Amino acid dipepetide frequency for Halodesulfurarchaeum formicicum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.556AlaAla: 13.556 ± 0.208	0.547AlaCys: 0.547 ± 0.036	8.701AlaAsp: 8.701 ± 0.141	9.378AlaGlu: 9.378 ± 0.154	3.579AlaPhe: 3.579 ± 0.084	10.008AlaGly: 10.008 ± 0.139	1.91AlaHis: 1.91 ± 0.057	5.99AlaIle: 5.99 ± 0.107	1.982AlaLys: 1.982 ± 0.056	9.911AlaLeu: 9.911 ± 0.184	2.271AlaMet: 2.271 ± 0.062	2.418AlaAsn: 2.418 ± 0.077	3.833AlaPro: 3.833 ± 0.08	2.571AlaGln: 2.571 ± 0.062	5.831AlaArg: 5.831 ± 0.108	5.039AlaSer: 5.039 ± 0.095	7.064AlaThr: 7.064 ± 0.119	10.296AlaVal: 10.296 ± 0.182	1.071AlaTrp: 1.071 ± 0.045	2.539AlaTyr: 2.539 ± 0.066	0.0AlaXaa: 0.0 ± 0.0
Cys	0.374CysAla: 0.374 ± 0.024	0.04CysCys: 0.04 ± 0.008	0.401CysAsp: 0.401 ± 0.029	0.423CysGlu: 0.423 ± 0.029	0.13CysPhe: 0.13 ± 0.014	0.69CysGly: 0.69 ± 0.042	0.152CysHis: 0.152 ± 0.018	0.213CysIle: 0.213 ± 0.02	0.098CysLys: 0.098 ± 0.013	0.353CysLeu: 0.353 ± 0.025	0.075CysMet: 0.075 ± 0.013	0.144CysAsn: 0.144 ± 0.018	0.577CysPro: 0.577 ± 0.037	0.156CysGln: 0.156 ± 0.017	0.358CysArg: 0.358 ± 0.023	0.329CysSer: 0.329 ± 0.025	0.34CysThr: 0.34 ± 0.025	0.332CysVal: 0.332 ± 0.026	0.053CysTrp: 0.053 ± 0.009	0.098CysTyr: 0.098 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.71AspAla: 7.71 ± 0.118	0.427AspCys: 0.427 ± 0.029	4.412AspAsp: 4.412 ± 0.131	6.495AspGlu: 6.495 ± 0.148	2.353AspPhe: 2.353 ± 0.066	6.897AspGly: 6.897 ± 0.135	1.625AspHis: 1.625 ± 0.053	3.267AspIle: 3.267 ± 0.089	0.912AspLys: 0.912 ± 0.041	7.629AspLeu: 7.629 ± 0.128	1.31AspMet: 1.31 ± 0.047	1.148AspAsn: 1.148 ± 0.069	4.822AspPro: 4.822 ± 0.09	2.167AspGln: 2.167 ± 0.055	6.835AspArg: 6.835 ± 0.121	3.785AspSer: 3.785 ± 0.08	4.394AspThr: 4.394 ± 0.101	6.517AspVal: 6.517 ± 0.12	1.023AspTrp: 1.023 ± 0.045	1.705AspTyr: 1.705 ± 0.068	0.0AspXaa: 0.0 ± 0.0
Glu	10.142GluAla: 10.142 ± 0.142	0.417GluCys: 0.417 ± 0.031	6.142GluAsp: 6.142 ± 0.151	6.767GluGlu: 6.767 ± 0.167	2.822GluPhe: 2.822 ± 0.075	5.614GluGly: 5.614 ± 0.1	1.936GluHis: 1.936 ± 0.055	4.692GluIle: 4.692 ± 0.106	2.022GluLys: 2.022 ± 0.069	7.73GluLeu: 7.73 ± 0.119	1.929GluMet: 1.929 ± 0.053	2.471GluAsn: 2.471 ± 0.069	4.627GluPro: 4.627 ± 0.098	3.071GluGln: 3.071 ± 0.072	6.792GluArg: 6.792 ± 0.123	6.166GluSer: 6.166 ± 0.116	7.629GluThr: 7.629 ± 0.126	5.655GluVal: 5.655 ± 0.111	0.917GluTrp: 0.917 ± 0.037	2.563GluTyr: 2.563 ± 0.068	0.0GluXaa: 0.0 ± 0.0
Phe	3.379PheAla: 3.379 ± 0.074	0.167PheCys: 0.167 ± 0.017	2.935PheAsp: 2.935 ± 0.074	3.815PheGlu: 3.815 ± 0.077	1.055PhePhe: 1.055 ± 0.049	3.185PheGly: 3.185 ± 0.079	0.63PheHis: 0.63 ± 0.028	1.087PheIle: 1.087 ± 0.045	0.492PheLys: 0.492 ± 0.032	2.89PheLeu: 2.89 ± 0.087	0.595PheMet: 0.595 ± 0.033	0.664PheAsn: 0.664 ± 0.035	1.35PhePro: 1.35 ± 0.046	0.94PheGln: 0.94 ± 0.037	1.759PheArg: 1.759 ± 0.065	1.623PheSer: 1.623 ± 0.049	1.859PheThr: 1.859 ± 0.054	2.936PheVal: 2.936 ± 0.084	0.377PheTrp: 0.377 ± 0.031	0.794PheTyr: 0.794 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	8.158GlyAla: 8.158 ± 0.123	0.505GlyCys: 0.505 ± 0.034	5.99GlyAsp: 5.99 ± 0.113	7.172GlyGlu: 7.172 ± 0.122	3.259GlyPhe: 3.259 ± 0.081	6.777GlyGly: 6.777 ± 0.136	1.753GlyHis: 1.753 ± 0.07	4.702GlyIle: 4.702 ± 0.098	1.836GlyLys: 1.836 ± 0.06	7.848GlyLeu: 7.848 ± 0.163	1.753GlyMet: 1.753 ± 0.06	1.857GlyAsn: 1.857 ± 0.066	3.83GlyPro: 3.83 ± 0.084	2.43GlyGln: 2.43 ± 0.062	4.696GlyArg: 4.696 ± 0.105	4.995GlySer: 4.995 ± 0.098	6.296GlyThr: 6.296 ± 0.103	7.253GlyVal: 7.253 ± 0.121	1.066GlyTrp: 1.066 ± 0.047	2.559GlyTyr: 2.559 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	1.886HisAla: 1.886 ± 0.057	0.16HisCys: 0.16 ± 0.017	1.514HisAsp: 1.514 ± 0.054	1.748HisGlu: 1.748 ± 0.054	0.59HisPhe: 0.59 ± 0.032	1.716HisGly: 1.716 ± 0.07	0.483HisHis: 0.483 ± 0.031	0.749HisIle: 0.749 ± 0.033	0.308HisLys: 0.308 ± 0.023	1.875HisLeu: 1.875 ± 0.051	0.298HisMet: 0.298 ± 0.024	0.433HisAsn: 0.433 ± 0.028	1.334HisPro: 1.334 ± 0.045	0.571HisGln: 0.571 ± 0.029	1.251HisArg: 1.251 ± 0.044	0.911HisSer: 0.911 ± 0.042	1.185HisThr: 1.185 ± 0.044	1.838HisVal: 1.838 ± 0.05	0.228HisTrp: 0.228 ± 0.019	0.52HisTyr: 0.52 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.335IleAla: 5.335 ± 0.112	0.239IleCys: 0.239 ± 0.016	4.392IleAsp: 4.392 ± 0.089	6.198IleGlu: 6.198 ± 0.124	1.116IlePhe: 1.116 ± 0.05	4.384IleGly: 4.384 ± 0.106	0.879IleHis: 0.879 ± 0.038	1.604IleIle: 1.604 ± 0.06	0.827IleLys: 0.827 ± 0.038	3.448IleLeu: 3.448 ± 0.094	0.553IleMet: 0.553 ± 0.029	1.062IleAsn: 1.062 ± 0.048	2.351IlePro: 2.351 ± 0.067	1.429IleGln: 1.429 ± 0.048	2.907IleArg: 2.907 ± 0.079	2.423IleSer: 2.423 ± 0.068	2.786IleThr: 2.786 ± 0.063	4.017IleVal: 4.017 ± 0.098	0.39IleTrp: 0.39 ± 0.026	0.975IleTyr: 0.975 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	1.963LysAla: 1.963 ± 0.062	0.115LysCys: 0.115 ± 0.017	1.049LysAsp: 1.049 ± 0.047	1.353LysGlu: 1.353 ± 0.054	0.573LysPhe: 0.573 ± 0.03	1.376LysGly: 1.376 ± 0.052	0.465LysHis: 0.465 ± 0.024	0.885LysIle: 0.885 ± 0.039	0.47LysLys: 0.47 ± 0.033	1.714LysLeu: 1.714 ± 0.054	0.358LysMet: 0.358 ± 0.024	0.641LysAsn: 0.641 ± 0.032	1.033LysPro: 1.033 ± 0.045	0.781LysGln: 0.781 ± 0.039	1.786LysArg: 1.786 ± 0.056	1.235LysSer: 1.235 ± 0.047	1.403LysThr: 1.403 ± 0.053	1.272LysVal: 1.272 ± 0.052	0.234LysTrp: 0.234 ± 0.019	0.59LysTyr: 0.59 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	10.983LeuAla: 10.983 ± 0.193	0.332LeuCys: 0.332 ± 0.023	7.71LeuAsp: 7.71 ± 0.127	7.993LeuGlu: 7.993 ± 0.138	3.053LeuPhe: 3.053 ± 0.093	8.318LeuGly: 8.318 ± 0.194	1.475LeuHis: 1.475 ± 0.046	3.4LeuIle: 3.4 ± 0.09	1.743LeuLys: 1.743 ± 0.06	8.974LeuLeu: 8.974 ± 0.192	1.297LeuMet: 1.297 ± 0.048	1.843LeuAsn: 1.843 ± 0.051	4.142LeuPro: 4.142 ± 0.089	2.566LeuGln: 2.566 ± 0.078	5.387LeuArg: 5.387 ± 0.106	5.754LeuSer: 5.754 ± 0.121	5.468LeuThr: 5.468 ± 0.092	7.879LeuVal: 7.879 ± 0.156	0.819LeuTrp: 0.819 ± 0.035	2.011LeuTyr: 2.011 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	2.17MetAla: 2.17 ± 0.062	0.103MetCys: 0.103 ± 0.012	1.445MetAsp: 1.445 ± 0.049	1.299MetGlu: 1.299 ± 0.047	0.449MetPhe: 0.449 ± 0.027	1.642MetGly: 1.642 ± 0.052	0.356MetHis: 0.356 ± 0.026	0.736MetIle: 0.736 ± 0.035	0.457MetLys: 0.457 ± 0.026	1.554MetLeu: 1.554 ± 0.057	0.318MetMet: 0.318 ± 0.024	0.552MetAsn: 0.552 ± 0.031	0.808MetPro: 0.808 ± 0.037	0.568MetGln: 0.568 ± 0.032	1.007MetArg: 1.007 ± 0.042	1.353MetSer: 1.353 ± 0.049	1.543MetThr: 1.543 ± 0.06	1.445MetVal: 1.445 ± 0.05	0.127MetTrp: 0.127 ± 0.014	0.356MetTyr: 0.356 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	2.489AsnAla: 2.489 ± 0.065	0.192AsnCys: 0.192 ± 0.017	1.437AsnAsp: 1.437 ± 0.06	1.798AsnGlu: 1.798 ± 0.058	0.704AsnPhe: 0.704 ± 0.037	1.896AsnGly: 1.896 ± 0.077	0.508AsnHis: 0.508 ± 0.031	0.962AsnIle: 0.962 ± 0.038	0.451AsnLys: 0.451 ± 0.026	2.022AsnLeu: 2.022 ± 0.069	0.462AsnMet: 0.462 ± 0.025	0.51AsnAsn: 0.51 ± 0.035	1.653AsnPro: 1.653 ± 0.045	0.608AsnGln: 0.608 ± 0.035	1.785AsnArg: 1.785 ± 0.049	1.058AsnSer: 1.058 ± 0.044	1.438AsnThr: 1.438 ± 0.055	2.171AsnVal: 2.171 ± 0.07	0.279AsnTrp: 0.279 ± 0.023	0.646AsnTyr: 0.646 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	5.252ProAla: 5.252 ± 0.108	0.225ProCys: 0.225 ± 0.022	4.461ProAsp: 4.461 ± 0.101	5.233ProGlu: 5.233 ± 0.097	1.61ProPhe: 1.61 ± 0.055	4.165ProGly: 4.165 ± 0.083	0.9ProHis: 0.9 ± 0.037	2.463ProIle: 2.463 ± 0.071	0.901ProLys: 0.901 ± 0.04	3.576ProLeu: 3.576 ± 0.085	0.892ProMet: 0.892 ± 0.035	1.158ProAsn: 1.158 ± 0.037	2.268ProPro: 2.268 ± 0.072	1.121ProGln: 1.121 ± 0.039	2.24ProArg: 2.24 ± 0.063	2.588ProSer: 2.588 ± 0.072	3.449ProThr: 3.449 ± 0.071	4.402ProVal: 4.402 ± 0.083	0.513ProTrp: 0.513 ± 0.03	1.082ProTyr: 1.082 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	3.448GlnAla: 3.448 ± 0.077	0.148GlnCys: 0.148 ± 0.015	1.738GlnAsp: 1.738 ± 0.061	2.202GlnGlu: 2.202 ± 0.066	1.153GlnPhe: 1.153 ± 0.043	1.926GlnGly: 1.926 ± 0.057	0.584GlnHis: 0.584 ± 0.03	1.499GlnIle: 1.499 ± 0.048	0.617GlnLys: 0.617 ± 0.037	2.523GlnLeu: 2.523 ± 0.062	0.552GlnMet: 0.552 ± 0.031	0.741GlnAsn: 0.741 ± 0.04	1.317GlnPro: 1.317 ± 0.049	0.994GlnGln: 0.994 ± 0.046	1.82GlnArg: 1.82 ± 0.059	1.804GlnSer: 1.804 ± 0.064	1.942GlnThr: 1.942 ± 0.058	2.367GlnVal: 2.367 ± 0.058	0.29GlnTrp: 0.29 ± 0.022	0.924GlnTyr: 0.924 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	6.447ArgAla: 6.447 ± 0.108	0.356ArgCys: 0.356 ± 0.03	4.457ArgAsp: 4.457 ± 0.085	6.471ArgGlu: 6.471 ± 0.106	2.128ArgPhe: 2.128 ± 0.058	4.388ArgGly: 4.388 ± 0.095	1.132ArgHis: 1.132 ± 0.053	3.278ArgIle: 3.278 ± 0.074	1.501ArgLys: 1.501 ± 0.056	5.932ArgLeu: 5.932 ± 0.101	1.281ArgMet: 1.281 ± 0.048	1.626ArgAsn: 1.626 ± 0.051	2.657ArgPro: 2.657 ± 0.075	1.896ArgGln: 1.896 ± 0.058	4.234ArgArg: 4.234 ± 0.104	3.616ArgSer: 3.616 ± 0.081	4.059ArgThr: 4.059 ± 0.093	5.045ArgVal: 5.045 ± 0.088	0.63ArgTrp: 0.63 ± 0.032	1.77ArgTyr: 1.77 ± 0.057	0.0ArgXaa: 0.0 ± 0.0
Ser	5.255SerAla: 5.255 ± 0.114	0.287SerCys: 0.287 ± 0.028	3.642SerAsp: 3.642 ± 0.084	4.497SerGlu: 4.497 ± 0.116	1.786SerPhe: 1.786 ± 0.051	5.353SerGly: 5.353 ± 0.094	1.116SerHis: 1.116 ± 0.049	2.965SerIle: 2.965 ± 0.073	1.302SerLys: 1.302 ± 0.052	5.072SerLeu: 5.072 ± 0.095	1.23SerMet: 1.23 ± 0.041	1.374SerAsn: 1.374 ± 0.061	2.521SerPro: 2.521 ± 0.06	1.642SerGln: 1.642 ± 0.05	3.207SerArg: 3.207 ± 0.076	2.569SerSer: 2.569 ± 0.064	3.647SerThr: 3.647 ± 0.086	5.342SerVal: 5.342 ± 0.109	0.581SerTrp: 0.581 ± 0.03	1.371SerTyr: 1.371 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	7.255ThrAla: 7.255 ± 0.123	0.39ThrCys: 0.39 ± 0.027	5.6ThrAsp: 5.6 ± 0.107	5.679ThrGlu: 5.679 ± 0.117	2.091ThrPhe: 2.091 ± 0.067	6.189ThrGly: 6.189 ± 0.122	1.27ThrHis: 1.27 ± 0.045	3.594ThrIle: 3.594 ± 0.091	1.086ThrLys: 1.086 ± 0.044	6.009ThrLeu: 6.009 ± 0.106	1.145ThrMet: 1.145 ± 0.048	1.544ThrAsn: 1.544 ± 0.048	3.305ThrPro: 3.305 ± 0.062	1.698ThrGln: 1.698 ± 0.051	3.57ThrArg: 3.57 ± 0.071	2.668ThrSer: 2.668 ± 0.07	4.157ThrThr: 4.157 ± 0.096	7.648ThrVal: 7.648 ± 0.123	0.633ThrTrp: 0.633 ± 0.032	1.706ThrTyr: 1.706 ± 0.063	0.0ThrXaa: 0.0 ± 0.0
Val	9.171ValAla: 9.171 ± 0.16	0.462ValCys: 0.462 ± 0.033	6.447ValAsp: 6.447 ± 0.122	8.309ValGlu: 8.309 ± 0.125	2.898ValPhe: 2.898 ± 0.077	7.189ValGly: 7.189 ± 0.139	1.636ValHis: 1.636 ± 0.046	3.895ValIle: 3.895 ± 0.089	1.615ValLys: 1.615 ± 0.055	8.44ValLeu: 8.44 ± 0.151	1.39ValMet: 1.39 ± 0.051	1.942ValAsn: 1.942 ± 0.069	4.364ValPro: 4.364 ± 0.094	2.237ValGln: 2.237 ± 0.063	4.97ValArg: 4.97 ± 0.106	5.305ValSer: 5.305 ± 0.1	6.439ValThr: 6.439 ± 0.136	7.412ValVal: 7.412 ± 0.149	0.751ValTrp: 0.751 ± 0.038	1.979ValTyr: 1.979 ± 0.059	0.0ValXaa: 0.0 ± 0.0
Trp	0.97TrpAla: 0.97 ± 0.046	0.061TrpCys: 0.061 ± 0.01	0.696TrpAsp: 0.696 ± 0.036	0.848TrpGlu: 0.848 ± 0.04	0.423TrpPhe: 0.423 ± 0.025	0.794TrpGly: 0.794 ± 0.036	0.191TrpHis: 0.191 ± 0.017	0.545TrpIle: 0.545 ± 0.028	0.265TrpLys: 0.265 ± 0.022	1.166TrpLeu: 1.166 ± 0.047	0.237TrpMet: 0.237 ± 0.02	0.31TrpAsn: 0.31 ± 0.026	0.446TrpPro: 0.446 ± 0.031	0.321TrpGln: 0.321 ± 0.023	0.715TrpArg: 0.715 ± 0.036	0.465TrpSer: 0.465 ± 0.027	0.682TrpThr: 0.682 ± 0.033	0.823TrpVal: 0.823 ± 0.036	0.189TrpTrp: 0.189 ± 0.018	0.354TrpTyr: 0.354 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.551TyrAla: 2.551 ± 0.078	0.164TyrCys: 0.164 ± 0.016	2.263TyrAsp: 2.263 ± 0.062	2.426TyrGlu: 2.426 ± 0.067	0.759TyrPhe: 0.759 ± 0.034	2.227TyrGly: 2.227 ± 0.064	0.598TyrHis: 0.598 ± 0.031	0.789TyrIle: 0.789 ± 0.037	0.411TyrLys: 0.411 ± 0.025	2.484TyrLeu: 2.484 ± 0.075	0.338TyrMet: 0.338 ± 0.025	0.632TyrAsn: 0.632 ± 0.033	1.262TyrPro: 1.262 ± 0.044	0.824TyrGln: 0.824 ± 0.037	1.754TyrArg: 1.754 ± 0.056	1.073TyrSer: 1.073 ± 0.044	1.458TyrThr: 1.458 ± 0.052	2.2TyrVal: 2.2 ± 0.054	0.329TyrTrp: 0.329 ± 0.023	0.773TyrTyr: 0.773 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2099 proteins (623574 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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