Amino acid dipepetide frequency for Nocardia cyriacigeorgica (strain GUH-2)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.751AlaAla: 21.751 ± 0.198	0.921AlaCys: 0.921 ± 0.029	9.079AlaAsp: 9.079 ± 0.094	9.201AlaGlu: 9.201 ± 0.087	3.324AlaPhe: 3.324 ± 0.046	12.583AlaGly: 12.583 ± 0.099	2.707AlaHis: 2.707 ± 0.044	5.297AlaIle: 5.297 ± 0.061	2.84AlaLys: 2.84 ± 0.056	13.55AlaLeu: 13.55 ± 0.117	2.755AlaMet: 2.755 ± 0.043	2.367AlaAsn: 2.367 ± 0.039	7.074AlaPro: 7.074 ± 0.102	4.061AlaGln: 4.061 ± 0.047	9.474AlaArg: 9.474 ± 0.096	5.301AlaSer: 5.301 ± 0.058	7.664AlaThr: 7.664 ± 0.076	11.682AlaVal: 11.682 ± 0.103	1.679AlaTrp: 1.679 ± 0.032	2.387AlaTyr: 2.387 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	1.06CysAla: 1.06 ± 0.032	0.085CysCys: 0.085 ± 0.008	0.434CysAsp: 0.434 ± 0.016	0.367CysGlu: 0.367 ± 0.015	0.205CysPhe: 0.205 ± 0.011	0.835CysGly: 0.835 ± 0.025	0.168CysHis: 0.168 ± 0.01	0.206CysIle: 0.206 ± 0.011	0.106CysLys: 0.106 ± 0.007	0.613CysLeu: 0.613 ± 0.021	0.103CysMet: 0.103 ± 0.007	0.119CysAsn: 0.119 ± 0.009	0.43CysPro: 0.43 ± 0.017	0.16CysGln: 0.16 ± 0.01	0.509CysArg: 0.509 ± 0.018	0.419CysSer: 0.419 ± 0.015	0.456CysThr: 0.456 ± 0.016	0.582CysVal: 0.582 ± 0.017	0.119CysTrp: 0.119 ± 0.009	0.158CysTyr: 0.158 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.902AspAla: 7.902 ± 0.09	0.393AspCys: 0.393 ± 0.019	4.003AspAsp: 4.003 ± 0.064	3.952AspGlu: 3.952 ± 0.05	1.669AspPhe: 1.669 ± 0.034	5.785AspGly: 5.785 ± 0.057	1.412AspHis: 1.412 ± 0.03	2.611AspIle: 2.611 ± 0.036	1.235AspLys: 1.235 ± 0.032	6.422AspLeu: 6.422 ± 0.075	0.946AspMet: 0.946 ± 0.024	1.242AspAsn: 1.242 ± 0.025	4.892AspPro: 4.892 ± 0.067	1.941AspGln: 1.941 ± 0.032	5.154AspArg: 5.154 ± 0.07	3.003AspSer: 3.003 ± 0.046	3.327AspThr: 3.327 ± 0.046	4.447AspVal: 4.447 ± 0.058	0.957AspTrp: 0.957 ± 0.027	1.394AspTyr: 1.394 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	6.404GluAla: 6.404 ± 0.075	0.36GluCys: 0.36 ± 0.015	2.3GluAsp: 2.3 ± 0.041	2.482GluGlu: 2.482 ± 0.047	2.05GluPhe: 2.05 ± 0.037	3.357GluGly: 3.357 ± 0.055	1.7GluHis: 1.7 ± 0.032	2.758GluIle: 2.758 ± 0.041	1.163GluLys: 1.163 ± 0.032	7.486GluLeu: 7.486 ± 0.104	1.053GluMet: 1.053 ± 0.023	1.028GluAsn: 1.028 ± 0.029	3.572GluPro: 3.572 ± 0.058	2.689GluGln: 2.689 ± 0.041	5.04GluArg: 5.04 ± 0.061	2.982GluSer: 2.982 ± 0.048	2.897GluThr: 2.897 ± 0.042	4.653GluVal: 4.653 ± 0.049	0.829GluTrp: 0.829 ± 0.022	1.223GluTyr: 1.223 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.197PheAla: 4.197 ± 0.064	0.244PheCys: 0.244 ± 0.012	2.481PheAsp: 2.481 ± 0.048	1.547PheGlu: 1.547 ± 0.035	0.853PhePhe: 0.853 ± 0.026	3.463PheGly: 3.463 ± 0.052	0.614PheHis: 0.614 ± 0.018	0.935PheIle: 0.935 ± 0.023	0.39PheLys: 0.39 ± 0.015	2.485PheLeu: 2.485 ± 0.046	0.432PheMet: 0.432 ± 0.016	0.538PheAsn: 0.538 ± 0.018	1.392PhePro: 1.392 ± 0.032	0.704PheGln: 0.704 ± 0.03	1.755PheArg: 1.755 ± 0.031	1.402PheSer: 1.402 ± 0.031	2.11PheThr: 2.11 ± 0.031	2.399PheVal: 2.399 ± 0.046	0.416PheTrp: 0.416 ± 0.016	0.631PheTyr: 0.631 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	10.806GlyAla: 10.806 ± 0.096	0.755GlyCys: 0.755 ± 0.026	4.885GlyAsp: 4.885 ± 0.068	4.875GlyGlu: 4.875 ± 0.068	2.923GlyPhe: 2.923 ± 0.046	7.756GlyGly: 7.756 ± 0.108	2.017GlyHis: 2.017 ± 0.039	4.059GlyIle: 4.059 ± 0.054	2.322GlyLys: 2.322 ± 0.048	8.642GlyLeu: 8.642 ± 0.087	2.11GlyMet: 2.11 ± 0.031	1.86GlyAsn: 1.86 ± 0.042	4.772GlyPro: 4.772 ± 0.062	2.594GlyGln: 2.594 ± 0.047	6.598GlyArg: 6.598 ± 0.061	5.248GlySer: 5.248 ± 0.071	5.536GlyThr: 5.536 ± 0.063	7.272GlyVal: 7.272 ± 0.06	1.53GlyTrp: 1.53 ± 0.034	2.391GlyTyr: 2.391 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.574HisAla: 2.574 ± 0.044	0.197HisCys: 0.197 ± 0.012	1.342HisAsp: 1.342 ± 0.026	1.118HisGlu: 1.118 ± 0.025	0.621HisPhe: 0.621 ± 0.02	2.112HisGly: 2.112 ± 0.034	0.659HisHis: 0.659 ± 0.026	0.85HisIle: 0.85 ± 0.022	0.335HisLys: 0.335 ± 0.015	2.148HisLeu: 2.148 ± 0.034	0.33HisMet: 0.33 ± 0.013	0.455HisAsn: 0.455 ± 0.019	1.767HisPro: 1.767 ± 0.038	0.628HisGln: 0.628 ± 0.019	2.04HisArg: 2.04 ± 0.037	1.094HisSer: 1.094 ± 0.025	1.258HisThr: 1.258 ± 0.025	1.438HisVal: 1.438 ± 0.034	0.343HisTrp: 0.343 ± 0.014	0.522HisTyr: 0.522 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.748IleAla: 6.748 ± 0.069	0.315IleCys: 0.315 ± 0.014	3.587IleAsp: 3.587 ± 0.043	2.79IleGlu: 2.79 ± 0.042	0.979IlePhe: 0.979 ± 0.027	4.509IleGly: 4.509 ± 0.054	0.708IleHis: 0.708 ± 0.019	1.383IleIle: 1.383 ± 0.035	0.713IleLys: 0.713 ± 0.022	3.086IleLeu: 3.086 ± 0.046	0.588IleMet: 0.588 ± 0.02	0.895IleAsn: 0.895 ± 0.028	2.351IlePro: 2.351 ± 0.037	0.887IleGln: 0.887 ± 0.025	2.764IleArg: 2.764 ± 0.041	2.122IleSer: 2.122 ± 0.034	2.79IleThr: 2.79 ± 0.044	3.629IleVal: 3.629 ± 0.048	0.452IleTrp: 0.452 ± 0.016	0.766IleTyr: 0.766 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	2.427LysAla: 2.427 ± 0.047	0.093LysCys: 0.093 ± 0.008	0.956LysAsp: 0.956 ± 0.027	0.88LysGlu: 0.88 ± 0.026	0.604LysPhe: 0.604 ± 0.019	1.386LysGly: 1.386 ± 0.034	0.436LysHis: 0.436 ± 0.016	0.969LysIle: 0.969 ± 0.028	0.613LysLys: 0.613 ± 0.024	2.078LysLeu: 2.078 ± 0.04	0.416LysMet: 0.416 ± 0.016	0.461LysAsn: 0.461 ± 0.018	1.364LysPro: 1.364 ± 0.03	0.727LysGln: 0.727 ± 0.022	1.382LysArg: 1.382 ± 0.033	1.114LysSer: 1.114 ± 0.031	1.208LysThr: 1.208 ± 0.029	1.694LysVal: 1.694 ± 0.038	0.267LysTrp: 0.267 ± 0.014	0.489LysTyr: 0.489 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	14.82LeuAla: 14.82 ± 0.11	0.743LeuCys: 0.743 ± 0.022	7.133LeuAsp: 7.133 ± 0.089	4.763LeuGlu: 4.763 ± 0.065	2.739LeuPhe: 2.739 ± 0.046	9.019LeuGly: 9.019 ± 0.074	2.11LeuHis: 2.11 ± 0.035	4.289LeuIle: 4.289 ± 0.052	1.425LeuLys: 1.425 ± 0.035	10.238LeuLeu: 10.238 ± 0.109	1.609LeuMet: 1.609 ± 0.034	1.822LeuAsn: 1.822 ± 0.034	6.156LeuPro: 6.156 ± 0.069	2.001LeuGln: 2.001 ± 0.03	8.382LeuArg: 8.382 ± 0.09	5.243LeuSer: 5.243 ± 0.05	6.706LeuThr: 6.706 ± 0.071	8.347LeuVal: 8.347 ± 0.08	1.15LeuTrp: 1.15 ± 0.026	1.662LeuTyr: 1.662 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	2.333MetAla: 2.333 ± 0.04	0.148MetCys: 0.148 ± 0.009	0.892MetAsp: 0.892 ± 0.023	0.687MetGlu: 0.687 ± 0.024	0.639MetPhe: 0.639 ± 0.02	1.387MetGly: 1.387 ± 0.029	0.393MetHis: 0.393 ± 0.014	0.938MetIle: 0.938 ± 0.023	0.393MetLys: 0.393 ± 0.014	2.005MetLeu: 2.005 ± 0.033	0.384MetMet: 0.384 ± 0.016	0.491MetAsn: 0.491 ± 0.017	1.195MetPro: 1.195 ± 0.03	0.517MetGln: 0.517 ± 0.018	1.576MetArg: 1.576 ± 0.032	1.448MetSer: 1.448 ± 0.033	1.602MetThr: 1.602 ± 0.032	1.638MetVal: 1.638 ± 0.029	0.265MetTrp: 0.265 ± 0.014	0.344MetTyr: 0.344 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.402AsnAla: 2.402 ± 0.034	0.162AsnCys: 0.162 ± 0.009	1.051AsnAsp: 1.051 ± 0.028	0.897AsnGlu: 0.897 ± 0.025	0.556AsnPhe: 0.556 ± 0.02	1.885AsnGly: 1.885 ± 0.043	0.429AsnHis: 0.429 ± 0.017	0.831AsnIle: 0.831 ± 0.024	0.424AsnLys: 0.424 ± 0.016	1.88AsnLeu: 1.88 ± 0.037	0.361AsnMet: 0.361 ± 0.015	0.508AsnAsn: 0.508 ± 0.02	1.625AsnPro: 1.625 ± 0.039	0.59AsnGln: 0.59 ± 0.022	1.502AsnArg: 1.502 ± 0.032	1.089AsnSer: 1.089 ± 0.024	1.223AsnThr: 1.223 ± 0.027	1.464AsnVal: 1.464 ± 0.031	0.342AsnTrp: 0.342 ± 0.014	0.467AsnTyr: 0.467 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	8.475ProAla: 8.475 ± 0.106	0.284ProCys: 0.284 ± 0.012	4.653ProAsp: 4.653 ± 0.065	4.415ProGlu: 4.415 ± 0.054	1.544ProPhe: 1.544 ± 0.035	6.222ProGly: 6.222 ± 0.075	1.254ProHis: 1.254 ± 0.031	2.28ProIle: 2.28 ± 0.034	1.17ProLys: 1.17 ± 0.027	4.936ProLeu: 4.936 ± 0.061	1.135ProMet: 1.135 ± 0.028	1.18ProAsn: 1.18 ± 0.026	3.551ProPro: 3.551 ± 0.105	1.895ProGln: 1.895 ± 0.048	3.618ProArg: 3.618 ± 0.053	3.07ProSer: 3.07 ± 0.052	3.426ProThr: 3.426 ± 0.054	5.35ProVal: 5.35 ± 0.076	0.813ProTrp: 0.813 ± 0.023	1.104ProTyr: 1.104 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.609GlnAla: 3.609 ± 0.056	0.181GlnCys: 0.181 ± 0.011	1.121GlnAsp: 1.121 ± 0.026	1.158GlnGlu: 1.158 ± 0.031	0.899GlnPhe: 0.899 ± 0.023	1.876GlnGly: 1.876 ± 0.04	0.729GlnHis: 0.729 ± 0.019	1.43GlnIle: 1.43 ± 0.03	0.502GlnLys: 0.502 ± 0.019	3.597GlnLeu: 3.597 ± 0.048	0.607GlnMet: 0.607 ± 0.02	0.537GlnAsn: 0.537 ± 0.017	2.015GlnPro: 2.015 ± 0.038	1.441GlnGln: 1.441 ± 0.04	2.853GlnArg: 2.853 ± 0.052	1.284GlnSer: 1.284 ± 0.027	1.45GlnThr: 1.45 ± 0.028	2.728GlnVal: 2.728 ± 0.058	0.519GlnTrp: 0.519 ± 0.019	0.619GlnTyr: 0.619 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	9.463ArgAla: 9.463 ± 0.084	0.523ArgCys: 0.523 ± 0.018	4.362ArgAsp: 4.362 ± 0.062	4.4ArgGlu: 4.4 ± 0.053	2.473ArgPhe: 2.473 ± 0.041	5.259ArgGly: 5.259 ± 0.058	1.767ArgHis: 1.767 ± 0.034	3.755ArgIle: 3.755 ± 0.045	1.695ArgLys: 1.695 ± 0.036	7.812ArgLeu: 7.812 ± 0.084	1.981ArgMet: 1.981 ± 0.037	1.535ArgAsn: 1.535 ± 0.036	4.405ArgPro: 4.405 ± 0.066	2.252ArgGln: 2.252 ± 0.038	6.906ArgArg: 6.906 ± 0.102	4.041ArgSer: 4.041 ± 0.047	5.069ArgThr: 5.069 ± 0.052	5.684ArgVal: 5.684 ± 0.055	1.357ArgTrp: 1.357 ± 0.027	1.86ArgTyr: 1.86 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	7.014SerAla: 7.014 ± 0.068	0.347SerCys: 0.347 ± 0.015	2.941SerAsp: 2.941 ± 0.043	2.622SerGlu: 2.622 ± 0.039	1.539SerPhe: 1.539 ± 0.03	5.854SerGly: 5.854 ± 0.065	0.921SerHis: 0.921 ± 0.021	2.023SerIle: 2.023 ± 0.035	1.052SerLys: 1.052 ± 0.024	4.354SerLeu: 4.354 ± 0.052	1.274SerMet: 1.274 ± 0.024	0.986SerAsn: 0.986 ± 0.028	2.942SerPro: 2.942 ± 0.044	1.212SerGln: 1.212 ± 0.029	3.488SerArg: 3.488 ± 0.045	2.842SerSer: 2.842 ± 0.054	3.383SerThr: 3.383 ± 0.047	4.173SerVal: 4.173 ± 0.049	0.89SerTrp: 0.89 ± 0.025	1.143SerTyr: 1.143 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	8.472ThrAla: 8.472 ± 0.083	0.401ThrCys: 0.401 ± 0.015	3.975ThrAsp: 3.975 ± 0.052	3.67ThrGlu: 3.67 ± 0.054	1.685ThrPhe: 1.685 ± 0.034	6.243ThrGly: 6.243 ± 0.056	1.214ThrHis: 1.214 ± 0.03	2.485ThrIle: 2.485 ± 0.039	1.145ThrLys: 1.145 ± 0.029	5.617ThrLeu: 5.617 ± 0.06	1.168ThrMet: 1.168 ± 0.026	1.145ThrAsn: 1.145 ± 0.031	3.984ThrPro: 3.984 ± 0.059	1.441ThrGln: 1.441 ± 0.032	3.786ThrArg: 3.786 ± 0.05	3.002ThrSer: 3.002 ± 0.036	4.105ThrThr: 4.105 ± 0.065	5.98ThrVal: 5.98 ± 0.062	0.815ThrTrp: 0.815 ± 0.024	1.212ThrTyr: 1.212 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	11.252ValAla: 11.252 ± 0.117	0.663ValCys: 0.663 ± 0.021	5.449ValAsp: 5.449 ± 0.063	4.508ValGlu: 4.508 ± 0.05	2.503ValPhe: 2.503 ± 0.038	6.504ValGly: 6.504 ± 0.071	1.851ValHis: 1.851 ± 0.033	3.702ValIle: 3.702 ± 0.05	1.432ValLys: 1.432 ± 0.03	9.238ValLeu: 9.238 ± 0.094	1.393ValMet: 1.393 ± 0.024	1.695ValAsn: 1.695 ± 0.036	4.931ValPro: 4.931 ± 0.068	2.075ValGln: 2.075 ± 0.031	6.539ValArg: 6.539 ± 0.061	4.252ValSer: 4.252 ± 0.047	5.223ValThr: 5.223 ± 0.06	8.102ValVal: 8.102 ± 0.093	1.018ValTrp: 1.018 ± 0.026	1.571ValTyr: 1.571 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.528TrpAla: 1.528 ± 0.03	0.126TrpCys: 0.126 ± 0.009	0.749TrpAsp: 0.749 ± 0.022	0.672TrpGlu: 0.672 ± 0.021	0.505TrpPhe: 0.505 ± 0.02	0.928TrpGly: 0.928 ± 0.027	0.32TrpHis: 0.32 ± 0.014	0.614TrpIle: 0.614 ± 0.019	0.308TrpLys: 0.308 ± 0.013	1.722TrpLeu: 1.722 ± 0.032	0.335TrpMet: 0.335 ± 0.015	0.402TrpAsn: 0.402 ± 0.018	0.754TrpPro: 0.754 ± 0.02	0.636TrpGln: 0.636 ± 0.022	1.224TrpArg: 1.224 ± 0.028	0.965TrpSer: 0.965 ± 0.024	0.934TrpThr: 0.934 ± 0.022	1.069TrpVal: 1.069 ± 0.024	0.342TrpTrp: 0.342 ± 0.015	0.32TrpTyr: 0.32 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.463TyrAla: 2.463 ± 0.04	0.192TyrCys: 0.192 ± 0.011	1.293TyrAsp: 1.293 ± 0.034	1.022TyrGlu: 1.022 ± 0.027	0.679TyrPhe: 0.679 ± 0.021	1.986TyrGly: 1.986 ± 0.038	0.421TyrHis: 0.421 ± 0.018	0.65TyrIle: 0.65 ± 0.021	0.305TyrLys: 0.305 ± 0.017	2.444TyrLeu: 2.444 ± 0.038	0.293TyrMet: 0.293 ± 0.014	0.42TyrAsn: 0.42 ± 0.016	1.205TyrPro: 1.205 ± 0.029	0.702TyrGln: 0.702 ± 0.02	2.011TyrArg: 2.011 ± 0.037	1.08TyrSer: 1.08 ± 0.025	1.176TyrThr: 1.176 ± 0.029	1.57TyrVal: 1.57 ± 0.037	0.35TyrTrp: 0.35 ± 0.016	0.446TyrTyr: 0.446 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5473 proteins (1788460 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---