Amino acid dipepetide frequency for Danaus plexippus plexippus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.935AlaAla: 6.935 ± 0.086	1.37AlaCys: 1.37 ± 0.038	3.285AlaAsp: 3.285 ± 0.026	4.046AlaGlu: 4.046 ± 0.034	2.228AlaPhe: 2.228 ± 0.021	4.135AlaGly: 4.135 ± 0.041	1.686AlaHis: 1.686 ± 0.022	3.301AlaIle: 3.301 ± 0.029	3.468AlaLys: 3.468 ± 0.03	6.868AlaLeu: 6.868 ± 0.058	1.506AlaMet: 1.506 ± 0.017	2.514AlaAsn: 2.514 ± 0.023	3.886AlaPro: 3.886 ± 0.043	2.283AlaGln: 2.283 ± 0.027	4.168AlaArg: 4.168 ± 0.039	4.987AlaSer: 4.987 ± 0.039	3.628AlaThr: 3.628 ± 0.029	4.643AlaVal: 4.643 ± 0.035	0.695AlaTrp: 0.695 ± 0.014	1.792AlaTyr: 1.792 ± 0.019	0.0AlaXaa: 0.0 ± 0.0
Cys	1.309CysAla: 1.309 ± 0.021	0.528CysCys: 0.528 ± 0.011	1.252CysAsp: 1.252 ± 0.023	1.255CysGlu: 1.255 ± 0.026	0.728CysPhe: 0.728 ± 0.012	1.544CysGly: 1.544 ± 0.048	0.51CysHis: 0.51 ± 0.012	1.071CysIle: 1.071 ± 0.035	1.162CysLys: 1.162 ± 0.028	1.821CysLeu: 1.821 ± 0.029	0.389CysMet: 0.389 ± 0.009	0.947CysAsn: 0.947 ± 0.021	1.086CysPro: 1.086 ± 0.037	0.724CysGln: 0.724 ± 0.022	1.229CysArg: 1.229 ± 0.039	1.693CysSer: 1.693 ± 0.042	1.06CysThr: 1.06 ± 0.026	1.454CysVal: 1.454 ± 0.031	0.225CysTrp: 0.225 ± 0.006	0.635CysTyr: 0.635 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	3.294AspAla: 3.294 ± 0.03	1.081AspCys: 1.081 ± 0.023	3.927AspAsp: 3.927 ± 0.039	4.306AspGlu: 4.306 ± 0.039	2.151AspPhe: 2.151 ± 0.019	3.221AspGly: 3.221 ± 0.032	1.185AspHis: 1.185 ± 0.019	3.57AspIle: 3.57 ± 0.031	3.587AspLys: 3.587 ± 0.033	4.869AspLeu: 4.869 ± 0.037	1.312AspMet: 1.312 ± 0.017	2.837AspAsn: 2.837 ± 0.028	2.561AspPro: 2.561 ± 0.038	1.623AspGln: 1.623 ± 0.018	2.832AspArg: 2.832 ± 0.03	4.302AspSer: 4.302 ± 0.036	3.059AspThr: 3.059 ± 0.03	3.945AspVal: 3.945 ± 0.03	0.617AspTrp: 0.617 ± 0.012	1.914AspTyr: 1.914 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	4.366GluAla: 4.366 ± 0.037	1.303GluCys: 1.303 ± 0.051	4.124GluAsp: 4.124 ± 0.036	5.76GluGlu: 5.76 ± 0.086	2.03GluPhe: 2.03 ± 0.022	3.185GluGly: 3.185 ± 0.032	1.535GluHis: 1.535 ± 0.022	3.705GluIle: 3.705 ± 0.033	4.903GluLys: 4.903 ± 0.052	5.878GluLeu: 5.878 ± 0.042	1.556GluMet: 1.556 ± 0.018	3.659GluAsn: 3.659 ± 0.03	2.912GluPro: 2.912 ± 0.041	2.521GluGln: 2.521 ± 0.032	4.116GluArg: 4.116 ± 0.038	4.508GluSer: 4.508 ± 0.046	3.624GluThr: 3.624 ± 0.034	3.975GluVal: 3.975 ± 0.043	0.694GluTrp: 0.694 ± 0.012	2.042GluTyr: 2.042 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	2.077PheAla: 2.077 ± 0.023	0.751PheCys: 0.751 ± 0.012	2.076PheAsp: 2.076 ± 0.021	2.081PheGlu: 2.081 ± 0.026	1.421PhePhe: 1.421 ± 0.021	2.248PheGly: 2.248 ± 0.027	0.888PheHis: 0.888 ± 0.015	2.139PheIle: 2.139 ± 0.024	2.146PheLys: 2.146 ± 0.022	3.289PheLeu: 3.289 ± 0.031	0.838PheMet: 0.838 ± 0.014	1.823PheAsn: 1.823 ± 0.017	1.566PhePro: 1.566 ± 0.02	1.256PheGln: 1.256 ± 0.014	1.824PheArg: 1.824 ± 0.019	2.762PheSer: 2.762 ± 0.027	2.102PheThr: 2.102 ± 0.021	2.367PheVal: 2.367 ± 0.022	0.415PheTrp: 0.415 ± 0.008	1.348PheTyr: 1.348 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	4.056GlyAla: 4.056 ± 0.04	1.081GlyCys: 1.081 ± 0.022	3.138GlyAsp: 3.138 ± 0.037	3.247GlyGlu: 3.247 ± 0.038	2.11GlyPhe: 2.11 ± 0.025	4.53GlyGly: 4.53 ± 0.061	1.441GlyHis: 1.441 ± 0.024	2.821GlyIle: 2.821 ± 0.027	3.116GlyLys: 3.116 ± 0.031	4.68GlyLeu: 4.68 ± 0.04	1.137GlyMet: 1.137 ± 0.02	2.407GlyAsn: 2.407 ± 0.027	2.601GlyPro: 2.601 ± 0.055	1.952GlyGln: 1.952 ± 0.029	3.337GlyArg: 3.337 ± 0.034	4.599GlySer: 4.599 ± 0.042	2.914GlyThr: 2.914 ± 0.028	3.836GlyVal: 3.836 ± 0.032	0.748GlyTrp: 0.748 ± 0.014	2.07GlyTyr: 2.07 ± 0.03	0.0GlyXaa: 0.0 ± 0.0
His	1.623HisAla: 1.623 ± 0.02	0.571HisCys: 0.571 ± 0.012	1.217HisAsp: 1.217 ± 0.016	1.379HisGlu: 1.379 ± 0.018	0.934HisPhe: 0.934 ± 0.015	1.393HisGly: 1.393 ± 0.019	0.975HisHis: 0.975 ± 0.031	1.371HisIle: 1.371 ± 0.017	1.418HisLys: 1.418 ± 0.021	2.355HisLeu: 2.355 ± 0.024	0.632HisMet: 0.632 ± 0.011	1.164HisAsn: 1.164 ± 0.015	1.347HisPro: 1.347 ± 0.021	0.955HisGln: 0.955 ± 0.016	1.502HisArg: 1.502 ± 0.018	1.91HisSer: 1.91 ± 0.021	1.5HisThr: 1.5 ± 0.018	1.567HisVal: 1.567 ± 0.017	0.303HisTrp: 0.303 ± 0.007	0.946HisTyr: 0.946 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	3.313IleAla: 3.313 ± 0.024	1.208IleCys: 1.208 ± 0.027	3.206IleAsp: 3.206 ± 0.029	3.539IleGlu: 3.539 ± 0.034	2.108IlePhe: 2.108 ± 0.024	2.664IleGly: 2.664 ± 0.029	1.286IleHis: 1.286 ± 0.015	3.239IleIle: 3.239 ± 0.028	3.795IleLys: 3.795 ± 0.034	4.872IleLeu: 4.872 ± 0.039	1.204IleMet: 1.204 ± 0.017	2.912IleAsn: 2.912 ± 0.036	2.732IlePro: 2.732 ± 0.025	2.155IleGln: 2.155 ± 0.021	2.654IleArg: 2.654 ± 0.021	4.149IleSer: 4.149 ± 0.032	3.303IleThr: 3.303 ± 0.031	3.429IleVal: 3.429 ± 0.029	0.523IleTrp: 0.523 ± 0.011	1.776IleTyr: 1.776 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	3.378LysAla: 3.378 ± 0.026	1.279LysCys: 1.279 ± 0.035	3.558LysAsp: 3.558 ± 0.032	4.799LysGlu: 4.799 ± 0.043	2.068LysPhe: 2.068 ± 0.02	2.677LysGly: 2.677 ± 0.037	1.585LysHis: 1.585 ± 0.02	3.836LysIle: 3.836 ± 0.038	5.469LysLys: 5.469 ± 0.056	5.611LysLeu: 5.611 ± 0.042	1.555LysMet: 1.555 ± 0.016	3.422LysAsn: 3.422 ± 0.029	3.218LysPro: 3.218 ± 0.043	2.571LysGln: 2.571 ± 0.03	3.746LysArg: 3.746 ± 0.031	4.55LysSer: 4.55 ± 0.045	3.7LysThr: 3.7 ± 0.034	3.617LysVal: 3.617 ± 0.034	0.643LysTrp: 0.643 ± 0.011	2.327LysTyr: 2.327 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	6.588LeuAla: 6.588 ± 0.049	1.889LeuCys: 1.889 ± 0.021	4.92LeuAsp: 4.92 ± 0.034	5.944LeuGlu: 5.944 ± 0.048	3.149LeuPhe: 3.149 ± 0.03	4.553LeuGly: 4.553 ± 0.035	2.378LeuHis: 2.378 ± 0.022	4.337LeuIle: 4.337 ± 0.036	6.003LeuLys: 6.003 ± 0.039	8.883LeuLeu: 8.883 ± 0.059	2.03LeuMet: 2.03 ± 0.02	4.278LeuAsn: 4.278 ± 0.032	4.872LeuPro: 4.872 ± 0.034	4.115LeuGln: 4.115 ± 0.032	5.536LeuArg: 5.536 ± 0.043	7.156LeuSer: 7.156 ± 0.044	4.986LeuThr: 4.986 ± 0.032	5.519LeuVal: 5.519 ± 0.041	0.961LeuTrp: 0.961 ± 0.014	2.853LeuTyr: 2.853 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	1.649MetAla: 1.649 ± 0.016	0.451MetCys: 0.451 ± 0.01	1.255MetAsp: 1.255 ± 0.014	1.551MetGlu: 1.551 ± 0.019	0.92MetPhe: 0.92 ± 0.015	1.164MetGly: 1.164 ± 0.022	0.49MetHis: 0.49 ± 0.01	1.048MetIle: 1.048 ± 0.015	1.53MetLys: 1.53 ± 0.018	2.012MetLeu: 2.012 ± 0.02	0.634MetMet: 0.634 ± 0.012	1.071MetAsn: 1.071 ± 0.016	1.099MetPro: 1.099 ± 0.022	0.874MetGln: 0.874 ± 0.012	1.246MetArg: 1.246 ± 0.016	1.862MetSer: 1.862 ± 0.019	1.283MetThr: 1.283 ± 0.015	1.269MetVal: 1.269 ± 0.016	0.274MetTrp: 0.274 ± 0.01	0.726MetTyr: 0.726 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.67AsnAla: 2.67 ± 0.032	0.928AsnCys: 0.928 ± 0.019	2.714AsnAsp: 2.714 ± 0.026	3.25AsnGlu: 3.25 ± 0.028	1.847AsnPhe: 1.847 ± 0.019	2.763AsnGly: 2.763 ± 0.03	1.025AsnHis: 1.025 ± 0.02	3.45AsnIle: 3.45 ± 0.029	3.487AsnLys: 3.487 ± 0.039	4.166AsnLeu: 4.166 ± 0.031	1.232AsnMet: 1.232 ± 0.015	3.046AsnAsn: 3.046 ± 0.042	2.202AsnPro: 2.202 ± 0.04	1.744AsnGln: 1.744 ± 0.026	2.297AsnArg: 2.297 ± 0.022	3.676AsnSer: 3.676 ± 0.033	2.857AsnThr: 2.857 ± 0.026	3.255AsnVal: 3.255 ± 0.031	0.478AsnTrp: 0.478 ± 0.01	1.748AsnTyr: 1.748 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	3.97ProAla: 3.97 ± 0.042	0.891ProCys: 0.891 ± 0.056	2.798ProAsp: 2.798 ± 0.022	3.623ProGlu: 3.623 ± 0.05	1.639ProPhe: 1.639 ± 0.022	3.019ProGly: 3.019 ± 0.071	1.42ProHis: 1.42 ± 0.022	2.532ProIle: 2.532 ± 0.025	2.989ProLys: 2.989 ± 0.038	4.459ProLeu: 4.459 ± 0.031	0.973ProMet: 0.973 ± 0.016	2.256ProAsn: 2.256 ± 0.036	4.912ProPro: 4.912 ± 0.061	2.203ProGln: 2.203 ± 0.032	3.064ProArg: 3.064 ± 0.033	4.326ProSer: 4.326 ± 0.045	3.037ProThr: 3.037 ± 0.036	3.507ProVal: 3.507 ± 0.036	0.527ProTrp: 0.527 ± 0.009	1.693ProTyr: 1.693 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	2.439GlnAla: 2.439 ± 0.026	0.8GlnCys: 0.8 ± 0.02	1.817GlnAsp: 1.817 ± 0.019	2.581GlnGlu: 2.581 ± 0.03	1.29GlnPhe: 1.29 ± 0.017	1.742GlnGly: 1.742 ± 0.032	1.08GlnHis: 1.08 ± 0.017	2.082GlnIle: 2.082 ± 0.017	2.41GlnLys: 2.41 ± 0.027	3.645GlnLeu: 3.645 ± 0.033	0.955GlnMet: 0.955 ± 0.017	2.122GlnAsn: 2.122 ± 0.025	2.057GlnPro: 2.057 ± 0.034	2.152GlnGln: 2.152 ± 0.047	2.378GlnArg: 2.378 ± 0.024	2.642GlnSer: 2.642 ± 0.029	2.123GlnThr: 2.123 ± 0.022	2.177GlnVal: 2.177 ± 0.019	0.44GlnTrp: 0.44 ± 0.009	1.337GlnTyr: 1.337 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	4.174ArgAla: 4.174 ± 0.04	1.214ArgCys: 1.214 ± 0.029	3.244ArgAsp: 3.244 ± 0.035	3.624ArgGlu: 3.624 ± 0.033	1.888ArgPhe: 1.888 ± 0.021	3.226ArgGly: 3.226 ± 0.034	1.691ArgHis: 1.691 ± 0.019	2.717ArgIle: 2.717 ± 0.026	3.645ArgLys: 3.645 ± 0.033	5.312ArgLeu: 5.312 ± 0.038	1.176ArgMet: 1.176 ± 0.015	2.687ArgAsn: 2.687 ± 0.024	3.127ArgPro: 3.127 ± 0.038	2.228ArgGln: 2.228 ± 0.023	4.834ArgArg: 4.834 ± 0.046	4.449ArgSer: 4.449 ± 0.045	2.94ArgThr: 2.94 ± 0.026	3.466ArgVal: 3.466 ± 0.029	0.68ArgTrp: 0.68 ± 0.011	1.811ArgTyr: 1.811 ± 0.021	0.0ArgXaa: 0.0 ± 0.0
Ser	4.935SerAla: 4.935 ± 0.038	1.541SerCys: 1.541 ± 0.041	4.677SerAsp: 4.677 ± 0.033	5.104SerGlu: 5.104 ± 0.058	2.662SerPhe: 2.662 ± 0.026	4.763SerGly: 4.763 ± 0.036	1.854SerHis: 1.854 ± 0.021	3.858SerIle: 3.858 ± 0.028	4.496SerLys: 4.496 ± 0.041	7.006SerLeu: 7.006 ± 0.042	1.573SerMet: 1.573 ± 0.017	3.771SerAsn: 3.771 ± 0.038	4.75SerPro: 4.75 ± 0.056	2.872SerGln: 2.872 ± 0.026	4.297SerArg: 4.297 ± 0.044	7.592SerSer: 7.592 ± 0.069	4.447SerThr: 4.447 ± 0.042	4.908SerVal: 4.908 ± 0.031	0.863SerTrp: 0.863 ± 0.014	2.357SerTyr: 2.357 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	3.761ThrAla: 3.761 ± 0.027	1.189ThrCys: 1.189 ± 0.027	3.034ThrAsp: 3.034 ± 0.029	3.652ThrGlu: 3.652 ± 0.038	2.058ThrPhe: 2.058 ± 0.022	3.071ThrGly: 3.071 ± 0.032	1.401ThrHis: 1.401 ± 0.019	3.089ThrIle: 3.089 ± 0.027	3.349ThrLys: 3.349 ± 0.033	5.177ThrLeu: 5.177 ± 0.039	1.192ThrMet: 1.192 ± 0.016	2.713ThrAsn: 2.713 ± 0.028	3.577ThrPro: 3.577 ± 0.039	2.019ThrGln: 2.019 ± 0.025	2.857ThrArg: 2.857 ± 0.024	4.79ThrSer: 4.79 ± 0.04	3.849ThrThr: 3.849 ± 0.06	3.808ThrVal: 3.808 ± 0.03	0.601ThrTrp: 0.601 ± 0.01	1.726ThrTyr: 1.726 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	4.424ValAla: 4.424 ± 0.032	1.54ValCys: 1.54 ± 0.029	3.403ValAsp: 3.403 ± 0.028	4.003ValGlu: 4.003 ± 0.036	2.393ValPhe: 2.393 ± 0.029	3.303ValGly: 3.303 ± 0.027	1.527ValHis: 1.527 ± 0.018	3.466ValIle: 3.466 ± 0.031	3.918ValLys: 3.918 ± 0.033	6.012ValLeu: 6.012 ± 0.038	1.443ValMet: 1.443 ± 0.016	2.867ValAsn: 2.867 ± 0.027	3.345ValPro: 3.345 ± 0.034	2.343ValGln: 2.343 ± 0.024	3.538ValArg: 3.538 ± 0.032	4.991ValSer: 4.991 ± 0.035	4.057ValThr: 4.057 ± 0.039	4.468ValVal: 4.468 ± 0.033	0.766ValTrp: 0.766 ± 0.012	2.021ValTyr: 2.021 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	0.652TrpAla: 0.652 ± 0.012	0.26TrpCys: 0.26 ± 0.007	0.597TrpAsp: 0.597 ± 0.011	0.624TrpGlu: 0.624 ± 0.012	0.43TrpPhe: 0.43 ± 0.007	0.637TrpGly: 0.637 ± 0.015	0.258TrpHis: 0.258 ± 0.006	0.563TrpIle: 0.563 ± 0.01	0.677TrpLys: 0.677 ± 0.012	1.131TrpLeu: 1.131 ± 0.017	0.288TrpMet: 0.288 ± 0.006	0.515TrpAsn: 0.515 ± 0.011	0.448TrpPro: 0.448 ± 0.009	0.436TrpGln: 0.436 ± 0.011	0.825TrpArg: 0.825 ± 0.013	0.902TrpSer: 0.902 ± 0.013	0.598TrpThr: 0.598 ± 0.011	0.624TrpVal: 0.624 ± 0.012	0.215TrpTrp: 0.215 ± 0.006	0.38TrpTyr: 0.38 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.811TyrAla: 1.811 ± 0.021	0.746TyrCys: 0.746 ± 0.014	1.949TyrAsp: 1.949 ± 0.023	2.026TyrGlu: 2.026 ± 0.018	1.36TyrPhe: 1.36 ± 0.016	1.984TyrGly: 1.984 ± 0.023	0.846TyrHis: 0.846 ± 0.012	1.871TyrIle: 1.871 ± 0.02	2.038TyrLys: 2.038 ± 0.022	2.906TyrLeu: 2.906 ± 0.031	0.785TyrMet: 0.785 ± 0.012	1.824TyrAsn: 1.824 ± 0.024	1.539TyrPro: 1.539 ± 0.026	1.246TyrGln: 1.246 ± 0.017	1.856TyrArg: 1.856 ± 0.021	2.483TyrSer: 2.483 ± 0.027	1.845TyrThr: 1.845 ± 0.02	1.992TyrVal: 1.992 ± 0.02	0.391TyrTrp: 0.391 ± 0.009	1.321TyrTyr: 1.321 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 15140 proteins (6413201 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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