Amino acid dipepetide frequency for Kazachstania saulgeensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.494AlaAla: 3.494 ± 0.058	0.58AlaCys: 0.58 ± 0.016	2.47AlaAsp: 2.47 ± 0.034	2.698AlaGlu: 2.698 ± 0.04	1.979AlaPhe: 1.979 ± 0.031	2.519AlaGly: 2.519 ± 0.035	0.931AlaHis: 0.931 ± 0.016	3.579AlaIle: 3.579 ± 0.038	3.489AlaLys: 3.489 ± 0.04	4.711AlaLeu: 4.711 ± 0.051	1.24AlaMet: 1.24 ± 0.02	2.857AlaAsn: 2.857 ± 0.033	1.987AlaPro: 1.987 ± 0.043	1.906AlaGln: 1.906 ± 0.038	2.044AlaArg: 2.044 ± 0.031	4.165AlaSer: 4.165 ± 0.046	3.626AlaThr: 3.626 ± 0.045	2.889AlaVal: 2.889 ± 0.038	0.44AlaTrp: 0.44 ± 0.014	1.527AlaTyr: 1.527 ± 0.027	0.0AlaXaa: 0.0 ± 0.0
Cys	0.556CysAla: 0.556 ± 0.015	0.252CysCys: 0.252 ± 0.01	0.65CysAsp: 0.65 ± 0.018	0.554CysGlu: 0.554 ± 0.013	0.589CysPhe: 0.589 ± 0.016	0.749CysGly: 0.749 ± 0.02	0.285CysHis: 0.285 ± 0.011	0.894CysIle: 0.894 ± 0.018	0.707CysLys: 0.707 ± 0.016	1.137CysLeu: 1.137 ± 0.023	0.247CysMet: 0.247 ± 0.009	0.647CysAsn: 0.647 ± 0.017	0.443CysPro: 0.443 ± 0.014	0.398CysGln: 0.398 ± 0.013	0.444CysArg: 0.444 ± 0.01	0.906CysSer: 0.906 ± 0.019	0.587CysThr: 0.587 ± 0.013	0.694CysVal: 0.694 ± 0.016	0.139CysTrp: 0.139 ± 0.007	0.458CysTyr: 0.458 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	2.832AspAla: 2.832 ± 0.039	0.602AspCys: 0.602 ± 0.016	5.14AspAsp: 5.14 ± 0.08	5.143AspGlu: 5.143 ± 0.052	2.632AspPhe: 2.632 ± 0.032	2.832AspGly: 2.832 ± 0.037	1.064AspHis: 1.064 ± 0.019	5.222AspIle: 5.222 ± 0.046	3.922AspLys: 3.922 ± 0.044	5.522AspLeu: 5.522 ± 0.051	1.366AspMet: 1.366 ± 0.021	4.232AspAsn: 4.232 ± 0.049	2.439AspPro: 2.439 ± 0.033	1.886AspGln: 1.886 ± 0.025	2.007AspArg: 2.007 ± 0.026	5.17AspSer: 5.17 ± 0.054	3.541AspThr: 3.541 ± 0.035	3.384AspVal: 3.384 ± 0.039	0.6AspTrp: 0.6 ± 0.015	2.183AspTyr: 2.183 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	2.97GluAla: 2.97 ± 0.037	0.596GluCys: 0.596 ± 0.016	4.374GluAsp: 4.374 ± 0.052	5.937GluGlu: 5.937 ± 0.08	2.607GluPhe: 2.607 ± 0.034	2.519GluGly: 2.519 ± 0.04	1.225GluHis: 1.225 ± 0.024	4.7GluIle: 4.7 ± 0.046	5.008GluLys: 5.008 ± 0.057	6.11GluLeu: 6.11 ± 0.058	1.435GluMet: 1.435 ± 0.022	4.784GluAsn: 4.784 ± 0.053	2.038GluPro: 2.038 ± 0.029	2.829GluGln: 2.829 ± 0.041	2.794GluArg: 2.794 ± 0.038	4.886GluSer: 4.886 ± 0.042	4.093GluThr: 4.093 ± 0.042	3.17GluVal: 3.17 ± 0.039	0.63GluTrp: 0.63 ± 0.017	2.279GluTyr: 2.279 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	2.129PheAla: 2.129 ± 0.033	0.508PheCys: 0.508 ± 0.015	2.814PheAsp: 2.814 ± 0.033	2.75PheGlu: 2.75 ± 0.039	1.887PhePhe: 1.887 ± 0.033	2.51PheGly: 2.51 ± 0.049	0.929PheHis: 0.929 ± 0.019	3.128PheIle: 3.128 ± 0.045	3.179PheLys: 3.179 ± 0.035	3.798PheLeu: 3.798 ± 0.054	0.912PheMet: 0.912 ± 0.02	2.946PheAsn: 2.946 ± 0.036	1.638PhePro: 1.638 ± 0.022	1.798PheGln: 1.798 ± 0.024	1.454PheArg: 1.454 ± 0.028	3.34PheSer: 3.34 ± 0.04	2.517PheThr: 2.517 ± 0.035	2.452PheVal: 2.452 ± 0.035	0.474PheTrp: 0.474 ± 0.014	1.517PheTyr: 1.517 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	2.527GlyAla: 2.527 ± 0.04	0.672GlyCys: 0.672 ± 0.018	2.649GlyAsp: 2.649 ± 0.035	2.62GlyGlu: 2.62 ± 0.036	2.235GlyPhe: 2.235 ± 0.032	2.963GlyGly: 2.963 ± 0.059	1.003GlyHis: 1.003 ± 0.021	3.671GlyIle: 3.671 ± 0.043	3.53GlyLys: 3.53 ± 0.047	4.25GlyLeu: 4.25 ± 0.047	1.029GlyMet: 1.029 ± 0.021	3.266GlyAsn: 3.266 ± 0.04	1.485GlyPro: 1.485 ± 0.028	1.594GlyGln: 1.594 ± 0.029	1.924GlyArg: 1.924 ± 0.035	4.547GlySer: 4.547 ± 0.049	3.114GlyThr: 3.114 ± 0.035	2.798GlyVal: 2.798 ± 0.039	0.528GlyTrp: 0.528 ± 0.016	1.763GlyTyr: 1.763 ± 0.028	0.0GlyXaa: 0.0 ± 0.0
His	0.841HisAla: 0.841 ± 0.02	0.27HisCys: 0.27 ± 0.01	1.224HisAsp: 1.224 ± 0.023	1.172HisGlu: 1.172 ± 0.021	0.926HisPhe: 0.926 ± 0.019	1.056HisGly: 1.056 ± 0.022	0.646HisHis: 0.646 ± 0.023	1.495HisIle: 1.495 ± 0.027	1.247HisLys: 1.247 ± 0.021	1.926HisLeu: 1.926 ± 0.026	0.451HisMet: 0.451 ± 0.014	1.317HisAsn: 1.317 ± 0.027	0.982HisPro: 0.982 ± 0.02	0.76HisGln: 0.76 ± 0.017	0.924HisArg: 0.924 ± 0.019	1.821HisSer: 1.821 ± 0.029	1.161HisThr: 1.161 ± 0.022	1.047HisVal: 1.047 ± 0.02	0.22HisTrp: 0.22 ± 0.009	0.776HisTyr: 0.776 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	3.63IleAla: 3.63 ± 0.038	0.906IleCys: 0.906 ± 0.021	4.815IleAsp: 4.815 ± 0.043	4.643IleGlu: 4.643 ± 0.048	3.06IlePhe: 3.06 ± 0.045	3.314IleGly: 3.314 ± 0.04	1.466IleHis: 1.466 ± 0.024	5.132IleIle: 5.132 ± 0.06	5.143IleLys: 5.143 ± 0.051	6.633IleLeu: 6.633 ± 0.065	1.508IleMet: 1.508 ± 0.024	4.851IleAsn: 4.851 ± 0.047	3.678IlePro: 3.678 ± 0.037	2.721IleGln: 2.721 ± 0.03	2.831IleArg: 2.831 ± 0.033	6.399IleSer: 6.399 ± 0.056	4.367IleThr: 4.367 ± 0.043	4.01IleVal: 4.01 ± 0.045	0.729IleTrp: 0.729 ± 0.019	2.31IleTyr: 2.31 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.044LysAla: 3.044 ± 0.04	0.751LysCys: 0.751 ± 0.019	4.48LysAsp: 4.48 ± 0.044	5.217LysGlu: 5.217 ± 0.059	3.22LysPhe: 3.22 ± 0.039	2.796LysGly: 2.796 ± 0.036	1.437LysHis: 1.437 ± 0.021	5.295LysIle: 5.295 ± 0.054	6.589LysLys: 6.589 ± 0.08	7.172LysLeu: 7.172 ± 0.061	1.585LysMet: 1.585 ± 0.024	4.99LysAsn: 4.99 ± 0.051	2.788LysPro: 2.788 ± 0.035	2.953LysGln: 2.953 ± 0.038	3.762LysArg: 3.762 ± 0.05	5.407LysSer: 5.407 ± 0.047	4.157LysThr: 4.157 ± 0.038	3.662LysVal: 3.662 ± 0.043	0.73LysTrp: 0.73 ± 0.015	2.861LysTyr: 2.861 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	4.724LeuAla: 4.724 ± 0.05	1.147LeuCys: 1.147 ± 0.022	5.365LeuAsp: 5.365 ± 0.052	5.855LeuGlu: 5.855 ± 0.061	4.015LeuPhe: 4.015 ± 0.057	4.238LeuGly: 4.238 ± 0.051	1.93LeuHis: 1.93 ± 0.028	6.019LeuIle: 6.019 ± 0.064	7.214LeuLys: 7.214 ± 0.062	9.195LeuLeu: 9.195 ± 0.08	1.961LeuMet: 1.961 ± 0.028	6.123LeuAsn: 6.123 ± 0.058	4.383LeuPro: 4.383 ± 0.04	4.206LeuGln: 4.206 ± 0.048	4.015LeuArg: 4.015 ± 0.04	7.865LeuSer: 7.865 ± 0.066	5.464LeuThr: 5.464 ± 0.05	4.776LeuVal: 4.776 ± 0.043	0.856LeuTrp: 0.856 ± 0.019	3.069LeuTyr: 3.069 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	1.337MetAla: 1.337 ± 0.022	0.245MetCys: 0.245 ± 0.009	1.426MetAsp: 1.426 ± 0.024	1.334MetGlu: 1.334 ± 0.023	0.927MetPhe: 0.927 ± 0.019	1.174MetGly: 1.174 ± 0.022	0.349MetHis: 0.349 ± 0.012	1.489MetIle: 1.489 ± 0.024	1.653MetLys: 1.653 ± 0.028	1.86MetLeu: 1.86 ± 0.027	0.558MetMet: 0.558 ± 0.018	1.623MetAsn: 1.623 ± 0.03	0.767MetPro: 0.767 ± 0.021	0.71MetGln: 0.71 ± 0.017	0.827MetArg: 0.827 ± 0.017	2.154MetSer: 2.154 ± 0.025	1.421MetThr: 1.421 ± 0.025	1.209MetVal: 1.209 ± 0.023	0.193MetTrp: 0.193 ± 0.009	0.632MetTyr: 0.632 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.057AsnAla: 3.057 ± 0.038	0.69AsnCys: 0.69 ± 0.017	5.035AsnAsp: 5.035 ± 0.052	4.848AsnGlu: 4.848 ± 0.049	2.641AsnPhe: 2.641 ± 0.034	3.761AsnGly: 3.761 ± 0.045	1.348AsnHis: 1.348 ± 0.024	5.387AsnIle: 5.387 ± 0.054	5.043AsnLys: 5.043 ± 0.055	5.461AsnLeu: 5.461 ± 0.056	1.508AsnMet: 1.508 ± 0.026	7.545AsnAsn: 7.545 ± 0.14	2.517AsnPro: 2.517 ± 0.032	2.371AsnGln: 2.371 ± 0.032	2.319AsnArg: 2.319 ± 0.031	6.36AsnSer: 6.36 ± 0.074	4.168AsnThr: 4.168 ± 0.053	3.709AsnVal: 3.709 ± 0.038	0.622AsnTrp: 0.622 ± 0.016	2.279AsnTyr: 2.279 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	1.851ProAla: 1.851 ± 0.032	0.328ProCys: 0.328 ± 0.014	2.108ProAsp: 2.108 ± 0.028	2.726ProGlu: 2.726 ± 0.034	1.833ProPhe: 1.833 ± 0.024	1.795ProGly: 1.795 ± 0.032	0.85ProHis: 0.85 ± 0.021	3.051ProIle: 3.051 ± 0.039	2.712ProLys: 2.712 ± 0.037	3.83ProLeu: 3.83 ± 0.039	0.876ProMet: 0.876 ± 0.019	2.603ProAsn: 2.603 ± 0.037	2.047ProPro: 2.047 ± 0.056	1.863ProGln: 1.863 ± 0.033	1.566ProArg: 1.566 ± 0.029	3.846ProSer: 3.846 ± 0.057	2.937ProThr: 2.937 ± 0.036	2.481ProVal: 2.481 ± 0.037	0.386ProTrp: 0.386 ± 0.013	1.339ProTyr: 1.339 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	1.781GlnAla: 1.781 ± 0.037	0.418GlnCys: 0.418 ± 0.014	2.159GlnAsp: 2.159 ± 0.034	2.618GlnGlu: 2.618 ± 0.035	1.77GlnPhe: 1.77 ± 0.029	1.661GlnGly: 1.661 ± 0.028	0.827GlnHis: 0.827 ± 0.018	2.678GlnIle: 2.678 ± 0.036	2.665GlnLys: 2.665 ± 0.039	4.124GlnLeu: 4.124 ± 0.045	0.921GlnMet: 0.921 ± 0.022	2.732GlnAsn: 2.732 ± 0.035	1.568GlnPro: 1.568 ± 0.031	3.142GlnGln: 3.142 ± 0.12	1.89GlnArg: 1.89 ± 0.029	2.976GlnSer: 2.976 ± 0.033	2.25GlnThr: 2.25 ± 0.038	1.908GlnVal: 1.908 ± 0.026	0.391GlnTrp: 0.391 ± 0.013	1.485GlnTyr: 1.485 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	2.017ArgAla: 2.017 ± 0.028	0.49ArgCys: 0.49 ± 0.014	2.435ArgAsp: 2.435 ± 0.032	2.451ArgGlu: 2.451 ± 0.033	1.767ArgPhe: 1.767 ± 0.024	1.937ArgGly: 1.937 ± 0.036	0.94ArgHis: 0.94 ± 0.02	2.831ArgIle: 2.831 ± 0.033	3.327ArgLys: 3.327 ± 0.045	3.79ArgLeu: 3.79 ± 0.043	0.892ArgMet: 0.892 ± 0.019	2.704ArgAsn: 2.704 ± 0.033	1.465ArgPro: 1.465 ± 0.027	1.622ArgGln: 1.622 ± 0.025	2.59ArgArg: 2.59 ± 0.044	3.399ArgSer: 3.399 ± 0.041	2.402ArgThr: 2.402 ± 0.032	2.135ArgVal: 2.135 ± 0.036	0.424ArgTrp: 0.424 ± 0.012	1.557ArgTyr: 1.557 ± 0.025	0.0ArgXaa: 0.0 ± 0.0
Ser	3.882SerAla: 3.882 ± 0.043	0.844SerCys: 0.844 ± 0.019	4.829SerAsp: 4.829 ± 0.057	4.625SerGlu: 4.625 ± 0.047	3.612SerPhe: 3.612 ± 0.05	4.15SerGly: 4.15 ± 0.051	1.768SerHis: 1.768 ± 0.028	6.395SerIle: 6.395 ± 0.053	6.239SerLys: 6.239 ± 0.065	7.992SerLeu: 7.992 ± 0.059	1.972SerMet: 1.972 ± 0.03	6.826SerAsn: 6.826 ± 0.078	3.441SerPro: 3.441 ± 0.047	3.367SerGln: 3.367 ± 0.041	3.531SerArg: 3.531 ± 0.043	10.274SerSer: 10.274 ± 0.164	6.381SerThr: 6.381 ± 0.083	4.481SerVal: 4.481 ± 0.047	0.722SerTrp: 0.722 ± 0.017	2.612SerTyr: 2.612 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	3.239ThrAla: 3.239 ± 0.04	0.634ThrCys: 0.634 ± 0.015	3.48ThrAsp: 3.48 ± 0.043	3.694ThrGlu: 3.694 ± 0.042	2.622ThrPhe: 2.622 ± 0.032	3.165ThrGly: 3.165 ± 0.038	1.229ThrHis: 1.229 ± 0.023	4.488ThrIle: 4.488 ± 0.039	4.434ThrLys: 4.434 ± 0.041	5.795ThrLeu: 5.795 ± 0.055	1.262ThrMet: 1.262 ± 0.02	4.453ThrAsn: 4.453 ± 0.051	3.08ThrPro: 3.08 ± 0.042	2.201ThrGln: 2.201 ± 0.029	2.303ThrArg: 2.303 ± 0.031	6.003ThrSer: 6.003 ± 0.074	5.303ThrThr: 5.303 ± 0.081	3.71ThrVal: 3.71 ± 0.047	0.548ThrTrp: 0.548 ± 0.015	1.904ThrTyr: 1.904 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	3.177ValAla: 3.177 ± 0.045	0.675ValCys: 0.675 ± 0.021	3.383ValAsp: 3.383 ± 0.035	3.537ValGlu: 3.537 ± 0.04	2.229ValPhe: 2.229 ± 0.036	2.715ValGly: 2.715 ± 0.035	1.063ValHis: 1.063 ± 0.021	3.688ValIle: 3.688 ± 0.038	3.693ValLys: 3.693 ± 0.042	4.878ValLeu: 4.878 ± 0.051	1.161ValMet: 1.161 ± 0.02	3.207ValAsn: 3.207 ± 0.035	2.629ValPro: 2.629 ± 0.036	1.927ValGln: 1.927 ± 0.028	2.156ValArg: 2.156 ± 0.032	4.802ValSer: 4.802 ± 0.053	3.651ValThr: 3.651 ± 0.045	3.314ValVal: 3.314 ± 0.039	0.523ValTrp: 0.523 ± 0.015	1.776ValTyr: 1.776 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	0.459TrpAla: 0.459 ± 0.014	0.208TrpCys: 0.208 ± 0.009	0.661TrpAsp: 0.661 ± 0.015	0.577TrpGlu: 0.577 ± 0.014	0.491TrpPhe: 0.491 ± 0.015	0.492TrpGly: 0.492 ± 0.015	0.189TrpHis: 0.189 ± 0.009	0.612TrpIle: 0.612 ± 0.017	0.813TrpLys: 0.813 ± 0.022	0.898TrpLeu: 0.898 ± 0.021	0.204TrpMet: 0.204 ± 0.01	0.659TrpAsn: 0.659 ± 0.017	0.27TrpPro: 0.27 ± 0.012	0.315TrpGln: 0.315 ± 0.01	0.447TrpArg: 0.447 ± 0.016	0.789TrpSer: 0.789 ± 0.019	0.533TrpThr: 0.533 ± 0.014	0.528TrpVal: 0.528 ± 0.014	0.134TrpTrp: 0.134 ± 0.007	0.385TrpTyr: 0.385 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.582TyrAla: 1.582 ± 0.023	0.521TyrCys: 0.521 ± 0.014	2.224TyrAsp: 2.224 ± 0.028	1.986TyrGlu: 1.986 ± 0.028	1.64TyrPhe: 1.64 ± 0.027	1.82TyrGly: 1.82 ± 0.029	0.785TyrHis: 0.785 ± 0.016	2.392TyrIle: 2.392 ± 0.031	2.287TyrLys: 2.287 ± 0.03	3.338TyrLeu: 3.338 ± 0.034	0.798TyrMet: 0.798 ± 0.019	2.306TyrAsn: 2.306 ± 0.028	1.382TyrPro: 1.382 ± 0.024	1.395TyrGln: 1.395 ± 0.025	1.346TyrArg: 1.346 ± 0.02	2.832TyrSer: 2.832 ± 0.036	1.877TyrThr: 1.877 ± 0.028	1.825TyrVal: 1.825 ± 0.026	0.377TyrTrp: 0.377 ± 0.013	1.482TyrTyr: 1.482 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5290 proteins (2691636 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---