Amino acid dipepetide frequency for Tibeticola sediminis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.058AlaAla: 21.058 ± 0.242
1.316AlaCys: 1.316 ± 0.039
6.339AlaAsp: 6.339 ± 0.1
8.13AlaGlu: 8.13 ± 0.116
4.12AlaPhe: 4.12 ± 0.084
10.227AlaGly: 10.227 ± 0.111
3.023AlaHis: 3.023 ± 0.067
4.939AlaIle: 4.939 ± 0.078
3.323AlaLys: 3.323 ± 0.078
17.337AlaLeu: 17.337 ± 0.222
3.264AlaMet: 3.264 ± 0.059
2.451AlaAsn: 2.451 ± 0.064
7.197AlaPro: 7.197 ± 0.136
6.632AlaGln: 6.632 ± 0.103
11.292AlaArg: 11.292 ± 0.155
6.449AlaSer: 6.449 ± 0.099
5.826AlaThr: 5.826 ± 0.108
9.617AlaVal: 9.617 ± 0.141
2.435AlaTrp: 2.435 ± 0.066
2.552AlaTyr: 2.552 ± 0.056
0.0AlaXaa: 0.0 ± 0.0
Cys
1.279CysAla: 1.279 ± 0.04
0.108CysCys: 0.108 ± 0.011
0.515CysAsp: 0.515 ± 0.026
0.484CysGlu: 0.484 ± 0.026
0.265CysPhe: 0.265 ± 0.019
1.0CysGly: 1.0 ± 0.034
0.3CysHis: 0.3 ± 0.024
0.397CysIle: 0.397 ± 0.022
0.209CysLys: 0.209 ± 0.016
0.766CysLeu: 0.766 ± 0.03
0.195CysMet: 0.195 ± 0.016
0.218CysAsn: 0.218 ± 0.017
0.614CysPro: 0.614 ± 0.028
0.209CysGln: 0.209 ± 0.016
0.632CysArg: 0.632 ± 0.027
0.462CysSer: 0.462 ± 0.024
0.505CysThr: 0.505 ± 0.024
0.687CysVal: 0.687 ± 0.029
0.117CysTrp: 0.117 ± 0.011
0.191CysTyr: 0.191 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
7.847AspAla: 7.847 ± 0.127
0.448AspCys: 0.448 ± 0.023
2.36AspAsp: 2.36 ± 0.063
3.284AspGlu: 3.284 ± 0.065
1.893AspPhe: 1.893 ± 0.049
4.157AspGly: 4.157 ± 0.072
1.003AspHis: 1.003 ± 0.033
2.061AspIle: 2.061 ± 0.053
1.257AspLys: 1.257 ± 0.047
5.324AspLeu: 5.324 ± 0.091
0.97AspMet: 0.97 ± 0.036
0.862AspAsn: 0.862 ± 0.034
3.322AspPro: 3.322 ± 0.064
1.345AspGln: 1.345 ± 0.041
3.553AspArg: 3.553 ± 0.065
1.735AspSer: 1.735 ± 0.049
2.243AspThr: 2.243 ± 0.054
3.702AspVal: 3.702 ± 0.066
1.055AspTrp: 1.055 ± 0.043
1.279AspTyr: 1.279 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
8.616GluAla: 8.616 ± 0.135
0.391GluCys: 0.391 ± 0.024
2.42GluAsp: 2.42 ± 0.059
2.731GluGlu: 2.731 ± 0.079
1.687GluPhe: 1.687 ± 0.051
4.3GluGly: 4.3 ± 0.073
1.456GluHis: 1.456 ± 0.043
2.779GluIle: 2.779 ± 0.072
1.704GluLys: 1.704 ± 0.054
5.993GluLeu: 5.993 ± 0.085
1.174GluMet: 1.174 ± 0.044
1.117GluAsn: 1.117 ± 0.04
3.402GluPro: 3.402 ± 0.076
2.599GluGln: 2.599 ± 0.065
6.408GluArg: 6.408 ± 0.104
2.5GluSer: 2.5 ± 0.059
2.68GluThr: 2.68 ± 0.053
4.499GluVal: 4.499 ± 0.077
0.793GluTrp: 0.793 ± 0.032
0.952GluTyr: 0.952 ± 0.04
0.0GluXaa: 0.0 ± 0.0
Phe
4.08PheAla: 4.08 ± 0.077
0.386PheCys: 0.386 ± 0.024
2.486PheAsp: 2.486 ± 0.058
2.335PheGlu: 2.335 ± 0.058
1.354PhePhe: 1.354 ± 0.045
3.263PheGly: 3.263 ± 0.062
0.682PheHis: 0.682 ± 0.033
1.452PheIle: 1.452 ± 0.043
1.007PheLys: 1.007 ± 0.038
2.954PheLeu: 2.954 ± 0.067
0.707PheMet: 0.707 ± 0.032
0.918PheAsn: 0.918 ± 0.033
1.437PhePro: 1.437 ± 0.044
0.978PheGln: 0.978 ± 0.031
1.873PheArg: 1.873 ± 0.053
1.86PheSer: 1.86 ± 0.052
1.612PheThr: 1.612 ± 0.039
2.65PheVal: 2.65 ± 0.056
0.557PheTrp: 0.557 ± 0.029
0.817PheTyr: 0.817 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
9.739GlyAla: 9.739 ± 0.128
0.989GlyCys: 0.989 ± 0.032
3.588GlyAsp: 3.588 ± 0.069
4.458GlyGlu: 4.458 ± 0.072
3.143GlyPhe: 3.143 ± 0.069
6.546GlyGly: 6.546 ± 0.124
1.978GlyHis: 1.978 ± 0.051
3.658GlyIle: 3.658 ± 0.074
2.794GlyLys: 2.794 ± 0.069
9.247GlyLeu: 9.247 ± 0.123
2.103GlyMet: 2.103 ± 0.05
1.758GlyAsn: 1.758 ± 0.048
3.463GlyPro: 3.463 ± 0.056
3.163GlyGln: 3.163 ± 0.061
6.023GlyArg: 6.023 ± 0.083
4.261GlySer: 4.261 ± 0.081
3.908GlyThr: 3.908 ± 0.081
6.716GlyVal: 6.716 ± 0.103
1.562GlyTrp: 1.562 ± 0.042
2.196GlyTyr: 2.196 ± 0.052
0.0GlyXaa: 0.0 ± 0.0
His
3.048HisAla: 3.048 ± 0.064
0.279HisCys: 0.279 ± 0.019
1.089HisAsp: 1.089 ± 0.035
1.201HisGlu: 1.201 ± 0.038
0.803HisPhe: 0.803 ± 0.03
2.174HisGly: 2.174 ± 0.05
0.624HisHis: 0.624 ± 0.029
0.949HisIle: 0.949 ± 0.035
0.497HisLys: 0.497 ± 0.027
2.219HisLeu: 2.219 ± 0.06
0.433HisMet: 0.433 ± 0.023
0.469HisAsn: 0.469 ± 0.025
1.712HisPro: 1.712 ± 0.048
0.686HisGln: 0.686 ± 0.028
1.752HisArg: 1.752 ± 0.047
0.902HisSer: 0.902 ± 0.036
1.113HisThr: 1.113 ± 0.036
1.531HisVal: 1.531 ± 0.041
0.432HisTrp: 0.432 ± 0.021
0.59HisTyr: 0.59 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
5.552IleAla: 5.552 ± 0.094
0.362IleCys: 0.362 ± 0.021
3.012IleAsp: 3.012 ± 0.06
3.723IleGlu: 3.723 ± 0.08
1.168IlePhe: 1.168 ± 0.042
3.866IleGly: 3.866 ± 0.082
0.883IleHis: 0.883 ± 0.031
1.45IleIle: 1.45 ± 0.048
1.256IleLys: 1.256 ± 0.044
3.37IleLeu: 3.37 ± 0.07
0.735IleMet: 0.735 ± 0.034
1.185IleAsn: 1.185 ± 0.041
1.946IlePro: 1.946 ± 0.052
1.216IleGln: 1.216 ± 0.035
2.769IleArg: 2.769 ± 0.057
1.974IleSer: 1.974 ± 0.05
2.071IleThr: 2.071 ± 0.051
3.414IleVal: 3.414 ± 0.069
0.509IleTrp: 0.509 ± 0.026
0.902IleTyr: 0.902 ± 0.032
0.0IleXaa: 0.0 ± 0.0
Lys
3.589LysAla: 3.589 ± 0.077
0.147LysCys: 0.147 ± 0.015
1.402LysAsp: 1.402 ± 0.041
1.314LysGlu: 1.314 ± 0.047
0.801LysPhe: 0.801 ± 0.036
2.129LysGly: 2.129 ± 0.063
0.539LysHis: 0.539 ± 0.023
1.326LysIle: 1.326 ± 0.046
1.326LysLys: 1.326 ± 0.046
2.992LysLeu: 2.992 ± 0.069
0.699LysMet: 0.699 ± 0.032
0.839LysAsn: 0.839 ± 0.037
1.984LysPro: 1.984 ± 0.055
0.907LysGln: 0.907 ± 0.034
2.056LysArg: 2.056 ± 0.059
1.456LysSer: 1.456 ± 0.048
1.658LysThr: 1.658 ± 0.046
2.151LysVal: 2.151 ± 0.075
0.28LysTrp: 0.28 ± 0.017
0.6LysTyr: 0.6 ± 0.028
0.0LysXaa: 0.0 ± 0.0
Leu
16.239LeuAla: 16.239 ± 0.199
1.007LeuCys: 1.007 ± 0.036
6.032LeuAsp: 6.032 ± 0.089
6.329LeuGlu: 6.329 ± 0.109
3.256LeuPhe: 3.256 ± 0.073
9.218LeuGly: 9.218 ± 0.137
2.435LeuHis: 2.435 ± 0.051
4.436LeuIle: 4.436 ± 0.073
3.251LeuLys: 3.251 ± 0.069
11.562LeuLeu: 11.562 ± 0.203
2.469LeuMet: 2.469 ± 0.064
2.394LeuAsn: 2.394 ± 0.058
6.382LeuPro: 6.382 ± 0.098
4.291LeuGln: 4.291 ± 0.083
9.078LeuArg: 9.078 ± 0.121
5.871LeuSer: 5.871 ± 0.092
5.135LeuThr: 5.135 ± 0.085
7.69LeuVal: 7.69 ± 0.108
1.588LeuTrp: 1.588 ± 0.055
2.015LeuTyr: 2.015 ± 0.046
0.0LeuXaa: 0.0 ± 0.0
Met
2.988MetAla: 2.988 ± 0.056
0.158MetCys: 0.158 ± 0.014
0.982MetAsp: 0.982 ± 0.043
0.972MetGlu: 0.972 ± 0.032
0.686MetPhe: 0.686 ± 0.03
1.739MetGly: 1.739 ± 0.053
0.505MetHis: 0.505 ± 0.023
0.865MetIle: 0.865 ± 0.035
0.975MetLys: 0.975 ± 0.037
2.392MetLeu: 2.392 ± 0.055
0.537MetMet: 0.537 ± 0.032
0.846MetAsn: 0.846 ± 0.029
1.38MetPro: 1.38 ± 0.043
0.899MetGln: 0.899 ± 0.035
1.652MetArg: 1.652 ± 0.047
1.419MetSer: 1.419 ± 0.037
1.39MetThr: 1.39 ± 0.049
1.492MetVal: 1.492 ± 0.049
0.191MetTrp: 0.191 ± 0.016
0.326MetTyr: 0.326 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
2.829AsnAla: 2.829 ± 0.062
0.279AsnCys: 0.279 ± 0.019
1.06AsnAsp: 1.06 ± 0.039
1.094AsnGlu: 1.094 ± 0.036
0.823AsnPhe: 0.823 ± 0.033
1.795AsnGly: 1.795 ± 0.044
0.434AsnHis: 0.434 ± 0.024
0.987AsnIle: 0.987 ± 0.036
0.651AsnLys: 0.651 ± 0.029
2.408AsnLeu: 2.408 ± 0.053
0.482AsnMet: 0.482 ± 0.024
0.561AsnAsn: 0.561 ± 0.029
1.835AsnPro: 1.835 ± 0.053
0.73AsnGln: 0.73 ± 0.036
1.565AsnArg: 1.565 ± 0.043
0.859AsnSer: 0.859 ± 0.034
1.221AsnThr: 1.221 ± 0.039
1.598AsnVal: 1.598 ± 0.048
0.362AsnTrp: 0.362 ± 0.018
0.546AsnTyr: 0.546 ± 0.028
0.0AsnXaa: 0.0 ± 0.0
Pro
7.669ProAla: 7.669 ± 0.127
0.405ProCys: 0.405 ± 0.021
3.208ProAsp: 3.208 ± 0.065
4.447ProGlu: 4.447 ± 0.076
1.816ProPhe: 1.816 ± 0.053
4.771ProGly: 4.771 ± 0.082
1.167ProHis: 1.167 ± 0.039
2.03ProIle: 2.03 ± 0.05
1.656ProLys: 1.656 ± 0.046
5.79ProLeu: 5.79 ± 0.098
1.334ProMet: 1.334 ± 0.04
1.362ProAsn: 1.362 ± 0.046
3.252ProPro: 3.252 ± 0.086
2.356ProGln: 2.356 ± 0.059
3.646ProArg: 3.646 ± 0.081
2.952ProSer: 2.952 ± 0.056
2.639ProThr: 2.639 ± 0.056
4.336ProVal: 4.336 ± 0.072
1.007ProTrp: 1.007 ± 0.036
1.182ProTyr: 1.182 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
5.889GlnAla: 5.889 ± 0.107
0.262GlnCys: 0.262 ± 0.02
1.352GlnAsp: 1.352 ± 0.041
1.589GlnGlu: 1.589 ± 0.051
1.167GlnPhe: 1.167 ± 0.038
2.871GlnGly: 2.871 ± 0.066
0.882GlnHis: 0.882 ± 0.034
1.756GlnIle: 1.756 ± 0.05
1.061GlnLys: 1.061 ± 0.038
3.787GlnLeu: 3.787 ± 0.072
0.872GlnMet: 0.872 ± 0.033
0.817GlnAsn: 0.817 ± 0.033
2.346GlnPro: 2.346 ± 0.057
1.749GlnGln: 1.749 ± 0.05
3.914GlnArg: 3.914 ± 0.08
1.859GlnSer: 1.859 ± 0.053
2.072GlnThr: 2.072 ± 0.06
2.706GlnVal: 2.706 ± 0.059
0.722GlnTrp: 0.722 ± 0.031
0.667GlnTyr: 0.667 ± 0.029
0.0GlnXaa: 0.0 ± 0.0
Arg
10.41ArgAla: 10.41 ± 0.127
0.68ArgCys: 0.68 ± 0.029
3.654ArgAsp: 3.654 ± 0.071
4.813ArgGlu: 4.813 ± 0.075
3.031ArgPhe: 3.031 ± 0.059
5.268ArgGly: 5.268 ± 0.083
1.983ArgHis: 1.983 ± 0.055
3.747ArgIle: 3.747 ± 0.071
1.877ArgLys: 1.877 ± 0.052
9.623ArgLeu: 9.623 ± 0.122
1.944ArgMet: 1.944 ± 0.049
1.522ArgAsn: 1.522 ± 0.043
4.016ArgPro: 4.016 ± 0.076
2.875ArgGln: 2.875 ± 0.065
6.466ArgArg: 6.466 ± 0.105
3.812ArgSer: 3.812 ± 0.065
3.302ArgThr: 3.302 ± 0.059
5.897ArgVal: 5.897 ± 0.088
1.627ArgTrp: 1.627 ± 0.055
2.006ArgTyr: 2.006 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
6.584SerAla: 6.584 ± 0.102
0.416SerCys: 0.416 ± 0.024
2.329SerAsp: 2.329 ± 0.049
2.532SerGlu: 2.532 ± 0.059
1.806SerPhe: 1.806 ± 0.05
4.999SerGly: 4.999 ± 0.09
0.989SerHis: 0.989 ± 0.035
2.012SerIle: 2.012 ± 0.052
1.242SerLys: 1.242 ± 0.042
5.14SerLeu: 5.14 ± 0.072
1.141SerMet: 1.141 ± 0.035
1.137SerAsn: 1.137 ± 0.041
2.773SerPro: 2.773 ± 0.062
1.452SerGln: 1.452 ± 0.045
3.282SerArg: 3.282 ± 0.059
2.565SerSer: 2.565 ± 0.079
2.574SerThr: 2.574 ± 0.056
3.796SerVal: 3.796 ± 0.071
0.645SerTrp: 0.645 ± 0.029
1.047SerTyr: 1.047 ± 0.039
0.0SerXaa: 0.0 ± 0.0
Thr
5.802ThrAla: 5.802 ± 0.085
0.357ThrCys: 0.357 ± 0.021
2.255ThrAsp: 2.255 ± 0.052
2.489ThrGlu: 2.489 ± 0.058
1.407ThrPhe: 1.407 ± 0.043
4.323ThrGly: 4.323 ± 0.085
1.112ThrHis: 1.112 ± 0.034
1.859ThrIle: 1.859 ± 0.054
1.028ThrLys: 1.028 ± 0.039
6.309ThrLeu: 6.309 ± 0.092
0.829ThrMet: 0.829 ± 0.033
1.056ThrAsn: 1.056 ± 0.04
3.839ThrPro: 3.839 ± 0.075
1.852ThrGln: 1.852 ± 0.049
3.375ThrArg: 3.375 ± 0.061
2.121ThrSer: 2.121 ± 0.056
2.366ThrThr: 2.366 ± 0.061
4.089ThrVal: 4.089 ± 0.068
0.611ThrTrp: 0.611 ± 0.031
0.922ThrTyr: 0.922 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
9.787ValAla: 9.787 ± 0.141
0.757ValCys: 0.757 ± 0.034
3.927ValAsp: 3.927 ± 0.07
4.49ValGlu: 4.49 ± 0.079
2.763ValPhe: 2.763 ± 0.058
5.629ValGly: 5.629 ± 0.089
1.694ValHis: 1.694 ± 0.049
3.145ValIle: 3.145 ± 0.068
2.107ValLys: 2.107 ± 0.057
8.766ValLeu: 8.766 ± 0.125
1.707ValMet: 1.707 ± 0.05
1.703ValAsn: 1.703 ± 0.047
4.122ValPro: 4.122 ± 0.079
2.884ValGln: 2.884 ± 0.062
5.814ValArg: 5.814 ± 0.092
3.61ValSer: 3.61 ± 0.068
3.688ValThr: 3.688 ± 0.068
6.153ValVal: 6.153 ± 0.107
1.183ValTrp: 1.183 ± 0.042
1.597ValTyr: 1.597 ± 0.051
0.0ValXaa: 0.0 ± 0.0
Trp
1.778TrpAla: 1.778 ± 0.056
0.182TrpCys: 0.182 ± 0.015
0.623TrpAsp: 0.623 ± 0.028
0.617TrpGlu: 0.617 ± 0.022
0.572TrpPhe: 0.572 ± 0.026
1.067TrpGly: 1.067 ± 0.038
0.363TrpHis: 0.363 ± 0.021
0.768TrpIle: 0.768 ± 0.032
0.412TrpLys: 0.412 ± 0.025
2.447TrpLeu: 2.447 ± 0.074
0.442TrpMet: 0.442 ± 0.023
0.368TrpAsn: 0.368 ± 0.021
0.883TrpPro: 0.883 ± 0.04
0.747TrpGln: 0.747 ± 0.03
1.629TrpArg: 1.629 ± 0.055
0.818TrpSer: 0.818 ± 0.034
0.735TrpThr: 0.735 ± 0.032
1.268TrpVal: 1.268 ± 0.046
0.314TrpTrp: 0.314 ± 0.02
0.296TrpTyr: 0.296 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.746TyrAla: 2.746 ± 0.062
0.223TyrCys: 0.223 ± 0.016
1.068TyrAsp: 1.068 ± 0.039
1.168TyrGlu: 1.168 ± 0.044
0.852TyrPhe: 0.852 ± 0.032
1.95TyrGly: 1.95 ± 0.053
0.449TyrHis: 0.449 ± 0.026
0.747TyrIle: 0.747 ± 0.033
0.564TyrLys: 0.564 ± 0.028
2.252TyrLeu: 2.252 ± 0.053
0.351TyrMet: 0.351 ± 0.022
0.538TyrAsn: 0.538 ± 0.026
1.119TyrPro: 1.119 ± 0.035
0.769TyrGln: 0.769 ± 0.031
1.771TyrArg: 1.771 ± 0.047
0.977TyrSer: 0.977 ± 0.033
1.263TyrThr: 1.263 ± 0.038
1.533TyrVal: 1.533 ± 0.038
0.339TyrTrp: 0.339 ± 0.02
0.543TyrTyr: 0.543 ± 0.027
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2531 proteins (831099 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski