Amino acid dipepetide frequency for Thiomonas intermedia (strain K12) (Thiobacillus intermedius)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.776AlaAla: 18.776 ± 0.213
1.235AlaCys: 1.235 ± 0.034
6.576AlaAsp: 6.576 ± 0.092
6.683AlaGlu: 6.683 ± 0.103
3.874AlaPhe: 3.874 ± 0.062
9.338AlaGly: 9.338 ± 0.101
2.913AlaHis: 2.913 ± 0.064
5.069AlaIle: 5.069 ± 0.072
3.543AlaLys: 3.543 ± 0.072
16.616AlaLeu: 16.616 ± 0.176
3.259AlaMet: 3.259 ± 0.07
2.593AlaAsn: 2.593 ± 0.066
6.573AlaPro: 6.573 ± 0.101
7.884AlaGln: 7.884 ± 0.132
8.806AlaArg: 8.806 ± 0.103
6.594AlaSer: 6.594 ± 0.093
5.689AlaThr: 5.689 ± 0.082
9.17AlaVal: 9.17 ± 0.11
1.908AlaTrp: 1.908 ± 0.049
2.663AlaTyr: 2.663 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
1.239CysAla: 1.239 ± 0.034
0.113CysCys: 0.113 ± 0.01
0.528CysAsp: 0.528 ± 0.025
0.453CysGlu: 0.453 ± 0.02
0.24CysPhe: 0.24 ± 0.016
1.033CysGly: 1.033 ± 0.037
0.3CysHis: 0.3 ± 0.021
0.405CysIle: 0.405 ± 0.023
0.226CysLys: 0.226 ± 0.015
0.743CysLeu: 0.743 ± 0.031
0.178CysMet: 0.178 ± 0.014
0.252CysAsn: 0.252 ± 0.016
0.574CysPro: 0.574 ± 0.026
0.24CysGln: 0.24 ± 0.015
0.517CysArg: 0.517 ± 0.026
0.506CysSer: 0.506 ± 0.023
0.465CysThr: 0.465 ± 0.023
0.652CysVal: 0.652 ± 0.029
0.116CysTrp: 0.116 ± 0.012
0.168CysTyr: 0.168 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
7.317AspAla: 7.317 ± 0.104
0.502AspCys: 0.502 ± 0.024
2.69AspAsp: 2.69 ± 0.054
2.613AspGlu: 2.613 ± 0.055
2.071AspPhe: 2.071 ± 0.047
3.999AspGly: 3.999 ± 0.069
1.186AspHis: 1.186 ± 0.033
2.349AspIle: 2.349 ± 0.049
1.679AspLys: 1.679 ± 0.042
5.901AspLeu: 5.901 ± 0.088
1.179AspMet: 1.179 ± 0.036
1.187AspAsn: 1.187 ± 0.042
2.969AspPro: 2.969 ± 0.065
1.756AspGln: 1.756 ± 0.041
3.05AspArg: 3.05 ± 0.059
2.268AspSer: 2.268 ± 0.044
2.466AspThr: 2.466 ± 0.056
3.61AspVal: 3.61 ± 0.064
1.065AspTrp: 1.065 ± 0.037
1.412AspTyr: 1.412 ± 0.044
0.0AspXaa: 0.0 ± 0.0
Glu
6.177GluAla: 6.177 ± 0.095
0.333GluCys: 0.333 ± 0.019
1.968GluAsp: 1.968 ± 0.049
2.141GluGlu: 2.141 ± 0.056
1.684GluPhe: 1.684 ± 0.046
3.4GluGly: 3.4 ± 0.054
1.348GluHis: 1.348 ± 0.037
2.488GluIle: 2.488 ± 0.059
1.615GluLys: 1.615 ± 0.048
5.366GluLeu: 5.366 ± 0.078
1.152GluMet: 1.152 ± 0.035
1.152GluAsn: 1.152 ± 0.029
2.37GluPro: 2.37 ± 0.056
3.073GluGln: 3.073 ± 0.071
4.119GluArg: 4.119 ± 0.08
2.293GluSer: 2.293 ± 0.048
2.377GluThr: 2.377 ± 0.056
3.636GluVal: 3.636 ± 0.07
0.673GluTrp: 0.673 ± 0.031
0.845GluTyr: 0.845 ± 0.03
0.0GluXaa: 0.0 ± 0.0
Phe
4.279PheAla: 4.279 ± 0.065
0.367PheCys: 0.367 ± 0.019
2.408PheAsp: 2.408 ± 0.054
1.826PheGlu: 1.826 ± 0.044
1.345PhePhe: 1.345 ± 0.045
3.302PheGly: 3.302 ± 0.062
0.793PheHis: 0.793 ± 0.029
1.614PheIle: 1.614 ± 0.038
1.074PheLys: 1.074 ± 0.032
3.052PheLeu: 3.052 ± 0.062
0.753PheMet: 0.753 ± 0.028
1.134PheAsn: 1.134 ± 0.037
1.457PhePro: 1.457 ± 0.036
1.079PheGln: 1.079 ± 0.033
1.679PheArg: 1.679 ± 0.044
2.159PheSer: 2.159 ± 0.052
1.966PheThr: 1.966 ± 0.042
2.576PheVal: 2.576 ± 0.055
0.557PheTrp: 0.557 ± 0.026
0.956PheTyr: 0.956 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
9.079GlyAla: 9.079 ± 0.117
0.858GlyCys: 0.858 ± 0.027
3.708GlyAsp: 3.708 ± 0.073
3.922GlyGlu: 3.922 ± 0.078
3.061GlyPhe: 3.061 ± 0.062
6.683GlyGly: 6.683 ± 0.114
1.874GlyHis: 1.874 ± 0.042
3.75GlyIle: 3.75 ± 0.076
3.221GlyLys: 3.221 ± 0.063
9.392GlyLeu: 9.392 ± 0.115
2.34GlyMet: 2.34 ± 0.051
2.111GlyAsn: 2.111 ± 0.046
2.97GlyPro: 2.97 ± 0.058
3.753GlyGln: 3.753 ± 0.064
4.999GlyArg: 4.999 ± 0.074
4.216GlySer: 4.216 ± 0.075
3.761GlyThr: 3.761 ± 0.071
6.527GlyVal: 6.527 ± 0.095
1.481GlyTrp: 1.481 ± 0.045
2.206GlyTyr: 2.206 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
3.146HisAla: 3.146 ± 0.064
0.305HisCys: 0.305 ± 0.019
1.301HisAsp: 1.301 ± 0.032
0.956HisGlu: 0.956 ± 0.032
0.899HisPhe: 0.899 ± 0.03
2.111HisGly: 2.111 ± 0.045
0.728HisHis: 0.728 ± 0.03
1.057HisIle: 1.057 ± 0.033
0.594HisLys: 0.594 ± 0.023
2.616HisLeu: 2.616 ± 0.058
0.506HisMet: 0.506 ± 0.022
0.573HisAsn: 0.573 ± 0.026
1.726HisPro: 1.726 ± 0.049
0.887HisGln: 0.887 ± 0.032
1.55HisArg: 1.55 ± 0.037
1.128HisSer: 1.128 ± 0.032
1.208HisThr: 1.208 ± 0.035
1.497HisVal: 1.497 ± 0.035
0.484HisTrp: 0.484 ± 0.022
0.656HisTyr: 0.656 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
6.473IleAla: 6.473 ± 0.081
0.378IleCys: 0.378 ± 0.02
3.219IleAsp: 3.219 ± 0.058
2.733IleGlu: 2.733 ± 0.056
1.267IlePhe: 1.267 ± 0.04
4.234IleGly: 4.234 ± 0.079
0.917IleHis: 0.917 ± 0.031
1.63IleIle: 1.63 ± 0.046
1.371IleLys: 1.371 ± 0.039
3.654IleLeu: 3.654 ± 0.073
0.735IleMet: 0.735 ± 0.028
1.38IleAsn: 1.38 ± 0.044
2.113IlePro: 2.113 ± 0.051
1.31IleGln: 1.31 ± 0.037
2.561IleArg: 2.561 ± 0.05
2.391IleSer: 2.391 ± 0.056
2.488IleThr: 2.488 ± 0.057
3.323IleVal: 3.323 ± 0.061
0.529IleTrp: 0.529 ± 0.027
1.049IleTyr: 1.049 ± 0.032
0.0IleXaa: 0.0 ± 0.0
Lys
3.721LysAla: 3.721 ± 0.069
0.131LysCys: 0.131 ± 0.011
1.392LysAsp: 1.392 ± 0.039
1.256LysGlu: 1.256 ± 0.038
0.834LysPhe: 0.834 ± 0.035
2.19LysGly: 2.19 ± 0.047
0.604LysHis: 0.604 ± 0.026
1.366LysIle: 1.366 ± 0.042
1.139LysLys: 1.139 ± 0.043
3.343LysLeu: 3.343 ± 0.058
0.755LysMet: 0.755 ± 0.03
0.884LysAsn: 0.884 ± 0.033
2.27LysPro: 2.27 ± 0.052
1.353LysGln: 1.353 ± 0.043
2.172LysArg: 2.172 ± 0.057
1.731LysSer: 1.731 ± 0.042
2.02LysThr: 2.02 ± 0.048
2.179LysVal: 2.179 ± 0.054
0.319LysTrp: 0.319 ± 0.018
0.596LysTyr: 0.596 ± 0.028
0.0LysXaa: 0.0 ± 0.0
Leu
14.6LeuAla: 14.6 ± 0.155
0.98LeuCys: 0.98 ± 0.03
6.268LeuAsp: 6.268 ± 0.089
4.89LeuGlu: 4.89 ± 0.076
3.86LeuPhe: 3.86 ± 0.073
9.036LeuGly: 9.036 ± 0.119
2.956LeuHis: 2.956 ± 0.055
4.799LeuIle: 4.799 ± 0.082
3.28LeuLys: 3.28 ± 0.06
12.926LeuLeu: 12.926 ± 0.184
2.488LeuMet: 2.488 ± 0.054
2.695LeuAsn: 2.695 ± 0.053
6.812LeuPro: 6.812 ± 0.089
5.826LeuGln: 5.826 ± 0.089
8.755LeuArg: 8.755 ± 0.11
6.748LeuSer: 6.748 ± 0.081
5.557LeuThr: 5.557 ± 0.077
7.398LeuVal: 7.398 ± 0.106
1.638LeuTrp: 1.638 ± 0.049
2.226LeuTyr: 2.226 ± 0.053
0.0LeuXaa: 0.0 ± 0.0
Met
2.837MetAla: 2.837 ± 0.06
0.154MetCys: 0.154 ± 0.013
1.062MetAsp: 1.062 ± 0.036
1.019MetGlu: 1.019 ± 0.031
0.687MetPhe: 0.687 ± 0.029
1.774MetGly: 1.774 ± 0.05
0.592MetHis: 0.592 ± 0.024
0.917MetIle: 0.917 ± 0.033
0.827MetLys: 0.827 ± 0.029
2.533MetLeu: 2.533 ± 0.059
0.535MetMet: 0.535 ± 0.024
0.88MetAsn: 0.88 ± 0.03
1.557MetPro: 1.557 ± 0.038
1.387MetGln: 1.387 ± 0.042
1.762MetArg: 1.762 ± 0.041
1.551MetSer: 1.551 ± 0.038
1.511MetThr: 1.511 ± 0.041
1.473MetVal: 1.473 ± 0.046
0.21MetTrp: 0.21 ± 0.017
0.336MetTyr: 0.336 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.338AsnAla: 3.338 ± 0.064
0.253AsnCys: 0.253 ± 0.016
1.159AsnAsp: 1.159 ± 0.036
0.971AsnGlu: 0.971 ± 0.03
0.872AsnPhe: 0.872 ± 0.034
2.165AsnGly: 2.165 ± 0.056
0.549AsnHis: 0.549 ± 0.023
1.147AsnIle: 1.147 ± 0.042
0.79AsnLys: 0.79 ± 0.03
2.822AsnLeu: 2.822 ± 0.062
0.583AsnMet: 0.583 ± 0.024
0.741AsnAsn: 0.741 ± 0.038
2.078AsnPro: 2.078 ± 0.054
0.951AsnGln: 0.951 ± 0.037
1.607AsnArg: 1.607 ± 0.041
1.189AsnSer: 1.189 ± 0.039
1.486AsnThr: 1.486 ± 0.042
1.761AsnVal: 1.761 ± 0.045
0.46AsnTrp: 0.46 ± 0.02
0.663AsnTyr: 0.663 ± 0.032
0.0AsnXaa: 0.0 ± 0.0
Pro
7.126ProAla: 7.126 ± 0.105
0.359ProCys: 0.359 ± 0.017
3.274ProAsp: 3.274 ± 0.068
3.266ProGlu: 3.266 ± 0.067
1.683ProPhe: 1.683 ± 0.046
4.704ProGly: 4.704 ± 0.077
1.271ProHis: 1.271 ± 0.039
1.997ProIle: 1.997 ± 0.04
1.663ProLys: 1.663 ± 0.046
5.832ProLeu: 5.832 ± 0.075
1.307ProMet: 1.307 ± 0.035
1.398ProAsn: 1.398 ± 0.035
3.145ProPro: 3.145 ± 0.068
3.121ProGln: 3.121 ± 0.058
3.053ProArg: 3.053 ± 0.064
3.067ProSer: 3.067 ± 0.059
2.816ProThr: 2.816 ± 0.054
4.146ProVal: 4.146 ± 0.073
0.861ProTrp: 0.861 ± 0.033
1.198ProTyr: 1.198 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
7.049GlnAla: 7.049 ± 0.11
0.339GlnCys: 0.339 ± 0.018
1.797GlnAsp: 1.797 ± 0.044
1.728GlnGlu: 1.728 ± 0.048
1.605GlnPhe: 1.605 ± 0.043
3.641GlnGly: 3.641 ± 0.064
1.199GlnHis: 1.199 ± 0.032
2.356GlnIle: 2.356 ± 0.048
1.178GlnLys: 1.178 ± 0.04
4.723GlnLeu: 4.723 ± 0.091
1.142GlnMet: 1.142 ± 0.03
1.119GlnAsn: 1.119 ± 0.037
2.884GlnPro: 2.884 ± 0.059
2.855GlnGln: 2.855 ± 0.071
4.108GlnArg: 4.108 ± 0.07
2.622GlnSer: 2.622 ± 0.058
3.122GlnThr: 3.122 ± 0.062
3.308GlnVal: 3.308 ± 0.061
0.805GlnTrp: 0.805 ± 0.032
0.917GlnTyr: 0.917 ± 0.032
0.0GlnXaa: 0.0 ± 0.0
Arg
7.962ArgAla: 7.962 ± 0.108
0.617ArgCys: 0.617 ± 0.028
3.642ArgAsp: 3.642 ± 0.067
3.979ArgGlu: 3.979 ± 0.067
2.617ArgPhe: 2.617 ± 0.056
4.501ArgGly: 4.501 ± 0.068
1.854ArgHis: 1.854 ± 0.047
3.524ArgIle: 3.524 ± 0.068
2.159ArgLys: 2.159 ± 0.05
8.201ArgLeu: 8.201 ± 0.105
1.753ArgMet: 1.753 ± 0.041
1.751ArgAsn: 1.751 ± 0.043
3.226ArgPro: 3.226 ± 0.065
3.237ArgGln: 3.237 ± 0.063
4.873ArgArg: 4.873 ± 0.083
3.349ArgSer: 3.349 ± 0.053
3.099ArgThr: 3.099 ± 0.057
4.762ArgVal: 4.762 ± 0.069
1.228ArgTrp: 1.228 ± 0.042
1.776ArgTyr: 1.776 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
7.266SerAla: 7.266 ± 0.1
0.439SerCys: 0.439 ± 0.026
2.405SerAsp: 2.405 ± 0.058
2.3SerGlu: 2.3 ± 0.051
1.804SerPhe: 1.804 ± 0.045
5.175SerGly: 5.175 ± 0.077
1.131SerHis: 1.131 ± 0.031
2.3SerIle: 2.3 ± 0.055
1.526SerLys: 1.526 ± 0.044
5.84SerLeu: 5.84 ± 0.087
1.334SerMet: 1.334 ± 0.038
1.506SerAsn: 1.506 ± 0.046
3.168SerPro: 3.168 ± 0.058
2.151SerGln: 2.151 ± 0.048
3.369SerArg: 3.369 ± 0.06
3.11SerSer: 3.11 ± 0.072
2.944SerThr: 2.944 ± 0.068
3.835SerVal: 3.835 ± 0.058
0.741SerTrp: 0.741 ± 0.028
1.17SerTyr: 1.17 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
6.39ThrAla: 6.39 ± 0.1
0.447ThrCys: 0.447 ± 0.021
2.508ThrAsp: 2.508 ± 0.056
2.315ThrGlu: 2.315 ± 0.051
1.662ThrPhe: 1.662 ± 0.042
4.315ThrGly: 4.315 ± 0.076
1.238ThrHis: 1.238 ± 0.034
1.921ThrIle: 1.921 ± 0.052
1.083ThrLys: 1.083 ± 0.038
6.927ThrLeu: 6.927 ± 0.095
0.881ThrMet: 0.881 ± 0.029
1.111ThrAsn: 1.111 ± 0.037
3.813ThrPro: 3.813 ± 0.067
2.399ThrGln: 2.399 ± 0.056
3.236ThrArg: 3.236 ± 0.053
2.605ThrSer: 2.605 ± 0.049
2.677ThrThr: 2.677 ± 0.057
3.995ThrVal: 3.995 ± 0.069
0.648ThrTrp: 0.648 ± 0.026
1.083ThrTyr: 1.083 ± 0.033
0.0ThrXaa: 0.0 ± 0.0
Val
8.432ValAla: 8.432 ± 0.113
0.718ValCys: 0.718 ± 0.028
3.735ValAsp: 3.735 ± 0.065
3.691ValGlu: 3.691 ± 0.063
2.774ValPhe: 2.774 ± 0.056
5.214ValGly: 5.214 ± 0.09
1.647ValHis: 1.647 ± 0.039
3.475ValIle: 3.475 ± 0.065
2.108ValLys: 2.108 ± 0.057
8.596ValLeu: 8.596 ± 0.098
1.794ValMet: 1.794 ± 0.047
2.059ValAsn: 2.059 ± 0.055
3.624ValPro: 3.624 ± 0.065
3.5ValGln: 3.5 ± 0.066
4.953ValArg: 4.953 ± 0.078
4.039ValSer: 4.039 ± 0.067
3.524ValThr: 3.524 ± 0.058
5.738ValVal: 5.738 ± 0.105
1.129ValTrp: 1.129 ± 0.034
1.464ValTyr: 1.464 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
1.6TrpAla: 1.6 ± 0.051
0.166TrpCys: 0.166 ± 0.012
0.587TrpAsp: 0.587 ± 0.021
0.578TrpGlu: 0.578 ± 0.03
0.577TrpPhe: 0.577 ± 0.024
1.028TrpGly: 1.028 ± 0.034
0.361TrpHis: 0.361 ± 0.017
0.737TrpIle: 0.737 ± 0.029
0.507TrpLys: 0.507 ± 0.024
2.23TrpLeu: 2.23 ± 0.068
0.508TrpMet: 0.508 ± 0.024
0.45TrpAsn: 0.45 ± 0.022
0.768TrpPro: 0.768 ± 0.03
0.87TrpGln: 0.87 ± 0.033
1.333TrpArg: 1.333 ± 0.044
0.801TrpSer: 0.801 ± 0.029
0.734TrpThr: 0.734 ± 0.03
1.099TrpVal: 1.099 ± 0.039
0.302TrpTrp: 0.302 ± 0.019
0.289TrpTyr: 0.289 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.955TyrAla: 2.955 ± 0.051
0.254TyrCys: 0.254 ± 0.015
1.04TyrAsp: 1.04 ± 0.033
0.891TyrGlu: 0.891 ± 0.03
0.961TyrPhe: 0.961 ± 0.03
2.07TyrGly: 2.07 ± 0.057
0.467TyrHis: 0.467 ± 0.021
0.852TyrIle: 0.852 ± 0.031
0.67TyrLys: 0.67 ± 0.029
2.423TyrLeu: 2.423 ± 0.048
0.421TyrMet: 0.421 ± 0.023
0.611TyrAsn: 0.611 ± 0.032
1.191TyrPro: 1.191 ± 0.041
0.864TyrGln: 0.864 ± 0.029
1.61TyrArg: 1.61 ± 0.04
1.149TyrSer: 1.149 ± 0.042
1.344TyrThr: 1.344 ± 0.043
1.531TyrVal: 1.531 ± 0.043
0.372TyrTrp: 0.372 ± 0.021
0.579TyrTyr: 0.579 ± 0.03
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3134 proteins (1016059 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski