Amino acid dipepetide frequency for Tobacco leaf curl Zimbabwe virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.446AlaAla: 6.446 ± 2.12
2.762AlaCys: 2.762 ± 0.875
0.921AlaAsp: 0.921 ± 0.623
1.842AlaGlu: 1.842 ± 0.981
0.0AlaPhe: 0.0 ± 0.0
0.921AlaGly: 0.921 ± 0.623
2.762AlaHis: 2.762 ± 2.044
3.683AlaIle: 3.683 ± 0.925
3.683AlaLys: 3.683 ± 1.173
4.604AlaLeu: 4.604 ± 1.054
0.921AlaMet: 0.921 ± 0.623
0.921AlaAsn: 0.921 ± 0.623
3.683AlaPro: 3.683 ± 2.075
3.683AlaGln: 3.683 ± 1.859
6.446AlaArg: 6.446 ± 2.935
3.683AlaSer: 3.683 ± 1.93
2.762AlaThr: 2.762 ± 0.887
2.762AlaVal: 2.762 ± 1.37
0.921AlaTrp: 0.921 ± 0.623
0.0AlaTyr: 0.0 ± 0.0
0.0AlaXaa: 0.0 ± 0.0
Cys
1.842CysAla: 1.842 ± 1.07
1.842CysCys: 1.842 ± 1.844
0.0CysAsp: 0.0 ± 0.0
0.921CysGlu: 0.921 ± 0.734
0.921CysPhe: 0.921 ± 1.116
2.762CysGly: 2.762 ± 1.469
0.0CysHis: 0.0 ± 0.0
0.921CysIle: 0.921 ± 0.734
2.762CysLys: 2.762 ± 1.319
1.842CysLeu: 1.842 ± 1.328
1.842CysMet: 1.842 ± 1.038
0.921CysAsn: 0.921 ± 0.623
1.842CysPro: 1.842 ± 1.844
0.921CysGln: 0.921 ± 0.623
1.842CysArg: 1.842 ± 1.07
1.842CysSer: 1.842 ± 1.07
0.921CysThr: 0.921 ± 0.734
0.921CysVal: 0.921 ± 0.922
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.762AspAla: 2.762 ± 1.868
0.0AspCys: 0.0 ± 0.0
1.842AspAsp: 1.842 ± 1.07
2.762AspGlu: 2.762 ± 1.115
1.842AspPhe: 1.842 ± 0.725
2.762AspGly: 2.762 ± 1.268
0.0AspHis: 0.0 ± 0.0
2.762AspIle: 2.762 ± 2.25
1.842AspLys: 1.842 ± 0.725
7.366AspLeu: 7.366 ± 2.96
0.0AspMet: 0.0 ± 0.0
3.683AspAsn: 3.683 ± 1.991
1.842AspPro: 1.842 ± 0.981
1.842AspGln: 1.842 ± 0.725
3.683AspArg: 3.683 ± 1.449
5.525AspSer: 5.525 ± 1.931
1.842AspThr: 1.842 ± 1.246
6.446AspVal: 6.446 ± 1.741
1.842AspTrp: 1.842 ± 1.07
0.921AspTyr: 0.921 ± 0.922
0.0AspXaa: 0.0 ± 0.0
Glu
5.525GluAla: 5.525 ± 1.558
0.0GluCys: 0.0 ± 0.0
0.921GluAsp: 0.921 ± 1.116
4.604GluGlu: 4.604 ± 1.897
3.683GluPhe: 3.683 ± 1.874
5.525GluGly: 5.525 ± 1.516
0.0GluHis: 0.0 ± 0.0
0.921GluIle: 0.921 ± 1.116
0.921GluLys: 0.921 ± 0.623
5.525GluLeu: 5.525 ± 2.13
0.0GluMet: 0.0 ± 0.0
6.446GluAsn: 6.446 ± 2.632
3.683GluPro: 3.683 ± 1.128
0.0GluGln: 0.0 ± 0.0
0.0GluArg: 0.0 ± 0.0
2.762GluSer: 2.762 ± 1.799
2.762GluThr: 2.762 ± 1.317
0.921GluVal: 0.921 ± 1.093
1.842GluTrp: 1.842 ± 1.07
0.921GluTyr: 0.921 ± 1.116
0.0GluXaa: 0.0 ± 0.0
Phe
0.0PheAla: 0.0 ± 0.0
0.921PheCys: 0.921 ± 0.734
4.604PheAsp: 4.604 ± 1.998
0.921PheGlu: 0.921 ± 0.623
3.683PhePhe: 3.683 ± 1.056
1.842PheGly: 1.842 ± 0.725
1.842PheHis: 1.842 ± 0.981
1.842PheIle: 1.842 ± 1.246
2.762PheLys: 2.762 ± 3.347
4.604PheLeu: 4.604 ± 2.138
0.0PheMet: 0.0 ± 0.0
2.762PheAsn: 2.762 ± 0.973
0.921PhePro: 0.921 ± 0.922
6.446PheGln: 6.446 ± 1.863
3.683PheArg: 3.683 ± 1.799
2.762PheSer: 2.762 ± 1.241
1.842PheThr: 1.842 ± 1.434
0.921PheVal: 0.921 ± 0.623
0.921PheTrp: 0.921 ± 0.734
1.842PheTyr: 1.842 ± 0.965
0.0PheXaa: 0.0 ± 0.0
Gly
2.762GlyAla: 2.762 ± 1.868
4.604GlyCys: 4.604 ± 1.734
4.604GlyAsp: 4.604 ± 1.812
3.683GlyGlu: 3.683 ± 1.232
1.842GlyPhe: 1.842 ± 1.26
4.604GlyGly: 4.604 ± 1.998
3.683GlyHis: 3.683 ± 1.374
3.683GlyIle: 3.683 ± 1.045
4.604GlyLys: 4.604 ± 1.799
1.842GlyLeu: 1.842 ± 0.965
0.0GlyMet: 0.0 ± 0.0
0.921GlyAsn: 0.921 ± 1.093
4.604GlyPro: 4.604 ± 1.998
1.842GlyGln: 1.842 ± 1.328
1.842GlyArg: 1.842 ± 1.07
1.842GlySer: 1.842 ± 0.981
1.842GlyThr: 1.842 ± 1.247
1.842GlyVal: 1.842 ± 2.231
0.921GlyTrp: 0.921 ± 0.623
0.0GlyTyr: 0.0 ± 0.0
0.0GlyXaa: 0.0 ± 0.0
His
2.762HisAla: 2.762 ± 1.647
1.842HisCys: 1.842 ± 1.26
0.921HisAsp: 0.921 ± 0.922
1.842HisGlu: 1.842 ± 1.019
2.762HisPhe: 2.762 ± 1.182
1.842HisGly: 1.842 ± 1.26
3.683HisHis: 3.683 ± 1.991
3.683HisIle: 3.683 ± 2.459
2.762HisLys: 2.762 ± 1.588
3.683HisLeu: 3.683 ± 1.232
0.0HisMet: 0.0 ± 0.0
1.842HisAsn: 1.842 ± 1.246
0.921HisPro: 0.921 ± 0.623
1.842HisGln: 1.842 ± 1.247
3.683HisArg: 3.683 ± 1.68
2.762HisSer: 2.762 ± 1.929
3.683HisThr: 3.683 ± 2.052
2.762HisVal: 2.762 ± 0.973
0.921HisTrp: 0.921 ± 0.623
0.921HisTyr: 0.921 ± 0.623
0.0HisXaa: 0.0 ± 0.0
Ile
0.0IleAla: 0.0 ± 0.0
1.842IleCys: 1.842 ± 0.981
3.683IleAsp: 3.683 ± 1.456
0.921IleGlu: 0.921 ± 0.623
2.762IlePhe: 2.762 ± 1.868
2.762IleGly: 2.762 ± 2.165
2.762IleHis: 2.762 ± 2.387
4.604IleIle: 4.604 ± 2.149
4.604IleLys: 4.604 ± 0.984
0.0IleLeu: 0.0 ± 0.0
0.921IleMet: 0.921 ± 0.925
0.921IleAsn: 0.921 ± 0.623
1.842IlePro: 1.842 ± 1.07
5.525IleGln: 5.525 ± 1.476
7.366IleArg: 7.366 ± 3.131
4.604IleSer: 4.604 ± 2.372
5.525IleThr: 5.525 ± 4.185
2.762IleVal: 2.762 ± 1.319
1.842IleTrp: 1.842 ± 0.725
1.842IleTyr: 1.842 ± 1.038
0.0IleXaa: 0.0 ± 0.0
Lys
4.604LysAla: 4.604 ± 2.64
1.842LysCys: 1.842 ± 1.019
1.842LysAsp: 1.842 ± 1.246
2.762LysGlu: 2.762 ± 1.134
1.842LysPhe: 1.842 ± 1.019
0.921LysGly: 0.921 ± 0.623
1.842LysHis: 1.842 ± 1.019
4.604LysIle: 4.604 ± 2.0
1.842LysLys: 1.842 ± 0.725
1.842LysLeu: 1.842 ± 1.019
0.0LysMet: 0.0 ± 0.0
4.604LysAsn: 4.604 ± 2.253
1.842LysPro: 1.842 ± 0.725
0.921LysGln: 0.921 ± 0.922
6.446LysArg: 6.446 ± 3.168
7.366LysSer: 7.366 ± 1.718
3.683LysThr: 3.683 ± 2.14
2.762LysVal: 2.762 ± 0.875
0.0LysTrp: 0.0 ± 0.0
4.604LysTyr: 4.604 ± 0.941
0.0LysXaa: 0.0 ± 0.0
Leu
1.842LeuAla: 1.842 ± 1.26
1.842LeuCys: 1.842 ± 1.246
5.525LeuAsp: 5.525 ± 2.274
5.525LeuGlu: 5.525 ± 2.352
1.842LeuPhe: 1.842 ± 1.345
5.525LeuGly: 5.525 ± 1.889
2.762LeuHis: 2.762 ± 1.469
4.604LeuIle: 4.604 ± 2.165
6.446LeuLys: 6.446 ± 1.863
3.683LeuLeu: 3.683 ± 1.3
0.921LeuMet: 0.921 ± 0.966
8.287LeuAsn: 8.287 ± 2.372
3.683LeuPro: 3.683 ± 1.91
4.604LeuGln: 4.604 ± 2.882
5.525LeuArg: 5.525 ± 3.299
2.762LeuSer: 2.762 ± 1.134
3.683LeuThr: 3.683 ± 1.091
0.921LeuVal: 0.921 ± 0.623
0.0LeuTrp: 0.0 ± 0.0
4.604LeuTyr: 4.604 ± 3.043
0.0LeuXaa: 0.0 ± 0.0
Met
2.762MetAla: 2.762 ± 1.134
0.0MetCys: 0.0 ± 0.0
1.842MetAsp: 1.842 ± 1.247
0.921MetGlu: 0.921 ± 1.093
2.762MetPhe: 2.762 ± 1.426
0.921MetGly: 0.921 ± 1.093
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
0.0MetLys: 0.0 ± 0.0
1.842MetLeu: 1.842 ± 1.566
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
0.0MetPro: 0.0 ± 0.0
0.921MetGln: 0.921 ± 0.953
0.0MetArg: 0.0 ± 0.0
0.921MetSer: 0.921 ± 0.734
0.0MetThr: 0.0 ± 0.0
0.0MetVal: 0.0 ± 0.0
0.921MetTrp: 0.921 ± 0.922
2.762MetTyr: 2.762 ± 2.203
0.0MetXaa: 0.0 ± 0.0
Asn
3.683AsnAla: 3.683 ± 1.681
0.921AsnCys: 0.921 ± 0.623
2.762AsnAsp: 2.762 ± 1.134
1.842AsnGlu: 1.842 ± 1.038
1.842AsnPhe: 1.842 ± 1.247
2.762AsnGly: 2.762 ± 1.205
6.446AsnHis: 6.446 ± 2.292
0.921AsnIle: 0.921 ± 0.623
1.842AsnLys: 1.842 ± 1.07
5.525AsnLeu: 5.525 ± 2.009
1.842AsnMet: 1.842 ± 1.366
0.921AsnAsn: 0.921 ± 1.116
2.762AsnPro: 2.762 ± 0.973
2.762AsnGln: 2.762 ± 1.241
0.921AsnArg: 0.921 ± 0.734
3.683AsnSer: 3.683 ± 2.075
3.683AsnThr: 3.683 ± 0.925
4.604AsnVal: 4.604 ± 0.941
0.0AsnTrp: 0.0 ± 0.0
4.604AsnTyr: 4.604 ± 2.215
0.0AsnXaa: 0.0 ± 0.0
Pro
0.921ProAla: 0.921 ± 0.922
1.842ProCys: 1.842 ± 1.038
1.842ProAsp: 1.842 ± 1.038
2.762ProGlu: 2.762 ± 1.36
1.842ProPhe: 1.842 ± 1.019
3.683ProGly: 3.683 ± 1.091
4.604ProHis: 4.604 ± 1.948
3.683ProIle: 3.683 ± 0.925
4.604ProLys: 4.604 ± 2.439
3.683ProLeu: 3.683 ± 2.079
0.921ProMet: 0.921 ± 0.601
2.762ProAsn: 2.762 ± 1.36
3.683ProPro: 3.683 ± 2.491
3.683ProGln: 3.683 ± 1.091
2.762ProArg: 2.762 ± 1.544
5.525ProSer: 5.525 ± 2.851
6.446ProThr: 6.446 ± 3.3
1.842ProVal: 1.842 ± 1.469
0.921ProTrp: 0.921 ± 0.623
2.762ProTyr: 2.762 ± 1.319
0.0ProXaa: 0.0 ± 0.0
Gln
3.683GlnAla: 3.683 ± 1.49
0.0GlnCys: 0.0 ± 0.0
2.762GlnAsp: 2.762 ± 0.875
2.762GlnGlu: 2.762 ± 1.772
0.921GlnPhe: 0.921 ± 0.623
1.842GlnGly: 1.842 ± 0.725
1.842GlnHis: 1.842 ± 1.345
2.762GlnIle: 2.762 ± 1.304
0.921GlnLys: 0.921 ± 0.922
2.762GlnLeu: 2.762 ± 1.244
0.921GlnMet: 0.921 ± 0.953
3.683GlnAsn: 3.683 ± 0.997
4.604GlnPro: 4.604 ± 2.475
0.0GlnGln: 0.0 ± 0.0
1.842GlnArg: 1.842 ± 0.725
3.683GlnSer: 3.683 ± 1.681
2.762GlnThr: 2.762 ± 1.702
7.366GlnVal: 7.366 ± 2.184
0.0GlnTrp: 0.0 ± 0.0
0.921GlnTyr: 0.921 ± 0.623
0.0GlnXaa: 0.0 ± 0.0
Arg
2.762ArgAla: 2.762 ± 1.37
1.842ArgCys: 1.842 ± 1.038
5.525ArgAsp: 5.525 ± 2.239
4.604ArgGlu: 4.604 ± 2.288
6.446ArgPhe: 6.446 ± 1.525
3.683ArgGly: 3.683 ± 1.211
2.762ArgHis: 2.762 ± 2.035
2.762ArgIle: 2.762 ± 1.241
3.683ArgLys: 3.683 ± 1.991
2.762ArgLeu: 2.762 ± 1.544
4.604ArgMet: 4.604 ± 3.132
0.921ArgAsn: 0.921 ± 0.953
6.446ArgPro: 6.446 ± 1.872
0.921ArgGln: 0.921 ± 0.922
6.446ArgArg: 6.446 ± 3.305
5.525ArgSer: 5.525 ± 1.725
3.683ArgThr: 3.683 ± 1.964
0.921ArgVal: 0.921 ± 1.116
0.0ArgTrp: 0.0 ± 0.0
1.842ArgTyr: 1.842 ± 1.038
0.0ArgXaa: 0.0 ± 0.0
Ser
3.683SerAla: 3.683 ± 1.986
0.0SerCys: 0.0 ± 0.0
3.683SerAsp: 3.683 ± 1.173
2.762SerGlu: 2.762 ± 1.929
2.762SerPhe: 2.762 ± 0.875
0.921SerGly: 0.921 ± 0.734
0.921SerHis: 0.921 ± 0.623
3.683SerIle: 3.683 ± 1.091
4.604SerLys: 4.604 ± 1.917
2.762SerLeu: 2.762 ± 1.134
0.0SerMet: 0.0 ± 0.883
5.525SerAsn: 5.525 ± 1.746
9.208SerPro: 9.208 ± 2.364
2.762SerGln: 2.762 ± 1.469
2.762SerArg: 2.762 ± 2.038
11.971SerSer: 11.971 ± 4.281
8.287SerThr: 8.287 ± 5.562
2.762SerVal: 2.762 ± 1.544
1.842SerTrp: 1.842 ± 0.725
4.604SerTyr: 4.604 ± 1.091
0.0SerXaa: 0.0 ± 0.0
Thr
3.683ThrAla: 3.683 ± 1.583
1.842ThrCys: 1.842 ± 1.328
1.842ThrAsp: 1.842 ± 2.185
0.921ThrGlu: 0.921 ± 0.734
1.842ThrPhe: 1.842 ± 1.038
5.525ThrGly: 5.525 ± 1.764
4.604ThrHis: 4.604 ± 2.518
3.683ThrIle: 3.683 ± 1.456
3.683ThrLys: 3.683 ± 1.456
7.366ThrLeu: 7.366 ± 2.186
0.0ThrMet: 0.0 ± 0.0
5.525ThrAsn: 5.525 ± 1.497
3.683ThrPro: 3.683 ± 1.68
1.842ThrGln: 1.842 ± 1.434
3.683ThrArg: 3.683 ± 1.384
2.762ThrSer: 2.762 ± 2.038
2.762ThrThr: 2.762 ± 1.791
4.604ThrVal: 4.604 ± 1.989
1.842ThrTrp: 1.842 ± 1.471
2.762ThrTyr: 2.762 ± 1.319
0.0ThrXaa: 0.0 ± 0.0
Val
0.921ValAla: 0.921 ± 1.116
0.921ValCys: 0.921 ± 0.623
2.762ValAsp: 2.762 ± 1.36
1.842ValGlu: 1.842 ± 1.844
2.762ValPhe: 2.762 ± 2.25
0.0ValGly: 0.0 ± 0.0
2.762ValHis: 2.762 ± 1.37
4.604ValIle: 4.604 ± 2.005
3.683ValLys: 3.683 ± 1.449
8.287ValLeu: 8.287 ± 3.133
0.0ValMet: 0.0 ± 0.0
0.0ValAsn: 0.0 ± 0.0
3.683ValPro: 3.683 ± 1.3
2.762ValGln: 2.762 ± 1.544
2.762ValArg: 2.762 ± 2.203
3.683ValSer: 3.683 ± 1.449
4.604ValThr: 4.604 ± 2.722
2.762ValVal: 2.762 ± 1.544
0.921ValTrp: 0.921 ± 1.116
1.842ValTyr: 1.842 ± 0.725
0.0ValXaa: 0.0 ± 0.0
Trp
0.921TrpAla: 0.921 ± 0.623
0.0TrpCys: 0.0 ± 0.0
0.921TrpAsp: 0.921 ± 0.922
0.921TrpGlu: 0.921 ± 1.116
0.0TrpPhe: 0.0 ± 0.0
0.921TrpGly: 0.921 ± 0.623
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.921TrpLys: 0.921 ± 0.623
0.0TrpLeu: 0.0 ± 0.0
0.921TrpMet: 0.921 ± 0.734
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.921TrpGln: 0.921 ± 0.623
1.842TrpArg: 1.842 ± 1.07
0.921TrpSer: 0.921 ± 0.953
2.762TrpThr: 2.762 ± 0.973
1.842TrpVal: 1.842 ± 0.725
0.0TrpTrp: 0.0 ± 0.0
1.842TrpTyr: 1.842 ± 1.038
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.842TyrAla: 1.842 ± 0.725
0.0TyrCys: 0.0 ± 0.0
2.762TyrAsp: 2.762 ± 2.25
1.842TyrGlu: 1.842 ± 1.038
2.762TyrPhe: 2.762 ± 0.973
1.842TyrGly: 1.842 ± 0.725
1.842TyrHis: 1.842 ± 1.019
3.683TyrIle: 3.683 ± 1.986
0.0TyrLys: 0.0 ± 0.0
4.604TyrLeu: 4.604 ± 1.425
1.842TyrMet: 1.842 ± 1.137
3.683TyrAsn: 3.683 ± 0.997
1.842TyrPro: 1.842 ± 1.038
1.842TyrGln: 1.842 ± 1.038
4.604TyrArg: 4.604 ± 2.722
1.842TyrSer: 1.842 ± 1.246
0.921TyrThr: 0.921 ± 0.734
1.842TyrVal: 1.842 ± 1.038
0.0TyrTrp: 0.0 ± 0.0
0.921TyrTyr: 0.921 ± 0.953
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (1087 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski