906IleAla: 5.906 ± 0.048	0.615IleCys: 0.615 ± 0.015	4.331IleAsp: 4.331 ± 0.047	4.057IleGlu: 4.057 ± 0.045	1.381IlePhe: 1.381 ± 0.028	4.285IleGly: 4.285 ± 0.042	1.187IleHis: 1.187 ± 0.023	1.734IleIle: 1.734 ± 0.027	1.559IleLys: 1.559 ± 0.024	3.989IleLeu: 3.989 ± 0.046	0.739IleMet: 0.739 ± 0.018	1.574IleAsn: 1.574 ± 0.031	2.58IlePro: 2.58 ± 0.036	1.826IleGln: 1.826 ± 0.025	3.547IleArg: 3.547 ± 0.042	3.012IleSer: 3.012 ± 0.037	2.721IleThr: 2.721 ± 0.049	3.995IleVal: 3.995 ± 0.042	0.632IleTrp: 0.632 ± 0.015	1.175IleTyr: 1.175 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	3.151LysAla: 3.151 ± 0.048	0.308LysCys: 0.308 ± 0.01	1.855LysAsp: 1.855 ± 0.032	2.006LysGlu: 2.006 ± 0.038	1.089LysPhe: 1.089 ± 0.021	2.26LysGly: 2.26 ± 0.034	0.9LysHis: 0.9 ± 0.019	1.866LysIle: 1.866 ± 0.029	1.723LysLys: 1.723 ± 0.041	3.639LysLeu: 3.639 ± 0.047	0.995LysMet: 0.995 ± 0.022	1.249LysAsn: 1.249 ± 0.024	2.407LysPro: 2.407 ± 0.036	1.879LysGln: 1.879 ± 0.03	2.639LysArg: 2.639 ± 0.037	2.38LysSer: 2.38 ± 0.032	2.419LysThr: 2.419 ± 0.032	2.437LysVal: 2.437 ± 0.032	0.62LysTrp: 0.62 ± 0.017	0.938LysTyr: 0.938 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	9.963LeuAla: 9.963 ± 0.081	1.183LeuCys: 1.183 ± 0.025	6.075LeuAsp: 6.075 ± 0.053	5.246LeuGlu: 5.246 ± 0.057	3.46LeuPhe: 3.46 ± 0.041	6.878LeuGly: 6.878 ± 0.06	1.979LeuHis: 1.979 ± 0.034	4.537LeuIle: 4.537 ± 0.048	3.388LeuLys: 3.388 ± 0.046	9.245LeuLeu: 9.245 ± 0.08	2.099LeuMet: 2.099 ± 0.032	2.775LeuAsn: 2.775 ± 0.033	5.164LeuPro: 5.164 ± 0.055	3.641LeuGln: 3.641 ± 0.041	6.533LeuArg: 6.533 ± 0.067	6.635LeuSer: 6.635 ± 0.051	5.347LeuThr: 5.347 ± 0.065	6.824LeuVal: 6.824 ± 0.055	1.248LeuTrp: 1.248 ± 0.023	2.169LeuTyr: 2.169 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	2.144MetAla: 2.144 ± 0.029	0.206MetCys: 0.206 ± 0.01	1.182MetAsp: 1.182 ± 0.021	1.14MetGlu: 1.14 ± 0.022	0.714MetPhe: 0.714 ± 0.018	1.556MetGly: 1.556 ± 0.026	0.484MetHis: 0.484 ± 0.013	1.369MetIle: 1.369 ± 0.023	1.124MetLys: 1.124 ± 0.024	2.405MetLeu: 2.405 ± 0.038	0.672MetMet: 0.672 ± 0.018	0.938MetAsn: 0.938 ± 0.018	1.377MetPro: 1.377 ± 0.026	1.038MetGln: 1.038 ± 0.021	1.516MetArg: 1.516 ± 0.026	1.542MetSer: 1.542 ± 0.026	1.649MetThr: 1.649 ± 0.029	1.648MetVal: 1.648 ± 0.027	0.243MetTrp: 0.243 ± 0.008	0.397MetTyr: 0.397 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.025AsnAla: 3.025 ± 0.042	0.344AsnCys: 0.344 ± 0.012	2.132AsnAsp: 2.132 ± 0.048	1.966AsnGlu: 1.966 ± 0.027	1.085AsnPhe: 1.085 ± 0.024	2.781AsnGly: 2.781 ± 0.05	0.884AsnHis: 0.884 ± 0.016	1.309AsnIle: 1.309 ± 0.023	0.924AsnLys: 0.924 ± 0.022	3.061AsnLeu: 3.061 ± 0.04	0.593AsnMet: 0.593 ± 0.015	1.069AsnAsn: 1.069 ± 0.028	2.165AsnPro: 2.165 ± 0.029	1.489AsnGln: 1.489 ± 0.026	2.529AsnArg: 2.529 ± 0.031	1.923AsnSer: 1.923 ± 0.033	1.725AsnThr: 1.725 ± 0.036	2.503AsnVal: 2.503 ± 0.039	0.567AsnTrp: 0.567 ± 0.015	0.823AsnTyr: 0.823 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	4.618ProAla: 4.618 ± 0.049	0.45ProCys: 0.45 ± 0.013	3.367ProAsp: 3.367 ± 0.035	3.597ProGlu: 3.597 ± 0.044	1.943ProPhe: 1.943 ± 0.03	3.702ProGly: 3.702 ± 0.047	1.137ProHis: 1.137 ± 0.018	2.805ProIle: 2.805 ± 0.033	2.002ProLys: 2.002 ± 0.031	4.589ProLeu: 4.589 ± 0.044	1.314ProMet: 1.314 ± 0.024	2.091ProAsn: 2.091 ± 0.032	2.618ProPro: 2.618 ± 0.046	1.86ProGln: 1.86 ± 0.028	2.734ProArg: 2.734 ± 0.039	3.882ProSer: 3.882 ± 0.051	3.226ProThr: 3.226 ± 0.04	3.704ProVal: 3.704 ± 0.047	0.794ProTrp: 0.794 ± 0.015	1.28ProTyr: 1.28 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.742GlnAla: 3.742 ± 0.04	0.413GlnCys: 0.413 ± 0.012	1.833GlnAsp: 1.833 ± 0.027	1.824GlnGlu: 1.824 ± 0.026	1.509GlnPhe: 1.509 ± 0.023	2.532GlnGly: 2.532 ± 0.033	0.951GlnHis: 0.951 ± 0.022	2.239GlnIle: 2.239 ± 0.03	1.343GlnLys: 1.343 ± 0.024	4.29GlnLeu: 4.29 ± 0.047	1.043GlnMet: 1.043 ± 0.02	1.218GlnAsn: 1.218 ± 0.023	2.247GlnPro: 2.247 ± 0.034	2.217GlnGln: 2.217 ± 0.039	3.059GlnArg: 3.059 ± 0.044	2.896GlnSer: 2.896 ± 0.039	2.484GlnThr: 2.484 ± 0.029	2.782GlnVal: 2.782 ± 0.03	0.811GlnTrp: 0.811 ± 0.02	1.005GlnTyr: 1.005 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	4.624ArgAla: 4.624 ± 0.05	0.857ArgCys: 0.857 ± 0.02	3.944ArgAsp: 3.944 ± 0.044	3.871ArgGlu: 3.871 ± 0.053	3.017ArgPhe: 3.017 ± 0.036	4.349ArgGly: 4.349 ± 0.045	1.448ArgHis: 1.448 ± 0.022	3.87ArgIle: 3.87 ± 0.043	2.437ArgLys: 2.437 ± 0.033	6.814ArgLeu: 6.814 ± 0.066	1.835ArgMet: 1.835 ± 0.03	2.084ArgAsn: 2.084 ± 0.031	3.088ArgPro: 3.088 ± 0.04	2.799ArgGln: 2.799 ± 0.038	5.017ArgArg: 5.017 ± 0.06	4.597ArgSer: 4.597 ± 0.052	3.285ArgThr: 3.285 ± 0.034	4.683ArgVal: 4.683 ± 0.044	1.278ArgTrp: 1.278 ± 0.025	2.026ArgTyr: 2.026 ± 0.026	0.0ArgXaa: 0.0 ± 0.0
Ser	5.658SerAla: 5.658 ± 0.05	0.717SerCys: 0.717 ± 0.018	4.488SerAsp: 4.488 ± 0.058	4.138SerGlu: 4.138 ± 0.043	2.424SerPhe: 2.424 ± 0.033	5.836SerGly: 5.836 ± 0.083	1.427SerHis: 1.427 ± 0.025	3.616SerIle: 3.616 ± 0.037	2.354SerLys: 2.354 ± 0.036	6.723SerLeu: 6.723 ± 0.051	1.608SerMet: 1.608 ± 0.026	2.154SerAsn: 2.154 ± 0.034	3.616SerPro: 3.616 ± 0.038	2.61SerGln: 2.61 ± 0.037	4.216SerArg: 4.216 ± 0.046	4.477SerSer: 4.477 ± 0.057	3.665SerThr: 3.665 ± 0.05	4.998SerVal: 4.998 ± 0.058	0.994SerTrp: 0.994 ± 0.02	1.489SerTyr: 1.489 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	5.322ThrAla: 5.322 ± 0.058	0.585ThrCys: 0.585 ± 0.016	3.572ThrAsp: 3.572 ± 0.076	3.17ThrGlu: 3.17 ± 0.041	2.098ThrPhe: 2.098 ± 0.039	4.561ThrGly: 4.561 ± 0.062	1.202ThrHis: 1.202 ± 0.019	3.379ThrIle: 3.379 ± 0.058	1.868ThrLys: 1.868 ± 0.031	5.936ThrLeu: 5.936 ± 0.07	1.232ThrMet: 1.232 ± 0.02	1.797ThrAsn: 1.797 ± 0.043	3.441ThrPro: 3.441 ± 0.039	2.04ThrGln: 2.04 ± 0.026	3.275ThrArg: 3.275 ± 0.037	3.654ThrSer: 3.654 ± 0.062	3.457ThrThr: 3.457 ± 0.062	4.334ThrVal: 4.334 ± 0.088	0.851ThrTrp: 0.851 ± 0.022	1.402ThrTyr: 1.402 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	7.434ValAla: 7.434 ± 0.055	1.008ValCys: 1.008 ± 0.02	4.898ValAsp: 4.898 ± 0.056	4.437ValGlu: 4.437 ± 0.043	2.734ValPhe: 2.734 ± 0.033	5.29ValGly: 5.29 ± 0.049	1.504ValHis: 1.504 ± 0.025	3.745ValIle: 3.745 ± 0.04	2.401ValLys: 2.401 ± 0.031	6.691ValLeu: 6.691 ± 0.052	1.661ValMet: 1.661 ± 0.028	2.28ValAsn: 2.28 ± 0.037	3.553ValPro: 3.553 ± 0.041	2.434ValGln: 2.434 ± 0.032	4.581ValArg: 4.581 ± 0.05	4.771ValSer: 4.771 ± 0.056	4.341ValThr: 4.341 ± 0.083	5.734ValVal: 5.734 ± 0.06	1.045ValTrp: 1.045 ± 0.021	1.741ValTyr: 1.741 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.097TrpAla: 1.097 ± 0.02	0.212TrpCys: 0.212 ± 0.008	0.942TrpAsp: 0.942 ± 0.023	0.747TrpGlu: 0.747 ± 0.019	0.619TrpPhe: 0.619 ± 0.016	1.008TrpGly: 1.008 ± 0.022	0.464TrpHis: 0.464 ± 0.012	0.935TrpIle: 0.935 ± 0.02	0.752TrpLys: 0.752 ± 0.02	1.634TrpLeu: 1.634 ± 0.029	0.46TrpMet: 0.46 ± 0.014	0.686TrpAsn: 0.686 ± 0.018	0.735TrpPro: 0.735 ± 0.017	0.782TrpGln: 0.782 ± 0.021	1.04TrpArg: 1.04 ± 0.021	1.066TrpSer: 1.066 ± 0.023	0.944TrpThr: 0.944 ± 0.023	0.981TrpVal: 0.981 ± 0.021	0.303TrpTrp: 0.303 ± 0.012	0.425TrpTyr: 0.425 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.291TyrAla: 2.291 ± 0.031	0.36TyrCys: 0.36 ± 0.012	1.759TyrAsp: 1.759 ± 0.043	1.511TyrGlu: 1.511 ± 0.026	1.113TyrPhe: 1.113 ± 0.018	2.122TyrGly: 2.122 ± 0.035	0.659TyrHis: 0.659 ± 0.016	0.841TyrIle: 0.841 ± 0.019	0.694TyrLys: 0.694 ± 0.017	2.426TyrLeu: 2.426 ± 0.031	0.424TyrMet: 0.424 ± 0.014	0.785TyrAsn: 0.785 ± 0.018	1.314TyrPro: 1.314 ± 0.023	1.14TyrGln: 1.14 ± 0.021	2.18TyrArg: 2.18 ± 0.034	1.488TyrSer: 1.488 ± 0.024	1.237TyrThr: 1.237 ± 0.034	1.687TyrVal: 1.687 ± 0.027	0.466TyrTrp: 0.466 ± 0.014	0.819TyrTyr: 0.819 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7087 proteins (2704480 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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