Human papillomavirus type 53

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Alphapapillomavirus; Alphapapillomavirus 6

Average proteome isoelectric point is 6.84

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 7 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|Q17UJ5|Q17UJ5_HPV53 Protein E6 OS=Human papillomavirus type 53 OX=333765 GN=E6 PE=3 SV=1
MM1 pKa = 7.38HH2 pKa = 7.36GNVPTLPQYY11 pKa = 10.6IIEE14 pKa = 5.74LIPQTEE20 pKa = 3.98IDD22 pKa = 4.21LQCHH26 pKa = 4.9EE27 pKa = 4.74QLNSSEE33 pKa = 5.77DD34 pKa = 3.7EE35 pKa = 4.85DD36 pKa = 4.35EE37 pKa = 5.86DD38 pKa = 4.92EE39 pKa = 4.48VDD41 pKa = 4.71HH42 pKa = 7.05LQEE45 pKa = 3.89QPQQARR51 pKa = 11.84RR52 pKa = 11.84DD53 pKa = 4.01EE54 pKa = 3.98QHH56 pKa = 6.29PCYY59 pKa = 10.41LIEE62 pKa = 4.28TQCCRR67 pKa = 11.84CEE69 pKa = 4.26SLVQLAVQSPTKK81 pKa = 9.27EE82 pKa = 3.79LRR84 pKa = 11.84MLQQMLMGTVEE95 pKa = 4.63LVCPLCATRR104 pKa = 11.84RR105 pKa = 3.74

Molecular weight: 12.19 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|B2WUX8|B2WUX8_HPV53 Major capsid protein L1 OS=Human papillomavirus type 53 OX=333765 GN=L1 PE=3 SV=1
MM1 pKa = 7.63RR2 pKa = 11.84AYY4 pKa = 9.69IIYY7 pKa = 7.33MTAIKK12 pKa = 10.26RR13 pKa = 11.84IIQTLKK19 pKa = 9.46TRR21 pKa = 11.84PPNMGVKK28 pKa = 10.05AHH30 pKa = 6.88GKK32 pKa = 9.63CIWEE36 pKa = 4.06TKK38 pKa = 9.83VFIVPTLCPVPLDD51 pKa = 3.42PTYY54 pKa = 10.95PLLKK58 pKa = 10.31LLTNTTPIRR67 pKa = 11.84PPPPPRR73 pKa = 11.84PWAPTKK79 pKa = 9.76PHH81 pKa = 6.53HH82 pKa = 5.98PCGRR86 pKa = 11.84EE87 pKa = 3.87NVSEE91 pKa = 4.15PQSPTVPTPPHH102 pKa = 6.47SPLPQPEE109 pKa = 4.6SPTHH113 pKa = 5.95SVSQGTQTTQTTTPEE128 pKa = 3.91NTSLVEE134 pKa = 4.56LRR136 pKa = 11.84VTTPKK141 pKa = 9.14STVVIRR147 pKa = 11.84LHH149 pKa = 6.18LL150 pKa = 4.16

Molecular weight: 16.66 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

7

0

7

2391

105

636

341.6

38.5

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

4.977 ± 0.351

2.969 ± 0.796

5.353 ± 0.581

5.186 ± 0.629

3.597 ± 0.462

5.312 ± 0.599

2.593 ± 0.391

5.186 ± 0.522

5.604 ± 0.778

7.361 ± 0.751

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.84 ± 0.249

4.182 ± 0.638

6.692 ± 1.52

5.312 ± 0.828

4.977 ± 0.374

7.737 ± 0.648

8.616 ± 1.19

7.068 ± 0.383

1.547 ± 0.198

3.89 ± 0.52
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski