Amino acid dipepetide frequency for Drosophila mojavensis (Fruit fly)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.459AlaAla: 10.459 ± 0.101	1.137AlaCys: 1.137 ± 0.02	3.655AlaAsp: 3.655 ± 0.022	4.896AlaGlu: 4.896 ± 0.038	2.125AlaPhe: 2.125 ± 0.017	4.813AlaGly: 4.813 ± 0.035	1.767AlaHis: 1.767 ± 0.013	3.595AlaIle: 3.595 ± 0.021	4.136AlaLys: 4.136 ± 0.028	6.68AlaLeu: 6.68 ± 0.034	1.75AlaMet: 1.75 ± 0.015	3.562AlaAsn: 3.562 ± 0.023	3.989AlaPro: 3.989 ± 0.038	3.657AlaGln: 3.657 ± 0.022	3.449AlaArg: 3.449 ± 0.019	6.244AlaSer: 6.244 ± 0.037	5.323AlaThr: 5.323 ± 0.034	4.48AlaVal: 4.48 ± 0.024	0.59AlaTrp: 0.59 ± 0.008	1.766AlaTyr: 1.766 ± 0.014	0.001AlaXaa: 0.001 ± 0.0
Cys	1.214CysAla: 1.214 ± 0.019	0.498CysCys: 0.498 ± 0.009	1.038CysAsp: 1.038 ± 0.015	1.105CysGlu: 1.105 ± 0.015	0.685CysPhe: 0.685 ± 0.01	1.228CysGly: 1.228 ± 0.023	0.47CysHis: 0.47 ± 0.008	0.995CysIle: 0.995 ± 0.016	0.943CysLys: 0.943 ± 0.011	1.715CysLeu: 1.715 ± 0.021	0.397CysMet: 0.397 ± 0.006	0.889CysAsn: 0.889 ± 0.014	0.89CysPro: 0.89 ± 0.025	0.818CysGln: 0.818 ± 0.019	1.033CysArg: 1.033 ± 0.025	1.521CysSer: 1.521 ± 0.02	0.951CysThr: 0.951 ± 0.015	1.115CysVal: 1.115 ± 0.02	0.198CysTrp: 0.198 ± 0.004	0.545CysTyr: 0.545 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.039AspAla: 4.039 ± 0.024	0.986AspCys: 0.986 ± 0.018	3.925AspAsp: 3.925 ± 0.032	4.364AspGlu: 4.364 ± 0.029	2.062AspPhe: 2.062 ± 0.016	3.042AspGly: 3.042 ± 0.026	1.048AspHis: 1.048 ± 0.011	2.985AspIle: 2.985 ± 0.02	2.79AspLys: 2.79 ± 0.026	4.653AspLeu: 4.653 ± 0.031	1.313AspMet: 1.313 ± 0.012	2.487AspAsn: 2.487 ± 0.015	2.307AspPro: 2.307 ± 0.028	1.884AspGln: 1.884 ± 0.015	2.431AspArg: 2.431 ± 0.023	3.874AspSer: 3.874 ± 0.023	2.527AspThr: 2.527 ± 0.017	3.374AspVal: 3.374 ± 0.023	0.579AspTrp: 0.579 ± 0.008	1.813AspTyr: 1.813 ± 0.014	0.001AspXaa: 0.001 ± 0.0
Glu	4.602GluAla: 4.602 ± 0.038	1.089GluCys: 1.089 ± 0.024	3.668GluAsp: 3.668 ± 0.025	5.654GluGlu: 5.654 ± 0.054	2.025GluPhe: 2.025 ± 0.014	2.642GluGly: 2.642 ± 0.024	1.709GluHis: 1.709 ± 0.016	3.216GluIle: 3.216 ± 0.024	4.076GluLys: 4.076 ± 0.039	6.656GluLeu: 6.656 ± 0.043	1.501GluMet: 1.501 ± 0.014	2.84GluAsn: 2.84 ± 0.017	2.92GluPro: 2.92 ± 0.03	4.072GluGln: 4.072 ± 0.033	4.286GluArg: 4.286 ± 0.041	4.437GluSer: 4.437 ± 0.032	3.444GluThr: 3.444 ± 0.029	3.436GluVal: 3.436 ± 0.044	0.549GluTrp: 0.549 ± 0.007	1.731GluTyr: 1.731 ± 0.014	0.001GluXaa: 0.001 ± 0.0
Phe	2.172PheAla: 2.172 ± 0.017	0.687PheCys: 0.687 ± 0.009	2.053PheAsp: 2.053 ± 0.016	2.049PheGlu: 2.049 ± 0.013	1.361PhePhe: 1.361 ± 0.018	2.245PheGly: 2.245 ± 0.02	0.851PheHis: 0.851 ± 0.008	1.89PheIle: 1.89 ± 0.016	1.882PheLys: 1.882 ± 0.013	3.104PheLeu: 3.104 ± 0.025	0.86PheMet: 0.86 ± 0.009	1.705PheAsn: 1.705 ± 0.015	1.321PhePro: 1.321 ± 0.012	1.357PheGln: 1.357 ± 0.011	1.76PheArg: 1.76 ± 0.013	2.432PheSer: 2.432 ± 0.017	1.778PheThr: 1.778 ± 0.017	2.312PheVal: 2.312 ± 0.017	0.394PheTrp: 0.394 ± 0.006	1.22PheTyr: 1.22 ± 0.014	0.001PheXaa: 0.001 ± 0.0
Gly	4.536GlyAla: 4.536 ± 0.038	0.976GlyCys: 0.976 ± 0.018	2.891GlyAsp: 2.891 ± 0.022	2.996GlyGlu: 2.996 ± 0.021	1.986GlyPhe: 1.986 ± 0.016	5.701GlyGly: 5.701 ± 0.072	1.486GlyHis: 1.486 ± 0.015	2.864GlyIle: 2.864 ± 0.02	2.909GlyLys: 2.909 ± 0.02	4.499GlyLeu: 4.499 ± 0.025	1.278GlyMet: 1.278 ± 0.013	3.069GlyAsn: 3.069 ± 0.031	2.228GlyPro: 2.228 ± 0.031	2.413GlyGln: 2.413 ± 0.024	2.903GlyArg: 2.903 ± 0.019	5.499GlySer: 5.499 ± 0.039	3.049GlyThr: 3.049 ± 0.025	3.419GlyVal: 3.419 ± 0.027	0.607GlyTrp: 0.607 ± 0.009	1.931GlyTyr: 1.931 ± 0.018	0.001GlyXaa: 0.001 ± 0.0
His	1.665HisAla: 1.665 ± 0.013	0.55HisCys: 0.55 ± 0.009	1.089HisAsp: 1.089 ± 0.011	1.479HisGlu: 1.479 ± 0.012	0.968HisPhe: 0.968 ± 0.009	1.439HisGly: 1.439 ± 0.013	1.251HisHis: 1.251 ± 0.02	1.374HisIle: 1.374 ± 0.013	1.35HisLys: 1.35 ± 0.011	2.491HisLeu: 2.491 ± 0.019	0.724HisMet: 0.724 ± 0.009	1.259HisAsn: 1.259 ± 0.012	1.321HisPro: 1.321 ± 0.014	1.574HisGln: 1.574 ± 0.02	1.4HisArg: 1.4 ± 0.013	2.177HisSer: 2.177 ± 0.018	1.335HisThr: 1.335 ± 0.013	1.437HisVal: 1.437 ± 0.013	0.278HisTrp: 0.278 ± 0.005	0.843HisTyr: 0.843 ± 0.009	0.0HisXaa: 0.0 ± 0.0
Ile	3.537IleAla: 3.537 ± 0.023	1.171IleCys: 1.171 ± 0.016	2.912IleAsp: 2.912 ± 0.022	3.417IleGlu: 3.417 ± 0.025	2.079IlePhe: 2.079 ± 0.021	2.684IleGly: 2.684 ± 0.02	1.084IleHis: 1.084 ± 0.011	2.858IleIle: 2.858 ± 0.019	2.972IleLys: 2.972 ± 0.021	4.161IleLeu: 4.161 ± 0.025	1.167IleMet: 1.167 ± 0.012	2.57IleAsn: 2.57 ± 0.018	2.268IlePro: 2.268 ± 0.018	1.973IleGln: 1.973 ± 0.014	2.441IleArg: 2.441 ± 0.017	4.133IleSer: 4.133 ± 0.024	2.873IleThr: 2.873 ± 0.019	3.284IleVal: 3.284 ± 0.02	0.529IleTrp: 0.529 ± 0.008	1.749IleTyr: 1.749 ± 0.014	0.002IleXaa: 0.002 ± 0.0
Lys	3.629LysAla: 3.629 ± 0.028	1.093LysCys: 1.093 ± 0.016	2.863LysAsp: 2.863 ± 0.021	3.825LysGlu: 3.825 ± 0.032	1.821LysPhe: 1.821 ± 0.016	2.275LysGly: 2.275 ± 0.022	1.431LysHis: 1.431 ± 0.013	2.782LysIle: 2.782 ± 0.021	3.96LysLys: 3.96 ± 0.041	5.543LysLeu: 5.543 ± 0.037	1.387LysMet: 1.387 ± 0.012	2.377LysAsn: 2.377 ± 0.016	3.059LysPro: 3.059 ± 0.038	2.994LysGln: 2.994 ± 0.022	3.721LysArg: 3.721 ± 0.024	4.213LysSer: 4.213 ± 0.027	3.087LysThr: 3.087 ± 0.024	2.937LysVal: 2.937 ± 0.019	0.574LysTrp: 0.574 ± 0.007	1.781LysTyr: 1.781 ± 0.015	0.001LysXaa: 0.001 ± 0.0
Leu	6.668LeuAla: 6.668 ± 0.033	1.722LeuCys: 1.722 ± 0.016	4.963LeuAsp: 4.963 ± 0.038	6.232LeuGlu: 6.232 ± 0.052	2.927LeuPhe: 2.927 ± 0.021	4.634LeuGly: 4.634 ± 0.02	2.514LeuHis: 2.514 ± 0.018	4.435LeuIle: 4.435 ± 0.03	5.349LeuLys: 5.349 ± 0.03	9.311LeuLeu: 9.311 ± 0.06	2.102LeuMet: 2.102 ± 0.015	4.511LeuAsn: 4.511 ± 0.025	5.115LeuPro: 5.115 ± 0.028	5.602LeuGln: 5.602 ± 0.041	5.657LeuArg: 5.657 ± 0.036	7.094LeuSer: 7.094 ± 0.025	4.909LeuThr: 4.909 ± 0.022	4.923LeuVal: 4.923 ± 0.029	0.841LeuTrp: 0.841 ± 0.01	2.496LeuTyr: 2.496 ± 0.018	0.004LeuXaa: 0.004 ± 0.001
Met	1.793MetAla: 1.793 ± 0.014	0.403MetCys: 0.403 ± 0.006	1.359MetAsp: 1.359 ± 0.011	1.573MetGlu: 1.573 ± 0.014	0.795MetPhe: 0.795 ± 0.01	1.356MetGly: 1.356 ± 0.015	0.666MetHis: 0.666 ± 0.008	0.932MetIle: 0.932 ± 0.011	1.22MetLys: 1.22 ± 0.012	2.276MetLeu: 2.276 ± 0.018	0.588MetMet: 0.588 ± 0.008	1.038MetAsn: 1.038 ± 0.011	1.391MetPro: 1.391 ± 0.015	1.371MetGln: 1.371 ± 0.014	1.467MetArg: 1.467 ± 0.012	1.862MetSer: 1.862 ± 0.014	1.139MetThr: 1.139 ± 0.011	1.146MetVal: 1.146 ± 0.01	0.223MetTrp: 0.223 ± 0.005	0.644MetTyr: 0.644 ± 0.007	0.001MetXaa: 0.001 ± 0.0
Asn	3.762AsnAla: 3.762 ± 0.024	0.951AsnCys: 0.951 ± 0.014	2.511AsnAsp: 2.511 ± 0.019	3.058AsnGlu: 3.058 ± 0.02	1.744AsnPhe: 1.744 ± 0.014	3.499AsnGly: 3.499 ± 0.039	1.079AsnHis: 1.079 ± 0.012	2.689AsnIle: 2.689 ± 0.019	2.488AsnLys: 2.488 ± 0.016	4.172AsnLeu: 4.172 ± 0.023	1.228AsnMet: 1.228 ± 0.011	3.832AsnAsn: 3.832 ± 0.04	2.048AsnPro: 2.048 ± 0.022	1.923AsnGln: 1.923 ± 0.016	2.322AsnArg: 2.322 ± 0.016	4.396AsnSer: 4.396 ± 0.035	2.557AsnThr: 2.557 ± 0.017	2.942AsnVal: 2.942 ± 0.018	0.513AsnTrp: 0.513 ± 0.009	1.588AsnTyr: 1.588 ± 0.014	0.001AsnXaa: 0.001 ± 0.0
Pro	4.437ProAla: 4.437 ± 0.038	0.71ProCys: 0.71 ± 0.031	2.45ProAsp: 2.45 ± 0.017	3.235ProGlu: 3.235 ± 0.033	1.532ProPhe: 1.532 ± 0.013	2.774ProGly: 2.774 ± 0.04	1.404ProHis: 1.404 ± 0.016	2.439ProIle: 2.439 ± 0.02	2.913ProLys: 2.913 ± 0.027	4.366ProLeu: 4.366 ± 0.023	1.106ProMet: 1.106 ± 0.013	2.381ProAsn: 2.381 ± 0.022	4.629ProPro: 4.629 ± 0.058	2.833ProGln: 2.833 ± 0.028	2.41ProArg: 2.41 ± 0.019	4.182ProSer: 4.182 ± 0.034	3.645ProThr: 3.645 ± 0.028	3.122ProVal: 3.122 ± 0.022	0.432ProTrp: 0.432 ± 0.007	1.411ProTyr: 1.411 ± 0.013	0.001ProXaa: 0.001 ± 0.0
Gln	3.531GlnAla: 3.531 ± 0.022	0.819GlnCys: 0.819 ± 0.017	1.91GlnAsp: 1.91 ± 0.016	3.001GlnGlu: 3.001 ± 0.025	1.501GlnPhe: 1.501 ± 0.012	1.925GlnGly: 1.925 ± 0.018	1.981GlnHis: 1.981 ± 0.022	2.265GlnIle: 2.265 ± 0.016	2.618GlnLys: 2.618 ± 0.022	6.049GlnLeu: 6.049 ± 0.044	1.297GlnMet: 1.297 ± 0.014	1.999GlnAsn: 1.999 ± 0.016	3.133GlnPro: 3.133 ± 0.03	9.767GlnGln: 9.767 ± 0.158	3.599GlnArg: 3.599 ± 0.025	3.674GlnSer: 3.674 ± 0.024	2.654GlnThr: 2.654 ± 0.018	2.432GlnVal: 2.432 ± 0.017	0.438GlnTrp: 0.438 ± 0.006	1.306GlnTyr: 1.306 ± 0.012	0.001GlnXaa: 0.001 ± 0.0
Arg	3.572ArgAla: 3.572 ± 0.021	1.049ArgCys: 1.049 ± 0.021	2.897ArgAsp: 2.897 ± 0.024	3.647ArgGlu: 3.647 ± 0.037	1.886ArgPhe: 1.886 ± 0.015	2.729ArgGly: 2.729 ± 0.021	1.532ArgHis: 1.532 ± 0.012	2.774ArgIle: 2.774 ± 0.017	3.507ArgLys: 3.507 ± 0.023	5.226ArgLeu: 5.226 ± 0.038	1.215ArgMet: 1.215 ± 0.011	2.743ArgAsn: 2.743 ± 0.019	2.649ArgPro: 2.649 ± 0.025	3.069ArgGln: 3.069 ± 0.026	4.339ArgArg: 4.339 ± 0.03	4.424ArgSer: 4.424 ± 0.031	2.743ArgThr: 2.743 ± 0.016	2.829ArgVal: 2.829 ± 0.017	0.553ArgTrp: 0.553 ± 0.008	1.675ArgTyr: 1.675 ± 0.015	0.002ArgXaa: 0.002 ± 0.0
Ser	6.156SerAla: 6.156 ± 0.037	1.446SerCys: 1.446 ± 0.022	4.038SerAsp: 4.038 ± 0.028	4.464SerGlu: 4.464 ± 0.027	2.53SerPhe: 2.53 ± 0.018	5.356SerGly: 5.356 ± 0.038	1.874SerHis: 1.874 ± 0.018	3.917SerIle: 3.917 ± 0.021	4.145SerLys: 4.145 ± 0.03	6.799SerLeu: 6.799 ± 0.031	1.782SerMet: 1.782 ± 0.014	4.664SerAsn: 4.664 ± 0.036	4.402SerPro: 4.402 ± 0.037	3.536SerGln: 3.536 ± 0.022	3.932SerArg: 3.932 ± 0.026	10.213SerSer: 10.213 ± 0.086	5.495SerThr: 5.495 ± 0.038	4.476SerVal: 4.476 ± 0.026	0.742SerTrp: 0.742 ± 0.008	2.221SerTyr: 2.221 ± 0.016	0.002SerXaa: 0.002 ± 0.001
Thr	5.186ThrAla: 5.186 ± 0.036	0.965ThrCys: 0.965 ± 0.015	2.736ThrAsp: 2.736 ± 0.022	3.396ThrGlu: 3.396 ± 0.027	1.825ThrPhe: 1.825 ± 0.015	3.293ThrGly: 3.293 ± 0.024	1.368ThrHis: 1.368 ± 0.014	2.899ThrIle: 2.899 ± 0.02	2.93ThrLys: 2.93 ± 0.024	5.166ThrLeu: 5.166 ± 0.025	1.218ThrMet: 1.218 ± 0.012	2.653ThrAsn: 2.653 ± 0.019	4.001ThrPro: 4.001 ± 0.036	2.51ThrGln: 2.51 ± 0.018	2.557ThrArg: 2.557 ± 0.016	4.804ThrSer: 4.804 ± 0.029	5.506ThrThr: 5.506 ± 0.081	3.515ThrVal: 3.515 ± 0.024	0.482ThrTrp: 0.482 ± 0.007	1.503ThrTyr: 1.503 ± 0.015	0.002ThrXaa: 0.002 ± 0.0
Val	4.566ValAla: 4.566 ± 0.025	1.163ValCys: 1.163 ± 0.016	3.271ValAsp: 3.271 ± 0.024	3.825ValGlu: 3.825 ± 0.03	1.963ValPhe: 1.963 ± 0.014	3.301ValGly: 3.301 ± 0.022	1.431ValHis: 1.431 ± 0.014	2.962ValIle: 2.962 ± 0.019	3.083ValLys: 3.083 ± 0.023	5.338ValLeu: 5.338 ± 0.029	1.27ValMet: 1.27 ± 0.011	2.691ValAsn: 2.691 ± 0.016	3.107ValPro: 3.107 ± 0.021	2.678ValGln: 2.678 ± 0.017	3.044ValArg: 3.044 ± 0.019	4.153ValSer: 4.153 ± 0.023	3.331ValThr: 3.331 ± 0.039	3.71ValVal: 3.71 ± 0.022	0.565ValTrp: 0.565 ± 0.008	1.682ValTyr: 1.682 ± 0.013	0.002ValXaa: 0.002 ± 0.0
Trp	0.558TrpAla: 0.558 ± 0.008	0.186TrpCys: 0.186 ± 0.004	0.49TrpAsp: 0.49 ± 0.006	0.503TrpGlu: 0.503 ± 0.007	0.354TrpPhe: 0.354 ± 0.006	0.461TrpGly: 0.461 ± 0.007	0.267TrpHis: 0.267 ± 0.005	0.511TrpIle: 0.511 ± 0.007	0.506TrpLys: 0.506 ± 0.008	1.159TrpLeu: 1.159 ± 0.014	0.258TrpMet: 0.258 ± 0.005	0.492TrpAsn: 0.492 ± 0.008	0.379TrpPro: 0.379 ± 0.006	0.532TrpGln: 0.532 ± 0.007	0.658TrpArg: 0.658 ± 0.008	0.733TrpSer: 0.733 ± 0.01	0.554TrpThr: 0.554 ± 0.009	0.51TrpVal: 0.51 ± 0.008	0.152TrpTrp: 0.152 ± 0.004	0.31TrpTyr: 0.31 ± 0.006	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.992TyrAla: 1.992 ± 0.013	0.646TyrCys: 0.646 ± 0.008	1.765TyrAsp: 1.765 ± 0.013	1.835TyrGlu: 1.835 ± 0.011	1.265TyrPhe: 1.265 ± 0.014	1.844TyrGly: 1.844 ± 0.018	0.789TyrHis: 0.789 ± 0.01	1.477TyrIle: 1.477 ± 0.014	1.574TyrLys: 1.574 ± 0.012	2.639TyrLeu: 2.639 ± 0.018	0.802TyrMet: 0.802 ± 0.009	1.541TyrAsn: 1.541 ± 0.013	1.251TyrPro: 1.251 ± 0.015	1.333TyrGln: 1.333 ± 0.012	1.649TyrArg: 1.649 ± 0.014	2.126TyrSer: 2.126 ± 0.018	1.617TyrThr: 1.617 ± 0.013	1.737TyrVal: 1.737 ± 0.014	0.334TyrTrp: 0.334 ± 0.006	1.161TyrTyr: 1.161 ± 0.013	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.001XaaCys: 0.001 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.003XaaHis: 0.003 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.0	0.003XaaLeu: 0.003 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.002XaaPro: 0.002 ± 0.0	0.003XaaGln: 0.003 ± 0.0	0.002XaaArg: 0.002 ± 0.0	0.002XaaSer: 0.002 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.001XaaTrp: 0.001 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	0.005XaaXaa: 0.005 ± 0.002

Statistics based on 18165 proteins (11695963 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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