Amino acid dipepetide frequency for Nonomuraea jiangxiensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.368AlaAla: 20.368 ± 0.113	1.083AlaCys: 1.083 ± 0.018	7.62AlaAsp: 7.62 ± 0.056	8.403AlaGlu: 8.403 ± 0.057	3.671AlaPhe: 3.671 ± 0.04	13.381AlaGly: 13.381 ± 0.085	2.599AlaHis: 2.599 ± 0.025	4.332AlaIle: 4.332 ± 0.038	2.608AlaLys: 2.608 ± 0.032	14.035AlaLeu: 14.035 ± 0.091	2.713AlaMet: 2.713 ± 0.029	2.086AlaAsn: 2.086 ± 0.026	6.245AlaPro: 6.245 ± 0.057	3.521AlaGln: 3.521 ± 0.036	10.284AlaArg: 10.284 ± 0.07	5.477AlaSer: 5.477 ± 0.046	7.186AlaThr: 7.186 ± 0.054	11.491AlaVal: 11.491 ± 0.068	1.971AlaTrp: 1.971 ± 0.026	2.765AlaTyr: 2.765 ± 0.027	0.0AlaXaa: 0.0 ± 0.0
Cys	0.964CysAla: 0.964 ± 0.018	0.106CysCys: 0.106 ± 0.007	0.488CysAsp: 0.488 ± 0.013	0.387CysGlu: 0.387 ± 0.012	0.233CysPhe: 0.233 ± 0.008	0.927CysGly: 0.927 ± 0.017	0.217CysHis: 0.217 ± 0.008	0.13CysIle: 0.13 ± 0.006	0.104CysLys: 0.104 ± 0.006	0.754CysLeu: 0.754 ± 0.015	0.129CysMet: 0.129 ± 0.007	0.119CysAsn: 0.119 ± 0.007	0.49CysPro: 0.49 ± 0.012	0.174CysGln: 0.174 ± 0.007	0.598CysArg: 0.598 ± 0.013	0.427CysSer: 0.427 ± 0.012	0.417CysThr: 0.417 ± 0.012	0.661CysVal: 0.661 ± 0.014	0.126CysTrp: 0.126 ± 0.006	0.173CysTyr: 0.173 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	6.411AspAla: 6.411 ± 0.048	0.375AspCys: 0.375 ± 0.012	3.459AspAsp: 3.459 ± 0.035	3.53AspGlu: 3.53 ± 0.032	1.612AspPhe: 1.612 ± 0.02	5.977AspGly: 5.977 ± 0.055	1.439AspHis: 1.439 ± 0.026	1.761AspIle: 1.761 ± 0.025	1.039AspLys: 1.039 ± 0.019	6.75AspLeu: 6.75 ± 0.048	0.81AspMet: 0.81 ± 0.016	0.992AspAsn: 0.992 ± 0.021	4.602AspPro: 4.602 ± 0.042	1.684AspGln: 1.684 ± 0.026	4.853AspArg: 4.853 ± 0.038	2.295AspSer: 2.295 ± 0.028	2.743AspThr: 2.743 ± 0.032	4.874AspVal: 4.874 ± 0.037	0.973AspTrp: 0.973 ± 0.017	1.272AspTyr: 1.272 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	6.802GluAla: 6.802 ± 0.056	0.358GluCys: 0.358 ± 0.011	2.441GluAsp: 2.441 ± 0.026	3.438GluGlu: 3.438 ± 0.033	1.492GluPhe: 1.492 ± 0.022	3.896GluGly: 3.896 ± 0.033	1.587GluHis: 1.587 ± 0.025	2.46GluIle: 2.46 ± 0.03	1.026GluLys: 1.026 ± 0.02	7.079GluLeu: 7.079 ± 0.057	0.903GluMet: 0.903 ± 0.016	0.88GluAsn: 0.88 ± 0.018	3.485GluPro: 3.485 ± 0.041	2.206GluGln: 2.206 ± 0.022	5.653GluArg: 5.653 ± 0.056	2.599GluSer: 2.599 ± 0.031	2.708GluThr: 2.708 ± 0.026	4.704GluVal: 4.704 ± 0.039	0.834GluTrp: 0.834 ± 0.016	1.024GluTyr: 1.024 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.716PheAla: 3.716 ± 0.039	0.248PheCys: 0.248 ± 0.009	2.045PheAsp: 2.045 ± 0.029	1.505PheGlu: 1.505 ± 0.024	0.897PhePhe: 0.897 ± 0.017	3.082PheGly: 3.082 ± 0.028	0.636PheHis: 0.636 ± 0.013	0.787PheIle: 0.787 ± 0.016	0.484PheLys: 0.484 ± 0.013	2.728PheLeu: 2.728 ± 0.034	0.466PheMet: 0.466 ± 0.012	0.609PheAsn: 0.609 ± 0.014	1.455PhePro: 1.455 ± 0.024	0.739PheGln: 0.739 ± 0.014	1.926PheArg: 1.926 ± 0.024	1.469PheSer: 1.469 ± 0.021	2.067PheThr: 2.067 ± 0.029	2.412PheVal: 2.412 ± 0.027	0.489PheTrp: 0.489 ± 0.014	0.639PheTyr: 0.639 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	10.193GlyAla: 10.193 ± 0.065	0.815GlyCys: 0.815 ± 0.017	5.114GlyAsp: 5.114 ± 0.047	5.136GlyGlu: 5.136 ± 0.05	2.899GlyPhe: 2.899 ± 0.034	8.646GlyGly: 8.646 ± 0.074	2.307GlyHis: 2.307 ± 0.027	3.419GlyIle: 3.419 ± 0.035	2.237GlyLys: 2.237 ± 0.031	9.999GlyLeu: 9.999 ± 0.056	2.077GlyMet: 2.077 ± 0.025	1.799GlyAsn: 1.799 ± 0.028	5.106GlyPro: 5.106 ± 0.051	2.806GlyGln: 2.806 ± 0.034	7.918GlyArg: 7.918 ± 0.055	4.914GlySer: 4.914 ± 0.044	5.882GlyThr: 5.882 ± 0.046	7.84GlyVal: 7.84 ± 0.056	1.804GlyTrp: 1.804 ± 0.022	2.389GlyTyr: 2.389 ± 0.027	0.001GlyXaa: 0.001 ± 0.0
His	2.651HisAla: 2.651 ± 0.029	0.188HisCys: 0.188 ± 0.007	1.403HisAsp: 1.403 ± 0.021	1.231HisGlu: 1.231 ± 0.022	0.627HisPhe: 0.627 ± 0.014	2.221HisGly: 2.221 ± 0.026	0.683HisHis: 0.683 ± 0.016	0.662HisIle: 0.662 ± 0.015	0.303HisLys: 0.303 ± 0.008	2.511HisLeu: 2.511 ± 0.029	0.328HisMet: 0.328 ± 0.01	0.396HisAsn: 0.396 ± 0.012	1.797HisPro: 1.797 ± 0.026	0.626HisGln: 0.626 ± 0.012	1.981HisArg: 1.981 ± 0.028	0.931HisSer: 0.931 ± 0.016	1.158HisThr: 1.158 ± 0.019	1.875HisVal: 1.875 ± 0.026	0.361HisTrp: 0.361 ± 0.01	0.517HisTyr: 0.517 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	5.069IleAla: 5.069 ± 0.041	0.318IleCys: 0.318 ± 0.01	2.527IleAsp: 2.527 ± 0.027	2.23IleGlu: 2.23 ± 0.025	0.858IlePhe: 0.858 ± 0.017	3.679IleGly: 3.679 ± 0.035	0.687IleHis: 0.687 ± 0.017	1.128IleIle: 1.128 ± 0.021	0.832IleLys: 0.832 ± 0.019	2.788IleLeu: 2.788 ± 0.031	0.631IleMet: 0.631 ± 0.014	0.787IleAsn: 0.787 ± 0.016	1.918IlePro: 1.918 ± 0.027	0.822IleGln: 0.822 ± 0.014	2.573IleArg: 2.573 ± 0.026	2.015IleSer: 2.015 ± 0.025	2.471IleThr: 2.471 ± 0.028	3.229IleVal: 3.229 ± 0.029	0.454IleTrp: 0.454 ± 0.012	0.694IleTyr: 0.694 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.457LysAla: 2.457 ± 0.035	0.111LysCys: 0.111 ± 0.006	1.078LysAsp: 1.078 ± 0.021	1.113LysGlu: 1.113 ± 0.019	0.451LysPhe: 0.451 ± 0.016	1.606LysGly: 1.606 ± 0.024	0.397LysHis: 0.397 ± 0.01	0.92LysIle: 0.92 ± 0.018	0.549LysLys: 0.549 ± 0.017	1.932LysLeu: 1.932 ± 0.026	0.335LysMet: 0.335 ± 0.01	0.423LysAsn: 0.423 ± 0.012	1.284LysPro: 1.284 ± 0.022	0.654LysGln: 0.654 ± 0.016	1.369LysArg: 1.369 ± 0.023	1.004LysSer: 1.004 ± 0.019	1.107LysThr: 1.107 ± 0.021	1.891LysVal: 1.891 ± 0.024	0.268LysTrp: 0.268 ± 0.01	0.4LysTyr: 0.4 ± 0.011	0.0LysXaa: 0.0 ± 0.0
Leu	16.022LeuAla: 16.022 ± 0.095	0.75LeuCys: 0.75 ± 0.013	6.733LeuAsp: 6.733 ± 0.051	4.772LeuGlu: 4.772 ± 0.046	2.736LeuPhe: 2.736 ± 0.032	9.573LeuGly: 9.573 ± 0.061	2.155LeuHis: 2.155 ± 0.025	3.923LeuIle: 3.923 ± 0.04	1.846LeuLys: 1.846 ± 0.026	11.422LeuLeu: 11.422 ± 0.089	1.788LeuMet: 1.788 ± 0.023	1.857LeuAsn: 1.857 ± 0.026	6.563LeuPro: 6.563 ± 0.048	2.151LeuGln: 2.151 ± 0.024	9.097LeuArg: 9.097 ± 0.064	5.679LeuSer: 5.679 ± 0.045	6.842LeuThr: 6.842 ± 0.047	9.171LeuVal: 9.171 ± 0.065	1.384LeuTrp: 1.384 ± 0.024	1.97LeuTyr: 1.97 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	2.417MetAla: 2.417 ± 0.027	0.139MetCys: 0.139 ± 0.007	0.908MetAsp: 0.908 ± 0.016	0.803MetGlu: 0.803 ± 0.015	0.511MetPhe: 0.511 ± 0.012	1.355MetGly: 1.355 ± 0.02	0.347MetHis: 0.347 ± 0.01	0.873MetIle: 0.873 ± 0.017	0.423MetLys: 0.423 ± 0.011	1.95MetLeu: 1.95 ± 0.024	0.338MetMet: 0.338 ± 0.01	0.458MetAsn: 0.458 ± 0.012	1.201MetPro: 1.201 ± 0.019	0.418MetGln: 0.418 ± 0.011	1.72MetArg: 1.72 ± 0.023	1.376MetSer: 1.376 ± 0.023	1.555MetThr: 1.555 ± 0.02	1.431MetVal: 1.431 ± 0.024	0.239MetTrp: 0.239 ± 0.009	0.335MetTyr: 0.335 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.268AsnAla: 2.268 ± 0.029	0.16AsnCys: 0.16 ± 0.007	0.997AsnAsp: 0.997 ± 0.019	0.853AsnGlu: 0.853 ± 0.015	0.491AsnPhe: 0.491 ± 0.012	1.946AsnGly: 1.946 ± 0.027	0.407AsnHis: 0.407 ± 0.011	0.636AsnIle: 0.636 ± 0.014	0.362AsnLys: 0.362 ± 0.013	1.891AsnLeu: 1.891 ± 0.025	0.296AsnMet: 0.296 ± 0.01	0.443AsnAsn: 0.443 ± 0.014	1.502AsnPro: 1.502 ± 0.023	0.54AsnGln: 0.54 ± 0.014	1.355AsnArg: 1.355 ± 0.022	0.904AsnSer: 0.904 ± 0.021	1.063AsnThr: 1.063 ± 0.019	1.593AsnVal: 1.593 ± 0.024	0.311AsnTrp: 0.311 ± 0.009	0.427AsnTyr: 0.427 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	8.613ProAla: 8.613 ± 0.063	0.359ProCys: 0.359 ± 0.011	4.355ProAsp: 4.355 ± 0.037	4.139ProGlu: 4.139 ± 0.037	1.65ProPhe: 1.65 ± 0.021	6.828ProGly: 6.828 ± 0.054	1.283ProHis: 1.283 ± 0.022	1.817ProIle: 1.817 ± 0.023	1.082ProLys: 1.082 ± 0.022	5.402ProLeu: 5.402 ± 0.04	1.148ProMet: 1.148 ± 0.017	1.009ProAsn: 1.009 ± 0.018	4.0ProPro: 4.0 ± 0.054	1.594ProGln: 1.594 ± 0.026	4.016ProArg: 4.016 ± 0.042	3.177ProSer: 3.177 ± 0.036	3.155ProThr: 3.155 ± 0.04	5.364ProVal: 5.364 ± 0.042	0.968ProTrp: 0.968 ± 0.018	1.492ProTyr: 1.492 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	4.083GlnAla: 4.083 ± 0.04	0.162GlnCys: 0.162 ± 0.007	1.335GlnAsp: 1.335 ± 0.021	1.458GlnGlu: 1.458 ± 0.02	0.699GlnPhe: 0.699 ± 0.016	2.219GlnGly: 2.219 ± 0.029	0.593GlnHis: 0.593 ± 0.014	1.217GlnIle: 1.217 ± 0.018	0.484GlnLys: 0.484 ± 0.013	2.797GlnLeu: 2.797 ± 0.032	0.463GlnMet: 0.463 ± 0.012	0.495GlnAsn: 0.495 ± 0.012	1.807GlnPro: 1.807 ± 0.028	1.054GlnGln: 1.054 ± 0.034	2.362GlnArg: 2.362 ± 0.028	1.243GlnSer: 1.243 ± 0.02	1.299GlnThr: 1.299 ± 0.023	2.728GlnVal: 2.728 ± 0.031	0.47GlnTrp: 0.47 ± 0.011	0.554GlnTyr: 0.554 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	9.784ArgAla: 9.784 ± 0.069	0.575ArgCys: 0.575 ± 0.014	4.416ArgAsp: 4.416 ± 0.043	4.697ArgGlu: 4.697 ± 0.047	2.49ArgPhe: 2.49 ± 0.031	5.804ArgGly: 5.804 ± 0.043	2.263ArgHis: 2.263 ± 0.027	3.209ArgIle: 3.209 ± 0.029	1.555ArgLys: 1.555 ± 0.022	9.804ArgLeu: 9.804 ± 0.07	1.922ArgMet: 1.922 ± 0.025	1.424ArgAsn: 1.424 ± 0.022	5.174ArgPro: 5.174 ± 0.042	2.587ArgGln: 2.587 ± 0.027	8.067ArgArg: 8.067 ± 0.069	3.992ArgSer: 3.992 ± 0.034	4.81ArgThr: 4.81 ± 0.04	6.292ArgVal: 6.292 ± 0.044	1.511ArgTrp: 1.511 ± 0.022	1.924ArgTyr: 1.924 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	6.334SerAla: 6.334 ± 0.044	0.419SerCys: 0.419 ± 0.012	2.548SerAsp: 2.548 ± 0.027	2.365SerGlu: 2.365 ± 0.029	1.555SerPhe: 1.555 ± 0.021	5.809SerGly: 5.809 ± 0.042	1.011SerHis: 1.011 ± 0.017	1.734SerIle: 1.734 ± 0.022	0.947SerLys: 0.947 ± 0.017	4.842SerLeu: 4.842 ± 0.042	1.196SerMet: 1.196 ± 0.017	0.905SerAsn: 0.905 ± 0.017	3.319SerPro: 3.319 ± 0.034	1.268SerGln: 1.268 ± 0.022	3.847SerArg: 3.847 ± 0.037	2.737SerSer: 2.737 ± 0.034	2.89SerThr: 2.89 ± 0.031	4.149SerVal: 4.149 ± 0.035	0.966SerTrp: 0.966 ± 0.017	1.219SerTyr: 1.219 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	7.816ThrAla: 7.816 ± 0.047	0.45ThrCys: 0.45 ± 0.012	3.068ThrAsp: 3.068 ± 0.034	2.822ThrGlu: 2.822 ± 0.028	1.788ThrPhe: 1.788 ± 0.023	6.418ThrGly: 6.418 ± 0.052	1.109ThrHis: 1.109 ± 0.018	2.165ThrIle: 2.165 ± 0.027	1.089ThrLys: 1.089 ± 0.021	5.907ThrLeu: 5.907 ± 0.043	1.156ThrMet: 1.156 ± 0.02	1.054ThrAsn: 1.054 ± 0.021	4.108ThrPro: 4.108 ± 0.044	1.36ThrGln: 1.36 ± 0.021	4.085ThrArg: 4.085 ± 0.035	3.213ThrSer: 3.213 ± 0.036	3.762ThrThr: 3.762 ± 0.048	5.532ThrVal: 5.532 ± 0.04	1.023ThrTrp: 1.023 ± 0.019	1.385ThrTyr: 1.385 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	11.479ValAla: 11.479 ± 0.067	0.663ValCys: 0.663 ± 0.013	4.561ValAsp: 4.561 ± 0.046	4.727ValGlu: 4.727 ± 0.042	2.538ValPhe: 2.538 ± 0.03	6.554ValGly: 6.554 ± 0.049	1.845ValHis: 1.845 ± 0.023	3.39ValIle: 3.39 ± 0.036	1.713ValLys: 1.713 ± 0.028	9.585ValLeu: 9.585 ± 0.061	1.492ValMet: 1.492 ± 0.023	1.817ValAsn: 1.817 ± 0.027	5.33ValPro: 5.33 ± 0.044	2.022ValGln: 2.022 ± 0.023	7.094ValArg: 7.094 ± 0.046	4.609ValSer: 4.609 ± 0.042	5.924ValThr: 5.924 ± 0.049	8.108ValVal: 8.108 ± 0.074	1.152ValTrp: 1.152 ± 0.02	1.629ValTyr: 1.629 ± 0.023	0.0ValXaa: 0.0 ± 0.0
Trp	1.692TrpAla: 1.692 ± 0.024	0.15TrpCys: 0.15 ± 0.007	0.862TrpAsp: 0.862 ± 0.019	0.756TrpGlu: 0.756 ± 0.015	0.522TrpPhe: 0.522 ± 0.012	1.074TrpGly: 1.074 ± 0.019	0.429TrpHis: 0.429 ± 0.013	0.621TrpIle: 0.621 ± 0.014	0.314TrpLys: 0.314 ± 0.011	1.927TrpLeu: 1.927 ± 0.025	0.336TrpMet: 0.336 ± 0.011	0.444TrpAsn: 0.444 ± 0.012	0.918TrpPro: 0.918 ± 0.017	0.61TrpGln: 0.61 ± 0.016	1.553TrpArg: 1.553 ± 0.024	0.996TrpSer: 0.996 ± 0.018	1.036TrpThr: 1.036 ± 0.02	1.058TrpVal: 1.058 ± 0.017	0.371TrpTrp: 0.371 ± 0.014	0.383TrpTyr: 0.383 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.7TyrAla: 2.7 ± 0.026	0.194TyrCys: 0.194 ± 0.008	1.493TyrAsp: 1.493 ± 0.027	1.206TyrGlu: 1.206 ± 0.02	0.678TyrPhe: 0.678 ± 0.015	2.306TyrGly: 2.306 ± 0.032	0.457TyrHis: 0.457 ± 0.011	0.528TyrIle: 0.528 ± 0.013	0.351TyrLys: 0.351 ± 0.011	2.329TyrLeu: 2.329 ± 0.028	0.271TyrMet: 0.271 ± 0.008	0.446TyrAsn: 0.446 ± 0.013	1.151TyrPro: 1.151 ± 0.02	0.686TyrGln: 0.686 ± 0.014	1.95TyrArg: 1.95 ± 0.023	1.005TyrSer: 1.005 ± 0.019	1.235TyrThr: 1.235 ± 0.021	1.829TyrVal: 1.829 ± 0.021	0.376TyrTrp: 0.376 ± 0.011	0.497TyrTyr: 0.497 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.004XaaXaa: 0.004 ± 0.002

Statistics based on 10809 proteins (3474277 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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