Amino acid dipepetide frequency for Piloderma croceum (strain F 1598)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.191AlaAla: 7.191 ± 0.04	1.198AlaCys: 1.198 ± 0.013	4.06AlaAsp: 4.06 ± 0.026	4.338AlaGlu: 4.338 ± 0.027	3.236AlaPhe: 3.236 ± 0.026	4.84AlaGly: 4.84 ± 0.03	1.997AlaHis: 1.997 ± 0.018	4.363AlaIle: 4.363 ± 0.028	3.802AlaLys: 3.802 ± 0.027	7.788AlaLeu: 7.788 ± 0.043	1.837AlaMet: 1.837 ± 0.017	2.789AlaAsn: 2.789 ± 0.022	4.194AlaPro: 4.194 ± 0.03	3.037AlaGln: 3.037 ± 0.023	4.561AlaArg: 4.561 ± 0.029	6.879AlaSer: 6.879 ± 0.04	4.708AlaThr: 4.708 ± 0.025	5.054AlaVal: 5.054 ± 0.032	1.092AlaTrp: 1.092 ± 0.013	2.059AlaTyr: 2.059 ± 0.017	0.0AlaXaa: 0.0 ± 0.0
Cys	1.08CysAla: 1.08 ± 0.014	0.339CysCys: 0.339 ± 0.008	0.767CysAsp: 0.767 ± 0.013	0.674CysGlu: 0.674 ± 0.01	0.622CysPhe: 0.622 ± 0.009	1.008CysGly: 1.008 ± 0.013	0.465CysHis: 0.465 ± 0.009	0.86CysIle: 0.86 ± 0.012	0.625CysLys: 0.625 ± 0.009	1.565CysLeu: 1.565 ± 0.018	0.355CysMet: 0.355 ± 0.008	0.512CysAsn: 0.512 ± 0.009	0.851CysPro: 0.851 ± 0.012	0.559CysGln: 0.559 ± 0.009	0.902CysArg: 0.902 ± 0.013	1.177CysSer: 1.177 ± 0.015	0.872CysThr: 0.872 ± 0.012	0.934CysVal: 0.934 ± 0.013	0.262CysTrp: 0.262 ± 0.006	0.387CysTyr: 0.387 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.5AspAla: 4.5 ± 0.026	0.706AspCys: 0.706 ± 0.01	4.396AspAsp: 4.396 ± 0.038	4.196AspGlu: 4.196 ± 0.034	2.135AspPhe: 2.135 ± 0.018	4.093AspGly: 4.093 ± 0.027	1.402AspHis: 1.402 ± 0.016	3.493AspIle: 3.493 ± 0.024	2.416AspLys: 2.416 ± 0.023	5.19AspLeu: 5.19 ± 0.034	1.28AspMet: 1.28 ± 0.012	2.049AspAsn: 2.049 ± 0.018	3.254AspPro: 3.254 ± 0.021	1.765AspGln: 1.765 ± 0.017	2.905AspArg: 2.905 ± 0.025	4.189AspSer: 4.189 ± 0.026	3.021AspThr: 3.021 ± 0.02	3.839AspVal: 3.839 ± 0.022	0.894AspTrp: 0.894 ± 0.012	1.437AspTyr: 1.437 ± 0.016	0.0AspXaa: 0.0 ± 0.0
Glu	4.464GluAla: 4.464 ± 0.03	0.76GluCys: 0.76 ± 0.011	3.891GluAsp: 3.891 ± 0.033	4.626GluGlu: 4.626 ± 0.041	1.851GluPhe: 1.851 ± 0.019	3.501GluGly: 3.501 ± 0.021	1.481GluHis: 1.481 ± 0.014	2.922GluIle: 2.922 ± 0.019	2.978GluLys: 2.978 ± 0.026	5.03GluLeu: 5.03 ± 0.031	1.425GluMet: 1.425 ± 0.015	2.039GluAsn: 2.039 ± 0.019	2.454GluPro: 2.454 ± 0.024	2.089GluGln: 2.089 ± 0.017	3.646GluArg: 3.646 ± 0.029	3.885GluSer: 3.885 ± 0.023	2.938GluThr: 2.938 ± 0.022	3.455GluVal: 3.455 ± 0.026	0.927GluTrp: 0.927 ± 0.013	1.492GluTyr: 1.492 ± 0.014	0.0GluXaa: 0.0 ± 0.0
Phe	3.006PheAla: 3.006 ± 0.023	0.635PheCys: 0.635 ± 0.01	2.335PheAsp: 2.335 ± 0.017	2.087PheGlu: 2.087 ± 0.02	1.614PhePhe: 1.614 ± 0.018	2.633PheGly: 2.633 ± 0.023	1.047PheHis: 1.047 ± 0.013	2.018PheIle: 2.018 ± 0.019	1.598PheLys: 1.598 ± 0.015	3.621PheLeu: 3.621 ± 0.026	0.846PheMet: 0.846 ± 0.013	1.47PheAsn: 1.47 ± 0.014	2.053PhePro: 2.053 ± 0.019	1.337PheGln: 1.337 ± 0.015	2.076PheArg: 2.076 ± 0.017	3.337PheSer: 3.337 ± 0.026	2.223PheThr: 2.223 ± 0.02	2.557PheVal: 2.557 ± 0.019	0.617PheTrp: 0.617 ± 0.009	1.069PheTyr: 1.069 ± 0.013	0.0PheXaa: 0.0 ± 0.0
Gly	4.376GlyAla: 4.376 ± 0.029	0.95GlyCys: 0.95 ± 0.012	3.53GlyAsp: 3.53 ± 0.023	3.255GlyGlu: 3.255 ± 0.022	2.465GlyPhe: 2.465 ± 0.021	5.025GlyGly: 5.025 ± 0.048	1.93GlyHis: 1.93 ± 0.025	3.33GlyIle: 3.33 ± 0.023	3.356GlyLys: 3.356 ± 0.026	5.534GlyLeu: 5.534 ± 0.029	1.533GlyMet: 1.533 ± 0.017	2.379GlyAsn: 2.379 ± 0.023	3.108GlyPro: 3.108 ± 0.024	2.319GlyGln: 2.319 ± 0.02	3.861GlyArg: 3.861 ± 0.024	5.453GlySer: 5.453 ± 0.038	3.777GlyThr: 3.777 ± 0.022	4.023GlyVal: 4.023 ± 0.027	1.057GlyTrp: 1.057 ± 0.014	1.832GlyTyr: 1.832 ± 0.019	0.0GlyXaa: 0.0 ± 0.0
His	2.097HisAla: 2.097 ± 0.017	0.485HisCys: 0.485 ± 0.008	1.454HisAsp: 1.454 ± 0.014	1.323HisGlu: 1.323 ± 0.015	1.115HisPhe: 1.115 ± 0.014	1.675HisGly: 1.675 ± 0.016	1.043HisHis: 1.043 ± 0.015	1.618HisIle: 1.618 ± 0.016	1.094HisLys: 1.094 ± 0.012	2.852HisLeu: 2.852 ± 0.022	0.552HisMet: 0.552 ± 0.01	1.024HisAsn: 1.024 ± 0.013	2.041HisPro: 2.041 ± 0.021	1.035HisGln: 1.035 ± 0.012	1.733HisArg: 1.733 ± 0.016	2.369HisSer: 2.369 ± 0.022	1.704HisThr: 1.704 ± 0.019	1.668HisVal: 1.668 ± 0.015	0.407HisTrp: 0.407 ± 0.008	0.733HisTyr: 0.733 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	4.187IleAla: 4.187 ± 0.025	0.96IleCys: 0.96 ± 0.013	2.996IleAsp: 2.996 ± 0.022	2.722IleGlu: 2.722 ± 0.021	2.189IlePhe: 2.189 ± 0.019	3.098IleGly: 3.098 ± 0.023	1.52IleHis: 1.52 ± 0.015	2.957IleIle: 2.957 ± 0.027	2.247IleLys: 2.247 ± 0.021	5.106IleLeu: 5.106 ± 0.031	1.111IleMet: 1.111 ± 0.013	1.931IleAsn: 1.931 ± 0.017	3.377IlePro: 3.377 ± 0.022	1.96IleGln: 1.96 ± 0.019	3.096IleArg: 3.096 ± 0.025	4.56IleSer: 4.56 ± 0.029	3.121IleThr: 3.121 ± 0.022	3.511IleVal: 3.511 ± 0.027	0.843IleTrp: 0.843 ± 0.013	1.538IleTyr: 1.538 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	3.994LysAla: 3.994 ± 0.032	0.641LysCys: 0.641 ± 0.01	2.613LysAsp: 2.613 ± 0.019	2.991LysGlu: 2.991 ± 0.026	1.523LysPhe: 1.523 ± 0.015	2.925LysGly: 2.925 ± 0.021	1.215LysHis: 1.215 ± 0.014	2.289LysIle: 2.289 ± 0.019	3.046LysLys: 3.046 ± 0.034	4.205LysLeu: 4.205 ± 0.028	1.022LysMet: 1.022 ± 0.011	1.647LysAsn: 1.647 ± 0.018	2.504LysPro: 2.504 ± 0.025	1.686LysGln: 1.686 ± 0.016	3.28LysArg: 3.28 ± 0.024	3.547LysSer: 3.547 ± 0.03	2.744LysThr: 2.744 ± 0.022	2.777LysVal: 2.777 ± 0.022	0.712LysTrp: 0.712 ± 0.01	1.348LysTyr: 1.348 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	7.779LeuAla: 7.779 ± 0.031	1.494LeuCys: 1.494 ± 0.017	5.278LeuAsp: 5.278 ± 0.029	5.29LeuGlu: 5.29 ± 0.031	3.515LeuPhe: 3.515 ± 0.026	5.629LeuGly: 5.629 ± 0.039	2.79LeuHis: 2.79 ± 0.024	4.26LeuIle: 4.26 ± 0.029	4.268LeuLys: 4.268 ± 0.028	8.873LeuLeu: 8.873 ± 0.053	1.872LeuMet: 1.872 ± 0.017	3.333LeuAsn: 3.333 ± 0.025	6.034LeuPro: 6.034 ± 0.034	3.861LeuGln: 3.861 ± 0.023	5.923LeuArg: 5.923 ± 0.04	8.28LeuSer: 8.28 ± 0.042	5.435LeuThr: 5.435 ± 0.034	5.727LeuVal: 5.727 ± 0.04	1.32LeuTrp: 1.32 ± 0.015	2.444LeuTyr: 2.444 ± 0.022	0.0LeuXaa: 0.0 ± 0.0
Met	1.869MetAla: 1.869 ± 0.017	0.308MetCys: 0.308 ± 0.007	1.358MetAsp: 1.358 ± 0.015	1.23MetGlu: 1.23 ± 0.012	0.777MetPhe: 0.777 ± 0.01	1.347MetGly: 1.347 ± 0.016	0.609MetHis: 0.609 ± 0.01	1.031MetIle: 1.031 ± 0.013	1.053MetLys: 1.053 ± 0.014	1.987MetLeu: 1.987 ± 0.016	0.574MetMet: 0.574 ± 0.011	0.834MetAsn: 0.834 ± 0.011	1.32MetPro: 1.32 ± 0.015	0.873MetGln: 0.873 ± 0.012	1.286MetArg: 1.286 ± 0.013	2.131MetSer: 2.131 ± 0.016	1.381MetThr: 1.381 ± 0.015	1.334MetVal: 1.334 ± 0.014	0.295MetTrp: 0.295 ± 0.007	0.556MetTyr: 0.556 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	3.001AsnAla: 3.001 ± 0.021	0.517AsnCys: 0.517 ± 0.01	2.052AsnAsp: 2.052 ± 0.018	1.891AsnGlu: 1.891 ± 0.017	1.393AsnPhe: 1.393 ± 0.014	2.672AsnGly: 2.672 ± 0.023	1.01AsnHis: 1.01 ± 0.011	2.331AsnIle: 2.331 ± 0.018	1.561AsnLys: 1.561 ± 0.015	3.548AsnLeu: 3.548 ± 0.03	0.863AsnMet: 0.863 ± 0.012	1.569AsnAsn: 1.569 ± 0.016	2.412AsnPro: 2.412 ± 0.018	1.295AsnGln: 1.295 ± 0.015	1.919AsnArg: 1.919 ± 0.016	2.903AsnSer: 2.903 ± 0.023	2.311AsnThr: 2.311 ± 0.022	2.451AsnVal: 2.451 ± 0.018	0.519AsnTrp: 0.519 ± 0.009	0.991AsnTyr: 0.991 ± 0.011	0.0AsnXaa: 0.0 ± 0.0
Pro	4.65ProAla: 4.65 ± 0.031	0.655ProCys: 0.655 ± 0.012	3.3ProAsp: 3.3 ± 0.025	3.177ProGlu: 3.177 ± 0.021	2.258ProPhe: 2.258 ± 0.02	3.427ProGly: 3.427 ± 0.025	1.697ProHis: 1.697 ± 0.017	2.942ProIle: 2.942 ± 0.022	2.502ProLys: 2.502 ± 0.025	5.238ProLeu: 5.238 ± 0.03	1.138ProMet: 1.138 ± 0.014	2.368ProAsn: 2.368 ± 0.02	5.751ProPro: 5.751 ± 0.056	2.267ProGln: 2.267 ± 0.023	3.237ProArg: 3.237 ± 0.027	6.844ProSer: 6.844 ± 0.049	4.27ProThr: 4.27 ± 0.032	3.508ProVal: 3.508 ± 0.024	0.705ProTrp: 0.705 ± 0.009	1.512ProTyr: 1.512 ± 0.016	0.0ProXaa: 0.0 ± 0.0
Gln	3.051GlnAla: 3.051 ± 0.023	0.571GlnCys: 0.571 ± 0.01	1.862GlnAsp: 1.862 ± 0.019	1.997GlnGlu: 1.997 ± 0.018	1.317GlnPhe: 1.317 ± 0.015	2.112GlnGly: 2.112 ± 0.018	1.14GlnHis: 1.14 ± 0.016	1.963GlnIle: 1.963 ± 0.015	1.757GlnLys: 1.757 ± 0.017	3.566GlnLeu: 3.566 ± 0.025	0.873GlnMet: 0.873 ± 0.012	1.457GlnAsn: 1.457 ± 0.015	2.347GlnPro: 2.347 ± 0.024	1.944GlnGln: 1.944 ± 0.03	2.359GlnArg: 2.359 ± 0.02	3.186GlnSer: 3.186 ± 0.025	2.338GlnThr: 2.338 ± 0.02	2.111GlnVal: 2.111 ± 0.016	0.587GlnTrp: 0.587 ± 0.01	1.076GlnTyr: 1.076 ± 0.013	0.0GlnXaa: 0.0 ± 0.0
Arg	4.404ArgAla: 4.404 ± 0.028	0.899ArgCys: 0.899 ± 0.013	3.176ArgAsp: 3.176 ± 0.023	3.418ArgGlu: 3.418 ± 0.026	2.256ArgPhe: 2.256 ± 0.02	3.402ArgGly: 3.402 ± 0.025	1.741ArgHis: 1.741 ± 0.016	3.111ArgIle: 3.111 ± 0.021	3.23ArgLys: 3.23 ± 0.024	5.628ArgLeu: 5.628 ± 0.03	1.404ArgMet: 1.404 ± 0.014	2.212ArgAsn: 2.212 ± 0.017	3.379ArgPro: 3.379 ± 0.029	2.387ArgGln: 2.387 ± 0.019	4.722ArgArg: 4.722 ± 0.035	4.992ArgSer: 4.992 ± 0.033	3.523ArgThr: 3.523 ± 0.022	3.563ArgVal: 3.563 ± 0.025	0.948ArgTrp: 0.948 ± 0.012	1.596ArgTyr: 1.596 ± 0.015	0.0ArgXaa: 0.0 ± 0.0
Ser	6.584SerAla: 6.584 ± 0.036	1.162SerCys: 1.162 ± 0.015	4.631SerAsp: 4.631 ± 0.026	3.933SerGlu: 3.933 ± 0.023	3.305SerPhe: 3.305 ± 0.023	5.562SerGly: 5.562 ± 0.041	2.397SerHis: 2.397 ± 0.019	4.431SerIle: 4.431 ± 0.031	3.724SerLys: 3.724 ± 0.024	7.952SerLeu: 7.952 ± 0.038	1.852SerMet: 1.852 ± 0.017	3.305SerAsn: 3.305 ± 0.025	6.092SerPro: 6.092 ± 0.047	3.289SerGln: 3.289 ± 0.024	5.13SerArg: 5.13 ± 0.033	9.87SerSer: 9.87 ± 0.068	6.09SerThr: 6.09 ± 0.039	5.101SerVal: 5.101 ± 0.029	1.105SerTrp: 1.105 ± 0.012	2.134SerTyr: 2.134 ± 0.016	0.0SerXaa: 0.0 ± 0.0
Thr	4.731ThrAla: 4.731 ± 0.027	0.888ThrCys: 0.888 ± 0.012	2.956ThrAsp: 2.956 ± 0.022	2.797ThrGlu: 2.797 ± 0.021	2.418ThrPhe: 2.418 ± 0.019	3.804ThrGly: 3.804 ± 0.024	1.643ThrHis: 1.643 ± 0.018	3.391ThrIle: 3.391 ± 0.026	2.594ThrLys: 2.594 ± 0.022	5.851ThrLeu: 5.851 ± 0.031	1.26ThrMet: 1.26 ± 0.013	2.272ThrAsn: 2.272 ± 0.018	4.387ThrPro: 4.387 ± 0.032	2.074ThrGln: 2.074 ± 0.017	3.358ThrArg: 3.358 ± 0.022	5.908ThrSer: 5.908 ± 0.036	4.209ThrThr: 4.209 ± 0.032	3.789ThrVal: 3.789 ± 0.023	0.813ThrTrp: 0.813 ± 0.011	1.614ThrTyr: 1.614 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	4.952ValAla: 4.952 ± 0.031	0.947ValCys: 0.947 ± 0.013	3.877ValAsp: 3.877 ± 0.023	3.678ValGlu: 3.678 ± 0.024	2.474ValPhe: 2.474 ± 0.017	3.767ValGly: 3.767 ± 0.027	1.675ValHis: 1.675 ± 0.015	3.368ValIle: 3.368 ± 0.023	2.919ValLys: 2.919 ± 0.023	5.89ValLeu: 5.89 ± 0.035	1.375ValMet: 1.375 ± 0.015	2.282ValAsn: 2.282 ± 0.019	3.685ValPro: 3.685 ± 0.026	2.323ValGln: 2.323 ± 0.02	3.476ValArg: 3.476 ± 0.024	4.917ValSer: 4.917 ± 0.032	3.571ValThr: 3.571 ± 0.022	4.363ValVal: 4.363 ± 0.033	1.023ValTrp: 1.023 ± 0.014	1.717ValTyr: 1.717 ± 0.017	0.0ValXaa: 0.0 ± 0.0
Trp	1.083TrpAla: 1.083 ± 0.013	0.255TrpCys: 0.255 ± 0.006	1.024TrpAsp: 1.024 ± 0.018	0.853TrpGlu: 0.853 ± 0.012	0.553TrpPhe: 0.553 ± 0.009	0.809TrpGly: 0.809 ± 0.012	0.388TrpHis: 0.388 ± 0.008	0.824TrpIle: 0.824 ± 0.011	0.817TrpLys: 0.817 ± 0.012	1.367TrpLeu: 1.367 ± 0.016	0.385TrpMet: 0.385 ± 0.007	0.655TrpAsn: 0.655 ± 0.011	0.655TrpPro: 0.655 ± 0.01	0.528TrpGln: 0.528 ± 0.008	0.962TrpArg: 0.962 ± 0.012	1.148TrpSer: 1.148 ± 0.013	0.909TrpThr: 0.909 ± 0.012	0.887TrpVal: 0.887 ± 0.011	0.303TrpTrp: 0.303 ± 0.007	0.403TrpTyr: 0.403 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.026TyrAla: 2.026 ± 0.018	0.447TyrCys: 0.447 ± 0.008	1.604TyrAsp: 1.604 ± 0.017	1.376TyrGlu: 1.376 ± 0.015	1.161TyrPhe: 1.161 ± 0.014	1.765TyrGly: 1.765 ± 0.016	0.831TyrHis: 0.831 ± 0.011	1.53TyrIle: 1.53 ± 0.016	1.123TyrLys: 1.123 ± 0.013	2.614TyrLeu: 2.614 ± 0.02	0.595TyrMet: 0.595 ± 0.011	1.08TyrAsn: 1.08 ± 0.014	1.546TyrPro: 1.546 ± 0.017	0.987TyrGln: 0.987 ± 0.011	1.558TyrArg: 1.558 ± 0.015	2.074TyrSer: 2.074 ± 0.018	1.616TyrThr: 1.616 ± 0.015	1.628TyrVal: 1.628 ± 0.015	0.38TyrTrp: 0.38 ± 0.007	0.861TyrTyr: 0.861 ± 0.012	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 21360 proteins (7081032 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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