Amino acid dipepetide frequency for Echinococcus granulosus (Hydatid tapeworm)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.327AlaAla: 7.327 ± 0.081	1.52AlaCys: 1.52 ± 0.02	3.452AlaAsp: 3.452 ± 0.03	4.502AlaGlu: 4.502 ± 0.033	3.131AlaPhe: 3.131 ± 0.026	3.848AlaGly: 3.848 ± 0.036	1.595AlaHis: 1.595 ± 0.018	3.605AlaIle: 3.605 ± 0.03	3.579AlaLys: 3.579 ± 0.03	6.998AlaLeu: 6.998 ± 0.046	1.626AlaMet: 1.626 ± 0.019	2.945AlaAsn: 2.945 ± 0.026	3.695AlaPro: 3.695 ± 0.036	2.513AlaGln: 2.513 ± 0.03	3.763AlaArg: 3.763 ± 0.032	7.124AlaSer: 7.124 ± 0.047	4.774AlaThr: 4.774 ± 0.034	5.092AlaVal: 5.092 ± 0.038	0.769AlaTrp: 0.769 ± 0.014	1.919AlaTyr: 1.919 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	1.343CysAla: 1.343 ± 0.018	0.634CysCys: 0.634 ± 0.015	1.078CysAsp: 1.078 ± 0.016	1.2CysGlu: 1.2 ± 0.018	0.971CysPhe: 0.971 ± 0.014	1.447CysGly: 1.447 ± 0.019	0.617CysHis: 0.617 ± 0.012	1.188CysIle: 1.188 ± 0.017	0.965CysLys: 0.965 ± 0.017	2.608CysLeu: 2.608 ± 0.028	0.416CysMet: 0.416 ± 0.01	0.813CysAsn: 0.813 ± 0.015	1.192CysPro: 1.192 ± 0.022	0.883CysGln: 0.883 ± 0.016	1.41CysArg: 1.41 ± 0.021	1.827CysSer: 1.827 ± 0.022	1.148CysThr: 1.148 ± 0.016	1.461CysVal: 1.461 ± 0.02	0.249CysTrp: 0.249 ± 0.006	0.58CysTyr: 0.58 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	3.688AspAla: 3.688 ± 0.028	1.055AspCys: 1.055 ± 0.016	3.073AspAsp: 3.073 ± 0.04	3.674AspGlu: 3.674 ± 0.034	2.323AspPhe: 2.323 ± 0.022	3.183AspGly: 3.183 ± 0.039	1.044AspHis: 1.044 ± 0.014	2.518AspIle: 2.518 ± 0.022	2.086AspLys: 2.086 ± 0.023	5.018AspLeu: 5.018 ± 0.038	1.015AspMet: 1.015 ± 0.013	1.768AspAsn: 1.768 ± 0.023	2.515AspPro: 2.515 ± 0.023	1.564AspGln: 1.564 ± 0.018	2.631AspArg: 2.631 ± 0.025	4.106AspSer: 4.106 ± 0.033	2.37AspThr: 2.37 ± 0.023	3.356AspVal: 3.356 ± 0.028	0.634AspTrp: 0.634 ± 0.012	1.47AspTyr: 1.47 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	5.125GluAla: 5.125 ± 0.045	1.168GluCys: 1.168 ± 0.019	3.437GluAsp: 3.437 ± 0.03	5.823GluGlu: 5.823 ± 0.063	2.101GluPhe: 2.101 ± 0.024	3.467GluGly: 3.467 ± 0.037	1.274GluHis: 1.274 ± 0.017	3.063GluIle: 3.063 ± 0.03	3.581GluLys: 3.581 ± 0.036	5.338GluLeu: 5.338 ± 0.044	1.594GluMet: 1.594 ± 0.018	2.645GluAsn: 2.645 ± 0.023	2.318GluPro: 2.318 ± 0.031	2.186GluGln: 2.186 ± 0.023	3.672GluArg: 3.672 ± 0.033	4.459GluSer: 4.459 ± 0.034	3.236GluThr: 3.236 ± 0.027	4.368GluVal: 4.368 ± 0.035	0.654GluTrp: 0.654 ± 0.012	1.483GluTyr: 1.483 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	2.848PheAla: 2.848 ± 0.026	1.084PheCys: 1.084 ± 0.016	2.199PheAsp: 2.199 ± 0.024	2.196PheGlu: 2.196 ± 0.025	1.907PhePhe: 1.907 ± 0.019	2.447PheGly: 2.447 ± 0.026	1.128PheHis: 1.128 ± 0.016	2.208PheIle: 2.208 ± 0.025	1.824PheLys: 1.824 ± 0.019	4.179PheLeu: 4.179 ± 0.033	0.843PheMet: 0.843 ± 0.012	1.71PheAsn: 1.71 ± 0.018	1.983PhePro: 1.983 ± 0.021	1.461PheGln: 1.461 ± 0.015	2.21PheArg: 2.21 ± 0.021	3.623PheSer: 3.623 ± 0.029	2.41PheThr: 2.41 ± 0.023	2.74PheVal: 2.74 ± 0.021	0.481PheTrp: 0.481 ± 0.01	1.389PheTyr: 1.389 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	3.855GlyAla: 3.855 ± 0.039	1.225GlyCys: 1.225 ± 0.017	3.136GlyAsp: 3.136 ± 0.039	3.529GlyGlu: 3.529 ± 0.053	2.297GlyPhe: 2.297 ± 0.026	5.392GlyGly: 5.392 ± 0.064	1.361GlyHis: 1.361 ± 0.017	2.765GlyIle: 2.765 ± 0.033	2.758GlyLys: 2.758 ± 0.026	5.096GlyLeu: 5.096 ± 0.036	1.182GlyMet: 1.182 ± 0.017	2.265GlyAsn: 2.265 ± 0.02	2.508GlyPro: 2.508 ± 0.099	2.021GlyGln: 2.021 ± 0.023	3.592GlyArg: 3.592 ± 0.039	5.143GlySer: 5.143 ± 0.043	3.062GlyThr: 3.062 ± 0.028	3.92GlyVal: 3.92 ± 0.034	0.667GlyTrp: 0.667 ± 0.013	1.584GlyTyr: 1.584 ± 0.02	0.0GlyXaa: 0.0 ± 0.0
His	1.468HisAla: 1.468 ± 0.018	0.665HisCys: 0.665 ± 0.013	0.972HisAsp: 0.972 ± 0.013	1.223HisGlu: 1.223 ± 0.016	1.283HisPhe: 1.283 ± 0.016	1.269HisGly: 1.269 ± 0.016	1.065HisHis: 1.065 ± 0.02	1.255HisIle: 1.255 ± 0.016	1.023HisLys: 1.023 ± 0.016	3.071HisLeu: 3.071 ± 0.032	0.509HisMet: 0.509 ± 0.01	0.904HisAsn: 0.904 ± 0.014	1.639HisPro: 1.639 ± 0.019	1.253HisGln: 1.253 ± 0.018	1.817HisArg: 1.817 ± 0.021	2.28HisSer: 2.28 ± 0.024	1.256HisThr: 1.256 ± 0.017	1.411HisVal: 1.411 ± 0.017	0.337HisTrp: 0.337 ± 0.008	0.783HisTyr: 0.783 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	3.547IleAla: 3.547 ± 0.025	1.338IleCys: 1.338 ± 0.019	2.606IleAsp: 2.606 ± 0.023	2.786IleGlu: 2.786 ± 0.027	2.35IlePhe: 2.35 ± 0.029	2.67IleGly: 2.67 ± 0.027	1.313IleHis: 1.313 ± 0.016	2.592IleIle: 2.592 ± 0.023	2.374IleLys: 2.374 ± 0.023	4.857IleLeu: 4.857 ± 0.037	0.96IleMet: 0.96 ± 0.014	2.149IleAsn: 2.149 ± 0.022	2.774IlePro: 2.774 ± 0.032	1.857IleGln: 1.857 ± 0.021	2.954IleArg: 2.954 ± 0.026	4.501IleSer: 4.501 ± 0.031	2.929IleThr: 2.929 ± 0.027	3.068IleVal: 3.068 ± 0.031	0.561IleTrp: 0.561 ± 0.011	1.581IleTyr: 1.581 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	3.566LysAla: 3.566 ± 0.035	1.045LysCys: 1.045 ± 0.017	2.173LysAsp: 2.173 ± 0.023	3.236LysGlu: 3.236 ± 0.037	1.752LysPhe: 1.752 ± 0.02	2.333LysGly: 2.333 ± 0.042	1.226LysHis: 1.226 ± 0.017	2.51LysIle: 2.51 ± 0.028	3.195LysLys: 3.195 ± 0.035	4.608LysLeu: 4.608 ± 0.041	1.271LysMet: 1.271 ± 0.018	2.018LysAsn: 2.018 ± 0.024	2.494LysPro: 2.494 ± 0.025	1.982LysGln: 1.982 ± 0.022	3.584LysArg: 3.584 ± 0.033	4.151LysSer: 4.151 ± 0.031	2.795LysThr: 2.795 ± 0.025	3.044LysVal: 3.044 ± 0.029	0.567LysTrp: 0.567 ± 0.011	1.363LysTyr: 1.363 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	7.141LeuAla: 7.141 ± 0.049	2.175LeuCys: 2.175 ± 0.022	4.672LeuAsp: 4.672 ± 0.037	5.814LeuGlu: 5.814 ± 0.047	4.024LeuPhe: 4.024 ± 0.035	4.701LeuGly: 4.701 ± 0.031	2.76LeuHis: 2.76 ± 0.028	4.923LeuIle: 4.923 ± 0.037	5.069LeuLys: 5.069 ± 0.037	10.641LeuLeu: 10.641 ± 0.074	2.067LeuMet: 2.067 ± 0.022	4.034LeuAsn: 4.034 ± 0.028	6.16LeuPro: 6.16 ± 0.043	4.409LeuGln: 4.409 ± 0.034	6.694LeuArg: 6.694 ± 0.044	8.595LeuSer: 8.595 ± 0.049	5.719LeuThr: 5.719 ± 0.036	5.89LeuVal: 5.89 ± 0.042	1.041LeuTrp: 1.041 ± 0.015	2.404LeuTyr: 2.404 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	1.784MetAla: 1.784 ± 0.018	0.414MetCys: 0.414 ± 0.01	1.227MetAsp: 1.227 ± 0.016	1.569MetGlu: 1.569 ± 0.018	0.676MetPhe: 0.676 ± 0.011	1.204MetGly: 1.204 ± 0.02	0.578MetHis: 0.578 ± 0.01	0.896MetIle: 0.896 ± 0.016	1.149MetLys: 1.149 ± 0.015	1.97MetLeu: 1.97 ± 0.02	0.479MetMet: 0.479 ± 0.01	0.916MetAsn: 0.916 ± 0.015	1.204MetPro: 1.204 ± 0.015	0.929MetGln: 0.929 ± 0.012	1.432MetArg: 1.432 ± 0.018	1.742MetSer: 1.742 ± 0.018	1.211MetThr: 1.211 ± 0.017	1.326MetVal: 1.326 ± 0.02	0.218MetTrp: 0.218 ± 0.006	0.496MetTyr: 0.496 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.066AsnAla: 3.066 ± 0.025	0.929AsnCys: 0.929 ± 0.015	1.974AsnAsp: 1.974 ± 0.023	2.422AsnGlu: 2.422 ± 0.023	1.848AsnPhe: 1.848 ± 0.02	2.603AsnGly: 2.603 ± 0.024	1.009AsnHis: 1.009 ± 0.015	2.077AsnIle: 2.077 ± 0.024	1.791AsnLys: 1.791 ± 0.021	4.134AsnLeu: 4.134 ± 0.031	0.816AsnMet: 0.816 ± 0.014	1.687AsnAsn: 1.687 ± 0.02	2.196AsnPro: 2.196 ± 0.021	1.597AsnGln: 1.597 ± 0.018	2.411AsnArg: 2.411 ± 0.021	3.573AsnSer: 3.573 ± 0.032	2.245AsnThr: 2.245 ± 0.02	2.527AsnVal: 2.527 ± 0.022	0.489AsnTrp: 0.489 ± 0.01	1.24AsnTyr: 1.24 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	3.521ProAla: 3.521 ± 0.034	0.954ProCys: 0.954 ± 0.016	2.456ProAsp: 2.456 ± 0.027	2.997ProGlu: 2.997 ± 0.029	2.095ProPhe: 2.095 ± 0.022	2.831ProGly: 2.831 ± 0.089	1.415ProHis: 1.415 ± 0.018	2.712ProIle: 2.712 ± 0.026	2.501ProLys: 2.501 ± 0.026	5.473ProLeu: 5.473 ± 0.042	1.088ProMet: 1.088 ± 0.015	2.246ProAsn: 2.246 ± 0.021	6.115ProPro: 6.115 ± 0.085	2.365ProGln: 2.365 ± 0.03	3.099ProArg: 3.099 ± 0.028	6.104ProSer: 6.104 ± 0.047	3.837ProThr: 3.837 ± 0.036	3.334ProVal: 3.334 ± 0.027	0.538ProTrp: 0.538 ± 0.01	1.348ProTyr: 1.348 ± 0.016	0.0ProXaa: 0.0 ± 0.0
Gln	2.641GlnAla: 2.641 ± 0.024	0.84GlnCys: 0.84 ± 0.014	1.379GlnAsp: 1.379 ± 0.017	2.157GlnGlu: 2.157 ± 0.023	1.409GlnPhe: 1.409 ± 0.017	1.675GlnGly: 1.675 ± 0.031	1.186GlnHis: 1.186 ± 0.015	2.081GlnIle: 2.081 ± 0.018	2.078GlnLys: 2.078 ± 0.023	4.221GlnLeu: 4.221 ± 0.031	1.096GlnMet: 1.096 ± 0.016	1.659GlnAsn: 1.659 ± 0.02	2.436GlnPro: 2.436 ± 0.032	2.903GlnGln: 2.903 ± 0.061	2.839GlnArg: 2.839 ± 0.026	3.336GlnSer: 3.336 ± 0.027	2.235GlnThr: 2.235 ± 0.021	2.213GlnVal: 2.213 ± 0.022	0.47GlnTrp: 0.47 ± 0.009	0.947GlnTyr: 0.947 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	3.829ArgAla: 3.829 ± 0.031	1.449ArgCys: 1.449 ± 0.025	2.675ArgAsp: 2.675 ± 0.025	3.46ArgGlu: 3.46 ± 0.031	2.52ArgPhe: 2.52 ± 0.021	3.43ArgGly: 3.43 ± 0.048	1.807ArgHis: 1.807 ± 0.021	3.216ArgIle: 3.216 ± 0.031	3.315ArgLys: 3.315 ± 0.029	6.945ArgLeu: 6.945 ± 0.045	1.324ArgMet: 1.324 ± 0.016	2.486ArgAsn: 2.486 ± 0.021	3.133ArgPro: 3.133 ± 0.031	2.777ArgGln: 2.777 ± 0.023	5.596ArgArg: 5.596 ± 0.049	5.115ArgSer: 5.115 ± 0.043	3.011ArgThr: 3.011 ± 0.028	3.65ArgVal: 3.65 ± 0.032	0.754ArgTrp: 0.754 ± 0.012	1.678ArgTyr: 1.678 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.716SerAla: 6.716 ± 0.04	1.757SerCys: 1.757 ± 0.022	4.263SerAsp: 4.263 ± 0.032	4.719SerGlu: 4.719 ± 0.037	3.303SerPhe: 3.303 ± 0.027	5.666SerGly: 5.666 ± 0.04	2.189SerHis: 2.189 ± 0.022	4.179SerIle: 4.179 ± 0.029	4.123SerLys: 4.123 ± 0.033	8.599SerLeu: 8.599 ± 0.052	1.77SerMet: 1.77 ± 0.017	3.613SerAsn: 3.613 ± 0.031	5.644SerPro: 5.644 ± 0.053	3.369SerGln: 3.369 ± 0.027	5.304SerArg: 5.304 ± 0.037	10.765SerSer: 10.765 ± 0.085	6.384SerThr: 6.384 ± 0.053	5.686SerVal: 5.686 ± 0.037	0.867SerTrp: 0.867 ± 0.013	1.986SerTyr: 1.986 ± 0.019	0.0SerXaa: 0.0 ± 0.0
Thr	4.877ThrAla: 4.877 ± 0.036	1.263ThrCys: 1.263 ± 0.021	2.784ThrAsp: 2.784 ± 0.025	3.296ThrGlu: 3.296 ± 0.028	2.353ThrPhe: 2.353 ± 0.023	3.397ThrGly: 3.397 ± 0.029	1.332ThrHis: 1.332 ± 0.018	2.749ThrIle: 2.749 ± 0.026	2.571ThrLys: 2.571 ± 0.026	5.321ThrLeu: 5.321 ± 0.037	1.184ThrMet: 1.184 ± 0.016	2.444ThrAsn: 2.444 ± 0.021	3.824ThrPro: 3.824 ± 0.03	1.98ThrGln: 1.98 ± 0.019	3.021ThrArg: 3.021 ± 0.024	6.126ThrSer: 6.126 ± 0.043	4.619ThrThr: 4.619 ± 0.051	3.877ThrVal: 3.877 ± 0.031	0.611ThrTrp: 0.611 ± 0.012	1.49ThrTyr: 1.49 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	4.934ValAla: 4.934 ± 0.039	1.555ValCys: 1.555 ± 0.021	3.692ValAsp: 3.692 ± 0.03	4.305ValGlu: 4.305 ± 0.035	2.664ValPhe: 2.664 ± 0.027	3.747ValGly: 3.747 ± 0.029	1.522ValHis: 1.522 ± 0.019	3.24ValIle: 3.24 ± 0.028	3.158ValLys: 3.158 ± 0.029	5.678ValLeu: 5.678 ± 0.039	1.315ValMet: 1.315 ± 0.018	2.747ValAsn: 2.747 ± 0.026	3.296ValPro: 3.296 ± 0.03	2.256ValGln: 2.256 ± 0.02	3.483ValArg: 3.483 ± 0.03	5.282ValSer: 5.282 ± 0.036	3.801ValThr: 3.801 ± 0.027	4.598ValVal: 4.598 ± 0.038	0.698ValTrp: 0.698 ± 0.013	1.824ValTyr: 1.824 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	0.624TrpAla: 0.624 ± 0.011	0.27TrpCys: 0.27 ± 0.008	0.537TrpAsp: 0.537 ± 0.01	0.547TrpGlu: 0.547 ± 0.013	0.47TrpPhe: 0.47 ± 0.009	0.494TrpGly: 0.494 ± 0.011	0.315TrpHis: 0.315 ± 0.008	0.645TrpIle: 0.645 ± 0.012	0.623TrpLys: 0.623 ± 0.012	1.215TrpLeu: 1.215 ± 0.017	0.321TrpMet: 0.321 ± 0.009	0.523TrpAsn: 0.523 ± 0.01	0.547TrpPro: 0.547 ± 0.012	0.452TrpGln: 0.452 ± 0.01	0.877TrpArg: 0.877 ± 0.014	0.948TrpSer: 0.948 ± 0.016	0.616TrpThr: 0.616 ± 0.011	0.607TrpVal: 0.607 ± 0.012	0.179TrpTrp: 0.179 ± 0.006	0.309TrpTyr: 0.309 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.879TyrAla: 1.879 ± 0.018	0.69TyrCys: 0.69 ± 0.013	1.308TyrAsp: 1.308 ± 0.016	1.536TyrGlu: 1.536 ± 0.02	1.392TyrPhe: 1.392 ± 0.015	1.556TyrGly: 1.556 ± 0.022	0.749TyrHis: 0.749 ± 0.011	1.345TyrIle: 1.345 ± 0.017	1.149TyrLys: 1.149 ± 0.017	2.962TyrLeu: 2.962 ± 0.029	0.542TyrMet: 0.542 ± 0.011	1.057TyrAsn: 1.057 ± 0.016	1.358TyrPro: 1.358 ± 0.018	1.046TyrGln: 1.046 ± 0.014	1.779TyrArg: 1.779 ± 0.021	2.102TyrSer: 2.102 ± 0.019	1.46TyrThr: 1.46 ± 0.018	1.627TyrVal: 1.627 ± 0.02	0.337TyrTrp: 0.337 ± 0.009	0.918TyrTyr: 0.918 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 11279 proteins (5264045 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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