Amino acid dipepetide frequency for Oryzias javanicus (Javanese ricefish) (Aplocheilus javanicus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.121AlaAla: 7.121 ± 0.05	1.304AlaCys: 1.304 ± 0.014	3.372AlaAsp: 3.372 ± 0.019	4.913AlaGlu: 4.913 ± 0.031	2.421AlaPhe: 2.421 ± 0.018	4.698AlaGly: 4.698 ± 0.032	1.506AlaHis: 1.506 ± 0.014	2.476AlaIle: 2.476 ± 0.018	3.309AlaLys: 3.309 ± 0.023	6.575AlaLeu: 6.575 ± 0.035	1.51AlaMet: 1.51 ± 0.013	2.081AlaAsn: 2.081 ± 0.015	3.881AlaPro: 3.881 ± 0.027	2.917AlaGln: 2.917 ± 0.023	3.228AlaArg: 3.228 ± 0.021	5.778AlaSer: 5.778 ± 0.036	3.273AlaThr: 3.273 ± 0.022	5.047AlaVal: 5.047 ± 0.023	0.667AlaTrp: 0.667 ± 0.009	1.389AlaTyr: 1.389 ± 0.012	0.0AlaXaa: 0.0 ± 0.0
Cys	1.216CysAla: 1.216 ± 0.013	0.695CysCys: 0.695 ± 0.011	1.14CysAsp: 1.14 ± 0.015	1.27CysGlu: 1.27 ± 0.017	0.877CysPhe: 0.877 ± 0.008	1.598CysGly: 1.598 ± 0.02	0.65CysHis: 0.65 ± 0.008	0.912CysIle: 0.912 ± 0.009	1.137CysLys: 1.137 ± 0.014	2.132CysLeu: 2.132 ± 0.017	0.455CysMet: 0.455 ± 0.006	0.799CysAsn: 0.799 ± 0.01	1.346CysPro: 1.346 ± 0.026	1.062CysGln: 1.062 ± 0.012	1.399CysArg: 1.399 ± 0.013	2.339CysSer: 2.339 ± 0.022	1.131CysThr: 1.131 ± 0.013	1.485CysVal: 1.485 ± 0.016	0.317CysTrp: 0.317 ± 0.005	0.582CysTyr: 0.582 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	3.17AspAla: 3.17 ± 0.024	1.168AspCys: 1.168 ± 0.013	2.99AspAsp: 2.99 ± 0.032	3.771AspGlu: 3.771 ± 0.021	2.181AspPhe: 2.181 ± 0.017	3.841AspGly: 3.841 ± 0.031	1.163AspHis: 1.163 ± 0.011	2.441AspIle: 2.441 ± 0.02	2.591AspLys: 2.591 ± 0.02	5.026AspLeu: 5.026 ± 0.025	1.24AspMet: 1.24 ± 0.01	1.759AspAsn: 1.759 ± 0.016	2.968AspPro: 2.968 ± 0.02	1.998AspGln: 1.998 ± 0.014	2.776AspArg: 2.776 ± 0.022	4.583AspSer: 4.583 ± 0.025	2.433AspThr: 2.433 ± 0.016	3.312AspVal: 3.312 ± 0.019	0.659AspTrp: 0.659 ± 0.009	1.441AspTyr: 1.441 ± 0.013	0.0AspXaa: 0.0 ± 0.0
Glu	4.892GluAla: 4.892 ± 0.032	1.213GluCys: 1.213 ± 0.018	4.609GluAsp: 4.609 ± 0.025	8.281GluGlu: 8.281 ± 0.065	1.947GluPhe: 1.947 ± 0.013	4.1GluGly: 4.1 ± 0.024	1.429GluHis: 1.429 ± 0.012	2.739GluIle: 2.739 ± 0.02	4.776GluLys: 4.776 ± 0.041	6.194GluLeu: 6.194 ± 0.039	1.738GluMet: 1.738 ± 0.015	2.811GluAsn: 2.811 ± 0.019	3.031GluPro: 3.031 ± 0.021	3.119GluGln: 3.119 ± 0.022	4.3GluArg: 4.3 ± 0.032	4.552GluSer: 4.552 ± 0.022	3.455GluThr: 3.455 ± 0.022	4.282GluVal: 4.282 ± 0.022	0.682GluTrp: 0.682 ± 0.009	1.482GluTyr: 1.482 ± 0.016	0.0GluXaa: 0.0 ± 0.0
Phe	1.874PheAla: 1.874 ± 0.017	0.992PheCys: 0.992 ± 0.009	1.729PheAsp: 1.729 ± 0.013	1.848PheGlu: 1.848 ± 0.015	1.581PhePhe: 1.581 ± 0.016	2.228PheGly: 2.228 ± 0.018	1.031PheHis: 1.031 ± 0.01	1.842PheIle: 1.842 ± 0.016	1.802PheLys: 1.802 ± 0.014	3.913PheLeu: 3.913 ± 0.027	0.818PheMet: 0.818 ± 0.01	1.418PheAsn: 1.418 ± 0.012	1.882PhePro: 1.882 ± 0.016	1.68PheGln: 1.68 ± 0.012	1.968PheArg: 1.968 ± 0.017	3.55PheSer: 3.55 ± 0.02	2.237PheThr: 2.237 ± 0.017	2.237PheVal: 2.237 ± 0.019	0.509PheTrp: 0.509 ± 0.011	1.188PheTyr: 1.188 ± 0.013	0.0PheXaa: 0.0 ± 0.0
Gly	4.377GlyAla: 4.377 ± 0.03	1.319GlyCys: 1.319 ± 0.013	3.181GlyAsp: 3.181 ± 0.023	4.116GlyGlu: 4.116 ± 0.027	2.497GlyPhe: 2.497 ± 0.018	5.646GlyGly: 5.646 ± 0.042	1.614GlyHis: 1.614 ± 0.013	2.467GlyIle: 2.467 ± 0.017	3.455GlyLys: 3.455 ± 0.023	5.517GlyLeu: 5.517 ± 0.032	1.389GlyMet: 1.389 ± 0.013	2.369GlyAsn: 2.369 ± 0.018	3.399GlyPro: 3.399 ± 0.045	2.71GlyGln: 2.71 ± 0.021	3.82GlyArg: 3.82 ± 0.023	6.03GlySer: 6.03 ± 0.031	3.267GlyThr: 3.267 ± 0.025	4.085GlyVal: 4.085 ± 0.026	0.782GlyTrp: 0.782 ± 0.01	1.717GlyTyr: 1.717 ± 0.015	0.0GlyXaa: 0.0 ± 0.0
His	1.417HisAla: 1.417 ± 0.013	0.724HisCys: 0.724 ± 0.01	0.948HisAsp: 0.948 ± 0.008	1.195HisGlu: 1.195 ± 0.011	1.06HisPhe: 1.06 ± 0.011	1.561HisGly: 1.561 ± 0.013	1.061HisHis: 1.061 ± 0.016	1.203HisIle: 1.203 ± 0.01	1.269HisLys: 1.269 ± 0.011	2.777HisLeu: 2.777 ± 0.02	0.657HisMet: 0.657 ± 0.009	0.951HisAsn: 0.951 ± 0.011	1.64HisPro: 1.64 ± 0.015	1.313HisGln: 1.313 ± 0.013	1.681HisArg: 1.681 ± 0.013	2.402HisSer: 2.402 ± 0.019	1.429HisThr: 1.429 ± 0.013	1.436HisVal: 1.436 ± 0.011	0.337HisTrp: 0.337 ± 0.005	0.786HisTyr: 0.786 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	2.292IleAla: 2.292 ± 0.015	1.038IleCys: 1.038 ± 0.01	1.902IleAsp: 1.902 ± 0.014	2.199IleGlu: 2.199 ± 0.018	1.737IlePhe: 1.737 ± 0.018	2.164IleGly: 2.164 ± 0.017	1.205IleHis: 1.205 ± 0.013	2.222IleIle: 2.222 ± 0.02	2.461IleLys: 2.461 ± 0.019	4.104IleLeu: 4.104 ± 0.022	0.979IleMet: 0.979 ± 0.011	1.813IleAsn: 1.813 ± 0.014	2.407IlePro: 2.407 ± 0.019	2.151IleGln: 2.151 ± 0.016	2.394IleArg: 2.394 ± 0.014	3.718IleSer: 3.718 ± 0.019	2.585IleThr: 2.585 ± 0.021	2.381IleVal: 2.381 ± 0.021	0.461IleTrp: 0.461 ± 0.007	1.29IleTyr: 1.29 ± 0.012	0.0IleXaa: 0.0 ± 0.0
Lys	3.794LysAla: 3.794 ± 0.025	0.996LysCys: 0.996 ± 0.012	3.219LysAsp: 3.219 ± 0.024	4.802LysGlu: 4.802 ± 0.042	1.573LysPhe: 1.573 ± 0.013	3.14LysGly: 3.14 ± 0.031	1.388LysHis: 1.388 ± 0.012	2.404LysIle: 2.404 ± 0.016	4.548LysLys: 4.548 ± 0.038	4.899LysLeu: 4.899 ± 0.027	1.501LysMet: 1.501 ± 0.013	2.278LysAsn: 2.278 ± 0.015	2.988LysPro: 2.988 ± 0.025	2.546LysGln: 2.546 ± 0.021	3.488LysArg: 3.488 ± 0.023	3.916LysSer: 3.916 ± 0.02	3.237LysThr: 3.237 ± 0.022	3.454LysVal: 3.454 ± 0.019	0.564LysTrp: 0.564 ± 0.008	1.385LysTyr: 1.385 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	5.828LeuAla: 5.828 ± 0.027	2.26LeuCys: 2.26 ± 0.018	4.803LeuAsp: 4.803 ± 0.022	6.451LeuGlu: 6.451 ± 0.042	3.362LeuPhe: 3.362 ± 0.024	5.068LeuGly: 5.068 ± 0.027	2.778LeuHis: 2.778 ± 0.019	3.63LeuIle: 3.63 ± 0.021	5.706LeuLys: 5.706 ± 0.034	10.384LeuLeu: 10.384 ± 0.057	2.147LeuMet: 2.147 ± 0.015	3.54LeuAsn: 3.54 ± 0.019	5.417LeuPro: 5.417 ± 0.028	5.768LeuGln: 5.768 ± 0.039	5.78LeuArg: 5.78 ± 0.026	8.495LeuSer: 8.495 ± 0.042	5.293LeuThr: 5.293 ± 0.024	5.353LeuVal: 5.353 ± 0.027	1.115LeuTrp: 1.115 ± 0.011	2.455LeuTyr: 2.455 ± 0.019	0.0LeuXaa: 0.0 ± 0.0
Met	1.829MetAla: 1.829 ± 0.015	0.459MetCys: 0.459 ± 0.006	1.406MetAsp: 1.406 ± 0.014	2.023MetGlu: 2.023 ± 0.017	0.841MetPhe: 0.841 ± 0.01	1.37MetGly: 1.37 ± 0.013	0.47MetHis: 0.47 ± 0.006	0.852MetIle: 0.852 ± 0.008	1.518MetLys: 1.518 ± 0.012	2.029MetLeu: 2.029 ± 0.017	0.713MetMet: 0.713 ± 0.01	0.882MetAsn: 0.882 ± 0.01	1.034MetPro: 1.034 ± 0.012	0.985MetGln: 0.985 ± 0.01	1.218MetArg: 1.218 ± 0.013	1.914MetSer: 1.914 ± 0.013	1.282MetThr: 1.282 ± 0.011	1.482MetVal: 1.482 ± 0.011	0.273MetTrp: 0.273 ± 0.005	0.575MetTyr: 0.575 ± 0.007	0.0MetXaa: 0.0 ± 0.0
Asn	2.117AsnAla: 2.117 ± 0.015	0.865AsnCys: 0.865 ± 0.01	1.599AsnAsp: 1.599 ± 0.015	2.028AsnGlu: 2.028 ± 0.015	1.419AsnPhe: 1.419 ± 0.014	2.645AsnGly: 2.645 ± 0.019	0.988AsnHis: 0.988 ± 0.01	2.003AsnIle: 2.003 ± 0.014	2.173AsnLys: 2.173 ± 0.015	3.586AsnLeu: 3.586 ± 0.023	0.991AsnMet: 0.991 ± 0.01	1.719AsnAsn: 1.719 ± 0.015	2.291AsnPro: 2.291 ± 0.015	1.84AsnGln: 1.84 ± 0.022	2.01AsnArg: 2.01 ± 0.014	3.233AsnSer: 3.233 ± 0.019	2.087AsnThr: 2.087 ± 0.016	2.214AsnVal: 2.214 ± 0.017	0.431AsnTrp: 0.431 ± 0.006	1.066AsnTyr: 1.066 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	4.637ProAla: 4.637 ± 0.031	1.111ProCys: 1.111 ± 0.018	3.009ProAsp: 3.009 ± 0.018	3.936ProGlu: 3.936 ± 0.022	1.826ProPhe: 1.826 ± 0.016	4.234ProGly: 4.234 ± 0.061	1.556ProHis: 1.556 ± 0.014	1.777ProIle: 1.777 ± 0.018	2.616ProLys: 2.616 ± 0.027	4.934ProLeu: 4.934 ± 0.024	0.985ProMet: 0.985 ± 0.012	1.929ProAsn: 1.929 ± 0.016	5.886ProPro: 5.886 ± 0.057	2.742ProGln: 2.742 ± 0.022	2.909ProArg: 2.909 ± 0.021	5.82ProSer: 5.82 ± 0.035	3.059ProThr: 3.059 ± 0.022	3.748ProVal: 3.748 ± 0.02	0.555ProTrp: 0.555 ± 0.008	1.319ProTyr: 1.319 ± 0.014	0.0ProXaa: 0.0 ± 0.0
Gln	3.108GlnAla: 3.108 ± 0.023	0.919GlnCys: 0.919 ± 0.013	2.32GlnAsp: 2.32 ± 0.018	3.677GlnGlu: 3.677 ± 0.028	1.35GlnPhe: 1.35 ± 0.012	2.605GlnGly: 2.605 ± 0.02	1.362GlnHis: 1.362 ± 0.012	1.922GlnIle: 1.922 ± 0.015	2.736GlnLys: 2.736 ± 0.022	4.545GlnLeu: 4.545 ± 0.03	1.167GlnMet: 1.167 ± 0.013	1.89GlnAsn: 1.89 ± 0.017	2.579GlnPro: 2.579 ± 0.023	3.341GlnGln: 3.341 ± 0.041	3.247GlnArg: 3.247 ± 0.022	3.624GlnSer: 3.624 ± 0.02	2.827GlnThr: 2.827 ± 0.028	2.733GlnVal: 2.733 ± 0.017	0.541GlnTrp: 0.541 ± 0.007	1.12GlnTyr: 1.12 ± 0.009	0.0GlnXaa: 0.0 ± 0.0
Arg	3.678ArgAla: 3.678 ± 0.022	1.332ArgCys: 1.332 ± 0.015	2.928ArgAsp: 2.928 ± 0.021	3.921ArgGlu: 3.921 ± 0.026	2.024ArgPhe: 2.024 ± 0.014	3.769ArgGly: 3.769 ± 0.027	1.569ArgHis: 1.569 ± 0.014	2.344ArgIle: 2.344 ± 0.016	3.568ArgLys: 3.568 ± 0.024	5.459ArgLeu: 5.459 ± 0.026	1.338ArgMet: 1.338 ± 0.013	2.117ArgAsn: 2.117 ± 0.014	3.075ArgPro: 3.075 ± 0.021	2.674ArgGln: 2.674 ± 0.02	5.007ArgArg: 5.007 ± 0.036	5.044ArgSer: 5.044 ± 0.027	3.06ArgThr: 3.06 ± 0.017	3.349ArgVal: 3.349 ± 0.019	0.731ArgTrp: 0.731 ± 0.01	1.439ArgTyr: 1.439 ± 0.013	0.0ArgXaa: 0.0 ± 0.0
Ser	6.073SerAla: 6.073 ± 0.032	2.176SerCys: 2.176 ± 0.02	4.507SerAsp: 4.507 ± 0.031	5.182SerGlu: 5.182 ± 0.027	3.267SerPhe: 3.267 ± 0.02	5.878SerGly: 5.878 ± 0.032	2.234SerHis: 2.234 ± 0.019	3.297SerIle: 3.297 ± 0.021	4.103SerLys: 4.103 ± 0.024	8.418SerLeu: 8.418 ± 0.038	1.856SerMet: 1.856 ± 0.012	3.039SerAsn: 3.039 ± 0.029	6.115SerPro: 6.115 ± 0.042	3.947SerGln: 3.947 ± 0.023	4.974SerArg: 4.974 ± 0.026	11.223SerSer: 11.223 ± 0.074	4.821SerThr: 4.821 ± 0.028	5.549SerVal: 5.549 ± 0.026	1.08SerTrp: 1.08 ± 0.012	2.051SerTyr: 2.051 ± 0.015	0.0SerXaa: 0.0 ± 0.0
Thr	4.067ThrAla: 4.067 ± 0.021	1.369ThrCys: 1.369 ± 0.021	2.821ThrAsp: 2.821 ± 0.018	3.727ThrGlu: 3.727 ± 0.02	2.112ThrPhe: 2.112 ± 0.017	3.545ThrGly: 3.545 ± 0.024	1.307ThrHis: 1.307 ± 0.014	2.244ThrIle: 2.244 ± 0.016	2.656ThrLys: 2.656 ± 0.018	5.234ThrLeu: 5.234 ± 0.026	1.162ThrMet: 1.162 ± 0.01	1.939ThrAsn: 1.939 ± 0.015	3.682ThrPro: 3.682 ± 0.03	2.311ThrGln: 2.311 ± 0.017	2.515ThrArg: 2.515 ± 0.015	4.884ThrSer: 4.884 ± 0.028	3.245ThrThr: 3.245 ± 0.04	4.057ThrVal: 4.057 ± 0.035	0.67ThrTrp: 0.67 ± 0.009	1.323ThrTyr: 1.323 ± 0.012	0.0ThrXaa: 0.0 ± 0.0
Val	3.987ValAla: 3.987 ± 0.022	1.692ValCys: 1.692 ± 0.017	3.109ValAsp: 3.109 ± 0.016	4.073ValGlu: 4.073 ± 0.022	2.653ValPhe: 2.653 ± 0.019	3.474ValGly: 3.474 ± 0.021	1.535ValHis: 1.535 ± 0.011	2.843ValIle: 2.843 ± 0.021	3.556ValLys: 3.556 ± 0.023	6.307ValLeu: 6.307 ± 0.029	1.518ValMet: 1.518 ± 0.011	2.328ValAsn: 2.328 ± 0.018	3.279ValPro: 3.279 ± 0.021	2.855ValGln: 2.855 ± 0.019	3.291ValArg: 3.291 ± 0.018	5.439ValSer: 5.439 ± 0.037	3.906ValThr: 3.906 ± 0.029	4.318ValVal: 4.318 ± 0.024	0.797ValTrp: 0.797 ± 0.01	1.709ValTyr: 1.709 ± 0.015	0.0ValXaa: 0.0 ± 0.0
Trp	0.659TrpAla: 0.659 ± 0.008	0.248TrpCys: 0.248 ± 0.005	0.637TrpAsp: 0.637 ± 0.008	0.75TrpGlu: 0.75 ± 0.009	0.478TrpPhe: 0.478 ± 0.007	0.635TrpGly: 0.635 ± 0.01	0.256TrpHis: 0.256 ± 0.005	0.582TrpIle: 0.582 ± 0.008	0.745TrpLys: 0.745 ± 0.008	1.153TrpLeu: 1.153 ± 0.012	0.365TrpMet: 0.365 ± 0.008	0.511TrpAsn: 0.511 ± 0.007	0.438TrpPro: 0.438 ± 0.007	0.465TrpGln: 0.465 ± 0.007	0.823TrpArg: 0.823 ± 0.009	1.018TrpSer: 1.018 ± 0.012	0.758TrpThr: 0.758 ± 0.01	0.681TrpVal: 0.681 ± 0.01	0.192TrpTrp: 0.192 ± 0.004	0.324TrpTyr: 0.324 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.331TyrAla: 1.331 ± 0.013	0.664TyrCys: 0.664 ± 0.01	1.283TyrAsp: 1.283 ± 0.012	1.471TyrGlu: 1.471 ± 0.013	1.121TyrPhe: 1.121 ± 0.011	1.559TyrGly: 1.559 ± 0.017	0.741TyrHis: 0.741 ± 0.009	1.305TyrIle: 1.305 ± 0.014	1.392TyrLys: 1.392 ± 0.014	2.448TyrLeu: 2.448 ± 0.019	0.625TyrMet: 0.625 ± 0.007	1.131TyrAsn: 1.131 ± 0.011	1.252TyrPro: 1.252 ± 0.013	1.186TyrGln: 1.186 ± 0.012	1.594TyrArg: 1.594 ± 0.013	2.231TyrSer: 2.231 ± 0.015	1.482TyrThr: 1.482 ± 0.013	1.464TyrVal: 1.464 ± 0.014	0.357TyrTrp: 0.357 ± 0.007	0.893TyrTyr: 0.893 ± 0.011	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 21400 proteins (11474022 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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