Amino acid dipepetide frequency for Treponema phagedenis F0421

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.796AlaAla: 7.796 ± 0.114
1.012AlaCys: 1.012 ± 0.041
4.254AlaAsp: 4.254 ± 0.072
6.268AlaGlu: 6.268 ± 0.109
3.674AlaPhe: 3.674 ± 0.071
5.468AlaGly: 5.468 ± 0.09
1.25AlaHis: 1.25 ± 0.038
5.796AlaIle: 5.796 ± 0.088
5.509AlaLys: 5.509 ± 0.093
8.157AlaLeu: 8.157 ± 0.101
1.964AlaMet: 1.964 ± 0.049
2.953AlaAsn: 2.953 ± 0.06
2.344AlaPro: 2.344 ± 0.061
2.785AlaGln: 2.785 ± 0.066
2.937AlaArg: 2.937 ± 0.062
4.483AlaSer: 4.483 ± 0.08
3.178AlaThr: 3.178 ± 0.064
5.808AlaVal: 5.808 ± 0.078
0.677AlaTrp: 0.677 ± 0.032
2.564AlaTyr: 2.564 ± 0.064
0.0AlaXaa: 0.0 ± 0.0
Cys
0.9CysAla: 0.9 ± 0.031
0.22CysCys: 0.22 ± 0.018
0.584CysAsp: 0.584 ± 0.03
0.597CysGlu: 0.597 ± 0.03
0.802CysPhe: 0.802 ± 0.031
1.0CysGly: 1.0 ± 0.043
0.19CysHis: 0.19 ± 0.015
1.161CysIle: 1.161 ± 0.041
0.815CysLys: 0.815 ± 0.032
1.075CysLeu: 1.075 ± 0.04
0.322CysMet: 0.322 ± 0.02
0.493CysAsn: 0.493 ± 0.027
0.513CysPro: 0.513 ± 0.032
0.263CysGln: 0.263 ± 0.018
0.584CysArg: 0.584 ± 0.028
0.811CysSer: 0.811 ± 0.035
0.741CysThr: 0.741 ± 0.037
0.757CysVal: 0.757 ± 0.028
0.079CysTrp: 0.079 ± 0.009
0.428CysTyr: 0.428 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
3.79AspAla: 3.79 ± 0.069
0.609AspCys: 0.609 ± 0.027
2.279AspAsp: 2.279 ± 0.066
3.864AspGlu: 3.864 ± 0.08
3.075AspPhe: 3.075 ± 0.071
3.201AspGly: 3.201 ± 0.076
0.522AspHis: 0.522 ± 0.026
4.392AspIle: 4.392 ± 0.072
3.564AspLys: 3.564 ± 0.074
4.292AspLeu: 4.292 ± 0.079
1.184AspMet: 1.184 ± 0.042
1.945AspAsn: 1.945 ± 0.049
1.824AspPro: 1.824 ± 0.049
0.885AspGln: 0.885 ± 0.037
1.791AspArg: 1.791 ± 0.048
3.483AspSer: 3.483 ± 0.067
2.951AspThr: 2.951 ± 0.058
2.908AspVal: 2.908 ± 0.063
0.531AspTrp: 0.531 ± 0.027
1.967AspTyr: 1.967 ± 0.053
0.0AspXaa: 0.0 ± 0.0
Glu
5.05GluAla: 5.05 ± 0.087
0.547GluCys: 0.547 ± 0.028
2.999GluAsp: 2.999 ± 0.073
5.242GluGlu: 5.242 ± 0.101
2.804GluPhe: 2.804 ± 0.063
3.598GluGly: 3.598 ± 0.072
1.08GluHis: 1.08 ± 0.037
5.5GluIle: 5.5 ± 0.091
7.229GluLys: 7.229 ± 0.101
6.135GluLeu: 6.135 ± 0.098
1.708GluMet: 1.708 ± 0.049
4.082GluAsn: 4.082 ± 0.08
2.02GluPro: 2.02 ± 0.056
2.689GluGln: 2.689 ± 0.063
3.027GluArg: 3.027 ± 0.062
3.624GluSer: 3.624 ± 0.072
3.795GluThr: 3.795 ± 0.073
3.566GluVal: 3.566 ± 0.086
0.588GluTrp: 0.588 ± 0.03
2.337GluTyr: 2.337 ± 0.052
0.0GluXaa: 0.0 ± 0.0
Phe
4.011PheAla: 4.011 ± 0.073
0.872PheCys: 0.872 ± 0.032
2.809PheAsp: 2.809 ± 0.064
2.758PheGlu: 2.758 ± 0.069
3.655PhePhe: 3.655 ± 0.096
3.255PheGly: 3.255 ± 0.066
0.769PheHis: 0.769 ± 0.031
4.42PheIle: 4.42 ± 0.084
3.172PheLys: 3.172 ± 0.064
5.466PheLeu: 5.466 ± 0.115
1.287PheMet: 1.287 ± 0.043
2.122PheAsn: 2.122 ± 0.047
1.815PhePro: 1.815 ± 0.058
1.409PheGln: 1.409 ± 0.047
1.62PheArg: 1.62 ± 0.044
4.393PheSer: 4.393 ± 0.088
3.133PheThr: 3.133 ± 0.067
2.859PheVal: 2.859 ± 0.063
0.482PheTrp: 0.482 ± 0.023
2.165PheTyr: 2.165 ± 0.057
0.0PheXaa: 0.0 ± 0.0
Gly
4.569GlyAla: 4.569 ± 0.087
0.82GlyCys: 0.82 ± 0.036
2.774GlyAsp: 2.774 ± 0.063
3.867GlyGlu: 3.867 ± 0.075
3.564GlyPhe: 3.564 ± 0.069
4.362GlyGly: 4.362 ± 0.095
0.894GlyHis: 0.894 ± 0.038
5.672GlyIle: 5.672 ± 0.103
5.511GlyLys: 5.511 ± 0.097
5.677GlyLeu: 5.677 ± 0.09
1.748GlyMet: 1.748 ± 0.053
2.66GlyAsn: 2.66 ± 0.07
1.084GlyPro: 1.084 ± 0.039
1.616GlyGln: 1.616 ± 0.048
2.447GlyArg: 2.447 ± 0.063
4.128GlySer: 4.128 ± 0.071
3.612GlyThr: 3.612 ± 0.072
4.022GlyVal: 4.022 ± 0.076
0.667GlyTrp: 0.667 ± 0.031
2.252GlyTyr: 2.252 ± 0.056
0.0GlyXaa: 0.0 ± 0.0
His
1.341HisAla: 1.341 ± 0.042
0.336HisCys: 0.336 ± 0.019
0.721HisAsp: 0.721 ± 0.028
0.99HisGlu: 0.99 ± 0.036
0.902HisPhe: 0.902 ± 0.037
1.117HisGly: 1.117 ± 0.041
0.334HisHis: 0.334 ± 0.022
1.342HisIle: 1.342 ± 0.035
1.081HisLys: 1.081 ± 0.038
1.449HisLeu: 1.449 ± 0.049
0.323HisMet: 0.323 ± 0.022
0.772HisAsn: 0.772 ± 0.031
0.779HisPro: 0.779 ± 0.035
0.514HisGln: 0.514 ± 0.027
0.791HisArg: 0.791 ± 0.032
1.019HisSer: 1.019 ± 0.033
1.006HisThr: 1.006 ± 0.033
0.893HisVal: 0.893 ± 0.034
0.198HisTrp: 0.198 ± 0.017
0.66HisTyr: 0.66 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
6.841IleAla: 6.841 ± 0.096
0.989IleCys: 0.989 ± 0.038
4.436IleAsp: 4.436 ± 0.069
5.549IleGlu: 5.549 ± 0.076
4.11IlePhe: 4.11 ± 0.082
4.995IleGly: 4.995 ± 0.098
1.399IleHis: 1.399 ± 0.036
6.808IleIle: 6.808 ± 0.112
5.857IleLys: 5.857 ± 0.097
7.625IleLeu: 7.625 ± 0.113
1.691IleMet: 1.691 ± 0.054
3.431IleAsn: 3.431 ± 0.08
3.766IlePro: 3.766 ± 0.071
2.878IleGln: 2.878 ± 0.059
3.59IleArg: 3.59 ± 0.081
5.379IleSer: 5.379 ± 0.085
4.8IleThr: 4.8 ± 0.082
4.548IleVal: 4.548 ± 0.089
0.552IleTrp: 0.552 ± 0.026
2.424IleTyr: 2.424 ± 0.053
0.0IleXaa: 0.0 ± 0.0
Lys
5.404LysAla: 5.404 ± 0.093
0.451LysCys: 0.451 ± 0.026
4.112LysAsp: 4.112 ± 0.074
6.261LysGlu: 6.261 ± 0.115
2.37LysPhe: 2.37 ± 0.048
3.788LysGly: 3.788 ± 0.077
1.31LysHis: 1.31 ± 0.038
6.865LysIle: 6.865 ± 0.088
8.114LysLys: 8.114 ± 0.119
6.665LysLeu: 6.665 ± 0.08
1.938LysMet: 1.938 ± 0.054
5.566LysAsn: 5.566 ± 0.095
2.655LysPro: 2.655 ± 0.063
2.998LysGln: 2.998 ± 0.063
3.322LysArg: 3.322 ± 0.066
3.923LysSer: 3.923 ± 0.061
5.604LysThr: 5.604 ± 0.091
3.542LysVal: 3.542 ± 0.07
0.47LysTrp: 0.47 ± 0.024
2.313LysTyr: 2.313 ± 0.061
0.0LysXaa: 0.0 ± 0.0
Leu
7.452LeuAla: 7.452 ± 0.112
1.443LeuCys: 1.443 ± 0.045
4.271LeuAsp: 4.271 ± 0.075
5.425LeuGlu: 5.425 ± 0.102
5.468LeuPhe: 5.468 ± 0.097
5.455LeuGly: 5.455 ± 0.087
1.933LeuHis: 1.933 ± 0.058
7.19LeuIle: 7.19 ± 0.123
7.104LeuLys: 7.104 ± 0.099
9.619LeuLeu: 9.619 ± 0.137
2.207LeuMet: 2.207 ± 0.055
4.048LeuAsn: 4.048 ± 0.068
4.292LeuPro: 4.292 ± 0.086
3.977LeuGln: 3.977 ± 0.08
4.403LeuArg: 4.403 ± 0.083
7.301LeuSer: 7.301 ± 0.101
5.18LeuThr: 5.18 ± 0.083
5.12LeuVal: 5.12 ± 0.088
0.786LeuTrp: 0.786 ± 0.036
3.488LeuTyr: 3.488 ± 0.069
0.0LeuXaa: 0.0 ± 0.0
Met
1.731MetAla: 1.731 ± 0.049
0.189MetCys: 0.189 ± 0.014
1.096MetAsp: 1.096 ± 0.032
1.5MetGlu: 1.5 ± 0.047
0.942MetPhe: 0.942 ± 0.031
1.398MetGly: 1.398 ± 0.048
0.445MetHis: 0.445 ± 0.021
1.739MetIle: 1.739 ± 0.051
2.015MetLys: 2.015 ± 0.048
2.51MetLeu: 2.51 ± 0.052
0.573MetMet: 0.573 ± 0.026
1.337MetAsn: 1.337 ± 0.042
1.12MetPro: 1.12 ± 0.041
1.313MetGln: 1.313 ± 0.035
1.25MetArg: 1.25 ± 0.038
1.467MetSer: 1.467 ± 0.045
1.161MetThr: 1.161 ± 0.035
1.401MetVal: 1.401 ± 0.045
0.114MetTrp: 0.114 ± 0.012
0.82MetTyr: 0.82 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
3.547AsnAla: 3.547 ± 0.069
0.565AsnCys: 0.565 ± 0.031
2.007AsnAsp: 2.007 ± 0.054
2.985AsnGlu: 2.985 ± 0.063
2.438AsnPhe: 2.438 ± 0.057
2.894AsnGly: 2.894 ± 0.076
0.665AsnHis: 0.665 ± 0.029
4.187AsnIle: 4.187 ± 0.075
3.453AsnLys: 3.453 ± 0.068
4.453AsnLeu: 4.453 ± 0.07
1.21AsnMet: 1.21 ± 0.034
2.074AsnAsn: 2.074 ± 0.051
2.199AsnPro: 2.199 ± 0.053
1.366AsnGln: 1.366 ± 0.042
2.026AsnArg: 2.026 ± 0.043
2.812AsnSer: 2.812 ± 0.064
2.9AsnThr: 2.9 ± 0.057
2.27AsnVal: 2.27 ± 0.05
0.437AsnTrp: 0.437 ± 0.026
1.763AsnTyr: 1.763 ± 0.046
0.0AsnXaa: 0.0 ± 0.0
Pro
3.026ProAla: 3.026 ± 0.078
0.483ProCys: 0.483 ± 0.025
2.14ProAsp: 2.14 ± 0.053
3.081ProGlu: 3.081 ± 0.067
1.95ProPhe: 1.95 ± 0.05
1.724ProGly: 1.724 ± 0.051
0.729ProHis: 0.729 ± 0.031
2.812ProIle: 2.812 ± 0.073
2.212ProLys: 2.212 ± 0.052
3.679ProLeu: 3.679 ± 0.076
0.847ProMet: 0.847 ± 0.039
1.461ProAsn: 1.461 ± 0.039
1.341ProPro: 1.341 ± 0.043
1.505ProGln: 1.505 ± 0.047
1.264ProArg: 1.264 ± 0.039
2.12ProSer: 2.12 ± 0.055
1.699ProThr: 1.699 ± 0.047
2.74ProVal: 2.74 ± 0.063
0.354ProTrp: 0.354 ± 0.022
1.398ProTyr: 1.398 ± 0.042
0.0ProXaa: 0.0 ± 0.0
Gln
2.714GlnAla: 2.714 ± 0.063
0.302GlnCys: 0.302 ± 0.019
1.467GlnAsp: 1.467 ± 0.035
2.377GlnGlu: 2.377 ± 0.068
1.399GlnPhe: 1.399 ± 0.044
2.064GlnGly: 2.064 ± 0.053
0.563GlnHis: 0.563 ± 0.025
2.567GlnIle: 2.567 ± 0.061
3.599GlnLys: 3.599 ± 0.076
2.725GlnLeu: 2.725 ± 0.051
0.874GlnMet: 0.874 ± 0.035
2.225GlnAsn: 2.225 ± 0.053
0.948GlnPro: 0.948 ± 0.033
1.338GlnGln: 1.338 ± 0.051
1.605GlnArg: 1.605 ± 0.047
2.089GlnSer: 2.089 ± 0.057
2.237GlnThr: 2.237 ± 0.055
1.809GlnVal: 1.809 ± 0.049
0.297GlnTrp: 0.297 ± 0.02
1.215GlnTyr: 1.215 ± 0.044
0.0GlnXaa: 0.0 ± 0.0
Arg
3.021ArgAla: 3.021 ± 0.067
0.62ArgCys: 0.62 ± 0.03
1.797ArgAsp: 1.797 ± 0.047
2.615ArgGlu: 2.615 ± 0.059
2.351ArgPhe: 2.351 ± 0.056
2.383ArgGly: 2.383 ± 0.052
0.688ArgHis: 0.688 ± 0.027
3.613ArgIle: 3.613 ± 0.072
3.385ArgLys: 3.385 ± 0.063
4.137ArgLeu: 4.137 ± 0.076
1.175ArgMet: 1.175 ± 0.041
1.979ArgAsn: 1.979 ± 0.047
1.206ArgPro: 1.206 ± 0.036
1.45ArgGln: 1.45 ± 0.048
2.125ArgArg: 2.125 ± 0.058
2.343ArgSer: 2.343 ± 0.059
2.251ArgThr: 2.251 ± 0.05
2.342ArgVal: 2.342 ± 0.058
0.43ArgTrp: 0.43 ± 0.024
1.737ArgTyr: 1.737 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
5.177SerAla: 5.177 ± 0.084
0.851SerCys: 0.851 ± 0.037
3.187SerAsp: 3.187 ± 0.063
4.118SerGlu: 4.118 ± 0.079
4.305SerPhe: 4.305 ± 0.079
5.026SerGly: 5.026 ± 0.092
0.832SerHis: 0.832 ± 0.034
5.344SerIle: 5.344 ± 0.088
4.095SerLys: 4.095 ± 0.075
6.461SerLeu: 6.461 ± 0.106
1.522SerMet: 1.522 ± 0.045
2.326SerAsn: 2.326 ± 0.057
2.169SerPro: 2.169 ± 0.049
1.775SerGln: 1.775 ± 0.046
2.163SerArg: 2.163 ± 0.05
4.061SerSer: 4.061 ± 0.086
2.918SerThr: 2.918 ± 0.055
4.457SerVal: 4.457 ± 0.069
0.575SerTrp: 0.575 ± 0.027
2.212SerTyr: 2.212 ± 0.049
0.0SerXaa: 0.0 ± 0.0
Thr
5.21ThrAla: 5.21 ± 0.076
0.561ThrCys: 0.561 ± 0.03
3.123ThrAsp: 3.123 ± 0.065
4.135ThrGlu: 4.135 ± 0.081
2.311ThrPhe: 2.311 ± 0.06
4.042ThrGly: 4.042 ± 0.078
1.009ThrHis: 1.009 ± 0.037
4.568ThrIle: 4.568 ± 0.08
3.561ThrLys: 3.561 ± 0.068
5.197ThrLeu: 5.197 ± 0.076
1.213ThrMet: 1.213 ± 0.043
2.194ThrAsn: 2.194 ± 0.053
2.305ThrPro: 2.305 ± 0.048
1.852ThrGln: 1.852 ± 0.059
1.977ThrArg: 1.977 ± 0.053
2.971ThrSer: 2.971 ± 0.067
2.529ThrThr: 2.529 ± 0.063
4.616ThrVal: 4.616 ± 0.081
0.471ThrTrp: 0.471 ± 0.027
1.696ThrTyr: 1.696 ± 0.05
0.0ThrXaa: 0.0 ± 0.0
Val
3.981ValAla: 3.981 ± 0.076
0.853ValCys: 0.853 ± 0.029
2.692ValAsp: 2.692 ± 0.064
3.294ValGlu: 3.294 ± 0.072
3.852ValPhe: 3.852 ± 0.075
3.4ValGly: 3.4 ± 0.068
1.075ValHis: 1.075 ± 0.038
4.535ValIle: 4.535 ± 0.093
4.14ValLys: 4.14 ± 0.073
6.628ValLeu: 6.628 ± 0.104
1.439ValMet: 1.439 ± 0.045
2.436ValAsn: 2.436 ± 0.055
2.498ValPro: 2.498 ± 0.066
2.226ValGln: 2.226 ± 0.058
2.603ValArg: 2.603 ± 0.064
4.515ValSer: 4.515 ± 0.078
3.02ValThr: 3.02 ± 0.067
3.468ValVal: 3.468 ± 0.072
0.521ValTrp: 0.521 ± 0.024
2.23ValTyr: 2.23 ± 0.061
0.0ValXaa: 0.0 ± 0.0
Trp
0.637TrpAla: 0.637 ± 0.027
0.092TrpCys: 0.092 ± 0.012
0.457TrpAsp: 0.457 ± 0.023
0.62TrpGlu: 0.62 ± 0.027
0.522TrpPhe: 0.522 ± 0.025
0.496TrpGly: 0.496 ± 0.025
0.176TrpHis: 0.176 ± 0.015
0.618TrpIle: 0.618 ± 0.03
0.683TrpLys: 0.683 ± 0.032
0.847TrpLeu: 0.847 ± 0.034
0.224TrpMet: 0.224 ± 0.017
0.496TrpAsn: 0.496 ± 0.023
0.183TrpPro: 0.183 ± 0.015
0.41TrpGln: 0.41 ± 0.022
0.397TrpArg: 0.397 ± 0.023
0.43TrpSer: 0.43 ± 0.026
0.482TrpThr: 0.482 ± 0.025
0.477TrpVal: 0.477 ± 0.027
0.089TrpTrp: 0.089 ± 0.01
0.386TrpTyr: 0.386 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.678TyrAla: 2.678 ± 0.064
0.519TyrCys: 0.519 ± 0.027
1.852TyrAsp: 1.852 ± 0.053
2.076TyrGlu: 2.076 ± 0.052
1.98TyrPhe: 1.98 ± 0.054
2.281TyrGly: 2.281 ± 0.057
0.703TyrHis: 0.703 ± 0.027
2.536TyrIle: 2.536 ± 0.055
2.571TyrLys: 2.571 ± 0.057
3.366TyrLeu: 3.366 ± 0.07
0.671TyrMet: 0.671 ± 0.028
1.651TyrAsn: 1.651 ± 0.046
1.505TyrPro: 1.505 ± 0.043
1.166TyrGln: 1.166 ± 0.037
1.725TyrArg: 1.725 ± 0.041
2.222TyrSer: 2.222 ± 0.044
2.344TyrThr: 2.344 ± 0.057
1.805TyrVal: 1.805 ± 0.049
0.404TyrTrp: 0.404 ± 0.023
1.335TyrTyr: 1.335 ± 0.042
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3146 proteins (824179 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski