Amino acid dipepetide frequency for Aspergillus sclerotialis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.676AlaAla: 7.676 ± 0.047	1.009AlaCys: 1.009 ± 0.016	4.051AlaAsp: 4.051 ± 0.031	4.904AlaGlu: 4.904 ± 0.044	3.083AlaPhe: 3.083 ± 0.028	5.457AlaGly: 5.457 ± 0.036	1.658AlaHis: 1.658 ± 0.018	4.17AlaIle: 4.17 ± 0.033	3.892AlaLys: 3.892 ± 0.033	7.153AlaLeu: 7.153 ± 0.044	1.925AlaMet: 1.925 ± 0.02	3.001AlaAsn: 3.001 ± 0.026	4.298AlaPro: 4.298 ± 0.042	3.063AlaGln: 3.063 ± 0.028	4.58AlaArg: 4.58 ± 0.034	6.787AlaSer: 6.787 ± 0.042	4.687AlaThr: 4.687 ± 0.034	5.099AlaVal: 5.099 ± 0.042	1.05AlaTrp: 1.05 ± 0.017	2.118AlaTyr: 2.118 ± 0.019	0.0AlaXaa: 0.0 ± 0.0
Cys	0.885CysAla: 0.885 ± 0.012	0.235CysCys: 0.235 ± 0.008	0.685CysAsp: 0.685 ± 0.013	0.599CysGlu: 0.599 ± 0.01	0.546CysPhe: 0.546 ± 0.012	0.916CysGly: 0.916 ± 0.015	0.336CysHis: 0.336 ± 0.01	0.69CysIle: 0.69 ± 0.013	0.506CysLys: 0.506 ± 0.011	1.275CysLeu: 1.275 ± 0.017	0.284CysMet: 0.284 ± 0.008	0.449CysAsn: 0.449 ± 0.01	0.67CysPro: 0.67 ± 0.015	0.459CysGln: 0.459 ± 0.01	0.758CysArg: 0.758 ± 0.012	0.91CysSer: 0.91 ± 0.014	0.638CysThr: 0.638 ± 0.013	0.793CysVal: 0.793 ± 0.016	0.2CysTrp: 0.2 ± 0.006	0.362CysTyr: 0.362 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.306AspAla: 4.306 ± 0.034	0.617AspCys: 0.617 ± 0.013	3.987AspAsp: 3.987 ± 0.04	4.49AspGlu: 4.49 ± 0.032	2.27AspPhe: 2.27 ± 0.022	4.029AspGly: 4.029 ± 0.033	1.284AspHis: 1.284 ± 0.015	3.332AspIle: 3.332 ± 0.031	2.445AspLys: 2.445 ± 0.023	5.193AspLeu: 5.193 ± 0.036	1.309AspMet: 1.309 ± 0.017	2.093AspAsn: 2.093 ± 0.024	3.507AspPro: 3.507 ± 0.03	2.014AspGln: 2.014 ± 0.022	3.214AspArg: 3.214 ± 0.036	4.385AspSer: 4.385 ± 0.033	2.995AspThr: 2.995 ± 0.024	3.609AspVal: 3.609 ± 0.03	0.884AspTrp: 0.884 ± 0.014	1.699AspTyr: 1.699 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	4.973GluAla: 4.973 ± 0.046	0.637GluCys: 0.637 ± 0.012	4.201GluAsp: 4.201 ± 0.035	5.496GluGlu: 5.496 ± 0.055	2.067GluPhe: 2.067 ± 0.022	3.791GluGly: 3.791 ± 0.026	1.396GluHis: 1.396 ± 0.017	3.168GluIle: 3.168 ± 0.031	3.914GluLys: 3.914 ± 0.035	5.217GluLeu: 5.217 ± 0.04	1.536GluMet: 1.536 ± 0.022	2.684GluAsn: 2.684 ± 0.023	2.888GluPro: 2.888 ± 0.036	2.532GluGln: 2.532 ± 0.026	3.963GluArg: 3.963 ± 0.034	4.684GluSer: 4.684 ± 0.039	3.56GluThr: 3.56 ± 0.029	3.581GluVal: 3.581 ± 0.028	0.884GluTrp: 0.884 ± 0.014	1.793GluTyr: 1.793 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	2.981PheAla: 2.981 ± 0.024	0.586PheCys: 0.586 ± 0.013	2.346PheAsp: 2.346 ± 0.02	2.145PheGlu: 2.145 ± 0.026	1.646PhePhe: 1.646 ± 0.023	2.945PheGly: 2.945 ± 0.031	0.936PheHis: 0.936 ± 0.013	1.92PheIle: 1.92 ± 0.023	1.537PheLys: 1.537 ± 0.018	3.575PheLeu: 3.575 ± 0.028	0.814PheMet: 0.814 ± 0.013	1.509PheAsn: 1.509 ± 0.016	2.08PhePro: 2.08 ± 0.02	1.425PheGln: 1.425 ± 0.019	2.025PheArg: 2.025 ± 0.021	3.105PheSer: 3.105 ± 0.03	2.162PheThr: 2.162 ± 0.022	2.395PheVal: 2.395 ± 0.028	0.658PheTrp: 0.658 ± 0.013	1.178PheTyr: 1.178 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	4.911GlyAla: 4.911 ± 0.041	0.885GlyCys: 0.885 ± 0.012	3.695GlyAsp: 3.695 ± 0.03	3.775GlyGlu: 3.775 ± 0.031	2.863GlyPhe: 2.863 ± 0.029	5.396GlyGly: 5.396 ± 0.058	1.646GlyHis: 1.646 ± 0.021	3.734GlyIle: 3.734 ± 0.031	3.588GlyLys: 3.588 ± 0.028	6.03GlyLeu: 6.03 ± 0.042	1.683GlyMet: 1.683 ± 0.019	2.68GlyAsn: 2.68 ± 0.025	3.371GlyPro: 3.371 ± 0.032	2.599GlyGln: 2.599 ± 0.025	4.099GlyArg: 4.099 ± 0.035	5.681GlySer: 5.681 ± 0.045	3.889GlyThr: 3.889 ± 0.033	4.388GlyVal: 4.388 ± 0.036	1.126GlyTrp: 1.126 ± 0.016	2.17GlyTyr: 2.17 ± 0.025	0.0GlyXaa: 0.0 ± 0.0
His	1.726HisAla: 1.726 ± 0.022	0.332HisCys: 0.332 ± 0.009	1.299HisAsp: 1.299 ± 0.018	1.357HisGlu: 1.357 ± 0.016	0.943HisPhe: 0.943 ± 0.014	1.711HisGly: 1.711 ± 0.02	0.797HisHis: 0.797 ± 0.015	1.249HisIle: 1.249 ± 0.017	0.873HisLys: 0.873 ± 0.013	2.276HisLeu: 2.276 ± 0.024	0.49HisMet: 0.49 ± 0.009	0.858HisAsn: 0.858 ± 0.012	1.702HisPro: 1.702 ± 0.022	0.954HisGln: 0.954 ± 0.015	1.544HisArg: 1.544 ± 0.018	1.947HisSer: 1.947 ± 0.019	1.247HisThr: 1.247 ± 0.015	1.401HisVal: 1.401 ± 0.017	0.352HisTrp: 0.352 ± 0.009	0.703HisTyr: 0.703 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.1IleAla: 4.1 ± 0.034	0.804IleCys: 0.804 ± 0.013	2.984IleAsp: 2.984 ± 0.025	2.961IleGlu: 2.961 ± 0.025	2.091IlePhe: 2.091 ± 0.023	3.333IleGly: 3.333 ± 0.031	1.288IleHis: 1.288 ± 0.015	2.666IleIle: 2.666 ± 0.028	2.19IleLys: 2.19 ± 0.019	4.726IleLeu: 4.726 ± 0.04	1.046IleMet: 1.046 ± 0.016	1.895IleAsn: 1.895 ± 0.02	3.363IlePro: 3.363 ± 0.024	2.04IleGln: 2.04 ± 0.023	2.95IleArg: 2.95 ± 0.02	4.078IleSer: 4.078 ± 0.032	2.843IleThr: 2.843 ± 0.028	3.162IleVal: 3.162 ± 0.033	0.726IleTrp: 0.726 ± 0.013	1.506IleTyr: 1.506 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	4.029LysAla: 4.029 ± 0.034	0.511LysCys: 0.511 ± 0.01	2.915LysAsp: 2.915 ± 0.028	3.596LysGlu: 3.596 ± 0.039	1.535LysPhe: 1.535 ± 0.019	3.085LysGly: 3.085 ± 0.029	1.135LysHis: 1.135 ± 0.017	2.291LysIle: 2.291 ± 0.024	3.23LysLys: 3.23 ± 0.044	4.141LysLeu: 4.141 ± 0.031	1.04LysMet: 1.04 ± 0.016	1.865LysAsn: 1.865 ± 0.022	2.831LysPro: 2.831 ± 0.027	1.95LysGln: 1.95 ± 0.022	3.46LysArg: 3.46 ± 0.029	3.682LysSer: 3.682 ± 0.032	2.726LysThr: 2.726 ± 0.028	2.866LysVal: 2.866 ± 0.027	0.685LysTrp: 0.685 ± 0.013	1.477LysTyr: 1.477 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	7.315LeuAla: 7.315 ± 0.044	1.188LeuCys: 1.188 ± 0.017	5.246LeuAsp: 5.246 ± 0.036	5.512LeuGlu: 5.512 ± 0.039	3.369LeuPhe: 3.369 ± 0.034	5.906LeuGly: 5.906 ± 0.044	2.267LeuHis: 2.267 ± 0.024	4.06LeuIle: 4.06 ± 0.036	4.261LeuLys: 4.261 ± 0.035	8.232LeuLeu: 8.232 ± 0.066	1.836LeuMet: 1.836 ± 0.02	3.381LeuAsn: 3.381 ± 0.027	5.413LeuPro: 5.413 ± 0.038	3.774LeuGln: 3.774 ± 0.032	5.737LeuArg: 5.737 ± 0.038	7.494LeuSer: 7.494 ± 0.051	4.73LeuThr: 4.73 ± 0.034	5.359LeuVal: 5.359 ± 0.038	1.181LeuTrp: 1.181 ± 0.019	2.424LeuTyr: 2.424 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.12MetAla: 2.12 ± 0.021	0.258MetCys: 0.258 ± 0.007	1.349MetAsp: 1.349 ± 0.016	1.377MetGlu: 1.377 ± 0.018	0.766MetPhe: 0.766 ± 0.013	1.555MetGly: 1.555 ± 0.019	0.496MetHis: 0.496 ± 0.01	1.055MetIle: 1.055 ± 0.016	1.09MetLys: 1.09 ± 0.016	1.853MetLeu: 1.853 ± 0.021	0.561MetMet: 0.561 ± 0.011	0.894MetAsn: 0.894 ± 0.014	1.265MetPro: 1.265 ± 0.019	0.852MetGln: 0.852 ± 0.014	1.274MetArg: 1.274 ± 0.013	1.907MetSer: 1.907 ± 0.018	1.311MetThr: 1.311 ± 0.015	1.39MetVal: 1.39 ± 0.017	0.25MetTrp: 0.25 ± 0.008	0.536MetTyr: 0.536 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.199AsnAla: 3.199 ± 0.028	0.466AsnCys: 0.466 ± 0.01	2.11AsnAsp: 2.11 ± 0.019	2.293AsnGlu: 2.293 ± 0.021	1.44AsnPhe: 1.44 ± 0.017	3.124AsnGly: 3.124 ± 0.036	0.908AsnHis: 0.908 ± 0.014	2.216AsnIle: 2.216 ± 0.023	1.675AsnLys: 1.675 ± 0.019	3.45AsnLeu: 3.45 ± 0.031	0.899AsnMet: 0.899 ± 0.014	1.599AsnAsn: 1.599 ± 0.021	2.694AsnPro: 2.694 ± 0.028	1.51AsnGln: 1.51 ± 0.02	2.176AsnArg: 2.176 ± 0.023	2.99AsnSer: 2.99 ± 0.027	2.278AsnThr: 2.278 ± 0.022	2.448AsnVal: 2.448 ± 0.023	0.603AsnTrp: 0.603 ± 0.011	1.126AsnTyr: 1.126 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	4.775ProAla: 4.775 ± 0.045	0.521ProCys: 0.521 ± 0.012	3.392ProAsp: 3.392 ± 0.031	4.07ProGlu: 4.07 ± 0.034	2.148ProPhe: 2.148 ± 0.023	4.007ProGly: 4.007 ± 0.036	1.328ProHis: 1.328 ± 0.018	2.649ProIle: 2.649 ± 0.024	2.736ProLys: 2.736 ± 0.028	4.638ProLeu: 4.638 ± 0.034	1.083ProMet: 1.083 ± 0.018	2.442ProAsn: 2.442 ± 0.025	4.964ProPro: 4.964 ± 0.069	2.426ProGln: 2.426 ± 0.031	3.382ProArg: 3.382 ± 0.035	6.304ProSer: 6.304 ± 0.056	3.927ProThr: 3.927 ± 0.039	3.683ProVal: 3.683 ± 0.029	0.742ProTrp: 0.742 ± 0.015	1.575ProTyr: 1.575 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	3.207GlnAla: 3.207 ± 0.031	0.44GlnCys: 0.44 ± 0.011	2.041GlnAsp: 2.041 ± 0.022	2.444GlnGlu: 2.444 ± 0.027	1.374GlnPhe: 1.374 ± 0.017	2.373GlnGly: 2.373 ± 0.025	0.991GlnHis: 0.991 ± 0.014	1.944GlnIle: 1.944 ± 0.021	2.123GlnLys: 2.123 ± 0.022	3.424GlnLeu: 3.424 ± 0.032	0.899GlnMet: 0.899 ± 0.014	1.745GlnAsn: 1.745 ± 0.021	2.581GlnPro: 2.581 ± 0.031	2.137GlnGln: 2.137 ± 0.039	2.606GlnArg: 2.606 ± 0.024	3.316GlnSer: 3.316 ± 0.033	2.315GlnThr: 2.315 ± 0.023	2.179GlnVal: 2.179 ± 0.022	0.561GlnTrp: 0.561 ± 0.011	1.144GlnTyr: 1.144 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	4.405ArgAla: 4.405 ± 0.035	0.705ArgCys: 0.705 ± 0.013	3.458ArgAsp: 3.458 ± 0.033	3.93ArgGlu: 3.93 ± 0.031	2.249ArgPhe: 2.249 ± 0.022	3.69ArgGly: 3.69 ± 0.037	1.544ArgHis: 1.544 ± 0.02	3.018ArgIle: 3.018 ± 0.025	3.552ArgLys: 3.552 ± 0.031	5.436ArgLeu: 5.436 ± 0.039	1.369ArgMet: 1.369 ± 0.017	2.461ArgAsn: 2.461 ± 0.022	3.446ArgPro: 3.446 ± 0.035	2.627ArgGln: 2.627 ± 0.027	5.187ArgArg: 5.187 ± 0.05	4.948ArgSer: 4.948 ± 0.041	3.206ArgThr: 3.206 ± 0.027	3.428ArgVal: 3.428 ± 0.028	0.916ArgTrp: 0.916 ± 0.014	1.734ArgTyr: 1.734 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	6.319SerAla: 6.319 ± 0.039	0.882SerCys: 0.882 ± 0.015	4.489SerAsp: 4.489 ± 0.036	4.531SerGlu: 4.531 ± 0.04	3.15SerPhe: 3.15 ± 0.029	5.653SerGly: 5.653 ± 0.042	2.025SerHis: 2.025 ± 0.023	4.165SerIle: 4.165 ± 0.033	3.991SerLys: 3.991 ± 0.034	7.446SerLeu: 7.446 ± 0.046	1.815SerMet: 1.815 ± 0.021	3.27SerAsn: 3.27 ± 0.028	5.666SerPro: 5.666 ± 0.054	3.442SerGln: 3.442 ± 0.031	5.165SerArg: 5.165 ± 0.04	8.926SerSer: 8.926 ± 0.074	5.469SerThr: 5.469 ± 0.044	4.753SerVal: 4.753 ± 0.036	1.107SerTrp: 1.107 ± 0.018	2.141SerTyr: 2.141 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	4.73ThrAla: 4.73 ± 0.032	0.699ThrCys: 0.699 ± 0.015	2.919ThrAsp: 2.919 ± 0.026	3.2ThrGlu: 3.2 ± 0.027	2.156ThrPhe: 2.156 ± 0.023	4.223ThrGly: 4.223 ± 0.034	1.241ThrHis: 1.241 ± 0.017	2.999ThrIle: 2.999 ± 0.029	2.552ThrLys: 2.552 ± 0.025	5.073ThrLeu: 5.073 ± 0.035	1.217ThrMet: 1.217 ± 0.015	2.106ThrAsn: 2.106 ± 0.021	4.277ThrPro: 4.277 ± 0.039	2.077ThrGln: 2.077 ± 0.022	3.068ThrArg: 3.068 ± 0.024	5.228ThrSer: 5.228 ± 0.038	3.898ThrThr: 3.898 ± 0.039	3.738ThrVal: 3.738 ± 0.029	0.81ThrTrp: 0.81 ± 0.013	1.575ThrTyr: 1.575 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	4.838ValAla: 4.838 ± 0.034	0.826ValCys: 0.826 ± 0.015	3.901ValAsp: 3.901 ± 0.03	3.839ValGlu: 3.839 ± 0.03	2.495ValPhe: 2.495 ± 0.024	3.989ValGly: 3.989 ± 0.03	1.399ValHis: 1.399 ± 0.018	3.096ValIle: 3.096 ± 0.029	2.92ValLys: 2.92 ± 0.025	5.507ValLeu: 5.507 ± 0.043	1.328ValMet: 1.328 ± 0.016	2.432ValAsn: 2.432 ± 0.025	3.595ValPro: 3.595 ± 0.032	2.328ValGln: 2.328 ± 0.023	3.432ValArg: 3.432 ± 0.027	4.846ValSer: 4.846 ± 0.029	3.435ValThr: 3.435 ± 0.029	4.112ValVal: 4.112 ± 0.034	0.831ValTrp: 0.831 ± 0.014	1.745ValTyr: 1.745 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.074TrpAla: 1.074 ± 0.015	0.186TrpCys: 0.186 ± 0.007	0.904TrpAsp: 0.904 ± 0.016	0.873TrpGlu: 0.873 ± 0.011	0.539TrpPhe: 0.539 ± 0.011	0.895TrpGly: 0.895 ± 0.015	0.337TrpHis: 0.337 ± 0.009	0.786TrpIle: 0.786 ± 0.014	0.817TrpLys: 0.817 ± 0.012	1.3TrpLeu: 1.3 ± 0.02	0.361TrpMet: 0.361 ± 0.008	0.654TrpAsn: 0.654 ± 0.012	0.587TrpPro: 0.587 ± 0.011	0.531TrpGln: 0.531 ± 0.012	0.953TrpArg: 0.953 ± 0.016	1.04TrpSer: 1.04 ± 0.015	0.864TrpThr: 0.864 ± 0.015	0.867TrpVal: 0.867 ± 0.015	0.265TrpTrp: 0.265 ± 0.007	0.43TrpTyr: 0.43 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.091TyrAla: 2.091 ± 0.025	0.41TyrCys: 0.41 ± 0.008	1.689TyrAsp: 1.689 ± 0.021	1.574TyrGlu: 1.574 ± 0.02	1.236TyrPhe: 1.236 ± 0.019	2.132TyrGly: 2.132 ± 0.026	0.748TyrHis: 0.748 ± 0.012	1.541TyrIle: 1.541 ± 0.019	1.157TyrLys: 1.157 ± 0.018	2.743TyrLeu: 2.743 ± 0.027	0.661TyrMet: 0.661 ± 0.014	1.186TyrAsn: 1.186 ± 0.015	1.592TyrPro: 1.592 ± 0.019	1.104TyrGln: 1.104 ± 0.017	1.741TyrArg: 1.741 ± 0.018	2.148TyrSer: 2.148 ± 0.022	1.608TyrThr: 1.608 ± 0.02	1.645TyrVal: 1.645 ± 0.017	0.433TyrTrp: 0.433 ± 0.01	0.995TyrTyr: 0.995 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 11306 proteins (4755854 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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