Amino acid dipepetide frequency for Thermoanaerobacterium phage THSA-485A

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.449AlaAla: 5.449 ± 1.091
0.389AlaCys: 0.389 ± 0.149
4.126AlaAsp: 4.126 ± 0.52
4.281AlaGlu: 4.281 ± 0.561
2.102AlaPhe: 2.102 ± 0.418
4.359AlaGly: 4.359 ± 0.794
1.09AlaHis: 1.09 ± 0.261
5.527AlaIle: 5.527 ± 0.821
5.138AlaLys: 5.138 ± 0.553
7.24AlaLeu: 7.24 ± 0.86
1.246AlaMet: 1.246 ± 0.325
3.036AlaAsn: 3.036 ± 0.516
2.258AlaPro: 2.258 ± 0.404
4.359AlaGln: 4.359 ± 0.399
1.868AlaArg: 1.868 ± 0.558
5.06AlaSer: 5.06 ± 0.794
4.593AlaThr: 4.593 ± 0.751
4.281AlaVal: 4.281 ± 0.647
0.701AlaTrp: 0.701 ± 0.241
2.569AlaTyr: 2.569 ± 0.375
0.0AlaXaa: 0.0 ± 0.0
Cys
0.545CysAla: 0.545 ± 0.2
0.078CysCys: 0.078 ± 0.08
0.778CysAsp: 0.778 ± 0.317
0.856CysGlu: 0.856 ± 0.284
0.311CysPhe: 0.311 ± 0.161
0.623CysGly: 0.623 ± 0.255
0.234CysHis: 0.234 ± 0.163
0.701CysIle: 0.701 ± 0.189
1.012CysLys: 1.012 ± 0.29
0.701CysLeu: 0.701 ± 0.246
0.234CysMet: 0.234 ± 0.127
0.467CysAsn: 0.467 ± 0.18
0.701CysPro: 0.701 ± 0.236
0.545CysGln: 0.545 ± 0.21
0.311CysArg: 0.311 ± 0.191
0.467CysSer: 0.467 ± 0.186
0.311CysThr: 0.311 ± 0.133
0.311CysVal: 0.311 ± 0.135
0.078CysTrp: 0.078 ± 0.068
0.545CysTyr: 0.545 ± 0.189
0.0CysXaa: 0.0 ± 0.0
Asp
4.048AspAla: 4.048 ± 0.587
0.623AspCys: 0.623 ± 0.202
3.659AspAsp: 3.659 ± 0.455
4.982AspGlu: 4.982 ± 0.786
2.258AspPhe: 2.258 ± 0.459
3.425AspGly: 3.425 ± 0.67
0.467AspHis: 0.467 ± 0.183
7.084AspIle: 7.084 ± 0.722
3.503AspLys: 3.503 ± 0.623
5.605AspLeu: 5.605 ± 0.715
2.491AspMet: 2.491 ± 0.412
3.192AspAsn: 3.192 ± 0.449
1.946AspPro: 1.946 ± 0.35
0.778AspGln: 0.778 ± 0.237
1.401AspArg: 1.401 ± 0.304
3.814AspSer: 3.814 ± 0.39
3.114AspThr: 3.114 ± 0.45
3.814AspVal: 3.814 ± 0.516
0.856AspTrp: 0.856 ± 0.31
2.18AspTyr: 2.18 ± 0.528
0.0AspXaa: 0.0 ± 0.0
Glu
4.671GluAla: 4.671 ± 0.54
0.234GluCys: 0.234 ± 0.143
3.892GluAsp: 3.892 ± 0.671
6.695GluGlu: 6.695 ± 0.991
2.413GluPhe: 2.413 ± 0.38
3.814GluGly: 3.814 ± 0.586
1.401GluHis: 1.401 ± 0.351
7.395GluIle: 7.395 ± 0.707
6.539GluLys: 6.539 ± 0.961
6.85GluLeu: 6.85 ± 0.723
1.946GluMet: 1.946 ± 0.329
3.425GluAsn: 3.425 ± 0.555
2.258GluPro: 2.258 ± 0.41
3.425GluGln: 3.425 ± 0.503
2.725GluArg: 2.725 ± 0.459
3.114GluSer: 3.114 ± 0.561
3.192GluThr: 3.192 ± 0.431
4.749GluVal: 4.749 ± 0.69
1.713GluTrp: 1.713 ± 0.35
2.258GluTyr: 2.258 ± 0.418
0.0GluXaa: 0.0 ± 0.0
Phe
3.114PheAla: 3.114 ± 0.408
0.078PheCys: 0.078 ± 0.093
2.958PheAsp: 2.958 ± 0.502
2.258PheGlu: 2.258 ± 0.408
1.713PhePhe: 1.713 ± 0.363
2.569PheGly: 2.569 ± 0.387
0.311PheHis: 0.311 ± 0.147
2.413PheIle: 2.413 ± 0.38
2.413PheLys: 2.413 ± 0.477
1.946PheLeu: 1.946 ± 0.344
0.778PheMet: 0.778 ± 0.198
2.18PheAsn: 2.18 ± 0.501
1.09PhePro: 1.09 ± 0.326
1.713PheGln: 1.713 ± 0.374
1.401PheArg: 1.401 ± 0.289
1.79PheSer: 1.79 ± 0.286
2.647PheThr: 2.647 ± 0.558
2.569PheVal: 2.569 ± 0.491
0.311PheTrp: 0.311 ± 0.143
1.479PheTyr: 1.479 ± 0.277
0.0PheXaa: 0.0 ± 0.0
Gly
3.27GlyAla: 3.27 ± 0.532
0.623GlyCys: 0.623 ± 0.207
2.802GlyAsp: 2.802 ± 0.525
3.97GlyGlu: 3.97 ± 0.751
2.335GlyPhe: 2.335 ± 0.453
4.904GlyGly: 4.904 ± 0.688
0.856GlyHis: 0.856 ± 0.277
5.293GlyIle: 5.293 ± 0.586
4.437GlyLys: 4.437 ± 0.605
4.982GlyLeu: 4.982 ± 0.619
1.401GlyMet: 1.401 ± 0.38
3.503GlyAsn: 3.503 ± 0.526
1.557GlyPro: 1.557 ± 0.267
4.048GlyGln: 4.048 ± 0.703
1.868GlyArg: 1.868 ± 0.368
4.359GlySer: 4.359 ± 0.544
5.138GlyThr: 5.138 ± 0.75
3.192GlyVal: 3.192 ± 0.546
1.168GlyTrp: 1.168 ± 0.297
2.18GlyTyr: 2.18 ± 0.413
0.0GlyXaa: 0.0 ± 0.0
His
1.246HisAla: 1.246 ± 0.259
0.078HisCys: 0.078 ± 0.077
0.623HisAsp: 0.623 ± 0.178
1.323HisGlu: 1.323 ± 0.315
0.623HisPhe: 0.623 ± 0.204
0.623HisGly: 0.623 ± 0.224
0.545HisHis: 0.545 ± 0.233
1.479HisIle: 1.479 ± 0.347
0.856HisLys: 0.856 ± 0.209
0.778HisLeu: 0.778 ± 0.272
0.078HisMet: 0.078 ± 0.072
0.467HisAsn: 0.467 ± 0.182
0.467HisPro: 0.467 ± 0.188
0.467HisGln: 0.467 ± 0.149
0.934HisArg: 0.934 ± 0.302
0.623HisSer: 0.623 ± 0.189
0.467HisThr: 0.467 ± 0.183
1.168HisVal: 1.168 ± 0.274
0.389HisTrp: 0.389 ± 0.194
0.934HisTyr: 0.934 ± 0.261
0.0HisXaa: 0.0 ± 0.0
Ile
6.383IleAla: 6.383 ± 0.876
1.012IleCys: 1.012 ± 0.37
5.216IleAsp: 5.216 ± 0.632
7.162IleGlu: 7.162 ± 0.662
2.569IlePhe: 2.569 ± 0.58
3.737IleGly: 3.737 ± 0.536
1.246IleHis: 1.246 ± 0.371
4.515IleIle: 4.515 ± 0.761
8.096IleLys: 8.096 ± 0.897
4.904IleLeu: 4.904 ± 0.706
1.323IleMet: 1.323 ± 0.352
5.605IleAsn: 5.605 ± 0.534
3.192IlePro: 3.192 ± 0.388
4.593IleGln: 4.593 ± 0.613
2.725IleArg: 2.725 ± 0.441
3.737IleSer: 3.737 ± 0.696
5.138IleThr: 5.138 ± 0.569
5.138IleVal: 5.138 ± 0.713
0.778IleTrp: 0.778 ± 0.244
4.048IleTyr: 4.048 ± 0.609
0.0IleXaa: 0.0 ± 0.0
Lys
5.371LysAla: 5.371 ± 0.765
1.323LysCys: 1.323 ± 0.387
4.671LysAsp: 4.671 ± 0.755
8.641LysGlu: 8.641 ± 0.947
2.725LysPhe: 2.725 ± 0.403
2.491LysGly: 2.491 ± 0.567
1.401LysHis: 1.401 ± 0.349
7.94LysIle: 7.94 ± 1.115
7.395LysLys: 7.395 ± 1.096
5.916LysLeu: 5.916 ± 0.7
2.725LysMet: 2.725 ± 0.5
5.06LysAsn: 5.06 ± 0.649
2.569LysPro: 2.569 ± 0.46
3.581LysGln: 3.581 ± 0.562
2.802LysArg: 2.802 ± 0.437
4.204LysSer: 4.204 ± 0.647
3.737LysThr: 3.737 ± 0.635
4.359LysVal: 4.359 ± 0.806
1.012LysTrp: 1.012 ± 0.338
2.958LysTyr: 2.958 ± 0.502
0.0LysXaa: 0.0 ± 0.0
Leu
5.138LeuAla: 5.138 ± 0.741
0.778LeuCys: 0.778 ± 0.211
5.527LeuAsp: 5.527 ± 0.886
5.683LeuGlu: 5.683 ± 0.862
2.335LeuPhe: 2.335 ± 0.429
4.904LeuGly: 4.904 ± 0.484
1.012LeuHis: 1.012 ± 0.272
5.216LeuIle: 5.216 ± 0.614
7.084LeuLys: 7.084 ± 0.7
6.461LeuLeu: 6.461 ± 0.877
1.557LeuMet: 1.557 ± 0.432
4.826LeuAsn: 4.826 ± 0.635
4.126LeuPro: 4.126 ± 0.538
4.982LeuGln: 4.982 ± 0.746
2.569LeuArg: 2.569 ± 0.503
5.683LeuSer: 5.683 ± 0.654
5.527LeuThr: 5.527 ± 0.859
4.515LeuVal: 4.515 ± 0.544
1.323LeuTrp: 1.323 ± 0.389
1.479LeuTyr: 1.479 ± 0.348
0.0LeuXaa: 0.0 ± 0.0
Met
1.635MetAla: 1.635 ± 0.313
0.156MetCys: 0.156 ± 0.095
1.246MetAsp: 1.246 ± 0.266
1.635MetGlu: 1.635 ± 0.352
1.168MetPhe: 1.168 ± 0.36
1.635MetGly: 1.635 ± 0.355
0.234MetHis: 0.234 ± 0.133
1.946MetIle: 1.946 ± 0.322
2.413MetLys: 2.413 ± 0.447
1.79MetLeu: 1.79 ± 0.299
0.311MetMet: 0.311 ± 0.142
1.246MetAsn: 1.246 ± 0.305
1.79MetPro: 1.79 ± 0.367
1.09MetGln: 1.09 ± 0.323
0.701MetArg: 0.701 ± 0.231
1.09MetSer: 1.09 ± 0.286
1.246MetThr: 1.246 ± 0.242
0.778MetVal: 0.778 ± 0.19
0.623MetTrp: 0.623 ± 0.194
1.168MetTyr: 1.168 ± 0.325
0.0MetXaa: 0.0 ± 0.0
Asn
4.437AsnAla: 4.437 ± 0.634
0.701AsnCys: 0.701 ± 0.243
4.204AsnAsp: 4.204 ± 0.547
2.725AsnGlu: 2.725 ± 0.58
2.491AsnPhe: 2.491 ± 0.451
5.293AsnGly: 5.293 ± 0.74
0.623AsnHis: 0.623 ± 0.23
4.826AsnIle: 4.826 ± 0.611
4.126AsnLys: 4.126 ± 0.687
4.281AsnLeu: 4.281 ± 0.65
1.479AsnMet: 1.479 ± 0.361
3.892AsnAsn: 3.892 ± 0.712
2.958AsnPro: 2.958 ± 0.454
1.868AsnGln: 1.868 ± 0.441
1.713AsnArg: 1.713 ± 0.338
3.581AsnSer: 3.581 ± 0.516
3.581AsnThr: 3.581 ± 0.554
3.97AsnVal: 3.97 ± 0.566
0.856AsnTrp: 0.856 ± 0.31
2.102AsnTyr: 2.102 ± 0.4
0.0AsnXaa: 0.0 ± 0.0
Pro
3.659ProAla: 3.659 ± 0.507
0.078ProCys: 0.078 ± 0.077
2.802ProAsp: 2.802 ± 0.578
2.725ProGlu: 2.725 ± 0.365
1.713ProPhe: 1.713 ± 0.391
2.102ProGly: 2.102 ± 0.375
0.389ProHis: 0.389 ± 0.173
2.413ProIle: 2.413 ± 0.41
2.335ProLys: 2.335 ± 0.649
3.114ProLeu: 3.114 ± 0.478
0.467ProMet: 0.467 ± 0.164
2.258ProAsn: 2.258 ± 0.498
1.479ProPro: 1.479 ± 0.387
1.479ProGln: 1.479 ± 0.413
1.401ProArg: 1.401 ± 0.358
2.335ProSer: 2.335 ± 0.376
3.114ProThr: 3.114 ± 0.552
2.413ProVal: 2.413 ± 0.372
0.156ProTrp: 0.156 ± 0.131
1.79ProTyr: 1.79 ± 0.398
0.0ProXaa: 0.0 ± 0.0
Gln
3.97GlnAla: 3.97 ± 0.679
0.311GlnCys: 0.311 ± 0.196
2.18GlnAsp: 2.18 ± 0.41
3.737GlnGlu: 3.737 ± 0.553
1.868GlnPhe: 1.868 ± 0.313
3.114GlnGly: 3.114 ± 0.534
0.389GlnHis: 0.389 ± 0.162
3.581GlnIle: 3.581 ± 0.466
4.437GlnLys: 4.437 ± 0.605
3.581GlnLeu: 3.581 ± 0.568
1.713GlnMet: 1.713 ± 0.427
2.725GlnAsn: 2.725 ± 0.541
1.868GlnPro: 1.868 ± 0.6
2.725GlnGln: 2.725 ± 0.561
1.635GlnArg: 1.635 ± 0.386
2.102GlnSer: 2.102 ± 0.328
1.79GlnThr: 1.79 ± 0.362
2.647GlnVal: 2.647 ± 0.438
0.856GlnTrp: 0.856 ± 0.265
1.946GlnTyr: 1.946 ± 0.426
0.0GlnXaa: 0.0 ± 0.0
Arg
1.323ArgAla: 1.323 ± 0.29
0.311ArgCys: 0.311 ± 0.136
1.557ArgAsp: 1.557 ± 0.295
2.958ArgGlu: 2.958 ± 0.543
0.856ArgPhe: 0.856 ± 0.282
1.79ArgGly: 1.79 ± 0.349
0.778ArgHis: 0.778 ± 0.216
2.569ArgIle: 2.569 ± 0.572
2.802ArgLys: 2.802 ± 0.5
3.036ArgLeu: 3.036 ± 0.531
1.012ArgMet: 1.012 ± 0.24
1.946ArgAsn: 1.946 ± 0.388
0.856ArgPro: 0.856 ± 0.322
1.479ArgGln: 1.479 ± 0.292
1.168ArgArg: 1.168 ± 0.283
1.635ArgSer: 1.635 ± 0.291
1.479ArgThr: 1.479 ± 0.323
1.713ArgVal: 1.713 ± 0.357
0.545ArgTrp: 0.545 ± 0.209
1.946ArgTyr: 1.946 ± 0.526
0.0ArgXaa: 0.0 ± 0.0
Ser
4.204SerAla: 4.204 ± 0.917
0.467SerCys: 0.467 ± 0.186
3.97SerAsp: 3.97 ± 0.486
2.958SerGlu: 2.958 ± 0.422
2.413SerPhe: 2.413 ± 0.416
4.515SerGly: 4.515 ± 0.629
0.701SerHis: 0.701 ± 0.244
4.749SerIle: 4.749 ± 0.692
3.27SerLys: 3.27 ± 0.575
5.371SerLeu: 5.371 ± 0.465
1.012SerMet: 1.012 ± 0.25
3.814SerAsn: 3.814 ± 0.741
2.258SerPro: 2.258 ± 0.425
2.102SerGln: 2.102 ± 0.51
1.479SerArg: 1.479 ± 0.373
4.437SerSer: 4.437 ± 0.913
3.814SerThr: 3.814 ± 0.473
3.659SerVal: 3.659 ± 0.617
0.934SerTrp: 0.934 ± 0.27
2.335SerTyr: 2.335 ± 0.467
0.0SerXaa: 0.0 ± 0.0
Thr
4.359ThrAla: 4.359 ± 0.61
0.856ThrCys: 0.856 ± 0.271
3.114ThrAsp: 3.114 ± 0.504
3.503ThrGlu: 3.503 ± 0.511
2.258ThrPhe: 2.258 ± 0.404
5.216ThrGly: 5.216 ± 0.718
0.701ThrHis: 0.701 ± 0.252
4.515ThrIle: 4.515 ± 0.603
3.892ThrLys: 3.892 ± 0.583
5.216ThrLeu: 5.216 ± 0.66
1.401ThrMet: 1.401 ± 0.402
3.192ThrAsn: 3.192 ± 0.547
2.725ThrPro: 2.725 ± 0.486
2.958ThrGln: 2.958 ± 0.506
1.012ThrArg: 1.012 ± 0.229
4.515ThrSer: 4.515 ± 0.626
3.737ThrThr: 3.737 ± 0.758
3.659ThrVal: 3.659 ± 0.498
0.934ThrTrp: 0.934 ± 0.29
2.725ThrTyr: 2.725 ± 0.535
0.0ThrXaa: 0.0 ± 0.0
Val
4.048ValAla: 4.048 ± 0.471
1.246ValCys: 1.246 ± 0.319
3.503ValAsp: 3.503 ± 0.492
3.581ValGlu: 3.581 ± 0.557
1.479ValPhe: 1.479 ± 0.453
2.569ValGly: 2.569 ± 0.448
1.168ValHis: 1.168 ± 0.404
3.97ValIle: 3.97 ± 0.707
6.539ValLys: 6.539 ± 0.925
4.593ValLeu: 4.593 ± 0.482
1.323ValMet: 1.323 ± 0.265
4.904ValAsn: 4.904 ± 0.639
2.335ValPro: 2.335 ± 0.392
2.725ValGln: 2.725 ± 0.396
1.946ValArg: 1.946 ± 0.455
2.88ValSer: 2.88 ± 0.491
4.359ValThr: 4.359 ± 0.659
4.204ValVal: 4.204 ± 0.691
1.012ValTrp: 1.012 ± 0.272
2.258ValTyr: 2.258 ± 0.44
0.0ValXaa: 0.0 ± 0.0
Trp
0.623TrpAla: 0.623 ± 0.229
0.078TrpCys: 0.078 ± 0.077
0.467TrpAsp: 0.467 ± 0.243
0.545TrpGlu: 0.545 ± 0.226
0.467TrpPhe: 0.467 ± 0.187
1.713TrpGly: 1.713 ± 0.453
0.234TrpHis: 0.234 ± 0.129
1.868TrpIle: 1.868 ± 0.416
1.168TrpLys: 1.168 ± 0.267
1.323TrpLeu: 1.323 ± 0.29
0.545TrpMet: 0.545 ± 0.18
1.479TrpAsn: 1.479 ± 0.51
0.234TrpPro: 0.234 ± 0.177
1.09TrpGln: 1.09 ± 0.342
0.701TrpArg: 0.701 ± 0.282
0.545TrpSer: 0.545 ± 0.179
0.778TrpThr: 0.778 ± 0.254
0.701TrpVal: 0.701 ± 0.201
0.156TrpTrp: 0.156 ± 0.106
0.389TrpTyr: 0.389 ± 0.133
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.18TyrAla: 2.18 ± 0.444
0.389TyrCys: 0.389 ± 0.169
1.946TyrAsp: 1.946 ± 0.389
2.491TyrGlu: 2.491 ± 0.463
1.635TyrPhe: 1.635 ± 0.381
2.491TyrGly: 2.491 ± 0.421
0.389TyrHis: 0.389 ± 0.189
3.114TyrIle: 3.114 ± 0.555
3.503TyrLys: 3.503 ± 0.615
3.036TyrLeu: 3.036 ± 0.462
0.778TyrMet: 0.778 ± 0.24
2.491TyrAsn: 2.491 ± 0.481
1.557TyrPro: 1.557 ± 0.316
1.168TyrGln: 1.168 ± 0.358
1.401TyrArg: 1.401 ± 0.246
2.491TyrSer: 2.491 ± 0.506
2.725TyrThr: 2.725 ± 0.617
2.802TyrVal: 2.802 ± 0.555
0.701TyrTrp: 0.701 ± 0.28
1.323TyrTyr: 1.323 ± 0.359
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 57 proteins (12847 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski