Amino acid dipepetide frequency for candidate division MSBL1 archaeon SCGC-AAA382N08

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.657AlaAla: 3.657 ± 0.244
0.572AlaCys: 0.572 ± 0.097
3.204AlaAsp: 3.204 ± 0.218
4.968AlaGlu: 4.968 ± 0.229
2.523AlaPhe: 2.523 ± 0.14
4.229AlaGly: 4.229 ± 0.245
0.739AlaHis: 0.739 ± 0.089
3.963AlaIle: 3.963 ± 0.215
3.844AlaLys: 3.844 ± 0.227
5.609AlaLeu: 5.609 ± 0.232
1.331AlaMet: 1.331 ± 0.12
1.962AlaAsn: 1.962 ± 0.185
1.784AlaPro: 1.784 ± 0.154
1.725AlaGln: 1.725 ± 0.158
2.75AlaArg: 2.75 ± 0.174
3.825AlaSer: 3.825 ± 0.222
3.046AlaThr: 3.046 ± 0.192
4.051AlaVal: 4.051 ± 0.22
0.69AlaTrp: 0.69 ± 0.078
1.715AlaTyr: 1.715 ± 0.142
0.0AlaXaa: 0.0 ± 0.0
Cys
0.473CysAla: 0.473 ± 0.07
0.118CysCys: 0.118 ± 0.034
0.582CysAsp: 0.582 ± 0.099
0.67CysGlu: 0.67 ± 0.076
0.355CysPhe: 0.355 ± 0.073
0.927CysGly: 0.927 ± 0.126
0.158CysHis: 0.158 ± 0.046
0.444CysIle: 0.444 ± 0.076
0.69CysLys: 0.69 ± 0.09
0.641CysLeu: 0.641 ± 0.078
0.158CysMet: 0.158 ± 0.04
0.483CysAsn: 0.483 ± 0.1
0.591CysPro: 0.591 ± 0.078
0.227CysGln: 0.227 ± 0.055
0.572CysArg: 0.572 ± 0.082
0.769CysSer: 0.769 ± 0.132
0.375CysThr: 0.375 ± 0.067
0.582CysVal: 0.582 ± 0.077
0.099CysTrp: 0.099 ± 0.029
0.227CysTyr: 0.227 ± 0.055
0.0CysXaa: 0.0 ± 0.0
Asp
2.661AspAla: 2.661 ± 0.213
0.532AspCys: 0.532 ± 0.099
2.967AspAsp: 2.967 ± 0.178
5.372AspGlu: 5.372 ± 0.249
3.381AspPhe: 3.381 ± 0.205
3.381AspGly: 3.381 ± 0.237
0.858AspHis: 0.858 ± 0.1
4.524AspIle: 4.524 ± 0.247
4.524AspLys: 4.524 ± 0.227
5.717AspLeu: 5.717 ± 0.269
1.36AspMet: 1.36 ± 0.117
2.326AspAsn: 2.326 ± 0.232
2.415AspPro: 2.415 ± 0.171
1.646AspGln: 1.646 ± 0.132
2.947AspArg: 2.947 ± 0.172
3.578AspSer: 3.578 ± 0.214
2.445AspThr: 2.445 ± 0.167
4.11AspVal: 4.11 ± 0.203
0.966AspTrp: 0.966 ± 0.114
2.454AspTyr: 2.454 ± 0.154
0.0AspXaa: 0.0 ± 0.0
Glu
5.323GluAla: 5.323 ± 0.251
0.72GluCys: 0.72 ± 0.082
5.441GluAsp: 5.441 ± 0.289
12.016GluGlu: 12.016 ± 0.494
3.253GluPhe: 3.253 ± 0.214
6.18GluGly: 6.18 ± 0.247
1.143GluHis: 1.143 ± 0.093
7.827GluIle: 7.827 ± 0.322
11.612GluLys: 11.612 ± 0.482
7.965GluLeu: 7.965 ± 0.319
2.494GluMet: 2.494 ± 0.158
5.55GluAsn: 5.55 ± 0.331
2.504GluPro: 2.504 ± 0.143
3.075GluGln: 3.075 ± 0.293
5.145GluArg: 5.145 ± 0.265
4.367GluSer: 4.367 ± 0.246
4.367GluThr: 4.367 ± 0.211
6.358GluVal: 6.358 ± 0.261
1.114GluTrp: 1.114 ± 0.112
2.888GluTyr: 2.888 ± 0.163
0.0GluXaa: 0.0 ± 0.0
Phe
1.883PheAla: 1.883 ± 0.134
0.453PheCys: 0.453 ± 0.068
2.563PheAsp: 2.563 ± 0.196
3.677PheGlu: 3.677 ± 0.205
1.745PhePhe: 1.745 ± 0.13
2.849PheGly: 2.849 ± 0.151
0.7PheHis: 0.7 ± 0.083
2.425PheIle: 2.425 ± 0.19
2.937PheLys: 2.937 ± 0.165
4.564PheLeu: 4.564 ± 0.235
0.769PheMet: 0.769 ± 0.091
1.469PheAsn: 1.469 ± 0.12
1.4PhePro: 1.4 ± 0.11
1.35PheGln: 1.35 ± 0.117
2.021PheArg: 2.021 ± 0.139
3.332PheSer: 3.332 ± 0.197
1.971PheThr: 1.971 ± 0.15
2.247PheVal: 2.247 ± 0.191
0.532PheTrp: 0.532 ± 0.078
1.587PheTyr: 1.587 ± 0.135
0.0PheXaa: 0.0 ± 0.0
Gly
3.844GlyAla: 3.844 ± 0.221
0.7GlyCys: 0.7 ± 0.1
3.588GlyAsp: 3.588 ± 0.244
6.91GlyGlu: 6.91 ± 0.259
3.006GlyPhe: 3.006 ± 0.225
5.402GlyGly: 5.402 ± 0.322
0.897GlyHis: 0.897 ± 0.094
5.047GlyIle: 5.047 ± 0.256
5.54GlyLys: 5.54 ± 0.194
6.299GlyLeu: 6.299 ± 0.264
1.873GlyMet: 1.873 ± 0.156
2.928GlyAsn: 2.928 ± 0.193
2.04GlyPro: 2.04 ± 0.19
1.607GlyGln: 1.607 ± 0.134
3.351GlyArg: 3.351 ± 0.179
4.603GlySer: 4.603 ± 0.265
3.854GlyThr: 3.854 ± 0.237
4.968GlyVal: 4.968 ± 0.224
1.035GlyTrp: 1.035 ± 0.109
2.523GlyTyr: 2.523 ± 0.175
0.0GlyXaa: 0.0 ± 0.0
His
0.917HisAla: 0.917 ± 0.098
0.168HisCys: 0.168 ± 0.042
0.887HisAsp: 0.887 ± 0.099
0.946HisGlu: 0.946 ± 0.11
0.631HisPhe: 0.631 ± 0.075
1.035HisGly: 1.035 ± 0.1
0.355HisHis: 0.355 ± 0.072
0.897HisIle: 0.897 ± 0.112
0.946HisLys: 0.946 ± 0.097
1.488HisLeu: 1.488 ± 0.12
0.197HisMet: 0.197 ± 0.044
0.582HisAsn: 0.582 ± 0.078
0.976HisPro: 0.976 ± 0.105
0.503HisGln: 0.503 ± 0.085
0.7HisArg: 0.7 ± 0.076
1.025HisSer: 1.025 ± 0.097
0.71HisThr: 0.71 ± 0.104
0.867HisVal: 0.867 ± 0.104
0.217HisTrp: 0.217 ± 0.048
0.562HisTyr: 0.562 ± 0.072
0.0HisXaa: 0.0 ± 0.0
Ile
4.258IleAla: 4.258 ± 0.226
0.601IleCys: 0.601 ± 0.068
4.268IleAsp: 4.268 ± 0.219
6.949IleGlu: 6.949 ± 0.292
2.395IlePhe: 2.395 ± 0.161
4.998IleGly: 4.998 ± 0.277
1.104IleHis: 1.104 ± 0.103
4.81IleIle: 4.81 ± 0.251
5.254IleLys: 5.254 ± 0.284
6.535IleLeu: 6.535 ± 0.307
1.39IleMet: 1.39 ± 0.138
3.223IleAsn: 3.223 ± 0.191
3.292IlePro: 3.292 ± 0.177
1.784IleGln: 1.784 ± 0.134
3.381IleArg: 3.381 ± 0.184
5.047IleSer: 5.047 ± 0.196
3.696IleThr: 3.696 ± 0.227
3.894IleVal: 3.894 ± 0.215
0.72IleTrp: 0.72 ± 0.073
1.991IleTyr: 1.991 ± 0.124
0.0IleXaa: 0.0 ± 0.0
Lys
4.998LysAla: 4.998 ± 0.217
0.72LysCys: 0.72 ± 0.095
5.017LysAsp: 5.017 ± 0.251
9.542LysGlu: 9.542 ± 0.41
3.046LysPhe: 3.046 ± 0.169
4.909LysGly: 4.909 ± 0.226
1.134LysHis: 1.134 ± 0.108
7.087LysIle: 7.087 ± 0.322
9.177LysLys: 9.177 ± 0.518
6.811LysLeu: 6.811 ± 0.327
2.139LysMet: 2.139 ± 0.141
4.712LysAsn: 4.712 ± 0.241
2.543LysPro: 2.543 ± 0.148
2.445LysGln: 2.445 ± 0.191
4.209LysArg: 4.209 ± 0.251
4.485LysSer: 4.485 ± 0.264
4.012LysThr: 4.012 ± 0.213
5.51LysVal: 5.51 ± 0.258
0.798LysTrp: 0.798 ± 0.086
2.74LysTyr: 2.74 ± 0.206
0.0LysXaa: 0.0 ± 0.0
Leu
5.658LeuAla: 5.658 ± 0.282
0.7LeuCys: 0.7 ± 0.101
5.136LeuAsp: 5.136 ± 0.238
9.266LeuGlu: 9.266 ± 0.318
3.489LeuPhe: 3.489 ± 0.27
5.954LeuGly: 5.954 ± 0.29
1.193LeuHis: 1.193 ± 0.103
6.042LeuIle: 6.042 ± 0.323
8.339LeuLys: 8.339 ± 0.375
7.058LeuLeu: 7.058 ± 0.328
1.538LeuMet: 1.538 ± 0.14
4.229LeuAsn: 4.229 ± 0.238
3.42LeuPro: 3.42 ± 0.213
2.454LeuGln: 2.454 ± 0.175
4.337LeuArg: 4.337 ± 0.227
6.516LeuSer: 6.516 ± 0.252
4.623LeuThr: 4.623 ± 0.255
5.766LeuVal: 5.766 ± 0.25
0.917LeuTrp: 0.917 ± 0.103
2.356LeuTyr: 2.356 ± 0.142
0.0LeuXaa: 0.0 ± 0.0
Met
1.567MetAla: 1.567 ± 0.123
0.138MetCys: 0.138 ± 0.032
1.193MetAsp: 1.193 ± 0.11
2.159MetGlu: 2.159 ± 0.153
0.621MetPhe: 0.621 ± 0.088
1.39MetGly: 1.39 ± 0.107
0.296MetHis: 0.296 ± 0.052
1.36MetIle: 1.36 ± 0.127
2.228MetLys: 2.228 ± 0.156
1.301MetLeu: 1.301 ± 0.103
0.503MetMet: 0.503 ± 0.077
1.242MetAsn: 1.242 ± 0.111
0.956MetPro: 0.956 ± 0.116
0.493MetGln: 0.493 ± 0.068
1.153MetArg: 1.153 ± 0.104
1.548MetSer: 1.548 ± 0.11
1.055MetThr: 1.055 ± 0.095
1.498MetVal: 1.498 ± 0.125
0.158MetTrp: 0.158 ± 0.047
0.493MetTyr: 0.493 ± 0.065
0.0MetXaa: 0.0 ± 0.0
Asn
2.307AsnAla: 2.307 ± 0.177
0.621AsnCys: 0.621 ± 0.099
2.05AsnAsp: 2.05 ± 0.137
3.568AsnGlu: 3.568 ± 0.217
2.129AsnPhe: 2.129 ± 0.163
2.681AsnGly: 2.681 ± 0.203
0.591AsnHis: 0.591 ± 0.073
3.627AsnIle: 3.627 ± 0.195
3.401AsnLys: 3.401 ± 0.216
5.264AsnLeu: 5.264 ± 0.222
0.887AsnMet: 0.887 ± 0.096
2.159AsnAsn: 2.159 ± 0.188
2.267AsnPro: 2.267 ± 0.137
1.548AsnGln: 1.548 ± 0.138
2.366AsnArg: 2.366 ± 0.164
3.016AsnSer: 3.016 ± 0.219
1.981AsnThr: 1.981 ± 0.156
2.997AsnVal: 2.997 ± 0.212
0.591AsnTrp: 0.591 ± 0.087
1.843AsnTyr: 1.843 ± 0.139
0.0AsnXaa: 0.0 ± 0.0
Pro
1.902ProAla: 1.902 ± 0.123
0.276ProCys: 0.276 ± 0.055
2.622ProAsp: 2.622 ± 0.167
4.465ProGlu: 4.465 ± 0.242
1.36ProPhe: 1.36 ± 0.105
2.454ProGly: 2.454 ± 0.204
0.7ProHis: 0.7 ± 0.083
2.159ProIle: 2.159 ± 0.141
2.671ProLys: 2.671 ± 0.166
2.691ProLeu: 2.691 ± 0.165
0.67ProMet: 0.67 ± 0.091
1.35ProAsn: 1.35 ± 0.118
1.508ProPro: 1.508 ± 0.123
1.232ProGln: 1.232 ± 0.133
1.794ProArg: 1.794 ± 0.14
2.859ProSer: 2.859 ± 0.166
1.912ProThr: 1.912 ± 0.148
2.316ProVal: 2.316 ± 0.119
0.345ProTrp: 0.345 ± 0.06
1.272ProTyr: 1.272 ± 0.124
0.0ProXaa: 0.0 ± 0.0
Gln
1.883GlnAla: 1.883 ± 0.155
0.177GlnCys: 0.177 ± 0.047
1.764GlnAsp: 1.764 ± 0.124
3.006GlnGlu: 3.006 ± 0.171
0.946GlnPhe: 0.946 ± 0.095
1.971GlnGly: 1.971 ± 0.168
0.355GlnHis: 0.355 ± 0.061
1.952GlnIle: 1.952 ± 0.152
3.016GlnLys: 3.016 ± 0.201
2.297GlnLeu: 2.297 ± 0.172
0.67GlnMet: 0.67 ± 0.074
1.607GlnAsn: 1.607 ± 0.145
0.877GlnPro: 0.877 ± 0.098
1.498GlnGln: 1.498 ± 0.253
1.686GlnArg: 1.686 ± 0.169
1.498GlnSer: 1.498 ± 0.121
1.429GlnThr: 1.429 ± 0.142
1.883GlnVal: 1.883 ± 0.153
0.335GlnTrp: 0.335 ± 0.068
0.798GlnTyr: 0.798 ± 0.091
0.0GlnXaa: 0.0 ± 0.0
Arg
2.997ArgAla: 2.997 ± 0.164
0.384ArgCys: 0.384 ± 0.06
3.036ArgAsp: 3.036 ± 0.178
5.717ArgGlu: 5.717 ± 0.249
1.912ArgPhe: 1.912 ± 0.157
3.489ArgGly: 3.489 ± 0.199
0.759ArgHis: 0.759 ± 0.081
3.105ArgIle: 3.105 ± 0.186
5.116ArgLys: 5.116 ± 0.302
4.101ArgLeu: 4.101 ± 0.222
0.996ArgMet: 0.996 ± 0.102
2.454ArgAsn: 2.454 ± 0.171
1.429ArgPro: 1.429 ± 0.139
1.469ArgGln: 1.469 ± 0.154
2.997ArgArg: 2.997 ± 0.202
2.435ArgSer: 2.435 ± 0.158
2.011ArgThr: 2.011 ± 0.144
3.411ArgVal: 3.411 ± 0.19
0.542ArgTrp: 0.542 ± 0.079
1.735ArgTyr: 1.735 ± 0.137
0.0ArgXaa: 0.0 ± 0.0
Ser
3.194SerAla: 3.194 ± 0.2
0.749SerCys: 0.749 ± 0.159
4.248SerAsp: 4.248 ± 0.234
6.111SerGlu: 6.111 ± 0.251
2.987SerPhe: 2.987 ± 0.19
5.579SerGly: 5.579 ± 0.285
0.956SerHis: 0.956 ± 0.08
4.022SerIle: 4.022 ± 0.205
4.623SerLys: 4.623 ± 0.223
6.121SerLeu: 6.121 ± 0.268
1.242SerMet: 1.242 ± 0.145
2.898SerAsn: 2.898 ± 0.203
2.425SerPro: 2.425 ± 0.164
2.04SerGln: 2.04 ± 0.15
2.918SerArg: 2.918 ± 0.179
5.007SerSer: 5.007 ± 0.311
3.144SerThr: 3.144 ± 0.182
3.894SerVal: 3.894 ± 0.211
0.749SerTrp: 0.749 ± 0.1
2.376SerTyr: 2.376 ± 0.195
0.0SerXaa: 0.0 ± 0.0
Thr
2.829ThrAla: 2.829 ± 0.232
0.444ThrCys: 0.444 ± 0.081
2.79ThrAsp: 2.79 ± 0.168
4.219ThrGlu: 4.219 ± 0.202
2.208ThrPhe: 2.208 ± 0.152
4.317ThrGly: 4.317 ± 0.23
0.72ThrHis: 0.72 ± 0.088
3.539ThrIle: 3.539 ± 0.207
3.332ThrLys: 3.332 ± 0.214
4.584ThrLeu: 4.584 ± 0.226
1.005ThrMet: 1.005 ± 0.11
1.863ThrAsn: 1.863 ± 0.141
2.1ThrPro: 2.1 ± 0.165
1.548ThrGln: 1.548 ± 0.126
1.971ThrArg: 1.971 ± 0.17
3.509ThrSer: 3.509 ± 0.267
2.809ThrThr: 2.809 ± 0.194
3.539ThrVal: 3.539 ± 0.208
0.532ThrTrp: 0.532 ± 0.074
1.41ThrTyr: 1.41 ± 0.115
0.0ThrXaa: 0.0 ± 0.0
Val
3.825ValAla: 3.825 ± 0.218
0.582ValCys: 0.582 ± 0.08
4.13ValAsp: 4.13 ± 0.238
6.249ValGlu: 6.249 ± 0.316
2.543ValPhe: 2.543 ± 0.182
4.899ValGly: 4.899 ± 0.267
1.055ValHis: 1.055 ± 0.121
4.199ValIle: 4.199 ± 0.244
5.52ValLys: 5.52 ± 0.27
5.589ValLeu: 5.589 ± 0.251
1.341ValMet: 1.341 ± 0.119
2.681ValAsn: 2.681 ± 0.177
2.425ValPro: 2.425 ± 0.142
1.587ValGln: 1.587 ± 0.108
2.878ValArg: 2.878 ± 0.18
4.741ValSer: 4.741 ± 0.257
3.618ValThr: 3.618 ± 0.197
4.653ValVal: 4.653 ± 0.256
0.591ValTrp: 0.591 ± 0.075
1.971ValTyr: 1.971 ± 0.15
0.0ValXaa: 0.0 ± 0.0
Trp
0.582TrpAla: 0.582 ± 0.078
0.138TrpCys: 0.138 ± 0.037
0.789TrpAsp: 0.789 ± 0.089
0.828TrpGlu: 0.828 ± 0.105
0.434TrpPhe: 0.434 ± 0.065
0.749TrpGly: 0.749 ± 0.093
0.187TrpHis: 0.187 ± 0.044
0.858TrpIle: 0.858 ± 0.101
1.124TrpLys: 1.124 ± 0.131
1.094TrpLeu: 1.094 ± 0.105
0.237TrpMet: 0.237 ± 0.049
0.66TrpAsn: 0.66 ± 0.089
0.286TrpPro: 0.286 ± 0.059
0.286TrpGln: 0.286 ± 0.063
0.779TrpArg: 0.779 ± 0.129
0.759TrpSer: 0.759 ± 0.092
0.542TrpThr: 0.542 ± 0.062
0.769TrpVal: 0.769 ± 0.09
0.177TrpTrp: 0.177 ± 0.04
0.315TrpTyr: 0.315 ± 0.061
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.429TyrAla: 1.429 ± 0.123
0.345TyrCys: 0.345 ± 0.069
1.893TyrAsp: 1.893 ± 0.186
2.701TyrGlu: 2.701 ± 0.163
1.508TyrPhe: 1.508 ± 0.131
2.622TyrGly: 2.622 ± 0.173
0.71TyrHis: 0.71 ± 0.089
1.705TyrIle: 1.705 ± 0.14
2.139TyrLys: 2.139 ± 0.14
3.263TyrLeu: 3.263 ± 0.169
0.542TyrMet: 0.542 ± 0.088
1.518TyrAsn: 1.518 ± 0.147
1.321TyrPro: 1.321 ± 0.133
1.134TyrGln: 1.134 ± 0.114
2.139TyrArg: 2.139 ± 0.147
2.366TyrSer: 2.366 ± 0.158
1.676TyrThr: 1.676 ± 0.144
1.764TyrVal: 1.764 ± 0.131
0.483TyrTrp: 0.483 ± 0.079
1.439TyrTyr: 1.439 ± 0.13
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 431 proteins (101451 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski