Amino acid dipepetide frequency for Xylaria flabelliformis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.893AlaAla: 8.893 ± 0.054	1.053AlaCys: 1.053 ± 0.013	4.316AlaAsp: 4.316 ± 0.031	5.0AlaGlu: 5.0 ± 0.043	3.095AlaPhe: 3.095 ± 0.024	5.628AlaGly: 5.628 ± 0.042	1.787AlaHis: 1.787 ± 0.018	4.451AlaIle: 4.451 ± 0.027	4.056AlaLys: 4.056 ± 0.032	7.655AlaLeu: 7.655 ± 0.041	1.867AlaMet: 1.867 ± 0.018	3.104AlaAsn: 3.104 ± 0.023	4.456AlaPro: 4.456 ± 0.033	3.305AlaGln: 3.305 ± 0.031	4.909AlaArg: 4.909 ± 0.032	7.171AlaSer: 7.171 ± 0.037	5.459AlaThr: 5.459 ± 0.038	5.339AlaVal: 5.339 ± 0.035	1.133AlaTrp: 1.133 ± 0.014	2.231AlaTyr: 2.231 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	0.908CysAla: 0.908 ± 0.011	0.226CysCys: 0.226 ± 0.007	0.694CysAsp: 0.694 ± 0.011	0.594CysGlu: 0.594 ± 0.011	0.509CysPhe: 0.509 ± 0.009	0.893CysGly: 0.893 ± 0.014	0.333CysHis: 0.333 ± 0.008	0.695CysIle: 0.695 ± 0.013	0.492CysLys: 0.492 ± 0.009	1.218CysLeu: 1.218 ± 0.016	0.247CysMet: 0.247 ± 0.006	0.448CysAsn: 0.448 ± 0.009	0.644CysPro: 0.644 ± 0.011	0.456CysGln: 0.456 ± 0.009	0.772CysArg: 0.772 ± 0.012	0.924CysSer: 0.924 ± 0.014	0.679CysThr: 0.679 ± 0.011	0.761CysVal: 0.761 ± 0.012	0.191CysTrp: 0.191 ± 0.006	0.386CysTyr: 0.386 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.755AspAla: 4.755 ± 0.032	0.652AspCys: 0.652 ± 0.011	4.51AspAsp: 4.51 ± 0.047	4.534AspGlu: 4.534 ± 0.037	2.236AspPhe: 2.236 ± 0.019	4.103AspGly: 4.103 ± 0.026	1.274AspHis: 1.274 ± 0.014	3.292AspIle: 3.292 ± 0.027	2.457AspLys: 2.457 ± 0.024	5.146AspLeu: 5.146 ± 0.029	1.274AspMet: 1.274 ± 0.017	2.075AspAsn: 2.075 ± 0.018	3.3AspPro: 3.3 ± 0.025	1.896AspGln: 1.896 ± 0.02	3.107AspArg: 3.107 ± 0.031	4.208AspSer: 4.208 ± 0.031	3.106AspThr: 3.106 ± 0.021	3.758AspVal: 3.758 ± 0.028	0.922AspTrp: 0.922 ± 0.013	1.698AspTyr: 1.698 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	5.267GluAla: 5.267 ± 0.041	0.64GluCys: 0.64 ± 0.012	4.088GluAsp: 4.088 ± 0.039	5.07GluGlu: 5.07 ± 0.047	1.99GluPhe: 1.99 ± 0.021	3.546GluGly: 3.546 ± 0.026	1.406GluHis: 1.406 ± 0.015	3.175GluIle: 3.175 ± 0.025	3.573GluLys: 3.573 ± 0.032	5.294GluLeu: 5.294 ± 0.041	1.371GluMet: 1.371 ± 0.014	2.377GluAsn: 2.377 ± 0.018	2.827GluPro: 2.827 ± 0.027	2.386GluGln: 2.386 ± 0.024	3.836GluArg: 3.836 ± 0.038	4.322GluSer: 4.322 ± 0.035	3.527GluThr: 3.527 ± 0.024	3.479GluVal: 3.479 ± 0.024	0.889GluTrp: 0.889 ± 0.012	1.661GluTyr: 1.661 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.018PheAla: 3.018 ± 0.021	0.516PheCys: 0.516 ± 0.011	2.344PheAsp: 2.344 ± 0.024	2.179PheGlu: 2.179 ± 0.02	1.518PhePhe: 1.518 ± 0.018	2.816PheGly: 2.816 ± 0.027	0.898PheHis: 0.898 ± 0.014	1.817PheIle: 1.817 ± 0.021	1.545PheLys: 1.545 ± 0.017	3.334PheLeu: 3.334 ± 0.029	0.716PheMet: 0.716 ± 0.012	1.46PheAsn: 1.46 ± 0.019	1.913PhePro: 1.913 ± 0.018	1.375PheGln: 1.375 ± 0.016	2.009PheArg: 2.009 ± 0.02	2.936PheSer: 2.936 ± 0.026	2.184PheThr: 2.184 ± 0.023	2.369PheVal: 2.369 ± 0.022	0.622PheTrp: 0.622 ± 0.011	1.107PheTyr: 1.107 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	5.249GlyAla: 5.249 ± 0.038	0.831GlyCys: 0.831 ± 0.013	3.726GlyAsp: 3.726 ± 0.028	3.479GlyGlu: 3.479 ± 0.025	2.753GlyPhe: 2.753 ± 0.025	5.534GlyGly: 5.534 ± 0.056	1.719GlyHis: 1.719 ± 0.021	3.573GlyIle: 3.573 ± 0.026	3.287GlyLys: 3.287 ± 0.028	6.016GlyLeu: 6.016 ± 0.035	1.406GlyMet: 1.406 ± 0.02	2.712GlyAsn: 2.712 ± 0.021	3.354GlyPro: 3.354 ± 0.028	2.473GlyGln: 2.473 ± 0.022	4.1GlyArg: 4.1 ± 0.031	5.691GlySer: 5.691 ± 0.039	4.028GlyThr: 4.028 ± 0.03	4.267GlyVal: 4.267 ± 0.031	1.129GlyTrp: 1.129 ± 0.015	2.115GlyTyr: 2.115 ± 0.021	0.0GlyXaa: 0.0 ± 0.0
His	1.828HisAla: 1.828 ± 0.02	0.335HisCys: 0.335 ± 0.007	1.413HisAsp: 1.413 ± 0.016	1.378HisGlu: 1.378 ± 0.016	0.921HisPhe: 0.921 ± 0.012	1.738HisGly: 1.738 ± 0.02	0.889HisHis: 0.889 ± 0.016	1.272HisIle: 1.272 ± 0.017	0.952HisLys: 0.952 ± 0.013	2.23HisLeu: 2.23 ± 0.023	0.493HisMet: 0.493 ± 0.009	0.9HisAsn: 0.9 ± 0.012	1.614HisPro: 1.614 ± 0.02	1.011HisGln: 1.011 ± 0.016	1.551HisArg: 1.551 ± 0.017	1.827HisSer: 1.827 ± 0.018	1.28HisThr: 1.28 ± 0.015	1.473HisVal: 1.473 ± 0.013	0.334HisTrp: 0.334 ± 0.008	0.727HisTyr: 0.727 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.35IleAla: 4.35 ± 0.03	0.738IleCys: 0.738 ± 0.012	3.111IleAsp: 3.111 ± 0.025	3.051IleGlu: 3.051 ± 0.024	1.952IlePhe: 1.952 ± 0.019	3.272IleGly: 3.272 ± 0.026	1.219IleHis: 1.219 ± 0.015	2.675IleIle: 2.675 ± 0.023	2.273IleLys: 2.273 ± 0.022	4.58IleLeu: 4.58 ± 0.029	1.045IleMet: 1.045 ± 0.013	1.934IleAsn: 1.934 ± 0.017	3.163IlePro: 3.163 ± 0.024	1.994IleGln: 1.994 ± 0.021	2.983IleArg: 2.983 ± 0.025	4.056IleSer: 4.056 ± 0.028	3.079IleThr: 3.079 ± 0.026	3.311IleVal: 3.311 ± 0.028	0.77IleTrp: 0.77 ± 0.013	1.414IleTyr: 1.414 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	4.167LysAla: 4.167 ± 0.033	0.504LysCys: 0.504 ± 0.01	2.719LysAsp: 2.719 ± 0.027	3.213LysGlu: 3.213 ± 0.03	1.459LysPhe: 1.459 ± 0.015	2.895LysGly: 2.895 ± 0.023	1.113LysHis: 1.113 ± 0.014	2.367LysIle: 2.367 ± 0.02	3.203LysLys: 3.203 ± 0.043	4.177LysLeu: 4.177 ± 0.029	0.984LysMet: 0.984 ± 0.013	1.8LysAsn: 1.8 ± 0.022	2.749LysPro: 2.749 ± 0.022	1.831LysGln: 1.831 ± 0.018	3.321LysArg: 3.321 ± 0.027	3.532LysSer: 3.532 ± 0.029	2.942LysThr: 2.942 ± 0.023	2.71LysVal: 2.71 ± 0.023	0.68LysTrp: 0.68 ± 0.012	1.372LysTyr: 1.372 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	7.789LeuAla: 7.789 ± 0.045	1.189LeuCys: 1.189 ± 0.014	5.238LeuAsp: 5.238 ± 0.034	5.525LeuGlu: 5.525 ± 0.038	3.237LeuPhe: 3.237 ± 0.028	5.937LeuGly: 5.937 ± 0.036	2.238LeuHis: 2.238 ± 0.02	4.056LeuIle: 4.056 ± 0.028	4.198LeuLys: 4.198 ± 0.03	8.292LeuLeu: 8.292 ± 0.061	1.661LeuMet: 1.661 ± 0.017	3.238LeuAsn: 3.238 ± 0.021	5.379LeuPro: 5.379 ± 0.036	3.763LeuGln: 3.763 ± 0.031	5.89LeuArg: 5.89 ± 0.037	7.354LeuSer: 7.354 ± 0.042	4.923LeuThr: 4.923 ± 0.03	5.442LeuVal: 5.442 ± 0.033	1.242LeuTrp: 1.242 ± 0.015	2.344LeuTyr: 2.344 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.099MetAla: 2.099 ± 0.019	0.219MetCys: 0.219 ± 0.007	1.2MetAsp: 1.2 ± 0.014	1.162MetGlu: 1.162 ± 0.016	0.678MetPhe: 0.678 ± 0.011	1.357MetGly: 1.357 ± 0.015	0.457MetHis: 0.457 ± 0.01	1.0MetIle: 1.0 ± 0.012	1.002MetLys: 1.002 ± 0.013	1.768MetLeu: 1.768 ± 0.018	0.566MetMet: 0.566 ± 0.01	0.81MetAsn: 0.81 ± 0.012	1.26MetPro: 1.26 ± 0.017	0.819MetGln: 0.819 ± 0.014	1.292MetArg: 1.292 ± 0.017	1.787MetSer: 1.787 ± 0.017	1.293MetThr: 1.293 ± 0.014	1.206MetVal: 1.206 ± 0.014	0.234MetTrp: 0.234 ± 0.006	0.484MetTyr: 0.484 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	3.234AsnAla: 3.234 ± 0.029	0.462AsnCys: 0.462 ± 0.009	2.16AsnAsp: 2.16 ± 0.02	2.151AsnGlu: 2.151 ± 0.018	1.399AsnPhe: 1.399 ± 0.016	3.069AsnGly: 3.069 ± 0.028	0.905AsnHis: 0.905 ± 0.013	2.136AsnIle: 2.136 ± 0.017	1.612AsnLys: 1.612 ± 0.018	3.384AsnLeu: 3.384 ± 0.025	0.851AsnMet: 0.851 ± 0.011	1.709AsnAsn: 1.709 ± 0.021	2.523AsnPro: 2.523 ± 0.02	1.411AsnGln: 1.411 ± 0.016	2.041AsnArg: 2.041 ± 0.02	2.973AsnSer: 2.973 ± 0.023	2.384AsnThr: 2.384 ± 0.019	2.357AsnVal: 2.357 ± 0.02	0.589AsnTrp: 0.589 ± 0.011	1.129AsnTyr: 1.129 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	4.934ProAla: 4.934 ± 0.035	0.518ProCys: 0.518 ± 0.009	3.279ProAsp: 3.279 ± 0.025	3.726ProGlu: 3.726 ± 0.032	2.019ProPhe: 2.019 ± 0.02	3.848ProGly: 3.848 ± 0.029	1.312ProHis: 1.312 ± 0.017	2.724ProIle: 2.724 ± 0.023	2.659ProLys: 2.659 ± 0.022	4.746ProLeu: 4.746 ± 0.032	1.058ProMet: 1.058 ± 0.013	2.35ProAsn: 2.35 ± 0.021	4.986ProPro: 4.986 ± 0.06	2.398ProGln: 2.398 ± 0.027	3.459ProArg: 3.459 ± 0.03	5.846ProSer: 5.846 ± 0.047	4.137ProThr: 4.137 ± 0.034	3.488ProVal: 3.488 ± 0.03	0.779ProTrp: 0.779 ± 0.013	1.548ProTyr: 1.548 ± 0.017	0.0ProXaa: 0.0 ± 0.0
Gln	3.334GlnAla: 3.334 ± 0.027	0.451GlnCys: 0.451 ± 0.01	2.139GlnAsp: 2.139 ± 0.02	2.301GlnGlu: 2.301 ± 0.024	1.317GlnPhe: 1.317 ± 0.014	2.351GlnGly: 2.351 ± 0.022	1.104GlnHis: 1.104 ± 0.014	1.945GlnIle: 1.945 ± 0.02	1.934GlnLys: 1.934 ± 0.019	3.526GlnLeu: 3.526 ± 0.03	0.826GlnMet: 0.826 ± 0.013	1.568GlnAsn: 1.568 ± 0.018	2.525GlnPro: 2.525 ± 0.028	2.334GlnGln: 2.334 ± 0.038	2.583GlnArg: 2.583 ± 0.025	3.142GlnSer: 3.142 ± 0.027	2.322GlnThr: 2.322 ± 0.022	2.207GlnVal: 2.207 ± 0.019	0.595GlnTrp: 0.595 ± 0.009	1.205GlnTyr: 1.205 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	4.708ArgAla: 4.708 ± 0.033	0.728ArgCys: 0.728 ± 0.011	3.613ArgAsp: 3.613 ± 0.031	3.783ArgGlu: 3.783 ± 0.033	2.2ArgPhe: 2.2 ± 0.017	3.723ArgGly: 3.723 ± 0.031	1.66ArgHis: 1.66 ± 0.019	3.053ArgIle: 3.053 ± 0.026	3.302ArgLys: 3.302 ± 0.028	5.565ArgLeu: 5.565 ± 0.036	1.264ArgMet: 1.264 ± 0.015	2.355ArgAsn: 2.355 ± 0.022	3.544ArgPro: 3.544 ± 0.032	2.715ArgGln: 2.715 ± 0.023	5.104ArgArg: 5.104 ± 0.041	4.763ArgSer: 4.763 ± 0.035	3.322ArgThr: 3.322 ± 0.026	3.391ArgVal: 3.391 ± 0.025	0.946ArgTrp: 0.946 ± 0.014	1.719ArgTyr: 1.719 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.519SerAla: 6.519 ± 0.038	0.874SerCys: 0.874 ± 0.014	4.303SerAsp: 4.303 ± 0.03	4.164SerGlu: 4.164 ± 0.031	3.021SerPhe: 3.021 ± 0.024	5.557SerGly: 5.557 ± 0.037	1.992SerHis: 1.992 ± 0.019	4.187SerIle: 4.187 ± 0.033	3.695SerLys: 3.695 ± 0.03	7.153SerLeu: 7.153 ± 0.04	1.673SerMet: 1.673 ± 0.018	3.183SerAsn: 3.183 ± 0.026	5.422SerPro: 5.422 ± 0.042	3.386SerGln: 3.386 ± 0.029	5.146SerArg: 5.146 ± 0.037	9.008SerSer: 9.008 ± 0.073	5.762SerThr: 5.762 ± 0.043	4.541SerVal: 4.541 ± 0.03	1.167SerTrp: 1.167 ± 0.015	2.17SerTyr: 2.17 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	5.27ThrAla: 5.27 ± 0.033	0.762ThrCys: 0.762 ± 0.013	2.974ThrAsp: 2.974 ± 0.022	3.15ThrGlu: 3.15 ± 0.028	2.241ThrPhe: 2.241 ± 0.023	4.193ThrGly: 4.193 ± 0.032	1.328ThrHis: 1.328 ± 0.014	3.299ThrIle: 3.299 ± 0.027	2.719ThrLys: 2.719 ± 0.027	5.258ThrLeu: 5.258 ± 0.032	1.236ThrMet: 1.236 ± 0.016	2.341ThrAsn: 2.341 ± 0.022	4.388ThrPro: 4.388 ± 0.039	2.199ThrGln: 2.199 ± 0.021	3.3ThrArg: 3.3 ± 0.028	5.614ThrSer: 5.614 ± 0.043	4.748ThrThr: 4.748 ± 0.047	3.709ThrVal: 3.709 ± 0.03	0.908ThrTrp: 0.908 ± 0.013	1.732ThrTyr: 1.732 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	5.263ValAla: 5.263 ± 0.038	0.766ValCys: 0.766 ± 0.012	3.799ValAsp: 3.799 ± 0.031	3.798ValGlu: 3.798 ± 0.03	2.39ValPhe: 2.39 ± 0.021	3.917ValGly: 3.917 ± 0.031	1.377ValHis: 1.377 ± 0.017	3.047ValIle: 3.047 ± 0.023	2.857ValLys: 2.857 ± 0.022	5.553ValLeu: 5.553 ± 0.032	1.243ValMet: 1.243 ± 0.014	2.33ValAsn: 2.33 ± 0.021	3.567ValPro: 3.567 ± 0.028	2.251ValGln: 2.251 ± 0.019	3.397ValArg: 3.397 ± 0.025	4.634ValSer: 4.634 ± 0.035	3.618ValThr: 3.618 ± 0.031	4.287ValVal: 4.287 ± 0.034	0.856ValTrp: 0.856 ± 0.014	1.738ValTyr: 1.738 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.155TrpAla: 1.155 ± 0.016	0.196TrpCys: 0.196 ± 0.006	0.94TrpAsp: 0.94 ± 0.014	0.861TrpGlu: 0.861 ± 0.012	0.552TrpPhe: 0.552 ± 0.01	0.956TrpGly: 0.956 ± 0.013	0.364TrpHis: 0.364 ± 0.008	0.793TrpIle: 0.793 ± 0.012	0.787TrpLys: 0.787 ± 0.012	1.36TrpLeu: 1.36 ± 0.016	0.328TrpMet: 0.328 ± 0.007	0.629TrpAsn: 0.629 ± 0.011	0.645TrpPro: 0.645 ± 0.011	0.575TrpGln: 0.575 ± 0.011	0.976TrpArg: 0.976 ± 0.013	1.06TrpSer: 1.06 ± 0.015	0.94TrpThr: 0.94 ± 0.013	0.902TrpVal: 0.902 ± 0.013	0.27TrpTrp: 0.27 ± 0.008	0.435TrpTyr: 0.435 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.167TyrAla: 2.167 ± 0.021	0.414TyrCys: 0.414 ± 0.008	1.737TyrAsp: 1.737 ± 0.018	1.604TyrGlu: 1.604 ± 0.018	1.189TyrPhe: 1.189 ± 0.018	2.105TyrGly: 2.105 ± 0.023	0.79TyrHis: 0.79 ± 0.012	1.413TyrIle: 1.413 ± 0.017	1.136TyrLys: 1.136 ± 0.014	2.68TyrLeu: 2.68 ± 0.022	0.582TyrMet: 0.582 ± 0.01	1.155TyrAsn: 1.155 ± 0.014	1.556TyrPro: 1.556 ± 0.024	1.134TyrGln: 1.134 ± 0.014	1.682TyrArg: 1.682 ± 0.02	2.075TyrSer: 2.075 ± 0.023	1.639TyrThr: 1.639 ± 0.017	1.691TyrVal: 1.691 ± 0.017	0.464TyrTrp: 0.464 ± 0.009	0.998TyrTyr: 0.998 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 11403 proteins (5968531 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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