Amino acid dipepetide frequency for Terrisporobacter othiniensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.411AlaAla: 3.411 ± 0.068	0.85AlaCys: 0.85 ± 0.033	2.564AlaAsp: 2.564 ± 0.058	2.847AlaGlu: 2.847 ± 0.064	2.387AlaPhe: 2.387 ± 0.054	3.812AlaGly: 3.812 ± 0.068	0.806AlaHis: 0.806 ± 0.026	5.94AlaIle: 5.94 ± 0.094	4.766AlaLys: 4.766 ± 0.079	5.595AlaLeu: 5.595 ± 0.085	1.783AlaMet: 1.783 ± 0.048	2.807AlaAsn: 2.807 ± 0.054	1.369AlaPro: 1.369 ± 0.04	1.422AlaGln: 1.422 ± 0.035	1.747AlaArg: 1.747 ± 0.041	3.293AlaSer: 3.293 ± 0.063	3.047AlaThr: 3.047 ± 0.072	3.769AlaVal: 3.769 ± 0.077	0.37AlaTrp: 0.37 ± 0.022	2.283AlaTyr: 2.283 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.762CysAla: 0.762 ± 0.031	0.248CysCys: 0.248 ± 0.02	0.841CysAsp: 0.841 ± 0.033	1.084CysGlu: 1.084 ± 0.03	0.496CysPhe: 0.496 ± 0.023	1.232CysGly: 1.232 ± 0.034	0.224CysHis: 0.224 ± 0.016	1.262CysIle: 1.262 ± 0.04	1.157CysLys: 1.157 ± 0.038	0.958CysLeu: 0.958 ± 0.03	0.363CysMet: 0.363 ± 0.021	0.856CysAsn: 0.856 ± 0.028	0.547CysPro: 0.547 ± 0.027	0.26CysGln: 0.26 ± 0.017	0.409CysArg: 0.409 ± 0.021	0.816CysSer: 0.816 ± 0.029	0.639CysThr: 0.639 ± 0.026	0.837CysVal: 0.837 ± 0.031	0.065CysTrp: 0.065 ± 0.008	0.435CysTyr: 0.435 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	2.782AspAla: 2.782 ± 0.065	0.728AspCys: 0.728 ± 0.029	3.196AspAsp: 3.196 ± 0.063	5.074AspGlu: 5.074 ± 0.079	2.799AspPhe: 2.799 ± 0.062	3.122AspGly: 3.122 ± 0.06	0.623AspHis: 0.623 ± 0.028	6.139AspIle: 6.139 ± 0.094	5.808AspLys: 5.808 ± 0.083	5.459AspLeu: 5.459 ± 0.073	1.678AspMet: 1.678 ± 0.041	3.651AspAsn: 3.651 ± 0.063	1.235AspPro: 1.235 ± 0.033	0.86AspGln: 0.86 ± 0.029	1.762AspArg: 1.762 ± 0.042	3.112AspSer: 3.112 ± 0.062	2.554AspThr: 2.554 ± 0.049	3.716AspVal: 3.716 ± 0.058	0.308AspTrp: 0.308 ± 0.02	2.852AspTyr: 2.852 ± 0.063	0.0AspXaa: 0.0 ± 0.0
Glu	3.777GluAla: 3.777 ± 0.067	0.782GluCys: 0.782 ± 0.03	4.92GluAsp: 4.92 ± 0.076	7.476GluGlu: 7.476 ± 0.119	2.932GluPhe: 2.932 ± 0.056	4.135GluGly: 4.135 ± 0.061	0.896GluHis: 0.896 ± 0.03	7.313GluIle: 7.313 ± 0.089	7.377GluLys: 7.377 ± 0.095	6.415GluLeu: 6.415 ± 0.091	1.999GluMet: 1.999 ± 0.047	5.838GluAsn: 5.838 ± 0.084	1.311GluPro: 1.311 ± 0.034	1.534GluGln: 1.534 ± 0.04	2.308GluArg: 2.308 ± 0.052	3.689GluSer: 3.689 ± 0.064	2.778GluThr: 2.778 ± 0.058	5.27GluVal: 5.27 ± 0.077	0.334GluTrp: 0.334 ± 0.019	3.125GluTyr: 3.125 ± 0.059	0.0GluXaa: 0.0 ± 0.0
Phe	2.481PheAla: 2.481 ± 0.055	0.527PheCys: 0.527 ± 0.02	2.585PheAsp: 2.585 ± 0.054	2.746PheGlu: 2.746 ± 0.057	1.829PhePhe: 1.829 ± 0.042	3.005PheGly: 3.005 ± 0.065	0.456PheHis: 0.456 ± 0.022	4.576PheIle: 4.576 ± 0.082	3.507PheLys: 3.507 ± 0.056	3.862PheLeu: 3.862 ± 0.076	1.3PheMet: 1.3 ± 0.044	2.798PheAsn: 2.798 ± 0.053	1.082PhePro: 1.082 ± 0.031	0.782PheGln: 0.782 ± 0.029	1.154PheArg: 1.154 ± 0.034	2.875PheSer: 2.875 ± 0.061	2.384PheThr: 2.384 ± 0.054	2.934PheVal: 2.934 ± 0.057	0.274PheTrp: 0.274 ± 0.015	1.765PheTyr: 1.765 ± 0.05	0.0PheXaa: 0.0 ± 0.0
Gly	4.169GlyAla: 4.169 ± 0.089	1.108GlyCys: 1.108 ± 0.035	3.254GlyAsp: 3.254 ± 0.054	4.089GlyGlu: 4.089 ± 0.072	3.145GlyPhe: 3.145 ± 0.067	4.44GlyGly: 4.44 ± 0.089	0.98GlyHis: 0.98 ± 0.029	6.728GlyIle: 6.728 ± 0.089	5.307GlyLys: 5.307 ± 0.079	5.567GlyLeu: 5.567 ± 0.089	1.941GlyMet: 1.941 ± 0.047	3.104GlyAsn: 3.104 ± 0.059	1.325GlyPro: 1.325 ± 0.036	1.477GlyGln: 1.477 ± 0.038	2.105GlyArg: 2.105 ± 0.051	3.809GlySer: 3.809 ± 0.071	3.253GlyThr: 3.253 ± 0.061	4.863GlyVal: 4.863 ± 0.077	0.429GlyTrp: 0.429 ± 0.025	3.034GlyTyr: 3.034 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	0.675HisAla: 0.675 ± 0.027	0.228HisCys: 0.228 ± 0.017	0.737HisAsp: 0.737 ± 0.031	0.954HisGlu: 0.954 ± 0.03	0.567HisPhe: 0.567 ± 0.024	0.972HisGly: 0.972 ± 0.036	0.262HisHis: 0.262 ± 0.017	1.346HisIle: 1.346 ± 0.033	1.093HisLys: 1.093 ± 0.03	1.194HisLeu: 1.194 ± 0.037	0.372HisMet: 0.372 ± 0.019	0.791HisAsn: 0.791 ± 0.027	0.58HisPro: 0.58 ± 0.022	0.295HisGln: 0.295 ± 0.019	0.467HisArg: 0.467 ± 0.022	0.822HisSer: 0.822 ± 0.029	0.668HisThr: 0.668 ± 0.027	0.813HisVal: 0.813 ± 0.033	0.103HisTrp: 0.103 ± 0.01	0.503HisTyr: 0.503 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	5.637IleAla: 5.637 ± 0.087	1.507IleCys: 1.507 ± 0.042	6.176IleAsp: 6.176 ± 0.093	7.078IleGlu: 7.078 ± 0.105	4.18IlePhe: 4.18 ± 0.076	6.438IleGly: 6.438 ± 0.093	1.293IleHis: 1.293 ± 0.037	9.69IleIle: 9.69 ± 0.122	8.648IleLys: 8.648 ± 0.099	9.192IleLeu: 9.192 ± 0.108	2.458IleMet: 2.458 ± 0.049	6.567IleAsn: 6.567 ± 0.091	3.213IlePro: 3.213 ± 0.066	1.969IleGln: 1.969 ± 0.049	2.69IleArg: 2.69 ± 0.057	7.104IleSer: 7.104 ± 0.093	4.831IleThr: 4.831 ± 0.072	6.611IleVal: 6.611 ± 0.076	0.489IleTrp: 0.489 ± 0.025	3.844IleTyr: 3.844 ± 0.078	0.0IleXaa: 0.0 ± 0.0
Lys	4.427LysAla: 4.427 ± 0.065	1.0LysCys: 1.0 ± 0.037	6.026LysAsp: 6.026 ± 0.103	8.947LysGlu: 8.947 ± 0.126	3.231LysPhe: 3.231 ± 0.06	4.747LysGly: 4.747 ± 0.076	1.067LysHis: 1.067 ± 0.033	8.312LysIle: 8.312 ± 0.088	8.061LysLys: 8.061 ± 0.101	7.493LysLeu: 7.493 ± 0.086	2.535LysMet: 2.535 ± 0.045	6.573LysAsn: 6.573 ± 0.106	1.886LysPro: 1.886 ± 0.04	1.989LysGln: 1.989 ± 0.051	2.73LysArg: 2.73 ± 0.066	5.535LysSer: 5.535 ± 0.075	4.068LysThr: 4.068 ± 0.065	5.923LysVal: 5.923 ± 0.075	0.536LysTrp: 0.536 ± 0.025	4.425LysTyr: 4.425 ± 0.079	0.0LysXaa: 0.0 ± 0.0
Leu	5.265LeuAla: 5.265 ± 0.082	1.225LeuCys: 1.225 ± 0.037	5.496LeuAsp: 5.496 ± 0.093	6.408LeuGlu: 6.408 ± 0.086	3.928LeuPhe: 3.928 ± 0.078	6.376LeuGly: 6.376 ± 0.097	1.084LeuHis: 1.084 ± 0.036	8.224LeuIle: 8.224 ± 0.128	7.783LeuLys: 7.783 ± 0.083	7.836LeuLeu: 7.836 ± 0.12	2.328LeuMet: 2.328 ± 0.047	5.943LeuAsn: 5.943 ± 0.084	2.731LeuPro: 2.731 ± 0.052	2.262LeuGln: 2.262 ± 0.047	2.866LeuArg: 2.866 ± 0.059	6.639LeuSer: 6.639 ± 0.11	4.291LeuThr: 4.291 ± 0.064	5.861LeuVal: 5.861 ± 0.091	0.497LeuTrp: 0.497 ± 0.024	3.271LeuTyr: 3.271 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	1.875MetAla: 1.875 ± 0.048	0.32MetCys: 0.32 ± 0.015	1.674MetAsp: 1.674 ± 0.043	2.019MetGlu: 2.019 ± 0.051	1.014MetPhe: 1.014 ± 0.032	2.005MetGly: 2.005 ± 0.044	0.327MetHis: 0.327 ± 0.016	2.566MetIle: 2.566 ± 0.054	2.668MetLys: 2.668 ± 0.047	2.256MetLeu: 2.256 ± 0.054	0.85MetMet: 0.85 ± 0.03	1.782MetAsn: 1.782 ± 0.042	0.878MetPro: 0.878 ± 0.026	0.646MetGln: 0.646 ± 0.03	0.854MetArg: 0.854 ± 0.033	1.866MetSer: 1.866 ± 0.045	1.348MetThr: 1.348 ± 0.04	1.691MetVal: 1.691 ± 0.037	0.168MetTrp: 0.168 ± 0.012	0.941MetTyr: 0.941 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	2.824AsnAla: 2.824 ± 0.056	0.795AsnCys: 0.795 ± 0.031	3.076AsnAsp: 3.076 ± 0.062	4.529AsnGlu: 4.529 ± 0.066	2.515AsnPhe: 2.515 ± 0.052	3.218AsnGly: 3.218 ± 0.058	0.933AsnHis: 0.933 ± 0.033	7.385AsnIle: 7.385 ± 0.098	6.845AsnLys: 6.845 ± 0.1	6.017AsnLeu: 6.017 ± 0.089	1.863AsnMet: 1.863 ± 0.043	4.751AsnAsn: 4.751 ± 0.099	2.173AsnPro: 2.173 ± 0.055	1.507AsnGln: 1.507 ± 0.041	1.876AsnArg: 1.876 ± 0.044	3.684AsnSer: 3.684 ± 0.072	2.988AsnThr: 2.988 ± 0.052	3.664AsnVal: 3.664 ± 0.069	0.399AsnTrp: 0.399 ± 0.021	2.821AsnTyr: 2.821 ± 0.058	0.0AsnXaa: 0.0 ± 0.0
Pro	1.452ProAla: 1.452 ± 0.046	0.364ProCys: 0.364 ± 0.02	1.356ProAsp: 1.356 ± 0.041	1.933ProGlu: 1.933 ± 0.044	1.296ProPhe: 1.296 ± 0.035	1.736ProGly: 1.736 ± 0.044	0.495ProHis: 0.495 ± 0.018	2.717ProIle: 2.717 ± 0.053	2.116ProLys: 2.116 ± 0.047	2.349ProLeu: 2.349 ± 0.054	0.763ProMet: 0.763 ± 0.026	1.512ProAsn: 1.512 ± 0.045	0.577ProPro: 0.577 ± 0.023	0.824ProGln: 0.824 ± 0.027	0.829ProArg: 0.829 ± 0.027	1.764ProSer: 1.764 ± 0.044	1.583ProThr: 1.583 ± 0.042	2.083ProVal: 2.083 ± 0.051	0.218ProTrp: 0.218 ± 0.015	1.26ProTyr: 1.26 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	1.299GlnAla: 1.299 ± 0.04	0.257GlnCys: 0.257 ± 0.017	1.152GlnAsp: 1.152 ± 0.038	1.616GlnGlu: 1.616 ± 0.047	0.885GlnPhe: 0.885 ± 0.032	1.52GlnGly: 1.52 ± 0.04	0.288GlnHis: 0.288 ± 0.017	2.193GlnIle: 2.193 ± 0.051	1.79GlnLys: 1.79 ± 0.041	2.122GlnLeu: 2.122 ± 0.044	0.67GlnMet: 0.67 ± 0.024	1.344GlnAsn: 1.344 ± 0.039	0.6GlnPro: 0.6 ± 0.023	0.608GlnGln: 0.608 ± 0.027	0.878GlnArg: 0.878 ± 0.033	1.404GlnSer: 1.404 ± 0.037	1.026GlnThr: 1.026 ± 0.033	1.575GlnVal: 1.575 ± 0.041	0.169GlnTrp: 0.169 ± 0.012	0.993GlnTyr: 0.993 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	1.708ArgAla: 1.708 ± 0.046	0.433ArgCys: 0.433 ± 0.022	1.8ArgAsp: 1.8 ± 0.038	2.655ArgGlu: 2.655 ± 0.062	1.277ArgPhe: 1.277 ± 0.034	1.904ArgGly: 1.904 ± 0.041	0.427ArgHis: 0.427 ± 0.02	2.763ArgIle: 2.763 ± 0.06	2.869ArgLys: 2.869 ± 0.052	2.607ArgLeu: 2.607 ± 0.05	0.902ArgMet: 0.902 ± 0.033	1.84ArgAsn: 1.84 ± 0.04	0.824ArgPro: 0.824 ± 0.029	0.917ArgGln: 0.917 ± 0.032	1.3ArgArg: 1.3 ± 0.041	1.475ArgSer: 1.475 ± 0.042	1.433ArgThr: 1.433 ± 0.037	2.228ArgVal: 2.228 ± 0.05	0.208ArgTrp: 0.208 ± 0.014	1.312ArgTyr: 1.312 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	3.229SerAla: 3.229 ± 0.061	0.782SerCys: 0.782 ± 0.03	3.116SerAsp: 3.116 ± 0.059	3.771SerGlu: 3.771 ± 0.067	3.031SerPhe: 3.031 ± 0.053	4.158SerGly: 4.158 ± 0.078	0.989SerHis: 0.989 ± 0.035	6.482SerIle: 6.482 ± 0.091	5.958SerLys: 5.958 ± 0.075	6.093SerLeu: 6.093 ± 0.083	1.738SerMet: 1.738 ± 0.043	3.894SerAsn: 3.894 ± 0.067	1.69SerPro: 1.69 ± 0.042	1.693SerGln: 1.693 ± 0.038	1.989SerArg: 1.989 ± 0.046	4.476SerSer: 4.476 ± 0.08	3.316SerThr: 3.316 ± 0.06	4.037SerVal: 4.037 ± 0.07	0.381SerTrp: 0.381 ± 0.021	2.69SerTyr: 2.69 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	2.7ThrAla: 2.7 ± 0.047	0.677ThrCys: 0.677 ± 0.028	2.372ThrAsp: 2.372 ± 0.047	2.601ThrGlu: 2.601 ± 0.052	2.165ThrPhe: 2.165 ± 0.051	3.514ThrGly: 3.514 ± 0.066	0.766ThrHis: 0.766 ± 0.025	4.847ThrIle: 4.847 ± 0.068	3.824ThrLys: 3.824 ± 0.064	4.863ThrLeu: 4.863 ± 0.067	1.211ThrMet: 1.211 ± 0.037	2.71ThrAsn: 2.71 ± 0.062	1.795ThrPro: 1.795 ± 0.045	1.071ThrGln: 1.071 ± 0.035	1.421ThrArg: 1.421 ± 0.037	3.413ThrSer: 3.413 ± 0.07	2.775ThrThr: 2.775 ± 0.066	3.476ThrVal: 3.476 ± 0.059	0.321ThrTrp: 0.321 ± 0.016	2.205ThrTyr: 2.205 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	4.054ValAla: 4.054 ± 0.071	1.025ValCys: 1.025 ± 0.033	4.127ValAsp: 4.127 ± 0.068	4.814ValGlu: 4.814 ± 0.075	3.0ValPhe: 3.0 ± 0.066	4.9ValGly: 4.9 ± 0.084	0.839ValHis: 0.839 ± 0.031	6.289ValIle: 6.289 ± 0.098	5.536ValLys: 5.536 ± 0.084	6.007ValLeu: 6.007 ± 0.086	1.72ValMet: 1.72 ± 0.04	3.766ValAsn: 3.766 ± 0.064	2.012ValPro: 2.012 ± 0.035	1.327ValGln: 1.327 ± 0.039	1.978ValArg: 1.978 ± 0.046	4.584ValSer: 4.584 ± 0.074	3.314ValThr: 3.314 ± 0.063	4.973ValVal: 4.973 ± 0.103	0.365ValTrp: 0.365 ± 0.019	2.593ValTyr: 2.593 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.356TrpAla: 0.356 ± 0.02	0.082TrpCys: 0.082 ± 0.009	0.336TrpAsp: 0.336 ± 0.021	0.398TrpGlu: 0.398 ± 0.023	0.283TrpPhe: 0.283 ± 0.018	0.404TrpGly: 0.404 ± 0.02	0.112TrpHis: 0.112 ± 0.011	0.607TrpIle: 0.607 ± 0.025	0.409TrpLys: 0.409 ± 0.023	0.512TrpLeu: 0.512 ± 0.022	0.182TrpMet: 0.182 ± 0.013	0.38TrpAsn: 0.38 ± 0.021	0.149TrpPro: 0.149 ± 0.014	0.185TrpGln: 0.185 ± 0.014	0.205TrpArg: 0.205 ± 0.014	0.375TrpSer: 0.375 ± 0.018	0.294TrpThr: 0.294 ± 0.019	0.386TrpVal: 0.386 ± 0.024	0.067TrpTrp: 0.067 ± 0.008	0.245TrpTyr: 0.245 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.987TyrAla: 1.987 ± 0.045	0.554TyrCys: 0.554 ± 0.023	2.653TyrAsp: 2.653 ± 0.054	3.168TyrGlu: 3.168 ± 0.065	1.962TyrPhe: 1.962 ± 0.05	2.489TyrGly: 2.489 ± 0.05	0.575TyrHis: 0.575 ± 0.025	4.235TyrIle: 4.235 ± 0.076	3.99TyrLys: 3.99 ± 0.069	3.922TyrLeu: 3.922 ± 0.066	1.09TyrMet: 1.09 ± 0.029	2.954TyrAsn: 2.954 ± 0.057	1.249TyrPro: 1.249 ± 0.033	0.763TyrGln: 0.763 ± 0.03	1.313TyrArg: 1.313 ± 0.037	2.778TyrSer: 2.778 ± 0.051	2.138TyrThr: 2.138 ± 0.051	2.513TyrVal: 2.513 ± 0.05	0.263TyrTrp: 0.263 ± 0.017	1.906TyrTyr: 1.906 ± 0.053	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3449 proteins (1029502 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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