Amino acid dipepetide frequency for Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686) (Bicoloured deceiver) (Laccaria laccata var. bicolor)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.952AlaAla: 6.952 ± 0.045	1.136AlaCys: 1.136 ± 0.013	3.559AlaAsp: 3.559 ± 0.023	4.249AlaGlu: 4.249 ± 0.03	3.13AlaPhe: 3.13 ± 0.021	4.674AlaGly: 4.674 ± 0.028	2.022AlaHis: 2.022 ± 0.019	3.94AlaIle: 3.94 ± 0.03	3.727AlaLys: 3.727 ± 0.029	7.687AlaLeu: 7.687 ± 0.037	1.693AlaMet: 1.693 ± 0.019	2.773AlaAsn: 2.773 ± 0.022	4.604AlaPro: 4.604 ± 0.033	3.038AlaGln: 3.038 ± 0.023	4.427AlaArg: 4.427 ± 0.028	6.927AlaSer: 6.927 ± 0.038	4.901AlaThr: 4.901 ± 0.031	4.84AlaVal: 4.84 ± 0.034	1.094AlaTrp: 1.094 ± 0.013	1.965AlaTyr: 1.965 ± 0.016	0.0AlaXaa: 0.0 ± 0.0
Cys	1.029CysAla: 1.029 ± 0.013	0.352CysCys: 0.352 ± 0.008	0.716CysAsp: 0.716 ± 0.01	0.675CysGlu: 0.675 ± 0.011	0.649CysPhe: 0.649 ± 0.01	1.018CysGly: 1.018 ± 0.013	0.467CysHis: 0.467 ± 0.009	0.819CysIle: 0.819 ± 0.011	0.647CysLys: 0.647 ± 0.01	1.566CysLeu: 1.566 ± 0.016	0.323CysMet: 0.323 ± 0.007	0.536CysAsn: 0.536 ± 0.009	0.959CysPro: 0.959 ± 0.013	0.581CysGln: 0.581 ± 0.01	0.91CysArg: 0.91 ± 0.012	1.245CysSer: 1.245 ± 0.016	0.873CysThr: 0.873 ± 0.012	0.909CysVal: 0.909 ± 0.013	0.253CysTrp: 0.253 ± 0.006	0.385CysTyr: 0.385 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.223AspAla: 4.223 ± 0.026	0.69AspCys: 0.69 ± 0.011	4.161AspAsp: 4.161 ± 0.04	4.044AspGlu: 4.044 ± 0.034	2.182AspPhe: 2.182 ± 0.021	3.641AspGly: 3.641 ± 0.025	1.366AspHis: 1.366 ± 0.017	3.066AspIle: 3.066 ± 0.026	2.192AspLys: 2.192 ± 0.021	5.015AspLeu: 5.015 ± 0.029	1.128AspMet: 1.128 ± 0.015	1.893AspAsn: 1.893 ± 0.018	3.201AspPro: 3.201 ± 0.023	1.679AspGln: 1.679 ± 0.017	2.645AspArg: 2.645 ± 0.026	4.112AspSer: 4.112 ± 0.027	2.837AspThr: 2.837 ± 0.022	3.818AspVal: 3.818 ± 0.027	0.877AspTrp: 0.877 ± 0.011	1.387AspTyr: 1.387 ± 0.014	0.0AspXaa: 0.0 ± 0.0
Glu	4.531GluAla: 4.531 ± 0.034	0.712GluCys: 0.712 ± 0.011	3.911GluAsp: 3.911 ± 0.032	5.189GluGlu: 5.189 ± 0.046	1.865GluPhe: 1.865 ± 0.017	3.707GluGly: 3.707 ± 0.026	1.408GluHis: 1.408 ± 0.014	2.907GluIle: 2.907 ± 0.022	3.223GluLys: 3.223 ± 0.028	5.024GluLeu: 5.024 ± 0.031	1.322GluMet: 1.322 ± 0.015	2.011GluAsn: 2.011 ± 0.018	2.455GluPro: 2.455 ± 0.022	2.043GluGln: 2.043 ± 0.018	3.699GluArg: 3.699 ± 0.038	3.911GluSer: 3.911 ± 0.027	2.943GluThr: 2.943 ± 0.022	3.514GluVal: 3.514 ± 0.03	0.92GluTrp: 0.92 ± 0.013	1.444GluTyr: 1.444 ± 0.015	0.0GluXaa: 0.0 ± 0.0
Phe	2.854PheAla: 2.854 ± 0.023	0.696PheCys: 0.696 ± 0.012	2.257PheAsp: 2.257 ± 0.02	2.077PheGlu: 2.077 ± 0.02	1.782PhePhe: 1.782 ± 0.016	2.577PheGly: 2.577 ± 0.023	1.091PheHis: 1.091 ± 0.015	2.012PheIle: 2.012 ± 0.02	1.642PheLys: 1.642 ± 0.016	3.891PheLeu: 3.891 ± 0.027	0.798PheMet: 0.798 ± 0.012	1.513PheAsn: 1.513 ± 0.014	2.314PhePro: 2.314 ± 0.02	1.466PheGln: 1.466 ± 0.015	2.056PheArg: 2.056 ± 0.018	3.52PheSer: 3.52 ± 0.026	2.323PheThr: 2.323 ± 0.022	2.505PheVal: 2.505 ± 0.02	0.622PheTrp: 0.622 ± 0.01	1.104PheTyr: 1.104 ± 0.014	0.001PheXaa: 0.001 ± 0.0
Gly	4.235GlyAla: 4.235 ± 0.033	1.008GlyCys: 1.008 ± 0.013	3.238GlyAsp: 3.238 ± 0.023	3.305GlyGlu: 3.305 ± 0.028	2.498GlyPhe: 2.498 ± 0.022	5.114GlyGly: 5.114 ± 0.056	1.736GlyHis: 1.736 ± 0.019	3.171GlyIle: 3.171 ± 0.025	3.408GlyLys: 3.408 ± 0.027	5.482GlyLeu: 5.482 ± 0.033	1.449GlyMet: 1.449 ± 0.018	2.331GlyAsn: 2.331 ± 0.018	3.176GlyPro: 3.176 ± 0.026	2.199GlyGln: 2.199 ± 0.021	3.873GlyArg: 3.873 ± 0.03	5.311GlySer: 5.311 ± 0.031	3.616GlyThr: 3.616 ± 0.026	4.141GlyVal: 4.141 ± 0.028	1.087GlyTrp: 1.087 ± 0.014	1.733GlyTyr: 1.733 ± 0.018	0.0GlyXaa: 0.0 ± 0.0
His	2.052HisAla: 2.052 ± 0.018	0.46HisCys: 0.46 ± 0.008	1.416HisAsp: 1.416 ± 0.018	1.295HisGlu: 1.295 ± 0.015	1.154HisPhe: 1.154 ± 0.014	1.643HisGly: 1.643 ± 0.018	1.17HisHis: 1.17 ± 0.02	1.517HisIle: 1.517 ± 0.017	1.043HisLys: 1.043 ± 0.012	2.908HisLeu: 2.908 ± 0.021	0.533HisMet: 0.533 ± 0.009	1.006HisAsn: 1.006 ± 0.011	2.108HisPro: 2.108 ± 0.02	1.167HisGln: 1.167 ± 0.014	1.707HisArg: 1.707 ± 0.02	2.28HisSer: 2.28 ± 0.023	1.606HisThr: 1.606 ± 0.017	1.707HisVal: 1.707 ± 0.017	0.423HisTrp: 0.423 ± 0.008	0.747HisTyr: 0.747 ± 0.011	0.001HisXaa: 0.001 ± 0.0
Ile	3.882IleAla: 3.882 ± 0.029	0.875IleCys: 0.875 ± 0.012	2.749IleAsp: 2.749 ± 0.02	2.62IleGlu: 2.62 ± 0.019	2.109IlePhe: 2.109 ± 0.02	2.859IleGly: 2.859 ± 0.023	1.452IleHis: 1.452 ± 0.016	2.679IleIle: 2.679 ± 0.02	2.197IleLys: 2.197 ± 0.017	4.864IleLeu: 4.864 ± 0.033	1.007IleMet: 1.007 ± 0.013	1.85IleAsn: 1.85 ± 0.018	3.526IlePro: 3.526 ± 0.029	1.955IleGln: 1.955 ± 0.016	2.865IleArg: 2.865 ± 0.019	4.382IleSer: 4.382 ± 0.029	2.947IleThr: 2.947 ± 0.021	3.224IleVal: 3.224 ± 0.026	0.776IleTrp: 0.776 ± 0.011	1.374IleTyr: 1.374 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	4.031LysAla: 4.031 ± 0.029	0.624LysCys: 0.624 ± 0.01	2.584LysAsp: 2.584 ± 0.024	3.176LysGlu: 3.176 ± 0.026	1.591LysPhe: 1.591 ± 0.017	3.024LysGly: 3.024 ± 0.027	1.237LysHis: 1.237 ± 0.014	2.24LysIle: 2.24 ± 0.02	3.385LysLys: 3.385 ± 0.035	4.165LysLeu: 4.165 ± 0.027	0.986LysMet: 0.986 ± 0.013	1.69LysAsn: 1.69 ± 0.017	2.718LysPro: 2.718 ± 0.026	1.677LysGln: 1.677 ± 0.019	3.503LysArg: 3.503 ± 0.028	3.57LysSer: 3.57 ± 0.028	2.856LysThr: 2.856 ± 0.021	2.893LysVal: 2.893 ± 0.021	0.684LysTrp: 0.684 ± 0.01	1.259LysTyr: 1.259 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	7.471LeuAla: 7.471 ± 0.037	1.551LeuCys: 1.551 ± 0.017	5.093LeuAsp: 5.093 ± 0.031	5.459LeuGlu: 5.459 ± 0.035	3.681LeuPhe: 3.681 ± 0.025	5.438LeuGly: 5.438 ± 0.027	2.728LeuHis: 2.728 ± 0.022	4.12LeuIle: 4.12 ± 0.027	4.565LeuLys: 4.565 ± 0.031	8.929LeuLeu: 8.929 ± 0.047	1.807LeuMet: 1.807 ± 0.019	3.396LeuAsn: 3.396 ± 0.022	6.616LeuPro: 6.616 ± 0.042	3.878LeuGln: 3.878 ± 0.027	5.989LeuArg: 5.989 ± 0.035	8.42LeuSer: 8.42 ± 0.04	5.549LeuThr: 5.549 ± 0.034	5.611LeuVal: 5.611 ± 0.035	1.283LeuTrp: 1.283 ± 0.014	2.379LeuTyr: 2.379 ± 0.021	0.0LeuXaa: 0.0 ± 0.0
Met	1.797MetAla: 1.797 ± 0.017	0.302MetCys: 0.302 ± 0.006	1.255MetAsp: 1.255 ± 0.014	1.22MetGlu: 1.22 ± 0.014	0.753MetPhe: 0.753 ± 0.012	1.328MetGly: 1.328 ± 0.016	0.534MetHis: 0.534 ± 0.008	0.948MetIle: 0.948 ± 0.011	1.035MetLys: 1.035 ± 0.012	1.76MetLeu: 1.76 ± 0.016	0.53MetMet: 0.53 ± 0.011	0.794MetAsn: 0.794 ± 0.012	1.268MetPro: 1.268 ± 0.015	0.787MetGln: 0.787 ± 0.012	1.219MetArg: 1.219 ± 0.015	1.912MetSer: 1.912 ± 0.018	1.341MetThr: 1.341 ± 0.015	1.228MetVal: 1.228 ± 0.013	0.288MetTrp: 0.288 ± 0.007	0.516MetTyr: 0.516 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	2.986AsnAla: 2.986 ± 0.022	0.499AsnCys: 0.499 ± 0.008	2.034AsnAsp: 2.034 ± 0.02	1.845AsnGlu: 1.845 ± 0.017	1.488AsnPhe: 1.488 ± 0.015	2.528AsnGly: 2.528 ± 0.021	1.052AsnHis: 1.052 ± 0.012	2.075AsnIle: 2.075 ± 0.017	1.521AsnLys: 1.521 ± 0.015	3.516AsnLeu: 3.516 ± 0.025	0.79AsnMet: 0.79 ± 0.011	1.488AsnAsn: 1.488 ± 0.015	2.566AsnPro: 2.566 ± 0.021	1.307AsnGln: 1.307 ± 0.016	1.865AsnArg: 1.865 ± 0.019	2.889AsnSer: 2.889 ± 0.022	2.277AsnThr: 2.277 ± 0.021	2.542AsnVal: 2.542 ± 0.02	0.542AsnTrp: 0.542 ± 0.01	0.953AsnTyr: 0.953 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	4.889ProAla: 4.889 ± 0.037	0.763ProCys: 0.763 ± 0.012	3.085ProAsp: 3.085 ± 0.023	3.258ProGlu: 3.258 ± 0.023	2.472ProPhe: 2.472 ± 0.021	3.53ProGly: 3.53 ± 0.026	1.871ProHis: 1.871 ± 0.018	3.014ProIle: 3.014 ± 0.022	2.619ProLys: 2.619 ± 0.023	5.769ProLeu: 5.769 ± 0.033	1.117ProMet: 1.117 ± 0.012	2.41ProAsn: 2.41 ± 0.017	6.708ProPro: 6.708 ± 0.066	2.483ProGln: 2.483 ± 0.021	3.609ProArg: 3.609 ± 0.03	7.536ProSer: 7.536 ± 0.052	4.845ProThr: 4.845 ± 0.032	3.679ProVal: 3.679 ± 0.03	0.749ProTrp: 0.749 ± 0.012	1.514ProTyr: 1.514 ± 0.018	0.001ProXaa: 0.001 ± 0.0
Gln	3.069GlnAla: 3.069 ± 0.022	0.583GlnCys: 0.583 ± 0.01	1.907GlnAsp: 1.907 ± 0.017	2.188GlnGlu: 2.188 ± 0.021	1.288GlnPhe: 1.288 ± 0.015	2.187GlnGly: 2.187 ± 0.021	1.182GlnHis: 1.182 ± 0.014	1.832GlnIle: 1.832 ± 0.018	1.842GlnLys: 1.842 ± 0.019	3.551GlnLeu: 3.551 ± 0.024	0.815GlnMet: 0.815 ± 0.012	1.427GlnAsn: 1.427 ± 0.017	2.506GlnPro: 2.506 ± 0.025	2.08GlnGln: 2.08 ± 0.037	2.594GlnArg: 2.594 ± 0.025	3.064GlnSer: 3.064 ± 0.025	2.314GlnThr: 2.314 ± 0.021	2.244GlnVal: 2.244 ± 0.02	0.586GlnTrp: 0.586 ± 0.01	0.993GlnTyr: 0.993 ± 0.013	0.0GlnXaa: 0.0 ± 0.0
Arg	4.281ArgAla: 4.281 ± 0.025	0.908ArgCys: 0.908 ± 0.013	2.996ArgAsp: 2.996 ± 0.027	3.483ArgGlu: 3.483 ± 0.037	2.2ArgPhe: 2.2 ± 0.016	3.569ArgGly: 3.569 ± 0.027	1.702ArgHis: 1.702 ± 0.016	2.922ArgIle: 2.922 ± 0.022	3.437ArgLys: 3.437 ± 0.026	5.659ArgLeu: 5.659 ± 0.034	1.317ArgMet: 1.317 ± 0.014	2.23ArgAsn: 2.23 ± 0.02	3.65ArgPro: 3.65 ± 0.025	2.437ArgGln: 2.437 ± 0.021	5.132ArgArg: 5.132 ± 0.044	5.08ArgSer: 5.08 ± 0.035	3.422ArgThr: 3.422 ± 0.026	3.54ArgVal: 3.54 ± 0.028	0.935ArgTrp: 0.935 ± 0.012	1.574ArgTyr: 1.574 ± 0.016	0.001ArgXaa: 0.001 ± 0.0
Ser	6.524SerAla: 6.524 ± 0.036	1.171SerCys: 1.171 ± 0.014	4.324SerAsp: 4.324 ± 0.031	3.959SerGlu: 3.959 ± 0.028	3.499SerPhe: 3.499 ± 0.027	5.299SerGly: 5.299 ± 0.034	2.358SerHis: 2.358 ± 0.022	4.36SerIle: 4.36 ± 0.03	3.768SerLys: 3.768 ± 0.028	8.48SerLeu: 8.48 ± 0.04	1.744SerMet: 1.744 ± 0.016	3.126SerAsn: 3.126 ± 0.024	6.633SerPro: 6.633 ± 0.056	3.339SerGln: 3.339 ± 0.026	5.154SerArg: 5.154 ± 0.032	10.345SerSer: 10.345 ± 0.072	6.353SerThr: 6.353 ± 0.039	4.965SerVal: 4.965 ± 0.037	1.176SerTrp: 1.176 ± 0.014	2.042SerTyr: 2.042 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	4.684ThrAla: 4.684 ± 0.031	0.952ThrCys: 0.952 ± 0.015	2.726ThrAsp: 2.726 ± 0.02	2.698ThrGlu: 2.698 ± 0.021	2.547ThrPhe: 2.547 ± 0.021	3.642ThrGly: 3.642 ± 0.028	1.71ThrHis: 1.71 ± 0.016	3.25ThrIle: 3.25 ± 0.024	2.675ThrLys: 2.675 ± 0.02	5.997ThrLeu: 5.997 ± 0.037	1.253ThrMet: 1.253 ± 0.014	2.263ThrAsn: 2.263 ± 0.019	4.876ThrPro: 4.876 ± 0.037	2.224ThrGln: 2.224 ± 0.017	3.417ThrArg: 3.417 ± 0.025	6.184ThrSer: 6.184 ± 0.038	4.985ThrThr: 4.985 ± 0.044	3.569ThrVal: 3.569 ± 0.023	0.868ThrTrp: 0.868 ± 0.013	1.596ThrTyr: 1.596 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	4.901ValAla: 4.901 ± 0.03	0.919ValCys: 0.919 ± 0.013	3.74ValAsp: 3.74 ± 0.024	3.802ValGlu: 3.802 ± 0.024	2.513ValPhe: 2.513 ± 0.02	3.797ValGly: 3.797 ± 0.027	1.628ValHis: 1.628 ± 0.017	3.138ValIle: 3.138 ± 0.024	3.008ValLys: 3.008 ± 0.02	5.766ValLeu: 5.766 ± 0.033	1.286ValMet: 1.286 ± 0.015	2.292ValAsn: 2.292 ± 0.019	3.802ValPro: 3.802 ± 0.023	2.4ValGln: 2.4 ± 0.021	3.314ValArg: 3.314 ± 0.025	4.762ValSer: 4.762 ± 0.03	3.593ValThr: 3.593 ± 0.027	4.524ValVal: 4.524 ± 0.033	1.003ValTrp: 1.003 ± 0.016	1.707ValTyr: 1.707 ± 0.016	0.0ValXaa: 0.0 ± 0.0
Trp	1.058TrpAla: 1.058 ± 0.015	0.258TrpCys: 0.258 ± 0.007	0.9TrpAsp: 0.9 ± 0.016	0.843TrpGlu: 0.843 ± 0.011	0.59TrpPhe: 0.59 ± 0.009	0.876TrpGly: 0.876 ± 0.011	0.387TrpHis: 0.387 ± 0.008	0.766TrpIle: 0.766 ± 0.012	0.871TrpLys: 0.871 ± 0.011	1.352TrpLeu: 1.352 ± 0.016	0.378TrpMet: 0.378 ± 0.008	0.663TrpAsn: 0.663 ± 0.01	0.66TrpPro: 0.66 ± 0.011	0.512TrpGln: 0.512 ± 0.01	0.991TrpArg: 0.991 ± 0.012	1.176TrpSer: 1.176 ± 0.012	0.944TrpThr: 0.944 ± 0.012	0.919TrpVal: 0.919 ± 0.013	0.322TrpTrp: 0.322 ± 0.008	0.412TrpTyr: 0.412 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.891TyrAla: 1.891 ± 0.015	0.455TyrCys: 0.455 ± 0.008	1.506TyrAsp: 1.506 ± 0.015	1.352TyrGlu: 1.352 ± 0.015	1.108TyrPhe: 1.108 ± 0.014	1.66TyrGly: 1.66 ± 0.016	0.841TyrHis: 0.841 ± 0.011	1.414TyrIle: 1.414 ± 0.014	1.089TyrLys: 1.089 ± 0.012	2.582TyrLeu: 2.582 ± 0.021	0.539TyrMet: 0.539 ± 0.01	1.069TyrAsn: 1.069 ± 0.014	1.573TyrPro: 1.573 ± 0.015	1.0TyrGln: 1.0 ± 0.012	1.506TyrArg: 1.506 ± 0.015	1.994TyrSer: 1.994 ± 0.018	1.592TyrThr: 1.592 ± 0.017	1.524TyrVal: 1.524 ± 0.016	0.39TyrTrp: 0.39 ± 0.008	0.829TyrTyr: 0.829 ± 0.011	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.001XaaCys: 0.001 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 17895 proteins (6645138 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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