Amino acid dipepetide frequency for Tremella mesenterica (Jelly fungus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.173AlaAla: 6.173 ± 0.058
0.791AlaCys: 0.791 ± 0.015
3.252AlaAsp: 3.252 ± 0.032
4.421AlaGlu: 4.421 ± 0.042
2.46AlaPhe: 2.46 ± 0.029
4.715AlaGly: 4.715 ± 0.039
1.552AlaHis: 1.552 ± 0.02
3.479AlaIle: 3.479 ± 0.034
3.418AlaLys: 3.418 ± 0.037
6.952AlaLeu: 6.952 ± 0.052
1.686AlaMet: 1.686 ± 0.02
2.124AlaAsn: 2.124 ± 0.028
4.201AlaPro: 4.201 ± 0.047
2.918AlaGln: 2.918 ± 0.032
4.354AlaArg: 4.354 ± 0.035
6.248AlaSer: 6.248 ± 0.042
4.136AlaThr: 4.136 ± 0.037
4.345AlaVal: 4.345 ± 0.035
0.98AlaTrp: 0.98 ± 0.017
1.752AlaTyr: 1.752 ± 0.022
0.0AlaXaa: 0.0 ± 0.0
Cys
0.635CysAla: 0.635 ± 0.014
0.184CysCys: 0.184 ± 0.009
0.518CysAsp: 0.518 ± 0.011
0.503CysGlu: 0.503 ± 0.011
0.387CysPhe: 0.387 ± 0.01
0.755CysGly: 0.755 ± 0.02
0.265CysHis: 0.265 ± 0.009
0.509CysIle: 0.509 ± 0.012
0.415CysLys: 0.415 ± 0.011
1.115CysLeu: 1.115 ± 0.019
0.219CysMet: 0.219 ± 0.007
0.292CysAsn: 0.292 ± 0.01
0.621CysPro: 0.621 ± 0.014
0.411CysGln: 0.411 ± 0.012
0.571CysArg: 0.571 ± 0.013
0.776CysSer: 0.776 ± 0.015
0.575CysThr: 0.575 ± 0.011
0.677CysVal: 0.677 ± 0.014
0.168CysTrp: 0.168 ± 0.006
0.266CysTyr: 0.266 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
3.425AspAla: 3.425 ± 0.031
0.504AspCys: 0.504 ± 0.011
4.21AspAsp: 4.21 ± 0.05
4.795AspGlu: 4.795 ± 0.049
1.834AspPhe: 1.834 ± 0.024
3.972AspGly: 3.972 ± 0.036
1.37AspHis: 1.37 ± 0.021
2.87AspIle: 2.87 ± 0.028
2.543AspLys: 2.543 ± 0.032
5.247AspLeu: 5.247 ± 0.043
1.319AspMet: 1.319 ± 0.018
1.682AspAsn: 1.682 ± 0.019
3.664AspPro: 3.664 ± 0.033
2.105AspGln: 2.105 ± 0.023
3.113AspArg: 3.113 ± 0.03
4.06AspSer: 4.06 ± 0.029
2.99AspThr: 2.99 ± 0.029
3.721AspVal: 3.721 ± 0.031
0.864AspTrp: 0.864 ± 0.014
1.323AspTyr: 1.323 ± 0.018
0.0AspXaa: 0.0 ± 0.0
Glu
4.554GluAla: 4.554 ± 0.039
0.535GluCys: 0.535 ± 0.013
4.517GluAsp: 4.517 ± 0.046
7.02GluGlu: 7.02 ± 0.065
1.593GluPhe: 1.593 ± 0.021
4.83GluGly: 4.83 ± 0.035
1.333GluHis: 1.333 ± 0.021
3.252GluIle: 3.252 ± 0.035
4.058GluLys: 4.058 ± 0.047
5.057GluLeu: 5.057 ± 0.043
1.885GluMet: 1.885 ± 0.024
2.228GluAsn: 2.228 ± 0.023
2.626GluPro: 2.626 ± 0.031
2.324GluGln: 2.324 ± 0.031
4.516GluArg: 4.516 ± 0.045
4.372GluSer: 4.372 ± 0.037
3.608GluThr: 3.608 ± 0.034
4.173GluVal: 4.173 ± 0.033
0.973GluTrp: 0.973 ± 0.016
1.542GluTyr: 1.542 ± 0.02
0.0GluXaa: 0.0 ± 0.0
Phe
2.301PheAla: 2.301 ± 0.028
0.424PheCys: 0.424 ± 0.01
2.053PheAsp: 2.053 ± 0.022
1.845PheGlu: 1.845 ± 0.023
1.277PhePhe: 1.277 ± 0.019
2.48PheGly: 2.48 ± 0.034
0.851PheHis: 0.851 ± 0.017
1.535PheIle: 1.535 ± 0.022
1.319PheLys: 1.319 ± 0.018
3.044PheLeu: 3.044 ± 0.03
0.603PheMet: 0.603 ± 0.013
1.142PheAsn: 1.142 ± 0.019
2.049PhePro: 2.049 ± 0.027
1.17PheGln: 1.17 ± 0.018
1.758PheArg: 1.758 ± 0.025
2.939PheSer: 2.939 ± 0.027
1.969PheThr: 1.969 ± 0.022
1.988PheVal: 1.988 ± 0.024
0.471PheTrp: 0.471 ± 0.01
0.823PheTyr: 0.823 ± 0.015
0.0PheXaa: 0.0 ± 0.0
Gly
4.008GlyAla: 4.008 ± 0.044
0.686GlyCys: 0.686 ± 0.016
3.577GlyAsp: 3.577 ± 0.036
4.612GlyGlu: 4.612 ± 0.038
2.29GlyPhe: 2.29 ± 0.028
6.025GlyGly: 6.025 ± 0.068
1.636GlyHis: 1.636 ± 0.023
3.345GlyIle: 3.345 ± 0.032
4.129GlyLys: 4.129 ± 0.038
5.989GlyLeu: 5.989 ± 0.043
2.003GlyMet: 2.003 ± 0.031
2.396GlyAsn: 2.396 ± 0.032
3.461GlyPro: 3.461 ± 0.036
2.867GlyGln: 2.867 ± 0.034
4.373GlyArg: 4.373 ± 0.038
5.773GlySer: 5.773 ± 0.046
3.859GlyThr: 3.859 ± 0.037
4.49GlyVal: 4.49 ± 0.037
1.29GlyTrp: 1.29 ± 0.021
1.843GlyTyr: 1.843 ± 0.024
0.0GlyXaa: 0.0 ± 0.0
His
1.581HisAla: 1.581 ± 0.02
0.257HisCys: 0.257 ± 0.009
1.246HisAsp: 1.246 ± 0.021
1.273HisGlu: 1.273 ± 0.019
0.848HisPhe: 0.848 ± 0.015
1.533HisGly: 1.533 ± 0.023
0.943HisHis: 0.943 ± 0.017
1.227HisIle: 1.227 ± 0.016
0.879HisLys: 0.879 ± 0.015
2.715HisLeu: 2.715 ± 0.032
0.47HisMet: 0.47 ± 0.01
0.799HisAsn: 0.799 ± 0.015
2.245HisPro: 2.245 ± 0.031
1.007HisGln: 1.007 ± 0.017
1.507HisArg: 1.507 ± 0.021
2.391HisSer: 2.391 ± 0.032
1.543HisThr: 1.543 ± 0.021
1.492HisVal: 1.492 ± 0.018
0.295HisTrp: 0.295 ± 0.008
0.584HisTyr: 0.584 ± 0.012
0.0HisXaa: 0.0 ± 0.0
Ile
3.399IleAla: 3.399 ± 0.034
0.598IleCys: 0.598 ± 0.012
2.818IleAsp: 2.818 ± 0.032
2.725IleGlu: 2.725 ± 0.028
1.693IlePhe: 1.693 ± 0.026
3.098IleGly: 3.098 ± 0.034
1.318IleHis: 1.318 ± 0.018
2.562IleIle: 2.562 ± 0.03
2.265IleLys: 2.265 ± 0.025
4.515IleLeu: 4.515 ± 0.043
0.957IleMet: 0.957 ± 0.014
1.791IleAsn: 1.791 ± 0.022
3.989IlePro: 3.989 ± 0.037
1.887IleGln: 1.887 ± 0.024
2.989IleArg: 2.989 ± 0.03
4.709IleSer: 4.709 ± 0.04
2.969IleThr: 2.969 ± 0.026
2.851IleVal: 2.851 ± 0.028
0.672IleTrp: 0.672 ± 0.014
1.196IleTyr: 1.196 ± 0.018
0.0IleXaa: 0.0 ± 0.0
Lys
3.74LysAla: 3.74 ± 0.034
0.426LysCys: 0.426 ± 0.012
2.787LysAsp: 2.787 ± 0.035
3.94LysGlu: 3.94 ± 0.044
1.199LysPhe: 1.199 ± 0.018
3.451LysGly: 3.451 ± 0.031
1.038LysHis: 1.038 ± 0.015
2.236LysIle: 2.236 ± 0.026
3.352LysLys: 3.352 ± 0.048
3.825LysLeu: 3.825 ± 0.038
1.1LysMet: 1.1 ± 0.018
1.572LysAsn: 1.572 ± 0.021
2.724LysPro: 2.724 ± 0.032
1.675LysGln: 1.675 ± 0.023
3.748LysArg: 3.748 ± 0.031
3.858LysSer: 3.858 ± 0.041
2.917LysThr: 2.917 ± 0.03
3.075LysVal: 3.075 ± 0.035
0.68LysTrp: 0.68 ± 0.015
1.143LysTyr: 1.143 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
6.979LeuAla: 6.979 ± 0.051
1.019LeuCys: 1.019 ± 0.017
5.063LeuAsp: 5.063 ± 0.04
5.514LeuGlu: 5.514 ± 0.042
2.924LeuPhe: 2.924 ± 0.029
5.999LeuGly: 5.999 ± 0.055
2.316LeuHis: 2.316 ± 0.025
4.132LeuIle: 4.132 ± 0.039
4.068LeuLys: 4.068 ± 0.042
8.617LeuLeu: 8.617 ± 0.07
1.609LeuMet: 1.609 ± 0.021
3.188LeuAsn: 3.188 ± 0.031
7.09LeuPro: 7.09 ± 0.054
3.528LeuGln: 3.528 ± 0.034
5.802LeuArg: 5.802 ± 0.04
9.027LeuSer: 9.027 ± 0.053
5.334LeuThr: 5.334 ± 0.039
5.268LeuVal: 5.268 ± 0.047
1.05LeuTrp: 1.05 ± 0.016
2.004LeuTyr: 2.004 ± 0.023
0.0LeuXaa: 0.0 ± 0.0
Met
1.683MetAla: 1.683 ± 0.021
0.21MetCys: 0.21 ± 0.006
1.306MetAsp: 1.306 ± 0.015
1.509MetGlu: 1.509 ± 0.021
0.683MetPhe: 0.683 ± 0.012
1.669MetGly: 1.669 ± 0.025
0.318MetHis: 0.318 ± 0.01
1.086MetIle: 1.086 ± 0.018
1.043MetLys: 1.043 ± 0.018
1.754MetLeu: 1.754 ± 0.02
0.587MetMet: 0.587 ± 0.013
0.849MetAsn: 0.849 ± 0.016
1.196MetPro: 1.196 ± 0.017
0.688MetGln: 0.688 ± 0.014
1.344MetArg: 1.344 ± 0.021
2.437MetSer: 2.437 ± 0.023
1.602MetThr: 1.602 ± 0.021
1.3MetVal: 1.3 ± 0.02
0.267MetTrp: 0.267 ± 0.008
0.495MetTyr: 0.495 ± 0.01
0.0MetXaa: 0.0 ± 0.0
Asn
2.332AsnAla: 2.332 ± 0.03
0.312AsnCys: 0.312 ± 0.009
1.926AsnAsp: 1.926 ± 0.021
2.01AsnGlu: 2.01 ± 0.02
1.096AsnPhe: 1.096 ± 0.017
2.872AsnGly: 2.872 ± 0.034
0.949AsnHis: 0.949 ± 0.017
1.805AsnIle: 1.805 ± 0.023
1.534AsnLys: 1.534 ± 0.021
3.276AsnLeu: 3.276 ± 0.027
0.773AsnMet: 0.773 ± 0.016
1.323AsnAsn: 1.323 ± 0.026
2.686AsnPro: 2.686 ± 0.031
1.456AsnGln: 1.456 ± 0.024
1.843AsnArg: 1.843 ± 0.02
2.951AsnSer: 2.951 ± 0.038
2.247AsnThr: 2.247 ± 0.029
2.339AsnVal: 2.339 ± 0.025
0.436AsnTrp: 0.436 ± 0.01
0.783AsnTyr: 0.783 ± 0.016
0.0AsnXaa: 0.0 ± 0.0
Pro
4.455ProAla: 4.455 ± 0.049
0.467ProCys: 0.467 ± 0.013
3.291ProAsp: 3.291 ± 0.034
3.562ProGlu: 3.562 ± 0.034
2.185ProPhe: 2.185 ± 0.025
3.866ProGly: 3.866 ± 0.043
1.784ProHis: 1.784 ± 0.025
3.495ProIle: 3.495 ± 0.035
2.711ProLys: 2.711 ± 0.028
6.081ProLeu: 6.081 ± 0.042
1.206ProMet: 1.206 ± 0.019
2.546ProAsn: 2.546 ± 0.028
7.581ProPro: 7.581 ± 0.1
2.677ProGln: 2.677 ± 0.04
3.823ProArg: 3.823 ± 0.041
9.155ProSer: 9.155 ± 0.084
5.54ProThr: 5.54 ± 0.049
3.822ProVal: 3.822 ± 0.033
0.68ProTrp: 0.68 ± 0.013
1.553ProTyr: 1.553 ± 0.022
0.0ProXaa: 0.0 ± 0.0
Gln
3.194GlnAla: 3.194 ± 0.034
0.353GlnCys: 0.353 ± 0.01
2.018GlnAsp: 2.018 ± 0.024
2.369GlnGlu: 2.369 ± 0.028
1.014GlnPhe: 1.014 ± 0.016
2.493GlnGly: 2.493 ± 0.029
1.004GlnHis: 1.004 ± 0.019
1.944GlnIle: 1.944 ± 0.023
1.656GlnLys: 1.656 ± 0.024
3.428GlnLeu: 3.428 ± 0.03
0.918GlnMet: 0.918 ± 0.019
1.52GlnAsn: 1.52 ± 0.024
2.782GlnPro: 2.782 ± 0.04
2.001GlnGln: 2.001 ± 0.055
2.477GlnArg: 2.477 ± 0.028
3.644GlnSer: 3.644 ± 0.036
2.675GlnThr: 2.675 ± 0.032
2.421GlnVal: 2.421 ± 0.026
0.505GlnTrp: 0.505 ± 0.012
0.98GlnTyr: 0.98 ± 0.018
0.0GlnXaa: 0.0 ± 0.0
Arg
4.282ArgAla: 4.282 ± 0.039
0.556ArgCys: 0.556 ± 0.012
3.235ArgAsp: 3.235 ± 0.033
4.214ArgGlu: 4.214 ± 0.041
1.872ArgPhe: 1.872 ± 0.022
3.923ArgGly: 3.923 ± 0.037
1.595ArgHis: 1.595 ± 0.022
2.902ArgIle: 2.902 ± 0.029
3.563ArgLys: 3.563 ± 0.035
5.674ArgLeu: 5.674 ± 0.042
1.483ArgMet: 1.483 ± 0.023
2.055ArgAsn: 2.055 ± 0.023
4.215ArgPro: 4.215 ± 0.042
2.668ArgGln: 2.668 ± 0.027
5.468ArgArg: 5.468 ± 0.057
5.466ArgSer: 5.466 ± 0.054
3.508ArgThr: 3.508 ± 0.032
3.393ArgVal: 3.393 ± 0.029
0.903ArgTrp: 0.903 ± 0.016
1.543ArgTyr: 1.543 ± 0.022
0.0ArgXaa: 0.0 ± 0.0
Ser
6.158SerAla: 6.158 ± 0.048
0.726SerCys: 0.726 ± 0.015
4.745SerAsp: 4.745 ± 0.043
4.67SerGlu: 4.67 ± 0.042
3.069SerPhe: 3.069 ± 0.028
6.025SerGly: 6.025 ± 0.05
2.592SerHis: 2.592 ± 0.035
4.517SerIle: 4.517 ± 0.034
3.962SerLys: 3.962 ± 0.036
8.61SerLeu: 8.61 ± 0.055
1.849SerMet: 1.849 ± 0.022
3.527SerAsn: 3.527 ± 0.037
7.837SerPro: 7.837 ± 0.084
3.855SerGln: 3.855 ± 0.041
5.543SerArg: 5.543 ± 0.044
12.773SerSer: 12.773 ± 0.134
7.452SerThr: 7.452 ± 0.057
4.966SerVal: 4.966 ± 0.036
1.007SerTrp: 1.007 ± 0.017
1.945SerTyr: 1.945 ± 0.026
0.0SerXaa: 0.0 ± 0.0
Thr
4.307ThrAla: 4.307 ± 0.04
0.641ThrCys: 0.641 ± 0.014
2.872ThrAsp: 2.872 ± 0.027
3.202ThrGlu: 3.202 ± 0.03
2.32ThrPhe: 2.32 ± 0.024
4.006ThrGly: 4.006 ± 0.037
1.542ThrHis: 1.542 ± 0.022
3.245ThrIle: 3.245 ± 0.029
2.591ThrLys: 2.591 ± 0.033
5.8ThrLeu: 5.8 ± 0.041
1.176ThrMet: 1.176 ± 0.018
2.275ThrAsn: 2.275 ± 0.025
5.596ThrPro: 5.596 ± 0.049
2.375ThrGln: 2.375 ± 0.03
3.422ThrArg: 3.422 ± 0.034
7.41ThrSer: 7.41 ± 0.065
4.604ThrThr: 4.604 ± 0.047
3.5ThrVal: 3.5 ± 0.03
0.766ThrTrp: 0.766 ± 0.015
1.595ThrTyr: 1.595 ± 0.02
0.0ThrXaa: 0.0 ± 0.0
Val
4.065ValAla: 4.065 ± 0.036
0.678ValCys: 0.678 ± 0.013
3.716ValAsp: 3.716 ± 0.033
4.433ValGlu: 4.433 ± 0.049
1.988ValPhe: 1.988 ± 0.024
4.3ValGly: 4.3 ± 0.04
1.411ValHis: 1.411 ± 0.019
3.048ValIle: 3.048 ± 0.029
3.268ValLys: 3.268 ± 0.032
5.351ValLeu: 5.351 ± 0.047
1.379ValMet: 1.379 ± 0.018
2.203ValAsn: 2.203 ± 0.025
3.781ValPro: 3.781 ± 0.032
2.309ValGln: 2.309 ± 0.026
3.576ValArg: 3.576 ± 0.032
4.87ValSer: 4.87 ± 0.038
3.35ValThr: 3.35 ± 0.029
4.172ValVal: 4.172 ± 0.037
0.835ValTrp: 0.835 ± 0.017
1.485ValTyr: 1.485 ± 0.021
0.0ValXaa: 0.0 ± 0.0
Trp
0.971TrpAla: 0.971 ± 0.017
0.179TrpCys: 0.179 ± 0.007
0.871TrpAsp: 0.871 ± 0.019
0.998TrpGlu: 0.998 ± 0.015
0.448TrpPhe: 0.448 ± 0.01
0.928TrpGly: 0.928 ± 0.018
0.283TrpHis: 0.283 ± 0.008
0.633TrpIle: 0.633 ± 0.012
0.75TrpLys: 0.75 ± 0.015
1.128TrpLeu: 1.128 ± 0.016
0.33TrpMet: 0.33 ± 0.011
0.542TrpAsn: 0.542 ± 0.012
0.553TrpPro: 0.553 ± 0.013
0.496TrpGln: 0.496 ± 0.01
0.93TrpArg: 0.93 ± 0.016
1.068TrpSer: 1.068 ± 0.016
0.864TrpThr: 0.864 ± 0.016
0.826TrpVal: 0.826 ± 0.015
0.292TrpTrp: 0.292 ± 0.009
0.366TrpTyr: 0.366 ± 0.009
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.716TyrAla: 1.716 ± 0.021
0.314TyrCys: 0.314 ± 0.008
1.588TyrAsp: 1.588 ± 0.022
1.381TyrGlu: 1.381 ± 0.023
0.863TyrPhe: 0.863 ± 0.014
1.707TyrGly: 1.707 ± 0.025
0.734TyrHis: 0.734 ± 0.013
1.178TyrIle: 1.178 ± 0.02
0.963TyrLys: 0.963 ± 0.017
2.354TyrLeu: 2.354 ± 0.023
0.474TyrMet: 0.474 ± 0.01
0.893TyrAsn: 0.893 ± 0.017
1.583TyrPro: 1.583 ± 0.025
0.979TyrGln: 0.979 ± 0.019
1.365TyrArg: 1.365 ± 0.02
1.9TyrSer: 1.9 ± 0.024
1.502TyrThr: 1.502 ± 0.021
1.402TyrVal: 1.402 ± 0.018
0.321TyrTrp: 0.321 ± 0.008
0.688TyrTyr: 0.688 ± 0.015
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8061 proteins (3984402 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski