Amino acid dipepetide frequency for Torque teno midi virus 13

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.039AlaAla: 12.039 ± 5.066
0.752AlaCys: 0.752 ± 0.435
3.01AlaAsp: 3.01 ± 1.102
3.762AlaGlu: 3.762 ± 0.779
0.752AlaPhe: 0.752 ± 0.809
1.505AlaGly: 1.505 ± 0.685
3.762AlaHis: 3.762 ± 1.491
0.752AlaIle: 0.752 ± 0.435
2.257AlaLys: 2.257 ± 0.814
3.01AlaLeu: 3.01 ± 1.111
0.0AlaMet: 0.0 ± 0.0
3.01AlaAsn: 3.01 ± 1.739
1.505AlaPro: 1.505 ± 0.685
0.752AlaGln: 0.752 ± 0.809
3.01AlaArg: 3.01 ± 0.559
3.01AlaSer: 3.01 ± 1.916
3.762AlaThr: 3.762 ± 1.478
1.505AlaVal: 1.505 ± 0.87
0.0AlaTrp: 0.0 ± 0.0
0.752AlaTyr: 0.752 ± 0.435
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.752CysCys: 0.752 ± 0.435
0.0CysAsp: 0.0 ± 0.0
0.752CysGlu: 0.752 ± 0.435
0.0CysPhe: 0.0 ± 0.0
0.0CysGly: 0.0 ± 0.0
3.01CysHis: 3.01 ± 1.102
0.0CysIle: 0.0 ± 0.0
0.752CysLys: 0.752 ± 0.435
0.752CysLeu: 0.752 ± 0.435
0.752CysMet: 0.752 ± 0.435
3.01CysAsn: 3.01 ± 1.102
0.0CysPro: 0.0 ± 0.0
0.752CysGln: 0.752 ± 0.748
3.762CysArg: 3.762 ± 0.779
2.257CysSer: 2.257 ± 1.483
0.752CysThr: 0.752 ± 0.435
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.752CysTyr: 0.752 ± 0.435
0.0CysXaa: 0.0 ± 0.0
Asp
0.0AspAla: 0.0 ± 0.0
0.0AspCys: 0.0 ± 0.0
2.257AspAsp: 2.257 ± 1.483
0.752AspGlu: 0.752 ± 0.435
3.762AspPhe: 3.762 ± 0.779
2.257AspGly: 2.257 ± 1.483
0.752AspHis: 0.752 ± 0.809
1.505AspIle: 1.505 ± 0.87
1.505AspLys: 1.505 ± 0.87
6.02AspLeu: 6.02 ± 2.204
3.01AspMet: 3.01 ± 1.102
3.01AspAsn: 3.01 ± 1.102
2.257AspPro: 2.257 ± 0.814
3.762AspGln: 3.762 ± 0.779
3.762AspArg: 3.762 ± 2.212
3.01AspSer: 3.01 ± 1.739
5.267AspThr: 5.267 ± 2.306
0.0AspVal: 0.0 ± 0.0
0.0AspTrp: 0.0 ± 0.0
3.01AspTyr: 3.01 ± 1.102
0.0AspXaa: 0.0 ± 0.0
Glu
0.752GluAla: 0.752 ± 0.435
0.752GluCys: 0.752 ± 0.748
6.772GluAsp: 6.772 ± 2.495
17.306GluGlu: 17.306 ± 8.983
0.0GluPhe: 0.0 ± 0.0
3.762GluGly: 3.762 ± 0.779
1.505GluHis: 1.505 ± 0.685
3.01GluIle: 3.01 ± 1.739
7.524GluLys: 7.524 ± 4.806
5.267GluLeu: 5.267 ± 0.726
0.752GluMet: 0.752 ± 0.809
3.01GluAsn: 3.01 ± 1.102
2.257GluPro: 2.257 ± 0.753
3.762GluGln: 3.762 ± 1.52
1.505GluArg: 1.505 ± 1.026
1.505GluSer: 1.505 ± 0.87
5.267GluThr: 5.267 ± 0.726
0.752GluVal: 0.752 ± 0.435
0.0GluTrp: 0.0 ± 0.0
0.0GluTyr: 0.0 ± 0.0
0.0GluXaa: 0.0 ± 0.0
Phe
2.257PheAla: 2.257 ± 1.483
2.257PheCys: 2.257 ± 1.483
0.752PheAsp: 0.752 ± 0.435
1.505PheGlu: 1.505 ± 0.685
3.01PhePhe: 3.01 ± 1.111
0.752PheGly: 0.752 ± 0.435
1.505PheHis: 1.505 ± 0.685
1.505PheIle: 1.505 ± 0.87
6.02PheLys: 6.02 ± 2.538
1.505PheLeu: 1.505 ± 0.611
0.752PheMet: 0.752 ± 0.674
2.257PheAsn: 2.257 ± 1.483
3.762PhePro: 3.762 ± 0.779
3.762PheGln: 3.762 ± 2.174
1.505PheArg: 1.505 ± 1.618
2.257PheSer: 2.257 ± 1.305
2.257PheThr: 2.257 ± 1.305
0.752PheVal: 0.752 ± 0.435
0.752PheTrp: 0.752 ± 0.435
6.772PheTyr: 6.772 ± 0.754
0.0PheXaa: 0.0 ± 0.0
Gly
3.762GlyAla: 3.762 ± 1.441
1.505GlyCys: 1.505 ± 0.87
0.0GlyAsp: 0.0 ± 0.0
6.772GlyGlu: 6.772 ± 4.45
6.02GlyPhe: 6.02 ± 0.644
11.287GlyGly: 11.287 ± 3.665
4.515GlyHis: 4.515 ± 2.967
2.257GlyIle: 2.257 ± 1.483
6.02GlyLys: 6.02 ± 2.133
0.752GlyLeu: 0.752 ± 0.435
1.505GlyMet: 1.505 ± 0.585
1.505GlyAsn: 1.505 ± 0.685
1.505GlyPro: 1.505 ± 0.611
2.257GlyGln: 2.257 ± 1.305
2.257GlyArg: 2.257 ± 1.435
0.0GlySer: 0.0 ± 0.0
3.762GlyThr: 3.762 ± 1.974
0.752GlyVal: 0.752 ± 0.435
0.752GlyTrp: 0.752 ± 0.435
3.762GlyTyr: 3.762 ± 2.174
0.0GlyXaa: 0.0 ± 0.0
His
0.752HisAla: 0.752 ± 0.435
2.257HisCys: 2.257 ± 1.483
2.257HisAsp: 2.257 ± 1.483
0.752HisGlu: 0.752 ± 0.435
1.505HisPhe: 1.505 ± 0.87
1.505HisGly: 1.505 ± 0.611
0.752HisHis: 0.752 ± 0.748
0.0HisIle: 0.0 ± 0.0
3.762HisLys: 3.762 ± 0.779
3.01HisLeu: 3.01 ± 1.893
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
3.01HisPro: 3.01 ± 1.111
1.505HisGln: 1.505 ± 0.611
1.505HisArg: 1.505 ± 0.87
0.752HisSer: 0.752 ± 0.809
0.752HisThr: 0.752 ± 0.809
0.752HisVal: 0.752 ± 0.748
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
0.752IleAla: 0.752 ± 0.435
0.752IleCys: 0.752 ± 0.435
3.01IleAsp: 3.01 ± 1.102
4.515IleGlu: 4.515 ± 2.967
3.01IlePhe: 3.01 ± 1.102
0.0IleGly: 0.0 ± 0.0
0.752IleHis: 0.752 ± 0.435
1.505IleIle: 1.505 ± 0.87
2.257IleLys: 2.257 ± 1.305
5.267IleLeu: 5.267 ± 0.726
0.0IleMet: 0.0 ± 0.0
3.01IleAsn: 3.01 ± 1.102
3.01IlePro: 3.01 ± 1.739
5.267IleGln: 5.267 ± 1.888
2.257IleArg: 2.257 ± 0.814
3.01IleSer: 3.01 ± 1.066
2.257IleThr: 2.257 ± 0.814
2.257IleVal: 2.257 ± 0.753
3.01IleTrp: 3.01 ± 1.102
1.505IleTyr: 1.505 ± 0.87
0.0IleXaa: 0.0 ± 0.0
Lys
4.515LysAla: 4.515 ± 1.629
0.752LysCys: 0.752 ± 0.435
3.762LysAsp: 3.762 ± 2.212
6.772LysGlu: 6.772 ± 2.505
2.257LysPhe: 2.257 ± 0.814
6.02LysGly: 6.02 ± 1.026
1.505LysHis: 1.505 ± 0.611
4.515LysIle: 4.515 ± 1.848
9.782LysLys: 9.782 ± 4.337
7.524LysLeu: 7.524 ± 1.074
0.752LysMet: 0.752 ± 0.435
2.257LysAsn: 2.257 ± 1.305
4.515LysPro: 4.515 ± 1.115
8.277LysGln: 8.277 ± 1.789
6.02LysArg: 6.02 ± 0.644
3.01LysSer: 3.01 ± 0.559
7.524LysThr: 7.524 ± 0.067
3.01LysVal: 3.01 ± 1.066
2.257LysTrp: 2.257 ± 1.305
2.257LysTyr: 2.257 ± 0.702
0.0LysXaa: 0.0 ± 0.0
Leu
8.277LeuAla: 8.277 ± 4.403
3.762LeuCys: 3.762 ± 0.779
3.762LeuAsp: 3.762 ± 1.478
0.752LeuGlu: 0.752 ± 0.435
3.762LeuPhe: 3.762 ± 1.478
3.762LeuGly: 3.762 ± 1.3
1.505LeuHis: 1.505 ± 0.87
6.02LeuIle: 6.02 ± 1.479
6.772LeuLys: 6.772 ± 1.26
6.772LeuLeu: 6.772 ± 0.807
0.752LeuMet: 0.752 ± 0.435
3.762LeuAsn: 3.762 ± 1.478
6.02LeuPro: 6.02 ± 2.963
4.515LeuGln: 4.515 ± 1.042
1.505LeuArg: 1.505 ± 0.87
3.762LeuSer: 3.762 ± 1.444
4.515LeuThr: 4.515 ± 1.115
3.01LeuVal: 3.01 ± 1.111
0.0LeuTrp: 0.0 ± 0.0
2.257LeuTyr: 2.257 ± 1.305
0.0LeuXaa: 0.0 ± 0.0
Met
0.752MetAla: 0.752 ± 0.809
0.752MetCys: 0.752 ± 0.435
0.0MetAsp: 0.0 ± 0.0
0.0MetGlu: 0.0 ± 0.0
0.752MetPhe: 0.752 ± 0.435
0.752MetGly: 0.752 ± 0.809
0.0MetHis: 0.0 ± 0.0
0.752MetIle: 0.752 ± 0.435
0.752MetLys: 0.752 ± 0.748
6.02MetLeu: 6.02 ± 1.026
0.0MetMet: 0.0 ± 0.0
0.752MetAsn: 0.752 ± 0.435
0.752MetPro: 0.752 ± 0.435
0.0MetGln: 0.0 ± 0.0
0.752MetArg: 0.752 ± 0.435
6.02MetSer: 6.02 ± 2.895
0.0MetThr: 0.0 ± 0.0
0.752MetVal: 0.752 ± 0.435
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
0.752AsnAla: 0.752 ± 0.435
0.0AsnCys: 0.0 ± 0.0
0.0AsnAsp: 0.0 ± 0.0
0.752AsnGlu: 0.752 ± 0.435
4.515AsnPhe: 4.515 ± 2.131
0.0AsnGly: 0.0 ± 0.0
0.0AsnHis: 0.0 ± 0.0
3.01AsnIle: 3.01 ± 1.111
2.257AsnLys: 2.257 ± 0.702
3.01AsnLeu: 3.01 ± 1.739
1.505AsnMet: 1.505 ± 0.805
0.752AsnAsn: 0.752 ± 0.435
6.02AsnPro: 6.02 ± 0.644
4.515AsnGln: 4.515 ± 1.152
2.257AsnArg: 2.257 ± 1.435
6.02AsnSer: 6.02 ± 2.941
3.762AsnThr: 3.762 ± 2.174
3.01AsnVal: 3.01 ± 1.739
0.752AsnTrp: 0.752 ± 0.435
3.01AsnTyr: 3.01 ± 1.739
0.0AsnXaa: 0.0 ± 0.0
Pro
5.267ProAla: 5.267 ± 1.899
0.0ProCys: 0.0 ± 0.0
4.515ProAsp: 4.515 ± 0.615
6.772ProGlu: 6.772 ± 2.548
8.277ProPhe: 8.277 ± 2.597
7.524ProGly: 7.524 ± 2.029
0.0ProHis: 0.0 ± 0.0
2.257ProIle: 2.257 ± 0.753
5.267ProLys: 5.267 ± 1.783
3.762ProLeu: 3.762 ± 1.478
0.752ProMet: 0.752 ± 0.748
2.257ProAsn: 2.257 ± 0.814
5.267ProPro: 5.267 ± 0.8
3.01ProGln: 3.01 ± 1.371
2.257ProArg: 2.257 ± 1.435
0.752ProSer: 0.752 ± 0.748
2.257ProThr: 2.257 ± 1.305
2.257ProVal: 2.257 ± 0.814
2.257ProTrp: 2.257 ± 0.814
3.01ProTyr: 3.01 ± 1.066
0.0ProXaa: 0.0 ± 0.0
Gln
3.01GlnAla: 3.01 ± 0.559
2.257GlnCys: 2.257 ± 1.483
0.0GlnAsp: 0.0 ± 0.0
5.267GlnGlu: 5.267 ± 0.726
0.752GlnPhe: 0.752 ± 0.435
5.267GlnGly: 5.267 ± 1.343
1.505GlnHis: 1.505 ± 0.611
7.524GlnIle: 7.524 ± 2.171
3.762GlnLys: 3.762 ± 1.441
6.772GlnLeu: 6.772 ± 3.194
2.257GlnMet: 2.257 ± 1.305
1.505GlnAsn: 1.505 ± 0.87
4.515GlnPro: 4.515 ± 1.848
7.524GlnGln: 7.524 ± 1.801
3.01GlnArg: 3.01 ± 1.223
2.257GlnSer: 2.257 ± 0.753
9.029GlnThr: 9.029 ± 1.434
1.505GlnVal: 1.505 ± 0.685
1.505GlnTrp: 1.505 ± 0.87
0.752GlnTyr: 0.752 ± 0.748
0.0GlnXaa: 0.0 ± 0.0
Arg
0.752ArgAla: 0.752 ± 0.435
0.0ArgCys: 0.0 ± 0.0
7.524ArgAsp: 7.524 ± 2.983
0.752ArgGlu: 0.752 ± 0.435
1.505ArgPhe: 1.505 ± 0.685
0.752ArgGly: 0.752 ± 0.809
1.505ArgHis: 1.505 ± 0.611
0.0ArgIle: 0.0 ± 0.0
6.772ArgLys: 6.772 ± 3.109
1.505ArgLeu: 1.505 ± 1.618
1.505ArgMet: 1.505 ± 0.922
3.01ArgAsn: 3.01 ± 2.442
6.02ArgPro: 6.02 ± 2.741
3.01ArgGln: 3.01 ± 1.223
12.792ArgArg: 12.792 ± 6.564
6.02ArgSer: 6.02 ± 2.895
0.752ArgThr: 0.752 ± 0.435
0.752ArgVal: 0.752 ± 0.435
0.752ArgTrp: 0.752 ± 0.435
3.762ArgTyr: 3.762 ± 2.174
0.0ArgXaa: 0.0 ± 0.0
Ser
0.0SerAla: 0.0 ± 0.0
0.0SerCys: 0.0 ± 0.0
0.752SerAsp: 0.752 ± 0.435
2.257SerGlu: 2.257 ± 0.753
1.505SerPhe: 1.505 ± 0.611
6.02SerGly: 6.02 ± 2.475
1.505SerHis: 1.505 ± 0.87
3.762SerIle: 3.762 ± 0.779
6.772SerLys: 6.772 ± 2.184
3.01SerLeu: 3.01 ± 1.066
0.0SerMet: 0.0 ± 0.0
2.257SerAsn: 2.257 ± 1.295
6.02SerPro: 6.02 ± 2.538
5.267SerGln: 5.267 ± 0.851
2.257SerArg: 2.257 ± 2.243
9.029SerSer: 9.029 ± 7.013
8.277SerThr: 8.277 ± 2.662
1.505SerVal: 1.505 ± 0.87
0.0SerTrp: 0.0 ± 0.0
3.01SerTyr: 3.01 ± 1.279
0.0SerXaa: 0.0 ± 0.0
Thr
3.01ThrAla: 3.01 ± 1.111
0.752ThrCys: 0.752 ± 0.435
6.02ThrAsp: 6.02 ± 0.706
2.257ThrGlu: 2.257 ± 0.814
3.01ThrPhe: 3.01 ± 1.739
6.772ThrGly: 6.772 ± 1.4
0.0ThrHis: 0.0 ± 0.0
3.762ThrIle: 3.762 ± 1.491
4.515ThrLys: 4.515 ± 1.042
6.772ThrLeu: 6.772 ± 1.625
1.505ThrMet: 1.505 ± 0.685
3.762ThrAsn: 3.762 ± 1.478
6.02ThrPro: 6.02 ± 0.644
6.02ThrGln: 6.02 ± 2.941
3.762ThrArg: 3.762 ± 1.072
5.267ThrSer: 5.267 ± 4.251
6.772ThrThr: 6.772 ± 3.109
0.0ThrVal: 0.0 ± 0.0
2.257ThrTrp: 2.257 ± 1.305
2.257ThrTyr: 2.257 ± 1.305
0.0ThrXaa: 0.0 ± 0.0
Val
0.0ValAla: 0.0 ± 0.0
0.752ValCys: 0.752 ± 0.435
0.0ValAsp: 0.0 ± 0.0
1.505ValGlu: 1.505 ± 0.685
0.0ValPhe: 0.0 ± 0.0
0.0ValGly: 0.0 ± 0.0
0.0ValHis: 0.0 ± 0.0
1.505ValIle: 1.505 ± 0.87
4.515ValLys: 4.515 ± 2.609
0.752ValLeu: 0.752 ± 0.435
0.0ValMet: 0.0 ± 0.0
3.762ValAsn: 3.762 ± 1.478
3.01ValPro: 3.01 ± 0.559
2.257ValGln: 2.257 ± 1.305
1.505ValArg: 1.505 ± 0.87
2.257ValSer: 2.257 ± 1.295
1.505ValThr: 1.505 ± 0.87
0.0ValVal: 0.0 ± 0.0
0.752ValTrp: 0.752 ± 0.435
0.752ValTyr: 0.752 ± 0.435
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.752TrpAsp: 0.752 ± 0.435
1.505TrpGlu: 1.505 ± 0.87
0.752TrpPhe: 0.752 ± 0.435
2.257TrpGly: 2.257 ± 1.305
0.752TrpHis: 0.752 ± 0.435
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
1.505TrpLeu: 1.505 ± 0.685
2.257TrpMet: 2.257 ± 1.483
1.505TrpAsn: 1.505 ± 0.87
0.0TrpPro: 0.0 ± 0.0
1.505TrpGln: 1.505 ± 0.87
1.505TrpArg: 1.505 ± 0.87
0.0TrpSer: 0.0 ± 0.0
2.257TrpThr: 2.257 ± 1.305
0.0TrpVal: 0.0 ± 0.0
0.752TrpTrp: 0.752 ± 0.435
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.257TyrAla: 2.257 ± 1.305
0.0TyrCys: 0.0 ± 0.0
0.752TyrAsp: 0.752 ± 0.435
0.752TyrGlu: 0.752 ± 0.435
0.752TyrPhe: 0.752 ± 0.435
0.752TyrGly: 0.752 ± 0.435
0.0TyrHis: 0.0 ± 0.0
3.762TyrIle: 3.762 ± 0.779
6.02TyrLys: 6.02 ± 1.479
2.257TyrLeu: 2.257 ± 0.814
0.752TyrMet: 0.752 ± 0.435
2.257TyrAsn: 2.257 ± 1.305
2.257TyrPro: 2.257 ± 0.702
2.257TyrGln: 2.257 ± 0.814
2.257TyrArg: 2.257 ± 1.305
3.01TyrSer: 3.01 ± 1.066
3.762TyrThr: 3.762 ± 1.444
2.257TyrVal: 2.257 ± 1.305
1.505TyrTrp: 1.505 ± 0.87
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (1330 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski