Amino acid dipepetide frequency for candidate division MSBL1 archaeon SCGC-AAA259A05

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.574AlaAla: 4.574 ± 0.169
0.761AlaCys: 0.761 ± 0.05
3.48AlaAsp: 3.48 ± 0.116
6.222AlaGlu: 6.222 ± 0.174
2.394AlaPhe: 2.394 ± 0.1
5.313AlaGly: 5.313 ± 0.142
1.053AlaHis: 1.053 ± 0.068
4.105AlaIle: 4.105 ± 0.127
3.972AlaLys: 3.972 ± 0.124
6.336AlaLeu: 6.336 ± 0.175
1.537AlaMet: 1.537 ± 0.086
1.711AlaAsn: 1.711 ± 0.075
2.169AlaPro: 2.169 ± 0.092
1.434AlaGln: 1.434 ± 0.069
3.924AlaArg: 3.924 ± 0.135
3.902AlaSer: 3.902 ± 0.119
3.0AlaThr: 3.0 ± 0.107
4.836AlaVal: 4.836 ± 0.149
0.831AlaTrp: 0.831 ± 0.056
1.773AlaTyr: 1.773 ± 0.09
0.0AlaXaa: 0.0 ± 0.0
Cys
0.635CysAla: 0.635 ± 0.051
0.126CysCys: 0.126 ± 0.026
0.58CysAsp: 0.58 ± 0.049
0.898CysGlu: 0.898 ± 0.063
0.384CysPhe: 0.384 ± 0.039
1.26CysGly: 1.26 ± 0.077
0.284CysHis: 0.284 ± 0.044
0.462CysIle: 0.462 ± 0.04
0.587CysLys: 0.587 ± 0.049
0.898CysLeu: 0.898 ± 0.063
0.244CysMet: 0.244 ± 0.032
0.303CysAsn: 0.303 ± 0.033
0.754CysPro: 0.754 ± 0.059
0.24CysGln: 0.24 ± 0.03
0.661CysArg: 0.661 ± 0.052
0.661CysSer: 0.661 ± 0.054
0.351CysThr: 0.351 ± 0.042
0.628CysVal: 0.628 ± 0.05
0.163CysTrp: 0.163 ± 0.025
0.277CysTyr: 0.277 ± 0.03
0.0CysXaa: 0.0 ± 0.0
Asp
3.192AspAla: 3.192 ± 0.11
0.543AspCys: 0.543 ± 0.047
2.656AspAsp: 2.656 ± 0.113
5.538AspGlu: 5.538 ± 0.166
2.719AspPhe: 2.719 ± 0.097
3.787AspGly: 3.787 ± 0.126
1.071AspHis: 1.071 ± 0.067
3.787AspIle: 3.787 ± 0.112
3.041AspLys: 3.041 ± 0.116
6.687AspLeu: 6.687 ± 0.158
1.249AspMet: 1.249 ± 0.061
1.541AspAsn: 1.541 ± 0.085
2.923AspPro: 2.923 ± 0.114
1.131AspGln: 1.131 ± 0.063
3.492AspArg: 3.492 ± 0.119
3.399AspSer: 3.399 ± 0.106
2.051AspThr: 2.051 ± 0.089
4.23AspVal: 4.23 ± 0.131
0.835AspTrp: 0.835 ± 0.066
2.051AspTyr: 2.051 ± 0.098
0.0AspXaa: 0.0 ± 0.0
Glu
6.122GluAla: 6.122 ± 0.171
0.746GluCys: 0.746 ± 0.056
5.93GluAsp: 5.93 ± 0.152
12.714GluGlu: 12.714 ± 0.268
3.34GluPhe: 3.34 ± 0.119
6.953GluGly: 6.953 ± 0.133
1.227GluHis: 1.227 ± 0.067
7.67GluIle: 7.67 ± 0.202
10.249GluLys: 10.249 ± 0.224
8.502GluLeu: 8.502 ± 0.174
2.339GluMet: 2.339 ± 0.094
5.35GluAsn: 5.35 ± 0.23
3.074GluPro: 3.074 ± 0.103
1.541GluGln: 1.541 ± 0.08
6.27GluArg: 6.27 ± 0.189
4.984GluSer: 4.984 ± 0.147
4.323GluThr: 4.323 ± 0.126
7.29GluVal: 7.29 ± 0.198
1.19GluTrp: 1.19 ± 0.071
2.523GluTyr: 2.523 ± 0.109
0.0GluXaa: 0.0 ± 0.0
Phe
2.42PheAla: 2.42 ± 0.104
0.451PheCys: 0.451 ± 0.034
2.32PheAsp: 2.32 ± 0.094
3.503PheGlu: 3.503 ± 0.114
1.895PhePhe: 1.895 ± 0.096
3.355PheGly: 3.355 ± 0.122
0.769PheHis: 0.769 ± 0.052
1.866PheIle: 1.866 ± 0.088
2.15PheLys: 2.15 ± 0.084
4.36PheLeu: 4.36 ± 0.15
0.839PheMet: 0.839 ± 0.061
1.012PheAsn: 1.012 ± 0.057
1.663PhePro: 1.663 ± 0.081
0.961PheGln: 0.961 ± 0.061
2.065PheArg: 2.065 ± 0.088
3.089PheSer: 3.089 ± 0.115
1.755PheThr: 1.755 ± 0.084
2.767PheVal: 2.767 ± 0.096
0.536PheTrp: 0.536 ± 0.049
1.134PheTyr: 1.134 ± 0.064
0.0PheXaa: 0.0 ± 0.0
Gly
4.859GlyAla: 4.859 ± 0.153
0.879GlyCys: 0.879 ± 0.062
3.953GlyAsp: 3.953 ± 0.111
7.582GlyGlu: 7.582 ± 0.161
2.93GlyPhe: 2.93 ± 0.12
6.211GlyGly: 6.211 ± 0.198
1.301GlyHis: 1.301 ± 0.069
5.856GlyIle: 5.856 ± 0.157
6.074GlyLys: 6.074 ± 0.148
6.71GlyLeu: 6.71 ± 0.162
1.991GlyMet: 1.991 ± 0.096
2.634GlyAsn: 2.634 ± 0.101
2.424GlyPro: 2.424 ± 0.102
1.408GlyGln: 1.408 ± 0.074
4.541GlyArg: 4.541 ± 0.14
4.759GlySer: 4.759 ± 0.131
3.547GlyThr: 3.547 ± 0.127
5.823GlyVal: 5.823 ± 0.152
1.083GlyTrp: 1.083 ± 0.067
2.413GlyTyr: 2.413 ± 0.099
0.0GlyXaa: 0.0 ± 0.0
His
1.064HisAla: 1.064 ± 0.064
0.292HisCys: 0.292 ± 0.033
1.038HisAsp: 1.038 ± 0.061
1.393HisGlu: 1.393 ± 0.067
0.735HisPhe: 0.735 ± 0.053
1.378HisGly: 1.378 ± 0.068
0.366HisHis: 0.366 ± 0.037
0.913HisIle: 0.913 ± 0.05
0.765HisLys: 0.765 ± 0.054
1.81HisLeu: 1.81 ± 0.076
0.321HisMet: 0.321 ± 0.039
0.473HisAsn: 0.473 ± 0.042
1.241HisPro: 1.241 ± 0.071
0.432HisGln: 0.432 ± 0.043
1.083HisArg: 1.083 ± 0.065
1.097HisSer: 1.097 ± 0.067
0.676HisThr: 0.676 ± 0.054
1.223HisVal: 1.223 ± 0.069
0.222HisTrp: 0.222 ± 0.026
0.558HisTyr: 0.558 ± 0.045
0.0HisXaa: 0.0 ± 0.0
Ile
4.733IleAla: 4.733 ± 0.15
0.724IleCys: 0.724 ± 0.052
3.939IleAsp: 3.939 ± 0.119
6.514IleGlu: 6.514 ± 0.156
2.546IlePhe: 2.546 ± 0.092
5.176IleGly: 5.176 ± 0.159
1.201IleHis: 1.201 ± 0.069
3.916IleIle: 3.916 ± 0.145
3.891IleLys: 3.891 ± 0.131
6.24IleLeu: 6.24 ± 0.17
1.249IleMet: 1.249 ± 0.073
2.221IleAsn: 2.221 ± 0.094
3.277IlePro: 3.277 ± 0.115
1.711IleGln: 1.711 ± 0.068
3.595IleArg: 3.595 ± 0.113
5.058IleSer: 5.058 ± 0.145
3.104IleThr: 3.104 ± 0.107
4.622IleVal: 4.622 ± 0.147
0.65IleTrp: 0.65 ± 0.058
1.958IleTyr: 1.958 ± 0.088
0.0IleXaa: 0.0 ± 0.0
Lys
4.593LysAla: 4.593 ± 0.145
0.669LysCys: 0.669 ± 0.054
3.78LysAsp: 3.78 ± 0.131
7.685LysGlu: 7.685 ± 0.202
2.734LysPhe: 2.734 ± 0.102
4.751LysGly: 4.751 ± 0.138
1.112LysHis: 1.112 ± 0.068
5.812LysIle: 5.812 ± 0.165
6.259LysLys: 6.259 ± 0.196
6.244LysLeu: 6.244 ± 0.166
1.714LysMet: 1.714 ± 0.08
3.31LysAsn: 3.31 ± 0.107
2.424LysPro: 2.424 ± 0.103
1.345LysGln: 1.345 ± 0.07
4.142LysArg: 4.142 ± 0.126
4.26LysSer: 4.26 ± 0.129
3.602LysThr: 3.602 ± 0.13
4.929LysVal: 4.929 ± 0.132
0.776LysTrp: 0.776 ± 0.053
1.973LysTyr: 1.973 ± 0.092
0.0LysXaa: 0.0 ± 0.0
Leu
6.322LeuAla: 6.322 ± 0.166
0.846LeuCys: 0.846 ± 0.057
5.875LeuAsp: 5.875 ± 0.154
9.68LeuGlu: 9.68 ± 0.214
3.381LeuPhe: 3.381 ± 0.125
7.5LeuGly: 7.5 ± 0.187
1.445LeuHis: 1.445 ± 0.071
5.686LeuIle: 5.686 ± 0.16
6.939LeuLys: 6.939 ± 0.176
8.08LeuLeu: 8.08 ± 0.22
1.884LeuMet: 1.884 ± 0.09
3.17LeuAsn: 3.17 ± 0.105
3.835LeuPro: 3.835 ± 0.128
1.991LeuGln: 1.991 ± 0.094
5.583LeuArg: 5.583 ± 0.149
6.987LeuSer: 6.987 ± 0.186
4.526LeuThr: 4.526 ± 0.123
5.982LeuVal: 5.982 ± 0.15
1.042LeuTrp: 1.042 ± 0.063
2.365LeuTyr: 2.365 ± 0.091
0.0LeuXaa: 0.0 ± 0.0
Met
1.5MetAla: 1.5 ± 0.07
0.188MetCys: 0.188 ± 0.023
1.404MetAsp: 1.404 ± 0.073
2.339MetGlu: 2.339 ± 0.088
0.635MetPhe: 0.635 ± 0.047
1.81MetGly: 1.81 ± 0.083
0.281MetHis: 0.281 ± 0.029
1.685MetIle: 1.685 ± 0.086
1.947MetLys: 1.947 ± 0.076
1.644MetLeu: 1.644 ± 0.079
0.506MetMet: 0.506 ± 0.044
0.909MetAsn: 0.909 ± 0.05
0.92MetPro: 0.92 ± 0.06
0.451MetGln: 0.451 ± 0.043
1.415MetArg: 1.415 ± 0.071
1.463MetSer: 1.463 ± 0.074
1.253MetThr: 1.253 ± 0.064
1.467MetVal: 1.467 ± 0.083
0.203MetTrp: 0.203 ± 0.03
0.392MetTyr: 0.392 ± 0.038
0.0MetXaa: 0.0 ± 0.0
Asn
1.899AsnAla: 1.899 ± 0.089
0.565AsnCys: 0.565 ± 0.048
1.552AsnAsp: 1.552 ± 0.079
2.738AsnGlu: 2.738 ± 0.101
1.766AsnPhe: 1.766 ± 0.088
2.18AsnGly: 2.18 ± 0.093
0.676AsnHis: 0.676 ± 0.048
2.439AsnIle: 2.439 ± 0.103
1.94AsnLys: 1.94 ± 0.088
4.26AsnLeu: 4.26 ± 0.138
0.839AsnMet: 0.839 ± 0.05
1.06AsnAsn: 1.06 ± 0.076
2.161AsnPro: 2.161 ± 0.094
1.031AsnGln: 1.031 ± 0.057
2.206AsnArg: 2.206 ± 0.102
2.439AsnSer: 2.439 ± 0.09
1.504AsnThr: 1.504 ± 0.077
2.523AsnVal: 2.523 ± 0.096
0.617AsnTrp: 0.617 ± 0.053
1.286AsnTyr: 1.286 ± 0.082
0.0AsnXaa: 0.0 ± 0.0
Pro
2.361ProAla: 2.361 ± 0.086
0.366ProCys: 0.366 ± 0.034
2.679ProAsp: 2.679 ± 0.104
4.762ProGlu: 4.762 ± 0.136
1.604ProPhe: 1.604 ± 0.078
2.9ProGly: 2.9 ± 0.126
0.894ProHis: 0.894 ± 0.059
2.597ProIle: 2.597 ± 0.108
2.645ProLys: 2.645 ± 0.102
3.665ProLeu: 3.665 ± 0.131
0.805ProMet: 0.805 ± 0.052
1.386ProAsn: 1.386 ± 0.074
1.999ProPro: 1.999 ± 0.094
1.023ProGln: 1.023 ± 0.061
2.176ProArg: 2.176 ± 0.075
3.104ProSer: 3.104 ± 0.114
1.906ProThr: 1.906 ± 0.084
2.974ProVal: 2.974 ± 0.113
0.418ProTrp: 0.418 ± 0.042
1.326ProTyr: 1.326 ± 0.076
0.0ProXaa: 0.0 ± 0.0
Gln
1.445GlnAla: 1.445 ± 0.07
0.163GlnCys: 0.163 ± 0.027
1.075GlnAsp: 1.075 ± 0.06
2.32GlnGlu: 2.32 ± 0.102
0.772GlnPhe: 0.772 ± 0.058
1.493GlnGly: 1.493 ± 0.074
0.381GlnHis: 0.381 ± 0.035
1.57GlnIle: 1.57 ± 0.084
1.895GlnLys: 1.895 ± 0.091
1.799GlnLeu: 1.799 ± 0.085
0.573GlnMet: 0.573 ± 0.039
0.975GlnAsn: 0.975 ± 0.061
0.75GlnPro: 0.75 ± 0.057
0.499GlnGln: 0.499 ± 0.046
1.227GlnArg: 1.227 ± 0.074
1.19GlnSer: 1.19 ± 0.067
1.071GlnThr: 1.071 ± 0.064
1.637GlnVal: 1.637 ± 0.089
0.214GlnTrp: 0.214 ± 0.029
0.547GlnTyr: 0.547 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
3.824ArgAla: 3.824 ± 0.145
0.539ArgCys: 0.539 ± 0.046
3.056ArgAsp: 3.056 ± 0.109
7.146ArgGlu: 7.146 ± 0.163
1.977ArgPhe: 1.977 ± 0.083
4.46ArgGly: 4.46 ± 0.148
0.894ArgHis: 0.894 ± 0.059
4.12ArgIle: 4.12 ± 0.11
5.697ArgLys: 5.697 ± 0.149
4.792ArgLeu: 4.792 ± 0.132
1.555ArgMet: 1.555 ± 0.07
2.354ArgAsn: 2.354 ± 0.096
2.032ArgPro: 2.032 ± 0.091
1.097ArgGln: 1.097 ± 0.062
4.016ArgArg: 4.016 ± 0.153
3.492ArgSer: 3.492 ± 0.118
2.697ArgThr: 2.697 ± 0.115
3.724ArgVal: 3.724 ± 0.115
0.658ArgTrp: 0.658 ± 0.046
1.611ArgTyr: 1.611 ± 0.081
0.0ArgXaa: 0.0 ± 0.0
Ser
3.861SerAla: 3.861 ± 0.132
0.717SerCys: 0.717 ± 0.049
3.617SerAsp: 3.617 ± 0.103
6.481SerGlu: 6.481 ± 0.171
2.886SerPhe: 2.886 ± 0.125
5.409SerGly: 5.409 ± 0.156
1.105SerHis: 1.105 ± 0.063
4.249SerIle: 4.249 ± 0.16
4.208SerLys: 4.208 ± 0.14
6.384SerLeu: 6.384 ± 0.146
1.482SerMet: 1.482 ± 0.077
2.025SerAsn: 2.025 ± 0.082
2.775SerPro: 2.775 ± 0.101
1.607SerGln: 1.607 ± 0.067
3.976SerArg: 3.976 ± 0.142
4.681SerSer: 4.681 ± 0.139
2.937SerThr: 2.937 ± 0.111
4.29SerVal: 4.29 ± 0.154
0.842SerTrp: 0.842 ± 0.057
2.054SerTyr: 2.054 ± 0.09
0.0SerXaa: 0.0 ± 0.0
Thr
3.141ThrAla: 3.141 ± 0.111
0.528ThrCys: 0.528 ± 0.047
2.597ThrAsp: 2.597 ± 0.106
3.99ThrGlu: 3.99 ± 0.113
1.851ThrPhe: 1.851 ± 0.085
4.042ThrGly: 4.042 ± 0.127
0.802ThrHis: 0.802 ± 0.055
2.959ThrIle: 2.959 ± 0.11
2.653ThrLys: 2.653 ± 0.094
4.212ThrLeu: 4.212 ± 0.134
0.894ThrMet: 0.894 ± 0.055
1.504ThrAsn: 1.504 ± 0.079
2.346ThrPro: 2.346 ± 0.098
0.946ThrGln: 0.946 ± 0.065
2.45ThrArg: 2.45 ± 0.088
3.196ThrSer: 3.196 ± 0.111
2.291ThrThr: 2.291 ± 0.093
3.588ThrVal: 3.588 ± 0.126
0.543ThrTrp: 0.543 ± 0.052
1.363ThrTyr: 1.363 ± 0.073
0.0ThrXaa: 0.0 ± 0.0
Val
4.515ValAla: 4.515 ± 0.137
0.691ValCys: 0.691 ± 0.056
4.193ValAsp: 4.193 ± 0.112
7.268ValGlu: 7.268 ± 0.167
2.568ValPhe: 2.568 ± 0.101
5.642ValGly: 5.642 ± 0.146
1.337ValHis: 1.337 ± 0.064
4.105ValIle: 4.105 ± 0.118
4.681ValLys: 4.681 ± 0.134
6.37ValLeu: 6.37 ± 0.185
1.448ValMet: 1.448 ± 0.077
2.269ValAsn: 2.269 ± 0.075
3.1ValPro: 3.1 ± 0.099
1.663ValGln: 1.663 ± 0.082
4.175ValArg: 4.175 ± 0.122
4.955ValSer: 4.955 ± 0.151
3.381ValThr: 3.381 ± 0.118
4.992ValVal: 4.992 ± 0.153
0.684ValTrp: 0.684 ± 0.049
1.958ValTyr: 1.958 ± 0.085
0.0ValXaa: 0.0 ± 0.0
Trp
0.687TrpAla: 0.687 ± 0.05
0.137TrpCys: 0.137 ± 0.022
0.654TrpAsp: 0.654 ± 0.052
1.001TrpGlu: 1.001 ± 0.066
0.491TrpPhe: 0.491 ± 0.045
0.791TrpGly: 0.791 ± 0.059
0.218TrpHis: 0.218 ± 0.032
0.972TrpIle: 0.972 ± 0.066
1.053TrpLys: 1.053 ± 0.065
1.053TrpLeu: 1.053 ± 0.061
0.299TrpMet: 0.299 ± 0.032
0.539TrpAsn: 0.539 ± 0.047
0.34TrpPro: 0.34 ± 0.04
0.266TrpGln: 0.266 ± 0.031
0.935TrpArg: 0.935 ± 0.07
0.876TrpSer: 0.876 ± 0.061
0.599TrpThr: 0.599 ± 0.052
0.698TrpVal: 0.698 ± 0.053
0.229TrpTrp: 0.229 ± 0.032
0.307TrpTyr: 0.307 ± 0.036
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.581TyrAla: 1.581 ± 0.081
0.466TyrCys: 0.466 ± 0.045
1.548TyrAsp: 1.548 ± 0.067
2.564TyrGlu: 2.564 ± 0.096
1.301TyrPhe: 1.301 ± 0.084
2.564TyrGly: 2.564 ± 0.096
0.665TyrHis: 0.665 ± 0.048
1.555TyrIle: 1.555 ± 0.085
1.467TyrLys: 1.467 ± 0.066
3.07TyrLeu: 3.07 ± 0.12
0.639TyrMet: 0.639 ± 0.044
0.935TyrAsn: 0.935 ± 0.064
1.386TyrPro: 1.386 ± 0.07
0.82TyrGln: 0.82 ± 0.064
1.81TyrArg: 1.81 ± 0.088
1.995TyrSer: 1.995 ± 0.079
1.323TyrThr: 1.323 ± 0.075
1.77TyrVal: 1.77 ± 0.084
0.41TyrTrp: 0.41 ± 0.043
0.99TyrTyr: 0.99 ± 0.066
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1212 proteins (270658 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski