Amino acid dipepetide frequency for Tobacco leaf curl Pusa virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.613AlaAla: 4.613 ± 2.102
0.923AlaCys: 0.923 ± 0.713
0.923AlaAsp: 0.923 ± 0.713
3.69AlaGlu: 3.69 ± 1.474
0.923AlaPhe: 0.923 ± 0.926
0.0AlaGly: 0.0 ± 0.0
5.535AlaHis: 5.535 ± 1.657
1.845AlaIle: 1.845 ± 1.006
4.613AlaLys: 4.613 ± 1.106
6.458AlaLeu: 6.458 ± 2.16
1.845AlaMet: 1.845 ± 1.005
1.845AlaAsn: 1.845 ± 1.277
3.69AlaPro: 3.69 ± 1.175
1.845AlaGln: 1.845 ± 1.031
3.69AlaArg: 3.69 ± 1.788
4.613AlaSer: 4.613 ± 2.207
3.69AlaThr: 3.69 ± 1.934
0.0AlaVal: 0.0 ± 0.0
0.923AlaTrp: 0.923 ± 0.638
0.923AlaTyr: 0.923 ± 0.638
0.0AlaXaa: 0.0 ± 0.0
Cys
0.923CysAla: 0.923 ± 0.926
1.845CysCys: 1.845 ± 2.088
0.923CysAsp: 0.923 ± 1.044
0.923CysGlu: 0.923 ± 0.713
0.923CysPhe: 0.923 ± 0.959
1.845CysGly: 1.845 ± 0.925
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.923CysLys: 0.923 ± 0.713
0.923CysLeu: 0.923 ± 1.154
1.845CysMet: 1.845 ± 1.428
0.923CysAsn: 0.923 ± 0.926
1.845CysPro: 1.845 ± 2.088
1.845CysGln: 1.845 ± 1.031
0.923CysArg: 0.923 ± 0.959
0.923CysSer: 0.923 ± 0.926
1.845CysThr: 1.845 ± 1.078
1.845CysVal: 1.845 ± 1.425
0.923CysTrp: 0.923 ± 0.638
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.69AspAla: 3.69 ± 1.909
0.923AspCys: 0.923 ± 0.926
0.923AspAsp: 0.923 ± 0.638
1.845AspGlu: 1.845 ± 0.786
0.923AspPhe: 0.923 ± 0.713
2.768AspGly: 2.768 ± 1.292
0.0AspHis: 0.0 ± 0.0
3.69AspIle: 3.69 ± 1.455
0.923AspLys: 0.923 ± 0.638
8.303AspLeu: 8.303 ± 2.832
0.923AspMet: 0.923 ± 1.044
2.768AspAsn: 2.768 ± 1.725
1.845AspPro: 1.845 ± 1.031
0.923AspGln: 0.923 ± 0.638
2.768AspArg: 2.768 ± 1.358
6.458AspSer: 6.458 ± 1.783
3.69AspThr: 3.69 ± 2.061
4.613AspVal: 4.613 ± 1.263
0.923AspTrp: 0.923 ± 0.638
0.923AspTyr: 0.923 ± 0.638
0.0AspXaa: 0.0 ± 0.0
Glu
2.768GluAla: 2.768 ± 1.242
0.923GluCys: 0.923 ± 0.638
2.768GluAsp: 2.768 ± 1.285
3.69GluGlu: 3.69 ± 1.816
2.768GluPhe: 2.768 ± 1.361
3.69GluGly: 3.69 ± 1.216
0.923GluHis: 0.923 ± 0.638
0.923GluIle: 0.923 ± 0.638
0.923GluLys: 0.923 ± 0.638
4.613GluLeu: 4.613 ± 1.574
0.0GluMet: 0.0 ± 0.0
2.768GluAsn: 2.768 ± 1.358
1.845GluPro: 1.845 ± 0.786
2.768GluGln: 2.768 ± 1.569
0.923GluArg: 0.923 ± 0.959
4.613GluSer: 4.613 ± 1.457
3.69GluThr: 3.69 ± 1.278
2.768GluVal: 2.768 ± 1.285
1.845GluTrp: 1.845 ± 0.925
0.0GluTyr: 0.0 ± 0.0
0.0GluXaa: 0.0 ± 0.0
Phe
0.923PheAla: 0.923 ± 0.638
1.845PheCys: 1.845 ± 1.126
2.768PheAsp: 2.768 ± 1.242
0.923PheGlu: 0.923 ± 0.638
0.923PhePhe: 0.923 ± 0.638
2.768PheGly: 2.768 ± 1.576
1.845PheHis: 1.845 ± 1.277
0.923PheIle: 0.923 ± 0.638
2.768PheLys: 2.768 ± 1.859
4.613PheLeu: 4.613 ± 2.798
0.923PheMet: 0.923 ± 0.713
1.845PheAsn: 1.845 ± 0.918
1.845PhePro: 1.845 ± 1.031
2.768PheGln: 2.768 ± 0.93
1.845PheArg: 1.845 ± 2.309
0.923PheSer: 0.923 ± 0.926
3.69PheThr: 3.69 ± 1.68
0.923PheVal: 0.923 ± 0.638
0.0PheTrp: 0.0 ± 0.0
2.768PheTyr: 2.768 ± 1.569
0.0PheXaa: 0.0 ± 0.0
Gly
0.923GlyAla: 0.923 ± 0.638
1.845GlyCys: 1.845 ± 1.078
2.768GlyAsp: 2.768 ± 1.192
3.69GlyGlu: 3.69 ± 1.539
0.923GlyPhe: 0.923 ± 0.926
1.845GlyGly: 1.845 ± 0.786
0.923GlyHis: 0.923 ± 0.638
0.923GlyIle: 0.923 ± 0.959
5.535GlyLys: 5.535 ± 2.358
3.69GlyLeu: 3.69 ± 1.644
0.0GlyMet: 0.0 ± 0.0
2.768GlyAsn: 2.768 ± 1.504
3.69GlyPro: 3.69 ± 1.812
5.535GlyGln: 5.535 ± 1.366
1.845GlyArg: 1.845 ± 0.925
1.845GlySer: 1.845 ± 1.277
4.613GlyThr: 4.613 ± 1.106
1.845GlyVal: 1.845 ± 1.918
0.0GlyTrp: 0.0 ± 0.0
0.0GlyTyr: 0.0 ± 0.0
0.0GlyXaa: 0.0 ± 0.0
His
0.923HisAla: 0.923 ± 0.713
2.768HisCys: 2.768 ± 2.102
1.845HisAsp: 1.845 ± 0.918
0.923HisGlu: 0.923 ± 0.959
3.69HisPhe: 3.69 ± 1.859
1.845HisGly: 1.845 ± 1.378
1.845HisHis: 1.845 ± 1.287
1.845HisIle: 1.845 ± 1.604
1.845HisLys: 1.845 ± 1.031
3.69HisLeu: 3.69 ± 1.859
0.0HisMet: 0.0 ± 0.0
2.768HisAsn: 2.768 ± 1.292
0.923HisPro: 0.923 ± 0.638
2.768HisGln: 2.768 ± 0.799
2.768HisArg: 2.768 ± 1.879
1.845HisSer: 1.845 ± 1.277
2.768HisThr: 2.768 ± 2.138
2.768HisVal: 2.768 ± 1.303
0.0HisTrp: 0.0 ± 0.0
0.923HisTyr: 0.923 ± 0.638
0.0HisXaa: 0.0 ± 0.0
Ile
1.845IleAla: 1.845 ± 1.078
2.768IleCys: 2.768 ± 1.278
2.768IleAsp: 2.768 ± 1.292
0.923IleGlu: 0.923 ± 0.638
0.923IlePhe: 0.923 ± 0.638
0.923IleGly: 0.923 ± 1.044
2.768IleHis: 2.768 ± 1.303
1.845IleIle: 1.845 ± 1.006
4.613IleLys: 4.613 ± 1.647
0.0IleLeu: 0.0 ± 0.0
0.923IleMet: 0.923 ± 0.805
2.768IleAsn: 2.768 ± 0.799
0.923IlePro: 0.923 ± 0.926
3.69IleGln: 3.69 ± 1.356
4.613IleArg: 4.613 ± 2.24
8.303IleSer: 8.303 ± 3.128
4.613IleThr: 4.613 ± 3.071
1.845IleVal: 1.845 ± 0.786
2.768IleTrp: 2.768 ± 1.517
2.768IleTyr: 2.768 ± 2.138
0.0IleXaa: 0.0 ± 0.0
Lys
2.768LysAla: 2.768 ± 1.303
0.923LysCys: 0.923 ± 0.638
3.69LysAsp: 3.69 ± 2.554
3.69LysGlu: 3.69 ± 1.198
1.845LysPhe: 1.845 ± 1.425
2.768LysGly: 2.768 ± 1.074
1.845LysHis: 1.845 ± 1.277
5.535LysIle: 5.535 ± 2.671
2.768LysLys: 2.768 ± 1.369
0.0LysLeu: 0.0 ± 0.0
0.0LysMet: 0.0 ± 0.0
7.38LysAsn: 7.38 ± 1.84
1.845LysPro: 1.845 ± 1.126
0.923LysGln: 0.923 ± 1.044
4.613LysArg: 4.613 ± 1.982
6.458LysSer: 6.458 ± 2.365
2.768LysThr: 2.768 ± 0.971
5.535LysVal: 5.535 ± 1.963
0.923LysTrp: 0.923 ± 0.638
5.535LysTyr: 5.535 ± 1.616
0.0LysXaa: 0.0 ± 0.0
Leu
3.69LeuAla: 3.69 ± 1.372
0.923LeuCys: 0.923 ± 0.638
5.535LeuAsp: 5.535 ± 2.612
2.768LeuGlu: 2.768 ± 1.915
1.845LeuPhe: 1.845 ± 1.378
3.69LeuGly: 3.69 ± 1.58
0.923LeuHis: 0.923 ± 0.638
5.535LeuIle: 5.535 ± 2.226
4.613LeuLys: 4.613 ± 1.647
4.613LeuLeu: 4.613 ± 2.593
0.923LeuMet: 0.923 ± 0.869
4.613LeuAsn: 4.613 ± 1.107
1.845LeuPro: 1.845 ± 1.851
7.38LeuGln: 7.38 ± 2.065
7.38LeuArg: 7.38 ± 3.918
4.613LeuSer: 4.613 ± 1.868
4.613LeuThr: 4.613 ± 2.067
4.613LeuVal: 4.613 ± 1.937
0.0LeuTrp: 0.0 ± 0.0
3.69LeuTyr: 3.69 ± 1.58
0.0LeuXaa: 0.0 ± 0.0
Met
0.923MetAla: 0.923 ± 0.713
0.0MetCys: 0.0 ± 0.0
3.69MetAsp: 3.69 ± 1.132
0.923MetGlu: 0.923 ± 1.154
0.923MetPhe: 0.923 ± 0.713
1.845MetGly: 1.845 ± 1.51
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
1.845MetLys: 1.845 ± 0.918
1.845MetLeu: 1.845 ± 1.51
0.923MetMet: 0.923 ± 1.154
0.0MetAsn: 0.0 ± 0.0
0.923MetPro: 0.923 ± 0.638
0.923MetGln: 0.923 ± 0.926
0.0MetArg: 0.0 ± 0.0
1.845MetSer: 1.845 ± 1.283
0.0MetThr: 0.0 ± 0.0
0.0MetVal: 0.0 ± 0.0
1.845MetTrp: 1.845 ± 1.031
2.768MetTyr: 2.768 ± 2.138
0.0MetXaa: 0.0 ± 0.0
Asn
3.69AsnAla: 3.69 ± 1.216
0.0AsnCys: 0.0 ± 0.0
4.613AsnAsp: 4.613 ± 1.082
1.845AsnGlu: 1.845 ± 1.126
0.923AsnPhe: 0.923 ± 0.713
2.768AsnGly: 2.768 ± 1.074
2.768AsnHis: 2.768 ± 2.138
1.845AsnIle: 1.845 ± 0.786
1.845AsnLys: 1.845 ± 0.918
5.535AsnLeu: 5.535 ± 2.612
0.923AsnMet: 0.923 ± 0.713
5.535AsnAsn: 5.535 ± 1.876
3.69AsnPro: 3.69 ± 1.118
0.923AsnGln: 0.923 ± 1.154
2.768AsnArg: 2.768 ± 1.074
4.613AsnSer: 4.613 ± 2.155
3.69AsnThr: 3.69 ± 1.156
3.69AsnVal: 3.69 ± 1.474
0.0AsnTrp: 0.0 ± 0.0
5.535AsnTyr: 5.535 ± 1.089
0.0AsnXaa: 0.0 ± 0.0
Pro
4.613ProAla: 4.613 ± 1.354
2.768ProCys: 2.768 ± 1.369
2.768ProAsp: 2.768 ± 2.051
2.768ProGlu: 2.768 ± 1.292
2.768ProPhe: 2.768 ± 0.799
1.845ProGly: 1.845 ± 1.067
4.613ProHis: 4.613 ± 2.424
2.768ProIle: 2.768 ± 1.709
6.458ProLys: 6.458 ± 3.041
4.613ProLeu: 4.613 ± 1.429
3.69ProMet: 3.69 ± 2.415
2.768ProAsn: 2.768 ± 1.292
0.923ProPro: 0.923 ± 0.638
1.845ProGln: 1.845 ± 1.604
2.768ProArg: 2.768 ± 1.709
2.768ProSer: 2.768 ± 1.461
2.768ProThr: 2.768 ± 1.242
4.613ProVal: 4.613 ± 2.549
0.923ProTrp: 0.923 ± 0.638
0.923ProTyr: 0.923 ± 0.713
0.0ProXaa: 0.0 ± 0.0
Gln
3.69GlnAla: 3.69 ± 0.997
1.845GlnCys: 1.845 ± 1.918
1.845GlnAsp: 1.845 ± 1.378
4.613GlnGlu: 4.613 ± 2.096
2.768GlnPhe: 2.768 ± 1.386
1.845GlnGly: 1.845 ± 1.031
2.768GlnHis: 2.768 ± 1.773
2.768GlnIle: 2.768 ± 1.915
4.613GlnLys: 4.613 ± 4.255
0.923GlnLeu: 0.923 ± 0.926
0.0GlnMet: 0.0 ± 0.0
4.613GlnAsn: 4.613 ± 1.106
4.613GlnPro: 4.613 ± 3.089
1.845GlnGln: 1.845 ± 0.925
1.845GlnArg: 1.845 ± 1.078
3.69GlnSer: 3.69 ± 1.198
0.923GlnThr: 0.923 ± 0.959
4.613GlnVal: 4.613 ± 1.099
0.0GlnTrp: 0.0 ± 0.0
1.845GlnTyr: 1.845 ± 0.918
0.0GlnXaa: 0.0 ± 0.0
Arg
2.768ArgAla: 2.768 ± 1.737
0.923ArgCys: 0.923 ± 1.044
2.768ArgAsp: 2.768 ± 1.358
4.613ArgGlu: 4.613 ± 1.794
3.69ArgPhe: 3.69 ± 1.132
2.768ArgGly: 2.768 ± 0.93
2.768ArgHis: 2.768 ± 1.369
5.535ArgIle: 5.535 ± 1.77
3.69ArgLys: 3.69 ± 1.132
4.613ArgLeu: 4.613 ± 2.632
0.923ArgMet: 0.923 ± 0.713
0.0ArgAsn: 0.0 ± 0.0
7.38ArgPro: 7.38 ± 1.59
0.923ArgGln: 0.923 ± 1.044
8.303ArgArg: 8.303 ± 4.025
6.458ArgSer: 6.458 ± 1.851
4.613ArgThr: 4.613 ± 2.24
3.69ArgVal: 3.69 ± 1.635
0.0ArgTrp: 0.0 ± 0.0
0.923ArgTyr: 0.923 ± 1.044
0.0ArgXaa: 0.0 ± 0.0
Ser
6.458SerAla: 6.458 ± 3.627
0.0SerCys: 0.0 ± 0.0
2.768SerAsp: 2.768 ± 0.93
1.845SerGlu: 1.845 ± 1.277
3.69SerPhe: 3.69 ± 1.278
2.768SerGly: 2.768 ± 1.158
3.69SerHis: 3.69 ± 2.265
6.458SerIle: 6.458 ± 1.524
4.613SerLys: 4.613 ± 2.058
3.69SerLeu: 3.69 ± 1.909
0.923SerMet: 0.923 ± 1.154
4.613SerAsn: 4.613 ± 1.207
13.838SerPro: 13.838 ± 2.36
2.768SerGln: 2.768 ± 1.386
7.38SerArg: 7.38 ± 1.641
13.838SerSer: 13.838 ± 4.545
3.69SerThr: 3.69 ± 2.566
2.768SerVal: 2.768 ± 0.93
0.923SerTrp: 0.923 ± 0.638
2.768SerTyr: 2.768 ± 0.93
0.0SerXaa: 0.0 ± 0.0
Thr
3.69ThrAla: 3.69 ± 1.934
0.923ThrCys: 0.923 ± 1.154
0.923ThrAsp: 0.923 ± 1.154
2.768ThrGlu: 2.768 ± 1.074
0.923ThrPhe: 0.923 ± 1.154
5.535ThrGly: 5.535 ± 1.65
4.613ThrHis: 4.613 ± 1.91
2.768ThrIle: 2.768 ± 1.209
2.768ThrLys: 2.768 ± 0.971
4.613ThrLeu: 4.613 ± 1.671
0.923ThrMet: 0.923 ± 0.638
2.768ThrAsn: 2.768 ± 1.725
3.69ThrPro: 3.69 ± 2.403
2.768ThrGln: 2.768 ± 1.773
2.768ThrArg: 2.768 ± 0.799
3.69ThrSer: 3.69 ± 1.89
0.0ThrThr: 0.0 ± 0.0
5.535ThrVal: 5.535 ± 2.551
2.768ThrTrp: 2.768 ± 1.517
2.768ThrTyr: 2.768 ± 1.303
0.0ThrXaa: 0.0 ± 0.0
Val
0.0ValAla: 0.0 ± 0.0
0.0ValCys: 0.0 ± 0.0
0.923ValAsp: 0.923 ± 0.638
0.0ValGlu: 0.0 ± 0.0
3.69ValPhe: 3.69 ± 0.875
1.845ValGly: 1.845 ± 1.078
0.923ValHis: 0.923 ± 1.044
6.458ValIle: 6.458 ± 1.835
3.69ValLys: 3.69 ± 1.132
5.535ValLeu: 5.535 ± 1.719
0.923ValMet: 0.923 ± 0.713
1.845ValAsn: 1.845 ± 1.126
3.69ValPro: 3.69 ± 1.111
8.303ValGln: 8.303 ± 4.323
5.535ValArg: 5.535 ± 1.963
6.458ValSer: 6.458 ± 2.17
2.768ValThr: 2.768 ± 2.138
0.923ValVal: 0.923 ± 0.713
0.923ValTrp: 0.923 ± 0.959
4.613ValTyr: 4.613 ± 1.099
0.0ValXaa: 0.0 ± 0.0
Trp
1.845TrpAla: 1.845 ± 1.277
0.0TrpCys: 0.0 ± 0.0
0.923TrpAsp: 0.923 ± 1.044
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
1.845TrpGly: 1.845 ± 1.277
0.0TrpHis: 0.0 ± 0.0
0.923TrpIle: 0.923 ± 1.154
0.0TrpLys: 0.0 ± 0.0
0.0TrpLeu: 0.0 ± 0.0
0.923TrpMet: 0.923 ± 0.713
0.923TrpAsn: 0.923 ± 0.638
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
2.768TrpArg: 2.768 ± 1.158
0.923TrpSer: 0.923 ± 1.154
1.845TrpThr: 1.845 ± 1.918
1.845TrpVal: 1.845 ± 0.786
0.0TrpTrp: 0.0 ± 0.0
0.923TrpTyr: 0.923 ± 0.638
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.768TyrAla: 2.768 ± 1.358
0.0TyrCys: 0.0 ± 0.0
3.69TyrAsp: 3.69 ± 1.934
2.768TyrGlu: 2.768 ± 0.971
2.768TyrPhe: 2.768 ± 1.175
0.0TyrGly: 0.0 ± 0.0
0.0TyrHis: 0.0 ± 0.0
0.0TyrIle: 0.0 ± 0.0
2.768TyrLys: 2.768 ± 1.358
5.535TyrLeu: 5.535 ± 1.547
2.768TyrMet: 2.768 ± 1.32
3.69TyrAsn: 3.69 ± 1.58
0.923TyrPro: 0.923 ± 0.638
0.923TyrGln: 0.923 ± 0.959
1.845TyrArg: 1.845 ± 1.425
4.613TyrSer: 4.613 ± 2.973
0.923TyrThr: 0.923 ± 0.959
4.613TyrVal: 4.613 ± 1.937
0.0TyrTrp: 0.0 ± 0.0
0.923TyrTyr: 0.923 ± 0.926
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (1085 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski