Amino acid dipepetide frequency for Candidatus Micrarchaeum sp. AZ1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.551AlaAla: 6.551 ± 0.213
0.605AlaCys: 0.605 ± 0.054
3.261AlaAsp: 3.261 ± 0.14
4.931AlaGlu: 4.931 ± 0.191
3.545AlaPhe: 3.545 ± 0.158
5.19AlaGly: 5.19 ± 0.179
1.173AlaHis: 1.173 ± 0.072
7.675AlaIle: 7.675 ± 0.21
6.426AlaLys: 6.426 ± 0.188
8.105AlaLeu: 8.105 ± 0.231
2.66AlaMet: 2.66 ± 0.107
3.583AlaAsn: 3.583 ± 0.13
2.15AlaPro: 2.15 ± 0.088
2.046AlaGln: 2.046 ± 0.105
3.328AlaArg: 3.328 ± 0.139
6.034AlaSer: 6.034 ± 0.149
3.67AlaThr: 3.67 ± 0.117
5.65AlaVal: 5.65 ± 0.196
0.56AlaTrp: 0.56 ± 0.05
3.679AlaTyr: 3.679 ± 0.136
0.0AlaXaa: 0.0 ± 0.0
Cys
0.526CysAla: 0.526 ± 0.05
0.058CysCys: 0.058 ± 0.019
0.367CysAsp: 0.367 ± 0.035
0.359CysGlu: 0.359 ± 0.039
0.205CysPhe: 0.205 ± 0.027
0.793CysGly: 0.793 ± 0.065
0.1CysHis: 0.1 ± 0.021
0.576CysIle: 0.576 ± 0.048
0.418CysLys: 0.418 ± 0.042
0.359CysLeu: 0.359 ± 0.039
0.271CysMet: 0.271 ± 0.04
0.405CysAsn: 0.405 ± 0.041
0.338CysPro: 0.338 ± 0.042
0.138CysGln: 0.138 ± 0.025
0.338CysArg: 0.338 ± 0.036
0.635CysSer: 0.635 ± 0.054
0.451CysThr: 0.451 ± 0.052
0.397CysVal: 0.397 ± 0.039
0.063CysTrp: 0.063 ± 0.019
0.23CysTyr: 0.23 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
3.829AspAla: 3.829 ± 0.131
0.246AspCys: 0.246 ± 0.031
1.871AspAsp: 1.871 ± 0.093
3.278AspGlu: 3.278 ± 0.138
2.33AspPhe: 2.33 ± 0.121
3.169AspGly: 3.169 ± 0.113
0.568AspHis: 0.568 ± 0.05
4.213AspIle: 4.213 ± 0.129
3.328AspLys: 3.328 ± 0.137
3.424AspLeu: 3.424 ± 0.132
1.595AspMet: 1.595 ± 0.086
1.821AspAsn: 1.821 ± 0.097
1.578AspPro: 1.578 ± 0.085
0.835AspGln: 0.835 ± 0.061
1.963AspArg: 1.963 ± 0.101
3.729AspSer: 3.729 ± 0.125
2.263AspThr: 2.263 ± 0.103
3.082AspVal: 3.082 ± 0.143
0.367AspTrp: 0.367 ± 0.045
2.497AspTyr: 2.497 ± 0.128
0.0AspXaa: 0.0 ± 0.0
Glu
5.128GluAla: 5.128 ± 0.165
0.367GluCys: 0.367 ± 0.039
2.885GluAsp: 2.885 ± 0.124
4.564GluGlu: 4.564 ± 0.2
2.748GluPhe: 2.748 ± 0.098
3.679GluGly: 3.679 ± 0.136
1.207GluHis: 1.207 ± 0.067
4.965GluIle: 4.965 ± 0.17
6.201GluLys: 6.201 ± 0.194
6.727GluLeu: 6.727 ± 0.2
1.804GluMet: 1.804 ± 0.079
2.99GluAsn: 2.99 ± 0.116
1.871GluPro: 1.871 ± 0.076
1.908GluGln: 1.908 ± 0.1
3.278GluArg: 3.278 ± 0.133
4.56GluSer: 4.56 ± 0.156
2.555GluThr: 2.555 ± 0.108
3.733GluVal: 3.733 ± 0.138
0.497GluTrp: 0.497 ± 0.044
2.501GluTyr: 2.501 ± 0.105
0.0GluXaa: 0.0 ± 0.0
Phe
3.578PheAla: 3.578 ± 0.12
0.338PheCys: 0.338 ± 0.04
2.393PheAsp: 2.393 ± 0.118
2.505PheGlu: 2.505 ± 0.109
1.816PhePhe: 1.816 ± 0.096
3.812PheGly: 3.812 ± 0.143
0.459PheHis: 0.459 ± 0.05
3.545PheIle: 3.545 ± 0.145
2.405PheLys: 2.405 ± 0.109
3.416PheLeu: 3.416 ± 0.136
1.328PheMet: 1.328 ± 0.074
2.167PheAsn: 2.167 ± 0.097
1.407PhePro: 1.407 ± 0.074
0.76PheGln: 0.76 ± 0.062
1.532PheArg: 1.532 ± 0.079
3.837PheSer: 3.837 ± 0.123
2.029PheThr: 2.029 ± 0.095
3.144PheVal: 3.144 ± 0.14
0.351PheTrp: 0.351 ± 0.043
2.092PheTyr: 2.092 ± 0.114
0.0PheXaa: 0.0 ± 0.0
Gly
4.835GlyAla: 4.835 ± 0.156
0.48GlyCys: 0.48 ± 0.042
2.969GlyAsp: 2.969 ± 0.119
3.178GlyGlu: 3.178 ± 0.133
3.708GlyPhe: 3.708 ± 0.113
3.971GlyGly: 3.971 ± 0.191
1.027GlyHis: 1.027 ± 0.06
7.737GlyIle: 7.737 ± 0.2
5.754GlyLys: 5.754 ± 0.166
6.092GlyLeu: 6.092 ± 0.189
2.51GlyMet: 2.51 ± 0.117
3.274GlyAsn: 3.274 ± 0.138
1.908GlyPro: 1.908 ± 0.107
1.628GlyGln: 1.628 ± 0.088
2.889GlyArg: 2.889 ± 0.114
5.846GlySer: 5.846 ± 0.16
4.301GlyThr: 4.301 ± 0.145
4.852GlyVal: 4.852 ± 0.153
0.639GlyTrp: 0.639 ± 0.057
3.161GlyTyr: 3.161 ± 0.125
0.0GlyXaa: 0.0 ± 0.0
His
1.198HisAla: 1.198 ± 0.075
0.129HisCys: 0.129 ± 0.025
0.789HisAsp: 0.789 ± 0.065
0.965HisGlu: 0.965 ± 0.068
0.56HisPhe: 0.56 ± 0.046
1.315HisGly: 1.315 ± 0.077
0.263HisHis: 0.263 ± 0.036
1.353HisIle: 1.353 ± 0.072
0.914HisLys: 0.914 ± 0.067
0.948HisLeu: 0.948 ± 0.07
0.589HisMet: 0.589 ± 0.047
0.701HisAsn: 0.701 ± 0.057
0.605HisPro: 0.605 ± 0.049
0.292HisGln: 0.292 ± 0.042
0.739HisArg: 0.739 ± 0.062
1.228HisSer: 1.228 ± 0.066
0.823HisThr: 0.823 ± 0.059
0.944HisVal: 0.944 ± 0.068
0.1HisTrp: 0.1 ± 0.019
0.668HisTyr: 0.668 ± 0.06
0.0HisXaa: 0.0 ± 0.0
Ile
7.742IleAla: 7.742 ± 0.191
0.522IleCys: 0.522 ± 0.042
4.138IleAsp: 4.138 ± 0.136
5.002IleGlu: 5.002 ± 0.151
3.52IlePhe: 3.52 ± 0.147
6.268IleGly: 6.268 ± 0.184
0.885IleHis: 0.885 ± 0.056
6.973IleIle: 6.973 ± 0.237
6.769IleLys: 6.769 ± 0.165
6.101IleLeu: 6.101 ± 0.205
2.121IleMet: 2.121 ± 0.099
4.23IleAsn: 4.23 ± 0.128
3.048IlePro: 3.048 ± 0.122
1.248IleGln: 1.248 ± 0.073
3.282IleArg: 3.282 ± 0.136
7.871IleSer: 7.871 ± 0.215
4.764IleThr: 4.764 ± 0.126
4.885IleVal: 4.885 ± 0.153
0.434IleTrp: 0.434 ± 0.05
3.073IleTyr: 3.073 ± 0.136
0.0IleXaa: 0.0 ± 0.0
Lys
6.343LysAla: 6.343 ± 0.156
0.526LysCys: 0.526 ± 0.054
4.071LysAsp: 4.071 ± 0.14
6.33LysGlu: 6.33 ± 0.219
2.514LysPhe: 2.514 ± 0.112
4.994LysGly: 4.994 ± 0.145
1.42LysHis: 1.42 ± 0.081
5.328LysIle: 5.328 ± 0.163
6.61LysLys: 6.61 ± 0.201
7.094LysLeu: 7.094 ± 0.188
2.397LysMet: 2.397 ± 0.102
3.95LysAsn: 3.95 ± 0.129
3.24LysPro: 3.24 ± 0.118
2.155LysGln: 2.155 ± 0.103
4.113LysArg: 4.113 ± 0.137
5.9LysSer: 5.9 ± 0.178
3.102LysThr: 3.102 ± 0.11
4.38LysVal: 4.38 ± 0.135
0.505LysTrp: 0.505 ± 0.048
3.031LysTyr: 3.031 ± 0.116
0.0LysXaa: 0.0 ± 0.0
Leu
7.374LeuAla: 7.374 ± 0.184
0.551LeuCys: 0.551 ± 0.047
4.163LeuAsp: 4.163 ± 0.151
5.888LeuGlu: 5.888 ± 0.182
4.084LeuPhe: 4.084 ± 0.156
6.664LeuGly: 6.664 ± 0.19
1.303LeuHis: 1.303 ± 0.077
6.389LeuIle: 6.389 ± 0.181
6.852LeuLys: 6.852 ± 0.194
8.147LeuLeu: 8.147 ± 0.25
2.443LeuMet: 2.443 ± 0.091
4.105LeuAsn: 4.105 ± 0.122
3.198LeuPro: 3.198 ± 0.114
2.004LeuGln: 2.004 ± 0.088
3.8LeuArg: 3.8 ± 0.139
7.733LeuSer: 7.733 ± 0.24
3.662LeuThr: 3.662 ± 0.132
5.65LeuVal: 5.65 ± 0.155
0.664LeuTrp: 0.664 ± 0.053
3.775LeuTyr: 3.775 ± 0.126
0.0LeuXaa: 0.0 ± 0.0
Met
2.827MetAla: 2.827 ± 0.119
0.205MetCys: 0.205 ± 0.026
1.599MetAsp: 1.599 ± 0.08
2.084MetGlu: 2.084 ± 0.092
0.99MetPhe: 0.99 ± 0.074
2.004MetGly: 2.004 ± 0.094
0.827MetHis: 0.827 ± 0.054
1.578MetIle: 1.578 ± 0.088
2.301MetLys: 2.301 ± 0.095
3.725MetLeu: 3.725 ± 0.132
0.668MetMet: 0.668 ± 0.055
1.219MetAsn: 1.219 ± 0.06
1.62MetPro: 1.62 ± 0.086
1.136MetGln: 1.136 ± 0.072
1.386MetArg: 1.386 ± 0.075
1.996MetSer: 1.996 ± 0.087
1.023MetThr: 1.023 ± 0.071
1.937MetVal: 1.937 ± 0.093
0.167MetTrp: 0.167 ± 0.026
0.864MetTyr: 0.864 ± 0.058
0.0MetXaa: 0.0 ± 0.0
Asn
4.443AsnAla: 4.443 ± 0.152
0.405AsnCys: 0.405 ± 0.043
2.063AsnAsp: 2.063 ± 0.096
2.885AsnGlu: 2.885 ± 0.114
1.954AsnPhe: 1.954 ± 0.096
4.151AsnGly: 4.151 ± 0.166
0.443AsnHis: 0.443 ± 0.047
3.946AsnIle: 3.946 ± 0.131
2.873AsnLys: 2.873 ± 0.119
3.353AsnLeu: 3.353 ± 0.117
1.42AsnMet: 1.42 ± 0.071
2.088AsnAsn: 2.088 ± 0.121
2.113AsnPro: 2.113 ± 0.1
0.944AsnGln: 0.944 ± 0.063
1.825AsnArg: 1.825 ± 0.088
4.092AsnSer: 4.092 ± 0.181
2.518AsnThr: 2.518 ± 0.129
3.507AsnVal: 3.507 ± 0.149
0.301AsnTrp: 0.301 ± 0.034
2.196AsnTyr: 2.196 ± 0.121
0.0AsnXaa: 0.0 ± 0.0
Pro
2.376ProAla: 2.376 ± 0.087
0.163ProCys: 0.163 ± 0.029
1.825ProAsp: 1.825 ± 0.092
2.981ProGlu: 2.981 ± 0.134
1.57ProPhe: 1.57 ± 0.079
2.342ProGly: 2.342 ± 0.107
0.61ProHis: 0.61 ± 0.054
2.731ProIle: 2.731 ± 0.1
2.956ProLys: 2.956 ± 0.118
2.944ProLeu: 2.944 ± 0.133
0.935ProMet: 0.935 ± 0.063
1.624ProAsn: 1.624 ± 0.08
0.96ProPro: 0.96 ± 0.081
0.923ProGln: 0.923 ± 0.059
1.144ProArg: 1.144 ± 0.074
2.722ProSer: 2.722 ± 0.137
1.791ProThr: 1.791 ± 0.098
2.597ProVal: 2.597 ± 0.11
0.217ProTrp: 0.217 ± 0.03
1.562ProTyr: 1.562 ± 0.09
0.0ProXaa: 0.0 ± 0.0
Gln
1.775GlnAla: 1.775 ± 0.087
0.146GlnCys: 0.146 ± 0.023
0.877GlnAsp: 0.877 ± 0.074
1.432GlnGlu: 1.432 ± 0.073
0.877GlnPhe: 0.877 ± 0.058
1.365GlnGly: 1.365 ± 0.07
0.422GlnHis: 0.422 ± 0.048
1.75GlnIle: 1.75 ± 0.087
2.484GlnLys: 2.484 ± 0.105
2.159GlnLeu: 2.159 ± 0.101
0.814GlnMet: 0.814 ± 0.059
1.319GlnAsn: 1.319 ± 0.073
0.894GlnPro: 0.894 ± 0.067
0.96GlnGln: 0.96 ± 0.093
1.148GlnArg: 1.148 ± 0.069
1.829GlnSer: 1.829 ± 0.095
1.04GlnThr: 1.04 ± 0.074
1.328GlnVal: 1.328 ± 0.078
0.163GlnTrp: 0.163 ± 0.025
0.873GlnTyr: 0.873 ± 0.061
0.0GlnXaa: 0.0 ± 0.0
Arg
3.057ArgAla: 3.057 ± 0.121
0.276ArgCys: 0.276 ± 0.032
1.983ArgAsp: 1.983 ± 0.1
2.789ArgGlu: 2.789 ± 0.113
2.0ArgPhe: 2.0 ± 0.081
2.484ArgGly: 2.484 ± 0.107
0.889ArgHis: 0.889 ± 0.062
3.733ArgIle: 3.733 ± 0.146
3.716ArgLys: 3.716 ± 0.133
4.297ArgLeu: 4.297 ± 0.138
1.495ArgMet: 1.495 ± 0.073
2.029ArgAsn: 2.029 ± 0.101
1.269ArgPro: 1.269 ± 0.083
1.148ArgGln: 1.148 ± 0.063
2.13ArgArg: 2.13 ± 0.105
3.178ArgSer: 3.178 ± 0.103
1.478ArgThr: 1.478 ± 0.086
2.376ArgVal: 2.376 ± 0.101
0.301ArgTrp: 0.301 ± 0.037
1.854ArgTyr: 1.854 ± 0.1
0.0ArgXaa: 0.0 ± 0.0
Ser
6.071SerAla: 6.071 ± 0.186
0.572SerCys: 0.572 ± 0.053
3.716SerAsp: 3.716 ± 0.119
5.47SerGlu: 5.47 ± 0.161
3.62SerPhe: 3.62 ± 0.136
6.556SerGly: 6.556 ± 0.196
1.015SerHis: 1.015 ± 0.07
7.069SerIle: 7.069 ± 0.168
6.693SerLys: 6.693 ± 0.205
6.627SerLeu: 6.627 ± 0.194
2.601SerMet: 2.601 ± 0.102
4.292SerAsn: 4.292 ± 0.184
2.317SerPro: 2.317 ± 0.109
1.954SerGln: 1.954 ± 0.089
3.462SerArg: 3.462 ± 0.113
7.119SerSer: 7.119 ± 0.284
4.376SerThr: 4.376 ± 0.237
5.04SerVal: 5.04 ± 0.156
0.514SerTrp: 0.514 ± 0.044
3.599SerTyr: 3.599 ± 0.145
0.0SerXaa: 0.0 ± 0.0
Thr
3.691ThrAla: 3.691 ± 0.127
0.359ThrCys: 0.359 ± 0.046
2.029ThrAsp: 2.029 ± 0.091
2.702ThrGlu: 2.702 ± 0.117
1.908ThrPhe: 1.908 ± 0.082
4.013ThrGly: 4.013 ± 0.16
0.818ThrHis: 0.818 ± 0.057
4.196ThrIle: 4.196 ± 0.148
3.257ThrLys: 3.257 ± 0.124
4.397ThrLeu: 4.397 ± 0.151
1.349ThrMet: 1.349 ± 0.074
2.138ThrAsn: 2.138 ± 0.116
1.908ThrPro: 1.908 ± 0.105
1.157ThrGln: 1.157 ± 0.064
1.766ThrArg: 1.766 ± 0.087
4.034ThrSer: 4.034 ± 0.247
2.919ThrThr: 2.919 ± 0.234
3.295ThrVal: 3.295 ± 0.12
0.33ThrTrp: 0.33 ± 0.04
2.042ThrTyr: 2.042 ± 0.106
0.0ThrXaa: 0.0 ± 0.0
Val
5.361ValAla: 5.361 ± 0.175
0.539ValCys: 0.539 ± 0.052
2.768ValAsp: 2.768 ± 0.134
3.862ValGlu: 3.862 ± 0.143
3.015ValPhe: 3.015 ± 0.134
4.088ValGly: 4.088 ± 0.145
1.031ValHis: 1.031 ± 0.068
5.311ValIle: 5.311 ± 0.172
4.727ValLys: 4.727 ± 0.154
6.213ValLeu: 6.213 ± 0.175
1.654ValMet: 1.654 ± 0.083
2.819ValAsn: 2.819 ± 0.115
2.819ValPro: 2.819 ± 0.125
1.466ValGln: 1.466 ± 0.083
2.418ValArg: 2.418 ± 0.107
5.624ValSer: 5.624 ± 0.181
3.136ValThr: 3.136 ± 0.124
4.43ValVal: 4.43 ± 0.158
0.426ValTrp: 0.426 ± 0.042
2.685ValTyr: 2.685 ± 0.117
0.0ValXaa: 0.0 ± 0.0
Trp
0.409TrpAla: 0.409 ± 0.042
0.1TrpCys: 0.1 ± 0.02
0.33TrpAsp: 0.33 ± 0.039
0.359TrpGlu: 0.359 ± 0.04
0.342TrpPhe: 0.342 ± 0.04
0.38TrpGly: 0.38 ± 0.044
0.15TrpHis: 0.15 ± 0.024
0.614TrpIle: 0.614 ± 0.052
0.497TrpLys: 0.497 ± 0.04
0.768TrpLeu: 0.768 ± 0.061
0.196TrpMet: 0.196 ± 0.03
0.476TrpAsn: 0.476 ± 0.046
0.309TrpPro: 0.309 ± 0.041
0.267TrpGln: 0.267 ± 0.034
0.326TrpArg: 0.326 ± 0.037
0.443TrpSer: 0.443 ± 0.047
0.301TrpThr: 0.301 ± 0.036
0.347TrpVal: 0.347 ± 0.042
0.1TrpTrp: 0.1 ± 0.023
0.38TrpTyr: 0.38 ± 0.04
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.708TyrAla: 3.708 ± 0.148
0.438TyrCys: 0.438 ± 0.048
1.887TyrAsp: 1.887 ± 0.084
2.601TyrGlu: 2.601 ± 0.103
1.612TyrPhe: 1.612 ± 0.089
3.52TyrGly: 3.52 ± 0.131
0.514TyrHis: 0.514 ± 0.04
3.194TyrIle: 3.194 ± 0.138
2.827TyrLys: 2.827 ± 0.117
3.553TyrLeu: 3.553 ± 0.117
1.303TyrMet: 1.303 ± 0.064
2.288TyrAsn: 2.288 ± 0.134
1.42TyrPro: 1.42 ± 0.074
0.685TyrGln: 0.685 ± 0.05
1.616TyrArg: 1.616 ± 0.077
4.276TyrSer: 4.276 ± 0.154
2.104TyrThr: 2.104 ± 0.102
2.819TyrVal: 2.819 ± 0.115
0.397TyrTrp: 0.397 ± 0.039
1.846TyrTyr: 1.846 ± 0.109
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 840 proteins (239489 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski