Amino acid dipepetide frequency for Torque teno midi virus 6

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.355AlaAla: 11.355 ± 4.782
1.514AlaCys: 1.514 ± 0.907
7.57AlaAsp: 7.57 ± 1.209
4.542AlaGlu: 4.542 ± 1.079
2.271AlaPhe: 2.271 ± 1.475
3.028AlaGly: 3.028 ± 0.988
4.542AlaHis: 4.542 ± 2.827
1.514AlaIle: 1.514 ± 0.907
1.514AlaLys: 1.514 ± 0.645
2.271AlaLeu: 2.271 ± 0.742
0.0AlaMet: 0.0 ± 0.419
2.271AlaAsn: 2.271 ± 1.414
3.028AlaPro: 3.028 ± 2.403
2.271AlaGln: 2.271 ± 0.866
1.514AlaArg: 1.514 ± 0.714
2.271AlaSer: 2.271 ± 1.414
4.542AlaThr: 4.542 ± 1.847
0.757AlaVal: 0.757 ± 0.825
0.757AlaTrp: 0.757 ± 0.453
1.514AlaTyr: 1.514 ± 0.907
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.757CysCys: 0.757 ± 0.453
0.0CysAsp: 0.0 ± 0.0
1.514CysGlu: 1.514 ± 0.907
0.0CysPhe: 0.0 ± 0.0
1.514CysGly: 1.514 ± 0.907
0.0CysHis: 0.0 ± 0.0
0.757CysIle: 0.757 ± 0.453
0.757CysLys: 0.757 ± 0.453
0.757CysLeu: 0.757 ± 0.453
0.0CysMet: 0.0 ± 0.0
4.542CysAsn: 4.542 ± 0.407
0.757CysPro: 0.757 ± 0.832
0.0CysGln: 0.0 ± 0.0
1.514CysArg: 1.514 ± 1.013
0.757CysSer: 0.757 ± 0.453
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
2.271CysTrp: 2.271 ± 1.414
0.757CysTyr: 0.757 ± 0.453
0.0CysXaa: 0.0 ± 0.0
Asp
7.57AspAla: 7.57 ± 4.613
0.0AspCys: 0.0 ± 0.0
3.028AspAsp: 3.028 ± 1.814
3.785AspGlu: 3.785 ± 0.604
3.785AspPhe: 3.785 ± 0.604
1.514AspGly: 1.514 ± 0.907
0.0AspHis: 0.0 ± 0.0
1.514AspIle: 1.514 ± 0.907
2.271AspLys: 2.271 ± 1.36
4.542AspLeu: 4.542 ± 0.407
0.0AspMet: 0.0 ± 0.0
0.757AspAsn: 0.757 ± 0.453
3.785AspPro: 3.785 ± 0.55
0.0AspGln: 0.0 ± 0.0
2.271AspArg: 2.271 ± 1.414
5.299AspSer: 5.299 ± 0.614
3.785AspThr: 3.785 ± 0.604
2.271AspVal: 2.271 ± 1.414
0.0AspTrp: 0.0 ± 0.0
2.271AspTyr: 2.271 ± 1.36
0.0AspXaa: 0.0 ± 0.0
Glu
1.514GluAla: 1.514 ± 0.645
1.514GluCys: 1.514 ± 0.645
7.57GluAsp: 7.57 ± 4.613
9.841GluGlu: 9.841 ± 5.222
0.0GluPhe: 0.0 ± 0.0
2.271GluGly: 2.271 ± 0.742
0.0GluHis: 0.0 ± 0.0
3.028GluIle: 3.028 ± 0.988
6.813GluLys: 6.813 ± 3.425
3.785GluLeu: 3.785 ± 1.467
0.757GluMet: 0.757 ± 0.825
4.542GluAsn: 4.542 ± 1.985
1.514GluPro: 1.514 ± 0.714
3.785GluGln: 3.785 ± 1.607
3.028GluArg: 3.028 ± 1.884
2.271GluSer: 2.271 ± 0.866
7.57GluThr: 7.57 ± 1.943
0.757GluVal: 0.757 ± 0.453
0.757GluTrp: 0.757 ± 0.453
3.028GluTyr: 3.028 ± 0.988
0.0GluXaa: 0.0 ± 0.0
Phe
3.028PheAla: 3.028 ± 0.988
0.0PheCys: 0.0 ± 0.0
0.0PheAsp: 0.0 ± 0.0
0.757PheGlu: 0.757 ± 0.825
1.514PhePhe: 1.514 ± 0.907
2.271PheGly: 2.271 ± 1.36
1.514PheHis: 1.514 ± 0.714
0.757PheIle: 0.757 ± 0.453
4.542PheLys: 4.542 ± 2.949
0.757PheLeu: 0.757 ± 0.453
1.514PheMet: 1.514 ± 0.66
3.028PheAsn: 3.028 ± 0.988
2.271PhePro: 2.271 ± 1.414
2.271PheGln: 2.271 ± 0.742
1.514PheArg: 1.514 ± 0.907
2.271PheSer: 2.271 ± 0.866
2.271PheThr: 2.271 ± 0.866
0.0PheVal: 0.0 ± 0.0
0.757PheTrp: 0.757 ± 0.453
4.542PheTyr: 4.542 ± 1.079
0.0PheXaa: 0.0 ± 0.0
Gly
0.757GlyAla: 0.757 ± 0.453
1.514GlyCys: 1.514 ± 0.907
2.271GlyAsp: 2.271 ± 1.414
5.299GlyGlu: 5.299 ± 3.388
1.514GlyPhe: 1.514 ± 0.714
7.57GlyGly: 7.57 ± 1.209
3.028GlyHis: 3.028 ± 0.988
0.0GlyIle: 0.0 ± 0.0
2.271GlyLys: 2.271 ± 0.742
3.785GlyLeu: 3.785 ± 0.604
0.0GlyMet: 0.0 ± 0.0
2.271GlyAsn: 2.271 ± 1.36
1.514GlyPro: 1.514 ± 0.907
1.514GlyGln: 1.514 ± 0.907
1.514GlyArg: 1.514 ± 0.907
0.757GlySer: 0.757 ± 0.453
5.299GlyThr: 5.299 ± 2.281
1.514GlyVal: 1.514 ± 0.645
1.514GlyTrp: 1.514 ± 0.907
2.271GlyTyr: 2.271 ± 1.36
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.0HisCys: 0.0 ± 0.0
2.271HisAsp: 2.271 ± 1.414
0.0HisGlu: 0.0 ± 0.0
2.271HisPhe: 2.271 ± 1.414
3.028HisGly: 3.028 ± 2.021
0.757HisHis: 0.757 ± 0.832
0.757HisIle: 0.757 ± 0.453
3.785HisLys: 3.785 ± 1.607
0.757HisLeu: 0.757 ± 0.825
2.271HisMet: 2.271 ± 1.414
0.757HisAsn: 0.757 ± 0.453
4.542HisPro: 4.542 ± 1.079
5.299HisGln: 5.299 ± 1.394
0.757HisArg: 0.757 ± 0.453
1.514HisSer: 1.514 ± 1.664
0.757HisThr: 0.757 ± 0.825
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
0.757HisTyr: 0.757 ± 0.453
0.0HisXaa: 0.0 ± 0.0
Ile
2.271IleAla: 2.271 ± 1.36
0.0IleCys: 0.0 ± 0.0
0.757IleAsp: 0.757 ± 0.453
2.271IleGlu: 2.271 ± 1.414
2.271IlePhe: 2.271 ± 1.414
0.757IleGly: 0.757 ± 0.453
1.514IleHis: 1.514 ± 0.645
3.785IleIle: 3.785 ± 0.604
2.271IleLys: 2.271 ± 1.36
8.327IleLeu: 8.327 ± 1.346
0.0IleMet: 0.0 ± 0.0
6.056IleAsn: 6.056 ± 3.681
1.514IlePro: 1.514 ± 0.714
2.271IleGln: 2.271 ± 0.742
1.514IleArg: 1.514 ± 0.907
6.056IleSer: 6.056 ± 0.999
3.785IleThr: 3.785 ± 0.604
3.785IleVal: 3.785 ± 0.604
0.757IleTrp: 0.757 ± 0.453
1.514IleTyr: 1.514 ± 0.907
0.0IleXaa: 0.0 ± 0.0
Lys
3.785LysAla: 3.785 ± 0.604
1.514LysCys: 1.514 ± 0.907
4.542LysAsp: 4.542 ± 0.407
12.112LysGlu: 12.112 ± 4.665
0.757LysPhe: 0.757 ± 0.825
3.028LysGly: 3.028 ± 1.814
3.028LysHis: 3.028 ± 0.988
6.056LysIle: 6.056 ± 1.094
9.841LysLys: 9.841 ± 3.345
2.271LysLeu: 2.271 ± 1.36
0.757LysMet: 0.757 ± 0.453
3.785LysAsn: 3.785 ± 1.433
3.028LysPro: 3.028 ± 1.184
6.813LysGln: 6.813 ± 1.456
5.299LysArg: 5.299 ± 1.816
3.785LysSer: 3.785 ± 0.948
4.542LysThr: 4.542 ± 2.875
1.514LysVal: 1.514 ± 0.907
2.271LysTrp: 2.271 ± 1.36
5.299LysTyr: 5.299 ± 2.413
0.0LysXaa: 0.0 ± 0.0
Leu
6.056LeuAla: 6.056 ± 0.652
1.514LeuCys: 1.514 ± 0.645
1.514LeuAsp: 1.514 ± 0.645
3.785LeuGlu: 3.785 ± 0.604
1.514LeuPhe: 1.514 ± 0.645
1.514LeuGly: 1.514 ± 0.907
1.514LeuHis: 1.514 ± 0.907
3.785LeuIle: 3.785 ± 2.267
7.57LeuLys: 7.57 ± 3.806
11.355LeuLeu: 11.355 ± 1.535
1.514LeuMet: 1.514 ± 0.645
1.514LeuAsn: 1.514 ± 0.714
1.514LeuPro: 1.514 ± 0.714
6.056LeuGln: 6.056 ± 1.094
4.542LeuArg: 4.542 ± 1.985
2.271LeuSer: 2.271 ± 1.36
8.327LeuThr: 8.327 ± 1.409
6.813LeuVal: 6.813 ± 0.819
3.785LeuTrp: 3.785 ± 0.604
3.785LeuTyr: 3.785 ± 1.433
0.0LeuXaa: 0.0 ± 0.0
Met
1.514MetAla: 1.514 ± 0.714
0.0MetCys: 0.0 ± 0.0
0.757MetAsp: 0.757 ± 0.453
0.0MetGlu: 0.0 ± 0.0
0.757MetPhe: 0.757 ± 0.825
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
0.757MetLys: 0.757 ± 0.453
3.785MetLeu: 3.785 ± 0.604
0.0MetMet: 0.0 ± 0.0
0.757MetAsn: 0.757 ± 0.832
0.0MetPro: 0.0 ± 0.0
3.028MetGln: 3.028 ± 0.988
0.0MetArg: 0.0 ± 0.0
4.542MetSer: 4.542 ± 1.079
0.757MetThr: 0.757 ± 0.832
0.0MetVal: 0.0 ± 0.0
0.0MetTrp: 0.0 ± 0.0
0.757MetTyr: 0.757 ± 0.453
0.0MetXaa: 0.0 ± 0.0
Asn
0.757AsnAla: 0.757 ± 0.453
3.785AsnCys: 3.785 ± 1.467
0.0AsnAsp: 0.0 ± 0.0
2.271AsnGlu: 2.271 ± 0.866
1.514AsnPhe: 1.514 ± 1.649
0.757AsnGly: 0.757 ± 0.453
0.0AsnHis: 0.0 ± 0.0
7.57AsnIle: 7.57 ± 1.943
3.028AsnLys: 3.028 ± 1.048
7.57AsnLeu: 7.57 ± 1.319
0.0AsnMet: 0.0 ± 0.0
0.757AsnAsn: 0.757 ± 0.832
6.056AsnPro: 6.056 ± 0.999
5.299AsnGln: 5.299 ± 2.397
1.514AsnArg: 1.514 ± 1.013
2.271AsnSer: 2.271 ± 1.36
3.785AsnThr: 3.785 ± 1.433
0.757AsnVal: 0.757 ± 0.832
0.757AsnTrp: 0.757 ± 0.453
3.028AsnTyr: 3.028 ± 1.814
0.0AsnXaa: 0.0 ± 0.0
Pro
2.271ProAla: 2.271 ± 1.475
0.757ProCys: 0.757 ± 0.453
0.757ProAsp: 0.757 ± 0.453
7.57ProGlu: 7.57 ± 2.145
3.785ProPhe: 3.785 ± 0.604
5.299ProGly: 5.299 ± 1.394
0.757ProHis: 0.757 ± 0.832
2.271ProIle: 2.271 ± 0.742
3.785ProLys: 3.785 ± 2.267
3.028ProLeu: 3.028 ± 1.428
0.757ProMet: 0.757 ± 0.453
2.271ProAsn: 2.271 ± 1.475
7.57ProPro: 7.57 ± 2.145
3.028ProGln: 3.028 ± 1.048
3.785ProArg: 3.785 ± 3.096
3.785ProSer: 3.785 ± 1.607
3.785ProThr: 3.785 ± 1.036
1.514ProVal: 1.514 ± 0.907
2.271ProTrp: 2.271 ± 0.866
0.757ProTyr: 0.757 ± 0.453
0.0ProXaa: 0.0 ± 0.0
Gln
3.028GlnAla: 3.028 ± 1.3
0.757GlnCys: 0.757 ± 0.453
1.514GlnAsp: 1.514 ± 0.907
3.785GlnGlu: 3.785 ± 1.433
0.757GlnPhe: 0.757 ± 0.453
0.757GlnGly: 0.757 ± 0.453
1.514GlnHis: 1.514 ± 0.714
5.299GlnIle: 5.299 ± 3.388
3.785GlnLys: 3.785 ± 1.315
6.056GlnLeu: 6.056 ± 1.683
0.757GlnMet: 0.757 ± 0.453
3.785GlnAsn: 3.785 ± 1.607
3.785GlnPro: 3.785 ± 2.267
6.813GlnGln: 6.813 ± 2.469
4.542GlnArg: 4.542 ± 0.94
1.514GlnSer: 1.514 ± 0.645
2.271GlnThr: 2.271 ± 0.742
3.028GlnVal: 3.028 ± 0.988
0.757GlnTrp: 0.757 ± 0.453
2.271GlnTyr: 2.271 ± 0.742
0.0GlnXaa: 0.0 ± 0.0
Arg
0.757ArgAla: 0.757 ± 0.825
0.757ArgCys: 0.757 ± 0.453
3.785ArgAsp: 3.785 ± 1.467
0.757ArgGlu: 0.757 ± 0.825
3.785ArgPhe: 3.785 ± 2.165
1.514ArgGly: 1.514 ± 0.907
0.757ArgHis: 0.757 ± 0.453
0.757ArgIle: 0.757 ± 0.453
10.598ArgLys: 10.598 ± 2.123
2.271ArgLeu: 2.271 ± 2.474
2.271ArgMet: 2.271 ± 0.805
4.542ArgAsn: 4.542 ± 1.22
3.028ArgPro: 3.028 ± 2.28
0.0ArgGln: 0.0 ± 0.0
14.383ArgArg: 14.383 ± 7.779
1.514ArgSer: 1.514 ± 0.645
3.785ArgThr: 3.785 ± 1.315
1.514ArgVal: 1.514 ± 0.714
0.757ArgTrp: 0.757 ± 0.453
5.299ArgTyr: 5.299 ± 3.174
0.0ArgXaa: 0.0 ± 0.0
Ser
6.056SerAla: 6.056 ± 0.941
0.0SerCys: 0.0 ± 0.0
2.271SerAsp: 2.271 ± 1.36
0.757SerGlu: 0.757 ± 0.453
1.514SerPhe: 1.514 ± 0.907
3.028SerGly: 3.028 ± 2.021
3.785SerHis: 3.785 ± 2.749
6.813SerIle: 6.813 ± 0.823
3.028SerLys: 3.028 ± 0.364
4.542SerLeu: 4.542 ± 1.85
1.514SerMet: 1.514 ± 1.506
3.028SerAsn: 3.028 ± 1.048
1.514SerPro: 1.514 ± 1.013
0.757SerGln: 0.757 ± 0.453
2.271SerArg: 2.271 ± 1.66
12.112SerSer: 12.112 ± 6.752
3.028SerThr: 3.028 ± 1.048
3.028SerVal: 3.028 ± 0.988
0.757SerTrp: 0.757 ± 0.453
0.757SerTyr: 0.757 ± 0.832
0.0SerXaa: 0.0 ± 0.0
Thr
2.271ThrAla: 2.271 ± 0.866
0.0ThrCys: 0.0 ± 0.0
6.813ThrAsp: 6.813 ± 1.426
4.542ThrGlu: 4.542 ± 2.803
3.028ThrPhe: 3.028 ± 1.814
4.542ThrGly: 4.542 ± 0.407
3.785ThrHis: 3.785 ± 2.3
3.785ThrIle: 3.785 ± 0.604
7.57ThrLys: 7.57 ± 1.109
6.056ThrLeu: 6.056 ± 1.811
0.757ThrMet: 0.757 ± 0.453
1.514ThrAsn: 1.514 ± 0.907
3.028ThrPro: 3.028 ± 1.3
3.028ThrGln: 3.028 ± 1.048
6.056ThrArg: 6.056 ± 1.541
5.299ThrSer: 5.299 ± 4.714
5.299ThrThr: 5.299 ± 0.829
1.514ThrVal: 1.514 ± 0.907
3.785ThrTrp: 3.785 ± 0.604
3.028ThrTyr: 3.028 ± 1.048
0.0ThrXaa: 0.0 ± 0.0
Val
6.056ValAla: 6.056 ± 2.957
2.271ValCys: 2.271 ± 1.414
0.0ValAsp: 0.0 ± 0.0
0.0ValGlu: 0.0 ± 0.0
1.514ValPhe: 1.514 ± 0.907
0.0ValGly: 0.0 ± 0.0
0.757ValHis: 0.757 ± 0.825
0.0ValIle: 0.0 ± 0.0
3.028ValLys: 3.028 ± 1.814
1.514ValLeu: 1.514 ± 0.907
0.0ValMet: 0.0 ± 0.0
2.271ValAsn: 2.271 ± 0.866
3.028ValPro: 3.028 ± 1.184
0.0ValGln: 0.0 ± 0.0
1.514ValArg: 1.514 ± 0.907
1.514ValSer: 1.514 ± 0.645
6.056ValThr: 6.056 ± 1.976
1.514ValVal: 1.514 ± 0.907
0.0ValTrp: 0.0 ± 0.0
0.757ValTyr: 0.757 ± 0.453
0.0ValXaa: 0.0 ± 0.0
Trp
0.757TrpAla: 0.757 ± 0.453
0.0TrpCys: 0.0 ± 0.0
0.757TrpAsp: 0.757 ± 0.453
0.0TrpGlu: 0.0 ± 0.0
2.271TrpPhe: 2.271 ± 1.36
0.757TrpGly: 0.757 ± 0.453
2.271TrpHis: 2.271 ± 1.414
0.0TrpIle: 0.0 ± 0.0
0.757TrpLys: 0.757 ± 0.453
2.271TrpLeu: 2.271 ± 0.866
2.271TrpMet: 2.271 ± 1.414
0.0TrpAsn: 0.0 ± 0.0
2.271TrpPro: 2.271 ± 1.414
2.271TrpGln: 2.271 ± 1.36
1.514TrpArg: 1.514 ± 0.907
0.0TrpSer: 0.0 ± 0.0
2.271TrpThr: 2.271 ± 1.36
0.757TrpVal: 0.757 ± 0.453
0.757TrpTrp: 0.757 ± 0.453
1.514TrpTyr: 1.514 ± 0.907
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.0TyrAla: 0.0 ± 0.0
0.0TyrCys: 0.0 ± 0.0
2.271TyrAsp: 2.271 ± 1.36
0.757TyrGlu: 0.757 ± 0.453
0.757TyrPhe: 0.757 ± 0.453
3.028TyrGly: 3.028 ± 1.814
0.757TyrHis: 0.757 ± 0.453
3.028TyrIle: 3.028 ± 0.988
6.056TyrLys: 6.056 ± 0.999
4.542TyrLeu: 4.542 ± 2.72
1.514TyrMet: 1.514 ± 0.714
3.028TyrAsn: 3.028 ± 1.814
6.056TyrPro: 6.056 ± 1.811
2.271TyrGln: 2.271 ± 1.418
3.785TyrArg: 3.785 ± 2.267
0.757TyrSer: 0.757 ± 0.832
3.785TyrThr: 3.785 ± 2.267
0.757TyrVal: 0.757 ± 0.453
0.757TyrTrp: 0.757 ± 0.453
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (1322 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski