Amino acid dipepetide frequency for Thiorhodococcus drewsii AZ1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.073AlaAla: 12.073 ± 0.141	1.189AlaCys: 1.189 ± 0.031	6.302AlaAsp: 6.302 ± 0.075	7.697AlaGlu: 7.697 ± 0.091	3.623AlaPhe: 3.623 ± 0.049	8.153AlaGly: 8.153 ± 0.085	2.241AlaHis: 2.241 ± 0.034	5.588AlaIle: 5.588 ± 0.067	3.082AlaLys: 3.082 ± 0.052	12.973AlaLeu: 12.973 ± 0.134	2.741AlaMet: 2.741 ± 0.046	2.771AlaAsn: 2.771 ± 0.042	4.756AlaPro: 4.756 ± 0.067	3.957AlaGln: 3.957 ± 0.057	8.158AlaArg: 8.158 ± 0.097	6.293AlaSer: 6.293 ± 0.067	5.079AlaThr: 5.079 ± 0.069	7.242AlaVal: 7.242 ± 0.078	1.474AlaTrp: 1.474 ± 0.037	2.318AlaTyr: 2.318 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	1.07CysAla: 1.07 ± 0.028	0.153CysCys: 0.153 ± 0.011	0.601CysAsp: 0.601 ± 0.022	0.623CysGlu: 0.623 ± 0.02	0.339CysPhe: 0.339 ± 0.015	1.015CysGly: 1.015 ± 0.03	0.32CysHis: 0.32 ± 0.018	0.466CysIle: 0.466 ± 0.018	0.221CysLys: 0.221 ± 0.01	1.076CysLeu: 1.076 ± 0.031	0.195CysMet: 0.195 ± 0.011	0.265CysAsn: 0.265 ± 0.014	0.557CysPro: 0.557 ± 0.021	0.344CysGln: 0.344 ± 0.015	0.812CysArg: 0.812 ± 0.021	0.619CysSer: 0.619 ± 0.023	0.448CysThr: 0.448 ± 0.02	0.711CysVal: 0.711 ± 0.022	0.142CysTrp: 0.142 ± 0.01	0.255CysTyr: 0.255 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.851AspAla: 6.851 ± 0.074	0.638AspCys: 0.638 ± 0.022	3.265AspAsp: 3.265 ± 0.052	3.599AspGlu: 3.599 ± 0.053	2.199AspPhe: 2.199 ± 0.039	4.843AspGly: 4.843 ± 0.07	1.27AspHis: 1.27 ± 0.033	2.7AspIle: 2.7 ± 0.042	1.46AspLys: 1.46 ± 0.035	7.429AspLeu: 7.429 ± 0.091	1.18AspMet: 1.18 ± 0.028	1.271AspAsn: 1.271 ± 0.031	4.015AspPro: 4.015 ± 0.051	2.493AspGln: 2.493 ± 0.038	4.871AspArg: 4.871 ± 0.062	3.179AspSer: 3.179 ± 0.046	2.795AspThr: 2.795 ± 0.045	3.498AspVal: 3.498 ± 0.044	1.282AspTrp: 1.282 ± 0.032	1.837AspTyr: 1.837 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	6.828GluAla: 6.828 ± 0.081	0.501GluCys: 0.501 ± 0.017	3.25GluAsp: 3.25 ± 0.048	3.614GluGlu: 3.614 ± 0.061	1.737GluPhe: 1.737 ± 0.032	4.329GluGly: 4.329 ± 0.052	1.57GluHis: 1.57 ± 0.034	3.618GluIle: 3.618 ± 0.054	1.636GluLys: 1.636 ± 0.038	6.607GluLeu: 6.607 ± 0.081	1.429GluMet: 1.429 ± 0.028	1.505GluAsn: 1.505 ± 0.034	3.133GluPro: 3.133 ± 0.056	3.17GluGln: 3.17 ± 0.059	6.612GluArg: 6.612 ± 0.089	3.711GluSer: 3.711 ± 0.058	4.096GluThr: 4.096 ± 0.065	4.246GluVal: 4.246 ± 0.056	0.732GluTrp: 0.732 ± 0.02	1.122GluTyr: 1.122 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	3.716PheAla: 3.716 ± 0.044	0.42PheCys: 0.42 ± 0.017	2.537PheAsp: 2.537 ± 0.042	2.322PheGlu: 2.322 ± 0.045	1.382PhePhe: 1.382 ± 0.036	3.206PheGly: 3.206 ± 0.053	0.735PheHis: 0.735 ± 0.021	1.574PheIle: 1.574 ± 0.032	1.036PheLys: 1.036 ± 0.028	3.435PheLeu: 3.435 ± 0.053	0.718PheMet: 0.718 ± 0.024	0.983PheAsn: 0.983 ± 0.027	1.443PhePro: 1.443 ± 0.031	1.147PheGln: 1.147 ± 0.025	2.131PheArg: 2.131 ± 0.036	2.254PheSer: 2.254 ± 0.046	1.641PheThr: 1.641 ± 0.036	2.567PheVal: 2.567 ± 0.042	0.537PheTrp: 0.537 ± 0.019	0.941PheTyr: 0.941 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	7.311GlyAla: 7.311 ± 0.089	1.023GlyCys: 1.023 ± 0.032	4.565GlyAsp: 4.565 ± 0.058	4.749GlyGlu: 4.749 ± 0.058	3.229GlyPhe: 3.229 ± 0.04	5.861GlyGly: 5.861 ± 0.076	1.943GlyHis: 1.943 ± 0.036	4.403GlyIle: 4.403 ± 0.069	2.518GlyLys: 2.518 ± 0.044	9.046GlyLeu: 9.046 ± 0.095	2.073GlyMet: 2.073 ± 0.039	2.031GlyAsn: 2.031 ± 0.046	2.871GlyPro: 2.871 ± 0.041	3.007GlyGln: 3.007 ± 0.044	6.057GlyArg: 6.057 ± 0.071	4.39GlySer: 4.39 ± 0.061	4.005GlyThr: 4.005 ± 0.063	5.749GlyVal: 5.749 ± 0.07	1.418GlyTrp: 1.418 ± 0.035	2.383GlyTyr: 2.383 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.318HisAla: 2.318 ± 0.041	0.311HisCys: 0.311 ± 0.016	1.164HisAsp: 1.164 ± 0.028	1.225HisGlu: 1.225 ± 0.034	0.915HisPhe: 0.915 ± 0.025	1.831HisGly: 1.831 ± 0.034	0.685HisHis: 0.685 ± 0.027	0.984HisIle: 0.984 ± 0.026	0.517HisLys: 0.517 ± 0.016	2.75HisLeu: 2.75 ± 0.054	0.405HisMet: 0.405 ± 0.018	0.493HisAsn: 0.493 ± 0.018	1.64HisPro: 1.64 ± 0.032	0.952HisGln: 0.952 ± 0.024	1.851HisArg: 1.851 ± 0.035	1.138HisSer: 1.138 ± 0.029	0.966HisThr: 0.966 ± 0.027	1.265HisVal: 1.265 ± 0.031	0.468HisTrp: 0.468 ± 0.018	0.665HisTyr: 0.665 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.353IleAla: 6.353 ± 0.075	0.516IleCys: 0.516 ± 0.017	3.617IleAsp: 3.617 ± 0.051	3.956IleGlu: 3.956 ± 0.055	1.41IlePhe: 1.41 ± 0.032	4.528IleGly: 4.528 ± 0.062	1.126IleHis: 1.126 ± 0.027	1.795IleIle: 1.795 ± 0.04	1.43IleLys: 1.43 ± 0.036	5.223IleLeu: 5.223 ± 0.058	0.826IleMet: 0.826 ± 0.028	1.333IleAsn: 1.333 ± 0.031	2.627IlePro: 2.627 ± 0.048	2.006IleGln: 2.006 ± 0.033	3.684IleArg: 3.684 ± 0.053	2.621IleSer: 2.621 ± 0.046	2.205IleThr: 2.205 ± 0.042	2.989IleVal: 2.989 ± 0.043	0.572IleTrp: 0.572 ± 0.02	1.1IleTyr: 1.1 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	2.978LysAla: 2.978 ± 0.044	0.18LysCys: 0.18 ± 0.01	1.607LysAsp: 1.607 ± 0.034	1.598LysGlu: 1.598 ± 0.037	0.632LysPhe: 0.632 ± 0.02	2.252LysGly: 2.252 ± 0.037	0.619LysHis: 0.619 ± 0.019	1.374LysIle: 1.374 ± 0.031	1.033LysLys: 1.033 ± 0.033	2.661LysLeu: 2.661 ± 0.043	0.503LysMet: 0.503 ± 0.017	0.771LysAsn: 0.771 ± 0.025	1.675LysPro: 1.675 ± 0.038	1.17LysGln: 1.17 ± 0.029	2.395LysArg: 2.395 ± 0.041	1.629LysSer: 1.629 ± 0.032	1.79LysThr: 1.79 ± 0.035	1.986LysVal: 1.986 ± 0.04	0.294LysTrp: 0.294 ± 0.012	0.572LysTyr: 0.572 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	13.339LeuAla: 13.339 ± 0.13	1.075LeuCys: 1.075 ± 0.03	7.885LeuAsp: 7.885 ± 0.084	6.94LeuGlu: 6.94 ± 0.092	4.046LeuPhe: 4.046 ± 0.056	9.034LeuGly: 9.034 ± 0.093	2.271LeuHis: 2.271 ± 0.036	5.858LeuIle: 5.858 ± 0.061	3.452LeuLys: 3.452 ± 0.054	12.293LeuLeu: 12.293 ± 0.14	2.597LeuMet: 2.597 ± 0.046	2.911LeuAsn: 2.911 ± 0.039	5.664LeuPro: 5.664 ± 0.065	3.472LeuGln: 3.472 ± 0.052	8.131LeuArg: 8.131 ± 0.085	7.07LeuSer: 7.07 ± 0.073	6.061LeuThr: 6.061 ± 0.074	8.21LeuVal: 8.21 ± 0.087	1.338LeuTrp: 1.338 ± 0.038	2.501LeuTyr: 2.501 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	2.454MetAla: 2.454 ± 0.04	0.156MetCys: 0.156 ± 0.009	1.328MetAsp: 1.328 ± 0.033	1.199MetGlu: 1.199 ± 0.032	0.528MetPhe: 0.528 ± 0.019	1.633MetGly: 1.633 ± 0.035	0.494MetHis: 0.494 ± 0.017	1.088MetIle: 1.088 ± 0.026	0.731MetLys: 0.731 ± 0.024	2.42MetLeu: 2.42 ± 0.049	0.513MetMet: 0.513 ± 0.019	0.712MetAsn: 0.712 ± 0.02	1.33MetPro: 1.33 ± 0.027	0.822MetGln: 0.822 ± 0.02	1.743MetArg: 1.743 ± 0.03	1.553MetSer: 1.553 ± 0.033	1.473MetThr: 1.473 ± 0.032	1.504MetVal: 1.504 ± 0.03	0.151MetTrp: 0.151 ± 0.01	0.276MetTyr: 0.276 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.933AsnAla: 2.933 ± 0.042	0.283AsnCys: 0.283 ± 0.016	1.458AsnAsp: 1.458 ± 0.034	1.314AsnGlu: 1.314 ± 0.034	0.787AsnPhe: 0.787 ± 0.024	2.142AsnGly: 2.142 ± 0.04	0.562AsnHis: 0.562 ± 0.02	1.156AsnIle: 1.156 ± 0.03	0.595AsnLys: 0.595 ± 0.022	3.122AsnLeu: 3.122 ± 0.05	0.515AsnMet: 0.515 ± 0.018	0.653AsnAsn: 0.653 ± 0.03	1.859AsnPro: 1.859 ± 0.035	1.1AsnGln: 1.1 ± 0.027	2.214AsnArg: 2.214 ± 0.039	1.204AsnSer: 1.204 ± 0.028	1.182AsnThr: 1.182 ± 0.028	1.519AsnVal: 1.519 ± 0.034	0.403AsnTrp: 0.403 ± 0.017	0.64AsnTyr: 0.64 ± 0.019	0.001AsnXaa: 0.001 ± 0.001
Pro	5.051ProAla: 5.051 ± 0.068	0.433ProCys: 0.433 ± 0.018	3.761ProAsp: 3.761 ± 0.058	4.25ProGlu: 4.25 ± 0.06	1.791ProPhe: 1.791 ± 0.032	4.167ProGly: 4.167 ± 0.059	1.0ProHis: 1.0 ± 0.024	2.471ProIle: 2.471 ± 0.034	1.458ProLys: 1.458 ± 0.033	5.317ProLeu: 5.317 ± 0.062	1.128ProMet: 1.128 ± 0.027	1.497ProAsn: 1.497 ± 0.031	2.713ProPro: 2.713 ± 0.048	1.672ProGln: 1.672 ± 0.037	2.994ProArg: 2.994 ± 0.049	3.247ProSer: 3.247 ± 0.05	2.571ProThr: 2.571 ± 0.046	3.825ProVal: 3.825 ± 0.057	0.783ProTrp: 0.783 ± 0.025	1.147ProTyr: 1.147 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.532GlnAla: 4.532 ± 0.057	0.316GlnCys: 0.316 ± 0.015	2.054GlnAsp: 2.054 ± 0.04	2.181GlnGlu: 2.181 ± 0.038	1.112GlnPhe: 1.112 ± 0.027	3.098GlnGly: 3.098 ± 0.049	0.878GlnHis: 0.878 ± 0.023	2.081GlnIle: 2.081 ± 0.036	0.844GlnLys: 0.844 ± 0.024	3.818GlnLeu: 3.818 ± 0.064	0.838GlnMet: 0.838 ± 0.021	0.826GlnAsn: 0.826 ± 0.027	1.939GlnPro: 1.939 ± 0.038	1.612GlnGln: 1.612 ± 0.034	3.176GlnArg: 3.176 ± 0.055	2.345GlnSer: 2.345 ± 0.04	2.124GlnThr: 2.124 ± 0.039	3.02GlnVal: 3.02 ± 0.048	0.491GlnTrp: 0.491 ± 0.019	0.748GlnTyr: 0.748 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	7.334ArgAla: 7.334 ± 0.077	0.81ArgCys: 0.81 ± 0.024	4.416ArgAsp: 4.416 ± 0.052	4.888ArgGlu: 4.888 ± 0.062	3.379ArgPhe: 3.379 ± 0.045	4.626ArgGly: 4.626 ± 0.059	2.089ArgHis: 2.089 ± 0.04	4.584ArgIle: 4.584 ± 0.058	1.924ArgLys: 1.924 ± 0.039	10.367ArgLeu: 10.367 ± 0.102	1.822ArgMet: 1.822 ± 0.034	1.917ArgAsn: 1.917 ± 0.036	3.645ArgPro: 3.645 ± 0.053	3.213ArgGln: 3.213 ± 0.052	6.319ArgArg: 6.319 ± 0.087	4.044ArgSer: 4.044 ± 0.057	3.577ArgThr: 3.577 ± 0.048	5.237ArgVal: 5.237 ± 0.06	1.285ArgTrp: 1.285 ± 0.031	2.228ArgTyr: 2.228 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.332SerAla: 6.332 ± 0.071	0.547SerCys: 0.547 ± 0.022	3.603SerAsp: 3.603 ± 0.045	3.589SerGlu: 3.589 ± 0.049	2.027SerPhe: 2.027 ± 0.036	5.498SerGly: 5.498 ± 0.07	1.286SerHis: 1.286 ± 0.026	2.845SerIle: 2.845 ± 0.042	1.61SerLys: 1.61 ± 0.037	6.326SerLeu: 6.326 ± 0.062	1.379SerMet: 1.379 ± 0.032	1.549SerAsn: 1.549 ± 0.033	2.927SerPro: 2.927 ± 0.043	2.005SerGln: 2.005 ± 0.039	4.126SerArg: 4.126 ± 0.055	3.458SerSer: 3.458 ± 0.057	2.922SerThr: 2.922 ± 0.046	4.066SerVal: 4.066 ± 0.065	0.76SerTrp: 0.76 ± 0.021	1.299SerTyr: 1.299 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	5.32ThrAla: 5.32 ± 0.07	0.464ThrCys: 0.464 ± 0.017	3.023ThrAsp: 3.023 ± 0.047	3.085ThrGlu: 3.085 ± 0.051	1.718ThrPhe: 1.718 ± 0.032	4.385ThrGly: 4.385 ± 0.061	1.202ThrHis: 1.202 ± 0.03	2.238ThrIle: 2.238 ± 0.035	1.273ThrLys: 1.273 ± 0.029	6.741ThrLeu: 6.741 ± 0.071	0.897ThrMet: 0.897 ± 0.022	1.327ThrAsn: 1.327 ± 0.031	3.279ThrPro: 3.279 ± 0.052	2.025ThrGln: 2.025 ± 0.041	3.525ThrArg: 3.525 ± 0.045	2.848ThrSer: 2.848 ± 0.049	2.648ThrThr: 2.648 ± 0.055	3.104ThrVal: 3.104 ± 0.049	0.706ThrTrp: 0.706 ± 0.024	1.132ThrTyr: 1.132 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	7.421ValAla: 7.421 ± 0.079	0.775ValCys: 0.775 ± 0.024	4.121ValAsp: 4.121 ± 0.053	4.676ValGlu: 4.676 ± 0.058	2.398ValPhe: 2.398 ± 0.043	5.156ValGly: 5.156 ± 0.063	1.379ValHis: 1.379 ± 0.029	3.426ValIle: 3.426 ± 0.051	1.919ValLys: 1.919 ± 0.037	7.553ValLeu: 7.553 ± 0.087	1.581ValMet: 1.581 ± 0.034	1.783ValAsn: 1.783 ± 0.037	3.263ValPro: 3.263 ± 0.052	2.283ValGln: 2.283 ± 0.038	5.147ValArg: 5.147 ± 0.065	4.236ValSer: 4.236 ± 0.057	3.672ValThr: 3.672 ± 0.058	5.023ValVal: 5.023 ± 0.068	0.889ValTrp: 0.889 ± 0.024	1.561ValTyr: 1.561 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.082TrpAla: 1.082 ± 0.027	0.164TrpCys: 0.164 ± 0.011	0.746TrpAsp: 0.746 ± 0.023	0.721TrpGlu: 0.721 ± 0.023	0.525TrpPhe: 0.525 ± 0.02	0.908TrpGly: 0.908 ± 0.026	0.349TrpHis: 0.349 ± 0.016	0.79TrpIle: 0.79 ± 0.022	0.426TrpLys: 0.426 ± 0.019	2.009TrpLeu: 2.009 ± 0.042	0.367TrpMet: 0.367 ± 0.014	0.433TrpAsn: 0.433 ± 0.019	0.679TrpPro: 0.679 ± 0.022	0.57TrpGln: 0.57 ± 0.022	1.337TrpArg: 1.337 ± 0.035	0.989TrpSer: 0.989 ± 0.026	0.748TrpThr: 0.748 ± 0.023	0.985TrpVal: 0.985 ± 0.026	0.241TrpTrp: 0.241 ± 0.015	0.318TrpTyr: 0.318 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.411TyrAla: 2.411 ± 0.041	0.278TyrCys: 0.278 ± 0.015	1.372TyrAsp: 1.372 ± 0.035	1.219TyrGlu: 1.219 ± 0.026	0.949TyrPhe: 0.949 ± 0.026	1.971TyrGly: 1.971 ± 0.041	0.525TyrHis: 0.525 ± 0.018	0.877TyrIle: 0.877 ± 0.023	0.551TyrLys: 0.551 ± 0.02	2.981TyrLeu: 2.981 ± 0.038	0.397TyrMet: 0.397 ± 0.015	0.611TyrAsn: 0.611 ± 0.023	1.262TyrPro: 1.262 ± 0.026	1.012TyrGln: 1.012 ± 0.027	2.422TyrArg: 2.422 ± 0.044	1.327TyrSer: 1.327 ± 0.031	0.94TyrThr: 0.94 ± 0.025	1.515TyrVal: 1.515 ± 0.029	0.426TyrTrp: 0.426 ± 0.019	0.699TyrTyr: 0.699 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4731 proteins (1618336 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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