Amino acid dipepetide frequency for Aspergillus bombycis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.336AlaAla: 8.336 ± 0.052	1.148AlaCys: 1.148 ± 0.015	4.106AlaAsp: 4.106 ± 0.025	4.87AlaGlu: 4.87 ± 0.036	3.239AlaPhe: 3.239 ± 0.022	5.68AlaGly: 5.68 ± 0.04	1.798AlaHis: 1.798 ± 0.019	4.439AlaIle: 4.439 ± 0.026	3.685AlaLys: 3.685 ± 0.029	7.92AlaLeu: 7.92 ± 0.038	1.98AlaMet: 1.98 ± 0.019	2.908AlaAsn: 2.908 ± 0.024	4.39AlaPro: 4.39 ± 0.034	3.321AlaGln: 3.321 ± 0.025	4.705AlaArg: 4.705 ± 0.03	6.972AlaSer: 6.972 ± 0.037	5.153AlaThr: 5.153 ± 0.031	5.516AlaVal: 5.516 ± 0.033	1.203AlaTrp: 1.203 ± 0.018	2.296AlaTyr: 2.296 ± 0.019	0.0AlaXaa: 0.0 ± 0.0
Cys	1.016CysAla: 1.016 ± 0.013	0.249CysCys: 0.249 ± 0.007	0.715CysAsp: 0.715 ± 0.013	0.628CysGlu: 0.628 ± 0.011	0.571CysPhe: 0.571 ± 0.009	0.958CysGly: 0.958 ± 0.014	0.368CysHis: 0.368 ± 0.008	0.776CysIle: 0.776 ± 0.012	0.5CysLys: 0.5 ± 0.01	1.403CysLeu: 1.403 ± 0.014	0.298CysMet: 0.298 ± 0.007	0.45CysAsn: 0.45 ± 0.01	0.671CysPro: 0.671 ± 0.013	0.506CysGln: 0.506 ± 0.01	0.798CysArg: 0.798 ± 0.011	1.005CysSer: 1.005 ± 0.014	0.745CysThr: 0.745 ± 0.011	0.873CysVal: 0.873 ± 0.014	0.22CysTrp: 0.22 ± 0.006	0.389CysTyr: 0.389 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.5AspAla: 4.5 ± 0.024	0.64AspCys: 0.64 ± 0.012	3.798AspAsp: 3.798 ± 0.039	4.102AspGlu: 4.102 ± 0.034	2.154AspPhe: 2.154 ± 0.018	3.933AspGly: 3.933 ± 0.027	1.289AspHis: 1.289 ± 0.014	3.246AspIle: 3.246 ± 0.026	2.212AspLys: 2.212 ± 0.019	5.173AspLeu: 5.173 ± 0.033	1.259AspMet: 1.259 ± 0.015	1.907AspAsn: 1.907 ± 0.02	3.363AspPro: 3.363 ± 0.023	1.949AspGln: 1.949 ± 0.018	3.078AspArg: 3.078 ± 0.028	4.088AspSer: 4.088 ± 0.027	3.06AspThr: 3.06 ± 0.026	3.675AspVal: 3.675 ± 0.025	0.892AspTrp: 0.892 ± 0.013	1.657AspTyr: 1.657 ± 0.016	0.0AspXaa: 0.0 ± 0.0
Glu	5.102GluAla: 5.102 ± 0.033	0.656GluCys: 0.656 ± 0.012	3.918GluAsp: 3.918 ± 0.031	5.111GluGlu: 5.111 ± 0.049	1.952GluPhe: 1.952 ± 0.018	3.63GluGly: 3.63 ± 0.031	1.415GluHis: 1.415 ± 0.017	3.099GluIle: 3.099 ± 0.025	3.525GluLys: 3.525 ± 0.03	5.231GluLeu: 5.231 ± 0.033	1.399GluMet: 1.399 ± 0.017	2.325GluAsn: 2.325 ± 0.022	2.718GluPro: 2.718 ± 0.033	2.508GluGln: 2.508 ± 0.024	3.786GluArg: 3.786 ± 0.032	4.352GluSer: 4.352 ± 0.033	3.539GluThr: 3.539 ± 0.029	3.526GluVal: 3.526 ± 0.028	0.887GluTrp: 0.887 ± 0.012	1.751GluTyr: 1.751 ± 0.017	0.0GluXaa: 0.0 ± 0.0
Phe	3.096PheAla: 3.096 ± 0.022	0.602PheCys: 0.602 ± 0.01	2.268PheAsp: 2.268 ± 0.019	2.089PheGlu: 2.089 ± 0.021	1.701PhePhe: 1.701 ± 0.023	2.875PheGly: 2.875 ± 0.025	0.985PheHis: 0.985 ± 0.012	1.952PheIle: 1.952 ± 0.02	1.426PheLys: 1.426 ± 0.016	3.752PheLeu: 3.752 ± 0.03	0.811PheMet: 0.811 ± 0.012	1.478PheAsn: 1.478 ± 0.015	2.033PhePro: 2.033 ± 0.018	1.491PheGln: 1.491 ± 0.016	2.011PheArg: 2.011 ± 0.022	3.068PheSer: 3.068 ± 0.024	2.238PheThr: 2.238 ± 0.016	2.457PheVal: 2.457 ± 0.021	0.684PheTrp: 0.684 ± 0.01	1.226PheTyr: 1.226 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	5.202GlyAla: 5.202 ± 0.034	0.957GlyCys: 0.957 ± 0.013	3.564GlyAsp: 3.564 ± 0.026	3.528GlyGlu: 3.528 ± 0.031	2.888GlyPhe: 2.888 ± 0.024	5.324GlyGly: 5.324 ± 0.044	1.722GlyHis: 1.722 ± 0.019	3.756GlyIle: 3.756 ± 0.028	3.264GlyLys: 3.264 ± 0.027	6.377GlyLeu: 6.377 ± 0.039	1.549GlyMet: 1.549 ± 0.019	2.541GlyAsn: 2.541 ± 0.019	3.33GlyPro: 3.33 ± 0.03	2.602GlyGln: 2.602 ± 0.025	3.966GlyArg: 3.966 ± 0.025	5.67GlySer: 5.67 ± 0.037	3.983GlyThr: 3.983 ± 0.026	4.579GlyVal: 4.579 ± 0.033	1.217GlyTrp: 1.217 ± 0.015	2.262GlyTyr: 2.262 ± 0.018	0.0GlyXaa: 0.0 ± 0.0
His	1.859HisAla: 1.859 ± 0.017	0.368HisCys: 0.368 ± 0.008	1.365HisAsp: 1.365 ± 0.017	1.342HisGlu: 1.342 ± 0.015	0.942HisPhe: 0.942 ± 0.012	1.755HisGly: 1.755 ± 0.017	0.854HisHis: 0.854 ± 0.016	1.333HisIle: 1.333 ± 0.015	0.853HisLys: 0.853 ± 0.012	2.36HisLeu: 2.36 ± 0.021	0.513HisMet: 0.513 ± 0.009	0.868HisAsn: 0.868 ± 0.014	1.711HisPro: 1.711 ± 0.018	0.976HisGln: 0.976 ± 0.015	1.584HisArg: 1.584 ± 0.016	1.913HisSer: 1.913 ± 0.019	1.338HisThr: 1.338 ± 0.014	1.47HisVal: 1.47 ± 0.016	0.386HisTrp: 0.386 ± 0.008	0.74HisTyr: 0.74 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.376IleAla: 4.376 ± 0.027	0.823IleCys: 0.823 ± 0.012	2.903IleAsp: 2.903 ± 0.021	2.873IleGlu: 2.873 ± 0.024	2.128IlePhe: 2.128 ± 0.021	3.401IleGly: 3.401 ± 0.03	1.305IleHis: 1.305 ± 0.014	2.675IleIle: 2.675 ± 0.026	2.034IleLys: 2.034 ± 0.018	4.906IleLeu: 4.906 ± 0.039	1.058IleMet: 1.058 ± 0.014	1.835IleAsn: 1.835 ± 0.018	3.244IlePro: 3.244 ± 0.023	2.057IleGln: 2.057 ± 0.019	2.857IleArg: 2.857 ± 0.021	4.05IleSer: 4.05 ± 0.029	2.929IleThr: 2.929 ± 0.026	3.391IleVal: 3.391 ± 0.024	0.77IleTrp: 0.77 ± 0.012	1.557IleTyr: 1.557 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	3.962LysAla: 3.962 ± 0.029	0.53LysCys: 0.53 ± 0.01	2.679LysAsp: 2.679 ± 0.022	3.184LysGlu: 3.184 ± 0.033	1.37LysPhe: 1.37 ± 0.014	2.859LysGly: 2.859 ± 0.023	1.072LysHis: 1.072 ± 0.014	2.131LysIle: 2.131 ± 0.018	2.795LysLys: 2.795 ± 0.039	3.918LysLeu: 3.918 ± 0.033	0.908LysMet: 0.908 ± 0.012	1.647LysAsn: 1.647 ± 0.018	2.51LysPro: 2.51 ± 0.026	1.792LysGln: 1.792 ± 0.02	3.117LysArg: 3.117 ± 0.027	3.28LysSer: 3.28 ± 0.027	2.581LysThr: 2.581 ± 0.024	2.779LysVal: 2.779 ± 0.024	0.657LysTrp: 0.657 ± 0.01	1.384LysTyr: 1.384 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	7.932LeuAla: 7.932 ± 0.036	1.317LeuCys: 1.317 ± 0.018	5.264LeuAsp: 5.264 ± 0.029	5.595LeuGlu: 5.595 ± 0.04	3.562LeuPhe: 3.562 ± 0.03	6.235LeuGly: 6.235 ± 0.038	2.387LeuHis: 2.387 ± 0.021	4.211LeuIle: 4.211 ± 0.03	4.053LeuLys: 4.053 ± 0.027	8.943LeuLeu: 8.943 ± 0.058	1.875LeuMet: 1.875 ± 0.017	3.322LeuAsn: 3.322 ± 0.025	5.543LeuPro: 5.543 ± 0.036	4.045LeuGln: 4.045 ± 0.031	5.882LeuArg: 5.882 ± 0.033	7.708LeuSer: 7.708 ± 0.043	4.984LeuThr: 4.984 ± 0.031	5.766LeuVal: 5.766 ± 0.034	1.278LeuTrp: 1.278 ± 0.016	2.618LeuTyr: 2.618 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	2.179MetAla: 2.179 ± 0.018	0.271MetCys: 0.271 ± 0.006	1.247MetAsp: 1.247 ± 0.015	1.288MetGlu: 1.288 ± 0.016	0.748MetPhe: 0.748 ± 0.012	1.498MetGly: 1.498 ± 0.019	0.484MetHis: 0.484 ± 0.009	1.044MetIle: 1.044 ± 0.014	0.981MetLys: 0.981 ± 0.012	1.938MetLeu: 1.938 ± 0.018	0.541MetMet: 0.541 ± 0.011	0.798MetAsn: 0.798 ± 0.011	1.181MetPro: 1.181 ± 0.016	0.861MetGln: 0.861 ± 0.013	1.24MetArg: 1.24 ± 0.012	1.835MetSer: 1.835 ± 0.018	1.298MetThr: 1.298 ± 0.014	1.415MetVal: 1.415 ± 0.015	0.266MetTrp: 0.266 ± 0.007	0.543MetTyr: 0.543 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.093AsnAla: 3.093 ± 0.025	0.484AsnCys: 0.484 ± 0.009	1.962AsnAsp: 1.962 ± 0.021	2.041AsnGlu: 2.041 ± 0.019	1.358AsnPhe: 1.358 ± 0.015	2.911AsnGly: 2.911 ± 0.027	0.879AsnHis: 0.879 ± 0.011	2.151AsnIle: 2.151 ± 0.021	1.452AsnLys: 1.452 ± 0.018	3.281AsnLeu: 3.281 ± 0.021	0.866AsnMet: 0.866 ± 0.012	1.455AsnAsn: 1.455 ± 0.018	2.474AsnPro: 2.474 ± 0.022	1.353AsnGln: 1.353 ± 0.018	1.947AsnArg: 1.947 ± 0.018	2.72AsnSer: 2.72 ± 0.024	2.225AsnThr: 2.225 ± 0.022	2.394AsnVal: 2.394 ± 0.021	0.577AsnTrp: 0.577 ± 0.01	1.104AsnTyr: 1.104 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	4.746ProAla: 4.746 ± 0.038	0.583ProCys: 0.583 ± 0.012	3.197ProAsp: 3.197 ± 0.022	3.882ProGlu: 3.882 ± 0.038	2.148ProPhe: 2.148 ± 0.02	3.891ProGly: 3.891 ± 0.025	1.301ProHis: 1.301 ± 0.017	2.55ProIle: 2.55 ± 0.02	2.473ProLys: 2.473 ± 0.021	4.8ProLeu: 4.8 ± 0.032	1.074ProMet: 1.074 ± 0.014	2.168ProAsn: 2.168 ± 0.023	4.393ProPro: 4.393 ± 0.059	2.374ProGln: 2.374 ± 0.027	3.253ProArg: 3.253 ± 0.027	5.887ProSer: 5.887 ± 0.048	3.888ProThr: 3.888 ± 0.029	3.676ProVal: 3.676 ± 0.028	0.81ProTrp: 0.81 ± 0.012	1.555ProTyr: 1.555 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	3.357GlnAla: 3.357 ± 0.028	0.502GlnCys: 0.502 ± 0.01	2.084GlnAsp: 2.084 ± 0.019	2.475GlnGlu: 2.475 ± 0.023	1.345GlnPhe: 1.345 ± 0.017	2.528GlnGly: 2.528 ± 0.021	1.056GlnHis: 1.056 ± 0.014	1.961GlnIle: 1.961 ± 0.018	1.967GlnLys: 1.967 ± 0.02	3.637GlnLeu: 3.637 ± 0.026	0.896GlnMet: 0.896 ± 0.013	1.572GlnAsn: 1.572 ± 0.018	2.483GlnPro: 2.483 ± 0.032	2.244GlnGln: 2.244 ± 0.037	2.625GlnArg: 2.625 ± 0.024	3.213GlnSer: 3.213 ± 0.028	2.373GlnThr: 2.373 ± 0.02	2.261GlnVal: 2.261 ± 0.021	0.618GlnTrp: 0.618 ± 0.011	1.236GlnTyr: 1.236 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	4.494ArgAla: 4.494 ± 0.031	0.752ArgCys: 0.752 ± 0.012	3.27ArgAsp: 3.27 ± 0.028	3.701ArgGlu: 3.701 ± 0.03	2.232ArgPhe: 2.232 ± 0.018	3.564ArgGly: 3.564 ± 0.026	1.555ArgHis: 1.555 ± 0.016	2.923ArgIle: 2.923 ± 0.021	3.235ArgLys: 3.235 ± 0.028	5.673ArgLeu: 5.673 ± 0.036	1.289ArgMet: 1.289 ± 0.014	2.217ArgAsn: 2.217 ± 0.02	3.347ArgPro: 3.347 ± 0.03	2.587ArgGln: 2.587 ± 0.021	4.835ArgArg: 4.835 ± 0.038	4.69ArgSer: 4.69 ± 0.041	3.21ArgThr: 3.21 ± 0.023	3.493ArgVal: 3.493 ± 0.028	0.989ArgTrp: 0.989 ± 0.014	1.76ArgTyr: 1.76 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	6.498SerAla: 6.498 ± 0.036	0.938SerCys: 0.938 ± 0.014	4.256SerAsp: 4.256 ± 0.03	4.222SerGlu: 4.222 ± 0.031	3.157SerPhe: 3.157 ± 0.023	5.553SerGly: 5.553 ± 0.034	2.031SerHis: 2.031 ± 0.021	4.14SerIle: 4.14 ± 0.026	3.561SerLys: 3.561 ± 0.028	7.576SerLeu: 7.576 ± 0.042	1.714SerMet: 1.714 ± 0.018	3.001SerAsn: 3.001 ± 0.022	5.232SerPro: 5.232 ± 0.044	3.357SerGln: 3.357 ± 0.027	4.876SerArg: 4.876 ± 0.038	8.477SerSer: 8.477 ± 0.069	5.496SerThr: 5.496 ± 0.039	4.805SerVal: 4.805 ± 0.03	1.212SerTrp: 1.212 ± 0.015	2.19SerTyr: 2.19 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	5.189ThrAla: 5.189 ± 0.029	0.787ThrCys: 0.787 ± 0.011	2.934ThrAsp: 2.934 ± 0.024	3.189ThrGlu: 3.189 ± 0.024	2.317ThrPhe: 2.317 ± 0.02	4.304ThrGly: 4.304 ± 0.029	1.333ThrHis: 1.333 ± 0.015	3.166ThrIle: 3.166 ± 0.025	2.447ThrLys: 2.447 ± 0.022	5.401ThrLeu: 5.401 ± 0.033	1.227ThrMet: 1.227 ± 0.015	2.084ThrAsn: 2.084 ± 0.019	4.142ThrPro: 4.142 ± 0.042	2.108ThrGln: 2.108 ± 0.02	3.03ThrArg: 3.03 ± 0.024	5.166ThrSer: 5.166 ± 0.03	4.121ThrThr: 4.121 ± 0.033	3.984ThrVal: 3.984 ± 0.029	0.906ThrTrp: 0.906 ± 0.014	1.692ThrTyr: 1.692 ± 0.016	0.0ThrXaa: 0.0 ± 0.0
Val	5.287ValAla: 5.287 ± 0.034	0.887ValCys: 0.887 ± 0.014	3.819ValAsp: 3.819 ± 0.027	3.824ValGlu: 3.824 ± 0.026	2.597ValPhe: 2.597 ± 0.025	4.177ValGly: 4.177 ± 0.03	1.506ValHis: 1.506 ± 0.016	3.215ValIle: 3.215 ± 0.025	2.768ValLys: 2.768 ± 0.023	5.892ValLeu: 5.892 ± 0.036	1.355ValMet: 1.355 ± 0.014	2.327ValAsn: 2.327 ± 0.02	3.647ValPro: 3.647 ± 0.028	2.51ValGln: 2.51 ± 0.022	3.512ValArg: 3.512 ± 0.027	4.952ValSer: 4.952 ± 0.033	3.686ValThr: 3.686 ± 0.025	4.445ValVal: 4.445 ± 0.029	0.902ValTrp: 0.902 ± 0.012	1.901ValTyr: 1.901 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.191TrpAla: 1.191 ± 0.015	0.207TrpCys: 0.207 ± 0.006	0.931TrpAsp: 0.931 ± 0.012	0.876TrpGlu: 0.876 ± 0.013	0.57TrpPhe: 0.57 ± 0.009	0.976TrpGly: 0.976 ± 0.014	0.375TrpHis: 0.375 ± 0.008	0.83TrpIle: 0.83 ± 0.011	0.844TrpLys: 0.844 ± 0.01	1.454TrpLeu: 1.454 ± 0.017	0.382TrpMet: 0.382 ± 0.008	0.661TrpAsn: 0.661 ± 0.011	0.631TrpPro: 0.631 ± 0.012	0.596TrpGln: 0.596 ± 0.01	0.982TrpArg: 0.982 ± 0.013	1.087TrpSer: 1.087 ± 0.017	0.95TrpThr: 0.95 ± 0.014	0.944TrpVal: 0.944 ± 0.014	0.294TrpTrp: 0.294 ± 0.008	0.468TrpTyr: 0.468 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.25TyrAla: 2.25 ± 0.019	0.439TyrCys: 0.439 ± 0.009	1.695TyrAsp: 1.695 ± 0.017	1.605TyrGlu: 1.605 ± 0.018	1.259TyrPhe: 1.259 ± 0.018	2.232TyrGly: 2.232 ± 0.022	0.812TyrHis: 0.812 ± 0.013	1.572TyrIle: 1.572 ± 0.016	1.08TyrLys: 1.08 ± 0.016	2.885TyrLeu: 2.885 ± 0.026	0.662TyrMet: 0.662 ± 0.011	1.165TyrAsn: 1.165 ± 0.014	1.606TyrPro: 1.606 ± 0.019	1.195TyrGln: 1.195 ± 0.014	1.732TyrArg: 1.732 ± 0.016	2.158TyrSer: 2.158 ± 0.02	1.735TyrThr: 1.735 ± 0.014	1.761TyrVal: 1.761 ± 0.017	0.484TyrTrp: 0.484 ± 0.008	1.002TyrTyr: 1.002 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 12265 proteins (6082457 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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