Amino acid dipepetide frequency for Pantherophis guttatus (Corn snake) (Elaphe guttata)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.83AlaAla: 5.83 ± 0.03	1.212AlaCys: 1.212 ± 0.009	2.77AlaAsp: 2.77 ± 0.012	4.707AlaGlu: 4.707 ± 0.024	2.463AlaPhe: 2.463 ± 0.012	3.806AlaGly: 3.806 ± 0.02	1.344AlaHis: 1.344 ± 0.008	3.017AlaIle: 3.017 ± 0.013	3.701AlaLys: 3.701 ± 0.019	6.211AlaLeu: 6.211 ± 0.022	1.45AlaMet: 1.45 ± 0.009	2.249AlaAsn: 2.249 ± 0.012	3.098AlaPro: 3.098 ± 0.019	2.88AlaGln: 2.88 ± 0.018	2.969AlaArg: 2.969 ± 0.014	5.533AlaSer: 5.533 ± 0.022	3.516AlaThr: 3.516 ± 0.016	4.25AlaVal: 4.25 ± 0.017	0.654AlaTrp: 0.654 ± 0.005	1.441AlaTyr: 1.441 ± 0.01	0.0AlaXaa: 0.0 ± 0.0
Cys	1.061CysAla: 1.061 ± 0.01	0.57CysCys: 0.57 ± 0.006	1.0CysAsp: 1.0 ± 0.011	1.208CysGlu: 1.208 ± 0.011	0.88CysPhe: 0.88 ± 0.008	1.564CysGly: 1.564 ± 0.019	0.628CysHis: 0.628 ± 0.006	1.124CysIle: 1.124 ± 0.01	1.216CysLys: 1.216 ± 0.01	2.144CysLeu: 2.144 ± 0.012	0.458CysMet: 0.458 ± 0.007	0.89CysAsn: 0.89 ± 0.009	1.263CysPro: 1.263 ± 0.014	1.043CysGln: 1.043 ± 0.008	1.119CysArg: 1.119 ± 0.008	2.007CysSer: 2.007 ± 0.013	1.097CysThr: 1.097 ± 0.009	1.149CysVal: 1.149 ± 0.009	0.258CysTrp: 0.258 ± 0.004	0.601CysTyr: 0.601 ± 0.006	0.0CysXaa: 0.0 ± 0.0
Asp	2.738AspAla: 2.738 ± 0.012	1.105AspCys: 1.105 ± 0.011	2.746AspAsp: 2.746 ± 0.016	3.55AspGlu: 3.55 ± 0.016	2.169AspPhe: 2.169 ± 0.01	3.211AspGly: 3.211 ± 0.02	1.19AspHis: 1.19 ± 0.008	2.898AspIle: 2.898 ± 0.014	2.698AspLys: 2.698 ± 0.014	4.939AspLeu: 4.939 ± 0.016	1.142AspMet: 1.142 ± 0.007	1.953AspAsn: 1.953 ± 0.013	2.679AspPro: 2.679 ± 0.015	1.935AspGln: 1.935 ± 0.012	2.287AspArg: 2.287 ± 0.011	4.269AspSer: 4.269 ± 0.018	2.45AspThr: 2.45 ± 0.009	2.925AspVal: 2.925 ± 0.014	0.582AspTrp: 0.582 ± 0.006	1.549AspTyr: 1.549 ± 0.01	0.0AspXaa: 0.0 ± 0.0
Glu	4.898GluAla: 4.898 ± 0.026	1.43GluCys: 1.43 ± 0.016	4.487GluAsp: 4.487 ± 0.016	8.627GluGlu: 8.627 ± 0.046	2.099GluPhe: 2.099 ± 0.01	3.962GluGly: 3.962 ± 0.016	1.558GluHis: 1.558 ± 0.009	3.797GluIle: 3.797 ± 0.017	6.259GluLys: 6.259 ± 0.034	6.484GluLeu: 6.484 ± 0.034	1.905GluMet: 1.905 ± 0.01	3.564GluAsn: 3.564 ± 0.016	2.83GluPro: 2.83 ± 0.017	3.368GluGln: 3.368 ± 0.019	4.073GluArg: 4.073 ± 0.019	4.828GluSer: 4.828 ± 0.018	3.743GluThr: 3.743 ± 0.016	4.094GluVal: 4.094 ± 0.018	0.706GluTrp: 0.706 ± 0.006	1.687GluTyr: 1.687 ± 0.01	0.001GluXaa: 0.001 ± 0.0
Phe	2.038PheAla: 2.038 ± 0.011	0.968PheCys: 0.968 ± 0.008	1.677PheAsp: 1.677 ± 0.01	2.095PheGlu: 2.095 ± 0.012	1.607PhePhe: 1.607 ± 0.011	2.137PheGly: 2.137 ± 0.013	1.07PheHis: 1.07 ± 0.008	2.017PheIle: 2.017 ± 0.011	1.886PheLys: 1.886 ± 0.01	4.08PheLeu: 4.08 ± 0.018	0.811PheMet: 0.811 ± 0.007	1.474PheAsn: 1.474 ± 0.01	2.029PhePro: 2.029 ± 0.012	1.917PheGln: 1.917 ± 0.01	1.856PheArg: 1.856 ± 0.011	3.506PheSer: 3.506 ± 0.013	2.011PheThr: 2.011 ± 0.01	2.075PheVal: 2.075 ± 0.011	0.476PheTrp: 0.476 ± 0.005	1.173PheTyr: 1.173 ± 0.008	0.001PheXaa: 0.001 ± 0.0
Gly	3.431GlyAla: 3.431 ± 0.019	1.144GlyCys: 1.144 ± 0.008	2.9GlyAsp: 2.9 ± 0.016	4.004GlyGlu: 4.004 ± 0.025	2.358GlyPhe: 2.358 ± 0.012	4.267GlyGly: 4.267 ± 0.034	1.5GlyHis: 1.5 ± 0.01	3.028GlyIle: 3.028 ± 0.014	4.061GlyLys: 4.061 ± 0.021	5.148GlyLeu: 5.148 ± 0.021	1.3GlyMet: 1.3 ± 0.01	2.609GlyAsn: 2.609 ± 0.013	3.061GlyPro: 3.061 ± 0.032	2.59GlyGln: 2.59 ± 0.014	3.214GlyArg: 3.214 ± 0.016	5.436GlySer: 5.436 ± 0.019	3.385GlyThr: 3.385 ± 0.016	3.038GlyVal: 3.038 ± 0.017	0.696GlyTrp: 0.696 ± 0.007	1.724GlyTyr: 1.724 ± 0.011	0.001GlyXaa: 0.001 ± 0.0
His	1.262HisAla: 1.262 ± 0.008	0.693HisCys: 0.693 ± 0.007	0.922HisAsp: 0.922 ± 0.006	1.42HisGlu: 1.42 ± 0.009	1.113HisPhe: 1.113 ± 0.007	1.423HisGly: 1.423 ± 0.01	0.944HisHis: 0.944 ± 0.009	1.367HisIle: 1.367 ± 0.009	1.493HisLys: 1.493 ± 0.011	2.924HisLeu: 2.924 ± 0.014	0.561HisMet: 0.561 ± 0.005	1.016HisAsn: 1.016 ± 0.007	1.584HisPro: 1.584 ± 0.01	1.448HisGln: 1.448 ± 0.013	1.476HisArg: 1.476 ± 0.009	2.394HisSer: 2.394 ± 0.013	1.499HisThr: 1.499 ± 0.014	1.367HisVal: 1.367 ± 0.008	0.314HisTrp: 0.314 ± 0.004	0.841HisTyr: 0.841 ± 0.007	0.0HisXaa: 0.0 ± 0.0
Ile	2.892IleAla: 2.892 ± 0.014	1.236IleCys: 1.236 ± 0.009	2.278IleAsp: 2.278 ± 0.011	2.975IleGlu: 2.975 ± 0.015	2.087IlePhe: 2.087 ± 0.013	2.459IleGly: 2.459 ± 0.012	1.555IleHis: 1.555 ± 0.013	2.833IleIle: 2.833 ± 0.016	3.071IleLys: 3.071 ± 0.014	5.027IleLeu: 5.027 ± 0.021	1.107IleMet: 1.107 ± 0.006	2.223IleAsn: 2.223 ± 0.013	2.93IlePro: 2.93 ± 0.013	2.676IleGln: 2.676 ± 0.013	2.51IleArg: 2.51 ± 0.009	4.376IleSer: 4.376 ± 0.015	2.877IleThr: 2.877 ± 0.015	2.824IleVal: 2.824 ± 0.015	0.552IleTrp: 0.552 ± 0.006	1.52IleTyr: 1.52 ± 0.01	0.001IleXaa: 0.001 ± 0.0
Lys	3.993LysAla: 3.993 ± 0.019	1.329LysCys: 1.329 ± 0.014	3.441LysAsp: 3.441 ± 0.016	5.971LysGlu: 5.971 ± 0.035	1.79LysPhe: 1.79 ± 0.01	3.407LysGly: 3.407 ± 0.02	1.587LysHis: 1.587 ± 0.009	3.288LysIle: 3.288 ± 0.014	5.362LysLys: 5.362 ± 0.029	5.655LysLeu: 5.655 ± 0.027	1.675LysMet: 1.675 ± 0.011	2.841LysAsn: 2.841 ± 0.015	3.273LysPro: 3.273 ± 0.023	3.082LysGln: 3.082 ± 0.017	3.601LysArg: 3.601 ± 0.014	4.54LysSer: 4.54 ± 0.02	3.41LysThr: 3.41 ± 0.013	3.579LysVal: 3.579 ± 0.019	0.664LysTrp: 0.664 ± 0.005	1.688LysTyr: 1.688 ± 0.011	0.001LysXaa: 0.001 ± 0.0
Leu	6.213LeuAla: 6.213 ± 0.023	2.018LeuCys: 2.018 ± 0.013	4.767LeuAsp: 4.767 ± 0.019	7.399LeuGlu: 7.399 ± 0.041	3.292LeuPhe: 3.292 ± 0.016	5.04LeuGly: 5.04 ± 0.017	2.828LeuHis: 2.828 ± 0.014	4.185LeuIle: 4.185 ± 0.016	6.326LeuLys: 6.326 ± 0.028	10.186LeuLeu: 10.186 ± 0.043	2.059LeuMet: 2.059 ± 0.01	3.96LeuAsn: 3.96 ± 0.02	5.687LeuPro: 5.687 ± 0.022	5.9LeuGln: 5.9 ± 0.033	5.205LeuArg: 5.205 ± 0.021	8.002LeuSer: 8.002 ± 0.026	4.845LeuThr: 4.845 ± 0.018	5.048LeuVal: 5.048 ± 0.02	1.016LeuTrp: 1.016 ± 0.008	2.52LeuTyr: 2.52 ± 0.013	0.001LeuXaa: 0.001 ± 0.0
Met	1.822MetAla: 1.822 ± 0.01	0.365MetCys: 0.365 ± 0.004	1.358MetAsp: 1.358 ± 0.009	2.123MetGlu: 2.123 ± 0.011	0.786MetPhe: 0.786 ± 0.007	1.267MetGly: 1.267 ± 0.009	0.515MetHis: 0.515 ± 0.005	0.97MetIle: 0.97 ± 0.007	1.654MetLys: 1.654 ± 0.009	2.043MetLeu: 2.043 ± 0.01	0.598MetMet: 0.598 ± 0.006	1.0MetAsn: 1.0 ± 0.008	1.141MetPro: 1.141 ± 0.009	1.063MetGln: 1.063 ± 0.009	1.02MetArg: 1.02 ± 0.008	1.629MetSer: 1.629 ± 0.009	1.163MetThr: 1.163 ± 0.007	1.402MetVal: 1.402 ± 0.01	0.238MetTrp: 0.238 ± 0.003	0.604MetTyr: 0.604 ± 0.006	0.0MetXaa: 0.0 ± 0.0
Asn	2.298AsnAla: 2.298 ± 0.011	0.938AsnCys: 0.938 ± 0.008	1.752AsnAsp: 1.752 ± 0.012	2.664AsnGlu: 2.664 ± 0.014	1.584AsnPhe: 1.584 ± 0.009	2.798AsnGly: 2.798 ± 0.019	1.068AsnHis: 1.068 ± 0.008	2.574AsnIle: 2.574 ± 0.014	2.603AsnLys: 2.603 ± 0.014	4.152AsnLeu: 4.152 ± 0.016	1.016AsnMet: 1.016 ± 0.007	1.947AsnAsn: 1.947 ± 0.014	2.296AsnPro: 2.296 ± 0.011	1.982AsnGln: 1.982 ± 0.012	2.053AsnArg: 2.053 ± 0.009	3.774AsnSer: 3.774 ± 0.018	2.203AsnThr: 2.203 ± 0.013	2.349AsnVal: 2.349 ± 0.013	0.489AsnTrp: 0.489 ± 0.005	1.281AsnTyr: 1.281 ± 0.01	0.0AsnXaa: 0.0 ± 0.0
Pro	3.851ProAla: 3.851 ± 0.021	1.009ProCys: 1.009 ± 0.01	2.646ProAsp: 2.646 ± 0.013	4.05ProGlu: 4.05 ± 0.019	1.992ProPhe: 1.992 ± 0.013	4.063ProGly: 4.063 ± 0.046	1.365ProHis: 1.365 ± 0.01	2.167ProIle: 2.167 ± 0.011	2.95ProLys: 2.95 ± 0.02	4.957ProLeu: 4.957 ± 0.021	1.014ProMet: 1.014 ± 0.008	2.041ProAsn: 2.041 ± 0.012	5.284ProPro: 5.284 ± 0.045	2.576ProGln: 2.576 ± 0.015	2.616ProArg: 2.616 ± 0.016	5.57ProSer: 5.57 ± 0.028	2.928ProThr: 2.928 ± 0.016	3.576ProVal: 3.576 ± 0.016	0.565ProTrp: 0.565 ± 0.006	1.544ProTyr: 1.544 ± 0.014	0.002ProXaa: 0.002 ± 0.0
Gln	3.192GlnAla: 3.192 ± 0.02	0.94GlnCys: 0.94 ± 0.01	2.313GlnAsp: 2.313 ± 0.012	4.114GlnGlu: 4.114 ± 0.024	1.484GlnPhe: 1.484 ± 0.009	2.577GlnGly: 2.577 ± 0.015	1.345GlnHis: 1.345 ± 0.008	2.334GlnIle: 2.334 ± 0.012	3.366GlnLys: 3.366 ± 0.018	4.827GlnLeu: 4.827 ± 0.026	1.257GlnMet: 1.257 ± 0.008	2.25GlnAsn: 2.25 ± 0.011	2.659GlnPro: 2.659 ± 0.018	3.495GlnGln: 3.495 ± 0.041	2.866GlnArg: 2.866 ± 0.016	3.47GlnSer: 3.47 ± 0.016	2.482GlnThr: 2.482 ± 0.012	2.667GlnVal: 2.667 ± 0.013	0.539GlnTrp: 0.539 ± 0.005	1.25GlnTyr: 1.25 ± 0.009	0.0GlnXaa: 0.0 ± 0.0
Arg	2.915ArgAla: 2.915 ± 0.013	1.068ArgCys: 1.068 ± 0.011	2.53ArgAsp: 2.53 ± 0.012	3.721ArgGlu: 3.721 ± 0.021	1.782ArgPhe: 1.782 ± 0.01	2.886ArgGly: 2.886 ± 0.018	1.459ArgHis: 1.459 ± 0.009	2.665ArgIle: 2.665 ± 0.015	3.862ArgLys: 3.862 ± 0.016	4.868ArgLeu: 4.868 ± 0.024	1.234ArgMet: 1.234 ± 0.007	2.312ArgAsn: 2.312 ± 0.012	2.62ArgPro: 2.62 ± 0.014	2.576ArgGln: 2.576 ± 0.014	3.843ArgArg: 3.843 ± 0.025	4.271ArgSer: 4.271 ± 0.026	2.813ArgThr: 2.813 ± 0.014	2.637ArgVal: 2.637 ± 0.013	0.613ArgTrp: 0.613 ± 0.007	1.448ArgTyr: 1.448 ± 0.009	0.001ArgXaa: 0.001 ± 0.0
Ser	5.172SerAla: 5.172 ± 0.023	1.824SerCys: 1.824 ± 0.012	4.092SerAsp: 4.092 ± 0.018	5.573SerGlu: 5.573 ± 0.019	3.347SerPhe: 3.347 ± 0.014	5.239SerGly: 5.239 ± 0.022	2.277SerHis: 2.277 ± 0.012	3.782SerIle: 3.782 ± 0.013	4.673SerLys: 4.673 ± 0.02	8.289SerLeu: 8.289 ± 0.025	1.733SerMet: 1.733 ± 0.008	3.305SerAsn: 3.305 ± 0.016	5.908SerPro: 5.908 ± 0.031	4.049SerGln: 4.049 ± 0.021	4.344SerArg: 4.344 ± 0.021	10.358SerSer: 10.358 ± 0.055	4.816SerThr: 4.816 ± 0.024	4.874SerVal: 4.874 ± 0.017	0.995SerTrp: 0.995 ± 0.007	2.224SerTyr: 2.224 ± 0.011	0.001SerXaa: 0.001 ± 0.0
Thr	3.586ThrAla: 3.586 ± 0.014	1.225ThrCys: 1.225 ± 0.013	2.556ThrAsp: 2.556 ± 0.011	3.859ThrGlu: 3.859 ± 0.016	2.149ThrPhe: 2.149 ± 0.011	3.523ThrGly: 3.523 ± 0.02	1.264ThrHis: 1.264 ± 0.012	2.757ThrIle: 2.757 ± 0.015	2.92ThrLys: 2.92 ± 0.014	5.139ThrLeu: 5.139 ± 0.018	1.186ThrMet: 1.186 ± 0.007	2.001ThrAsn: 2.001 ± 0.012	3.338ThrPro: 3.338 ± 0.018	2.266ThrGln: 2.266 ± 0.012	2.278ThrArg: 2.278 ± 0.011	5.008ThrSer: 5.008 ± 0.022	3.142ThrThr: 3.142 ± 0.02	3.697ThrVal: 3.697 ± 0.016	0.649ThrTrp: 0.649 ± 0.006	1.464ThrTyr: 1.464 ± 0.009	0.001ThrXaa: 0.001 ± 0.0
Val	3.905ValAla: 3.905 ± 0.017	1.3ValCys: 1.3 ± 0.008	2.843ValAsp: 2.843 ± 0.013	3.865ValGlu: 3.865 ± 0.018	2.263ValPhe: 2.263 ± 0.012	3.012ValGly: 3.012 ± 0.014	1.472ValHis: 1.472 ± 0.008	3.013ValIle: 3.013 ± 0.016	3.564ValLys: 3.564 ± 0.017	5.607ValLeu: 5.607 ± 0.018	1.318ValMet: 1.318 ± 0.008	2.35ValAsn: 2.35 ± 0.012	3.342ValPro: 3.342 ± 0.018	2.722ValGln: 2.722 ± 0.013	2.631ValArg: 2.631 ± 0.013	4.718ValSer: 4.718 ± 0.017	3.491ValThr: 3.491 ± 0.018	3.598ValVal: 3.598 ± 0.017	0.661ValTrp: 0.661 ± 0.007	1.552ValTyr: 1.552 ± 0.01	0.001ValXaa: 0.001 ± 0.0
Trp	0.629TrpAla: 0.629 ± 0.006	0.219TrpCys: 0.219 ± 0.003	0.606TrpAsp: 0.606 ± 0.006	0.756TrpGlu: 0.756 ± 0.006	0.413TrpPhe: 0.413 ± 0.004	0.576TrpGly: 0.576 ± 0.008	0.3TrpHis: 0.3 ± 0.004	0.62TrpIle: 0.62 ± 0.007	0.835TrpLys: 0.835 ± 0.006	1.161TrpLeu: 1.161 ± 0.011	0.307TrpMet: 0.307 ± 0.003	0.59TrpAsn: 0.59 ± 0.006	0.466TrpPro: 0.466 ± 0.005	0.537TrpGln: 0.537 ± 0.006	0.629TrpArg: 0.629 ± 0.006	0.837TrpSer: 0.837 ± 0.007	0.627TrpThr: 0.627 ± 0.007	0.605TrpVal: 0.605 ± 0.006	0.172TrpTrp: 0.172 ± 0.003	0.318TrpTyr: 0.318 ± 0.005	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.375TyrAla: 1.375 ± 0.008	0.685TyrCys: 0.685 ± 0.006	1.333TyrAsp: 1.333 ± 0.01	1.717TyrGlu: 1.717 ± 0.011	1.249TyrPhe: 1.249 ± 0.009	1.677TyrGly: 1.677 ± 0.011	0.79TyrHis: 0.79 ± 0.006	1.574TyrIle: 1.574 ± 0.009	1.674TyrLys: 1.674 ± 0.014	2.655TyrLeu: 2.655 ± 0.014	0.631TyrMet: 0.631 ± 0.006	1.247TyrAsn: 1.247 ± 0.009	1.276TyrPro: 1.276 ± 0.009	1.324TyrGln: 1.324 ± 0.009	1.534TyrArg: 1.534 ± 0.008	2.348TyrSer: 2.348 ± 0.012	1.507TyrThr: 1.507 ± 0.01	1.472TyrVal: 1.472 ± 0.009	0.362TyrTrp: 0.362 ± 0.006	0.981TyrTyr: 0.981 ± 0.008	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.001XaaHis: 0.001 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.001XaaLys: 0.001 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.001XaaPro: 0.001 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.01XaaXaa: 0.01 ± 0.001

Statistics based on 33951 proteins (23272350 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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