Amino acid dipepetide frequency for archaeon HR06

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.103AlaAla: 3.103 ± 0.133
0.823AlaCys: 0.823 ± 0.06
1.935AlaAsp: 1.935 ± 0.078
3.46AlaGlu: 3.46 ± 0.111
2.697AlaPhe: 2.697 ± 0.1
3.71AlaGly: 3.71 ± 0.156
0.831AlaHis: 0.831 ± 0.061
4.912AlaIle: 4.912 ± 0.135
5.956AlaLys: 5.956 ± 0.16
8.611AlaLeu: 8.611 ± 0.201
1.1AlaMet: 1.1 ± 0.071
1.95AlaAsn: 1.95 ± 0.074
1.559AlaPro: 1.559 ± 0.086
1.29AlaGln: 1.29 ± 0.069
2.428AlaArg: 2.428 ± 0.103
3.41AlaSer: 3.41 ± 0.104
2.477AlaThr: 2.477 ± 0.105
2.659AlaVal: 2.659 ± 0.108
0.649AlaTrp: 0.649 ± 0.054
2.272AlaTyr: 2.272 ± 0.098
0.0AlaXaa: 0.0 ± 0.0
Cys
0.387CysAla: 0.387 ± 0.039
0.137CysCys: 0.137 ± 0.025
0.501CysAsp: 0.501 ± 0.041
0.778CysGlu: 0.778 ± 0.062
0.395CysPhe: 0.395 ± 0.037
0.937CysGly: 0.937 ± 0.075
0.159CysHis: 0.159 ± 0.024
0.797CysIle: 0.797 ± 0.062
1.024CysLys: 1.024 ± 0.065
0.8CysLeu: 0.8 ± 0.06
0.174CysMet: 0.174 ± 0.023
0.432CysAsn: 0.432 ± 0.045
0.641CysPro: 0.641 ± 0.058
0.133CysGln: 0.133 ± 0.021
0.444CysArg: 0.444 ± 0.041
0.652CysSer: 0.652 ± 0.041
0.368CysThr: 0.368 ± 0.033
0.508CysVal: 0.508 ± 0.046
0.083CysTrp: 0.083 ± 0.017
0.421CysTyr: 0.421 ± 0.045
0.0CysXaa: 0.0 ± 0.0
Asp
2.094AspAla: 2.094 ± 0.093
0.402AspCys: 0.402 ± 0.04
1.753AspAsp: 1.753 ± 0.078
3.816AspGlu: 3.816 ± 0.117
2.701AspPhe: 2.701 ± 0.104
2.784AspGly: 2.784 ± 0.117
0.599AspHis: 0.599 ± 0.049
4.787AspIle: 4.787 ± 0.146
4.639AspLys: 4.639 ± 0.153
6.536AspLeu: 6.536 ± 0.163
1.066AspMet: 1.066 ± 0.067
1.608AspAsn: 1.608 ± 0.076
2.189AspPro: 2.189 ± 0.092
0.573AspGln: 0.573 ± 0.051
2.045AspArg: 2.045 ± 0.091
2.496AspSer: 2.496 ± 0.107
1.624AspThr: 1.624 ± 0.067
3.035AspVal: 3.035 ± 0.113
0.58AspTrp: 0.58 ± 0.055
2.291AspTyr: 2.291 ± 0.074
0.0AspXaa: 0.0 ± 0.0
Glu
5.766GluAla: 5.766 ± 0.154
0.505GluCys: 0.505 ± 0.039
4.886GluAsp: 4.886 ± 0.133
9.29GluGlu: 9.29 ± 0.22
3.312GluPhe: 3.312 ± 0.118
5.398GluGly: 5.398 ± 0.164
0.8GluHis: 0.8 ± 0.062
7.526GluIle: 7.526 ± 0.166
7.446GluLys: 7.446 ± 0.177
8.004GluLeu: 8.004 ± 0.198
1.445GluMet: 1.445 ± 0.078
2.864GluAsn: 2.864 ± 0.103
2.215GluPro: 2.215 ± 0.098
0.945GluGln: 0.945 ± 0.053
4.552GluArg: 4.552 ± 0.131
2.709GluSer: 2.709 ± 0.115
2.215GluThr: 2.215 ± 0.093
6.4GluVal: 6.4 ± 0.154
0.713GluTrp: 0.713 ± 0.052
2.557GluTyr: 2.557 ± 0.104
0.0GluXaa: 0.0 ± 0.0
Phe
1.961PheAla: 1.961 ± 0.096
0.573PheCys: 0.573 ± 0.05
2.128PheAsp: 2.128 ± 0.095
3.126PheGlu: 3.126 ± 0.108
2.724PhePhe: 2.724 ± 0.128
3.209PheGly: 3.209 ± 0.115
0.641PheHis: 0.641 ± 0.051
4.101PheIle: 4.101 ± 0.139
4.617PheLys: 4.617 ± 0.141
6.407PheLeu: 6.407 ± 0.204
0.926PheMet: 0.926 ± 0.068
2.303PheAsn: 2.303 ± 0.092
1.893PhePro: 1.893 ± 0.085
0.99PheGln: 0.99 ± 0.066
1.745PheArg: 1.745 ± 0.078
3.661PheSer: 3.661 ± 0.142
2.158PheThr: 2.158 ± 0.084
2.268PheVal: 2.268 ± 0.097
0.607PheTrp: 0.607 ± 0.05
2.064PheTyr: 2.064 ± 0.094
0.0PheXaa: 0.0 ± 0.0
Gly
3.664GlyAla: 3.664 ± 0.124
0.599GlyCys: 0.599 ± 0.05
2.997GlyAsp: 2.997 ± 0.107
4.719GlyGlu: 4.719 ± 0.135
3.403GlyPhe: 3.403 ± 0.107
4.643GlyGly: 4.643 ± 0.164
0.922GlyHis: 0.922 ± 0.069
6.468GlyIle: 6.468 ± 0.156
6.597GlyLys: 6.597 ± 0.177
7.371GlyLeu: 7.371 ± 0.175
1.476GlyMet: 1.476 ± 0.078
2.25GlyAsn: 2.25 ± 0.094
1.84GlyPro: 1.84 ± 0.082
0.979GlyGln: 0.979 ± 0.067
2.947GlyArg: 2.947 ± 0.107
4.002GlySer: 4.002 ± 0.139
2.451GlyThr: 2.451 ± 0.1
4.067GlyVal: 4.067 ± 0.129
0.694GlyTrp: 0.694 ± 0.045
2.944GlyTyr: 2.944 ± 0.109
0.0GlyXaa: 0.0 ± 0.0
His
0.744HisAla: 0.744 ± 0.052
0.171HisCys: 0.171 ± 0.025
0.512HisAsp: 0.512 ± 0.044
0.819HisGlu: 0.819 ± 0.049
0.649HisPhe: 0.649 ± 0.05
0.907HisGly: 0.907 ± 0.062
0.277HisHis: 0.277 ± 0.038
1.176HisIle: 1.176 ± 0.07
0.876HisLys: 0.876 ± 0.057
1.639HisLeu: 1.639 ± 0.09
0.292HisMet: 0.292 ± 0.032
0.486HisAsn: 0.486 ± 0.036
0.922HisPro: 0.922 ± 0.054
0.228HisGln: 0.228 ± 0.029
0.596HisArg: 0.596 ± 0.048
0.702HisSer: 0.702 ± 0.048
0.561HisThr: 0.561 ± 0.045
0.709HisVal: 0.709 ± 0.048
0.193HisTrp: 0.193 ± 0.026
0.577HisTyr: 0.577 ± 0.047
0.0HisXaa: 0.0 ± 0.0
Ile
5.383IleAla: 5.383 ± 0.155
0.975IleCys: 0.975 ± 0.064
4.313IleAsp: 4.313 ± 0.134
5.827IleGlu: 5.827 ± 0.148
4.814IlePhe: 4.814 ± 0.139
5.364IleGly: 5.364 ± 0.175
1.385IleHis: 1.385 ± 0.077
8.459IleIle: 8.459 ± 0.21
9.044IleLys: 9.044 ± 0.184
10.371IleLeu: 10.371 ± 0.214
1.916IleMet: 1.916 ± 0.083
4.142IleAsn: 4.142 ± 0.142
4.055IlePro: 4.055 ± 0.128
1.555IleGln: 1.555 ± 0.083
3.964IleArg: 3.964 ± 0.134
5.622IleSer: 5.622 ± 0.152
4.252IleThr: 4.252 ± 0.151
5.994IleVal: 5.994 ± 0.171
0.804IleTrp: 0.804 ± 0.058
3.755IleTyr: 3.755 ± 0.132
0.0IleXaa: 0.0 ± 0.0
Lys
5.827LysAla: 5.827 ± 0.163
0.652LysCys: 0.652 ± 0.054
6.388LysAsp: 6.388 ± 0.131
11.217LysGlu: 11.217 ± 0.238
3.513LysPhe: 3.513 ± 0.115
7.151LysGly: 7.151 ± 0.173
0.808LysHis: 0.808 ± 0.057
8.607LysIle: 8.607 ± 0.195
7.45LysLys: 7.45 ± 0.187
8.945LysLeu: 8.945 ± 0.186
1.897LysMet: 1.897 ± 0.081
3.957LysAsn: 3.957 ± 0.132
3.209LysPro: 3.209 ± 0.105
0.891LysGln: 0.891 ± 0.06
5.683LysArg: 5.683 ± 0.142
4.093LysSer: 4.093 ± 0.136
2.5LysThr: 2.5 ± 0.114
8.634LysVal: 8.634 ± 0.19
0.713LysTrp: 0.713 ± 0.062
3.088LysTyr: 3.088 ± 0.119
0.0LysXaa: 0.0 ± 0.0
Leu
7.837LeuAla: 7.837 ± 0.179
1.051LeuCys: 1.051 ± 0.06
5.808LeuAsp: 5.808 ± 0.168
9.222LeuGlu: 9.222 ± 0.239
4.545LeuPhe: 4.545 ± 0.18
8.091LeuGly: 8.091 ± 0.201
1.29LeuHis: 1.29 ± 0.078
10.656LeuIle: 10.656 ± 0.261
12.53LeuLys: 12.53 ± 0.293
12.014LeuLeu: 12.014 ± 0.284
2.253LeuMet: 2.253 ± 0.096
5.519LeuAsn: 5.519 ± 0.16
4.833LeuPro: 4.833 ± 0.152
2.193LeuGln: 2.193 ± 0.094
5.231LeuArg: 5.231 ± 0.166
7.826LeuSer: 7.826 ± 0.185
5.39LeuThr: 5.39 ± 0.153
6.343LeuVal: 6.343 ± 0.143
1.111LeuTrp: 1.111 ± 0.068
3.809LeuTyr: 3.809 ± 0.12
0.0LeuXaa: 0.0 ± 0.0
Met
1.445MetAla: 1.445 ± 0.083
0.095MetCys: 0.095 ± 0.018
1.089MetAsp: 1.089 ± 0.071
1.764MetGlu: 1.764 ± 0.088
0.55MetPhe: 0.55 ± 0.045
1.711MetGly: 1.711 ± 0.082
0.254MetHis: 0.254 ± 0.033
1.715MetIle: 1.715 ± 0.076
1.992MetLys: 1.992 ± 0.092
1.984MetLeu: 1.984 ± 0.083
0.474MetMet: 0.474 ± 0.045
0.914MetAsn: 0.914 ± 0.057
0.759MetPro: 0.759 ± 0.053
0.296MetGln: 0.296 ± 0.033
1.066MetArg: 1.066 ± 0.073
1.331MetSer: 1.331 ± 0.069
0.505MetThr: 0.505 ± 0.043
1.965MetVal: 1.965 ± 0.098
0.133MetTrp: 0.133 ± 0.021
0.523MetTyr: 0.523 ± 0.041
0.0MetXaa: 0.0 ± 0.0
Asn
1.297AsnAla: 1.297 ± 0.076
0.546AsnCys: 0.546 ± 0.049
1.138AsnAsp: 1.138 ± 0.06
2.325AsnGlu: 2.325 ± 0.104
2.94AsnPhe: 2.94 ± 0.12
1.809AsnGly: 1.809 ± 0.094
0.531AsnHis: 0.531 ± 0.048
3.638AsnIle: 3.638 ± 0.137
3.205AsnLys: 3.205 ± 0.105
7.321AsnLeu: 7.321 ± 0.206
0.861AsnMet: 0.861 ± 0.055
1.468AsnAsn: 1.468 ± 0.079
2.492AsnPro: 2.492 ± 0.092
0.74AsnGln: 0.74 ± 0.049
1.828AsnArg: 1.828 ± 0.082
2.591AsnSer: 2.591 ± 0.114
1.582AsnThr: 1.582 ± 0.075
2.109AsnVal: 2.109 ± 0.094
0.577AsnTrp: 0.577 ± 0.045
2.318AsnTyr: 2.318 ± 0.1
0.0AsnXaa: 0.0 ± 0.0
Pro
1.555ProAla: 1.555 ± 0.107
0.326ProCys: 0.326 ± 0.034
1.859ProAsp: 1.859 ± 0.088
2.777ProGlu: 2.777 ± 0.111
2.287ProPhe: 2.287 ± 0.107
1.699ProGly: 1.699 ± 0.094
0.615ProHis: 0.615 ± 0.058
3.414ProIle: 3.414 ± 0.125
3.517ProLys: 3.517 ± 0.127
5.193ProLeu: 5.193 ± 0.138
0.706ProMet: 0.706 ± 0.056
1.904ProAsn: 1.904 ± 0.087
1.734ProPro: 1.734 ± 0.093
0.819ProGln: 0.819 ± 0.055
1.358ProArg: 1.358 ± 0.084
2.64ProSer: 2.64 ± 0.102
1.802ProThr: 1.802 ± 0.086
1.992ProVal: 1.992 ± 0.097
0.463ProTrp: 0.463 ± 0.041
1.935ProTyr: 1.935 ± 0.087
0.0ProXaa: 0.0 ± 0.0
Gln
1.195GlnAla: 1.195 ± 0.069
0.125GlnCys: 0.125 ± 0.019
0.744GlnAsp: 0.744 ± 0.058
1.388GlnGlu: 1.388 ± 0.079
0.747GlnPhe: 0.747 ± 0.054
1.009GlnGly: 1.009 ± 0.062
0.186GlnHis: 0.186 ± 0.024
1.779GlnIle: 1.779 ± 0.082
1.233GlnLys: 1.233 ± 0.074
1.722GlnLeu: 1.722 ± 0.091
0.311GlnMet: 0.311 ± 0.033
0.679GlnAsn: 0.679 ± 0.051
0.516GlnPro: 0.516 ± 0.045
0.296GlnGln: 0.296 ± 0.038
1.218GlnArg: 1.218 ± 0.07
0.918GlnSer: 0.918 ± 0.056
0.717GlnThr: 0.717 ± 0.075
1.146GlnVal: 1.146 ± 0.069
0.197GlnTrp: 0.197 ± 0.025
0.634GlnTyr: 0.634 ± 0.051
0.0GlnXaa: 0.0 ± 0.0
Arg
3.137ArgAla: 3.137 ± 0.119
0.417ArgCys: 0.417 ± 0.042
2.397ArgAsp: 2.397 ± 0.088
5.098ArgGlu: 5.098 ± 0.131
2.045ArgPhe: 2.045 ± 0.092
3.145ArgGly: 3.145 ± 0.098
0.467ArgHis: 0.467 ± 0.041
4.931ArgIle: 4.931 ± 0.143
3.949ArgLys: 3.949 ± 0.128
4.514ArgLeu: 4.514 ± 0.129
1.119ArgMet: 1.119 ± 0.062
1.696ArgAsn: 1.696 ± 0.072
1.271ArgPro: 1.271 ± 0.076
0.675ArgGln: 0.675 ± 0.055
3.111ArgArg: 3.111 ± 0.117
2.337ArgSer: 2.337 ± 0.092
1.4ArgThr: 1.4 ± 0.072
3.312ArgVal: 3.312 ± 0.134
0.459ArgTrp: 0.459 ± 0.04
1.703ArgTyr: 1.703 ± 0.083
0.0ArgXaa: 0.0 ± 0.0
Ser
2.261SerAla: 2.261 ± 0.1
0.649SerCys: 0.649 ± 0.053
2.143SerAsp: 2.143 ± 0.092
3.535SerGlu: 3.535 ± 0.127
3.687SerPhe: 3.687 ± 0.133
3.327SerGly: 3.327 ± 0.11
0.823SerHis: 0.823 ± 0.053
5.106SerIle: 5.106 ± 0.139
6.153SerLys: 6.153 ± 0.177
9.26SerLeu: 9.26 ± 0.223
1.313SerMet: 1.313 ± 0.068
2.314SerAsn: 2.314 ± 0.093
2.428SerPro: 2.428 ± 0.113
1.123SerGln: 1.123 ± 0.065
2.185SerArg: 2.185 ± 0.083
4.423SerSer: 4.423 ± 0.15
2.375SerThr: 2.375 ± 0.125
2.849SerVal: 2.849 ± 0.12
0.683SerTrp: 0.683 ± 0.057
2.621SerTyr: 2.621 ± 0.109
0.0SerXaa: 0.0 ± 0.0
Thr
2.117ThrAla: 2.117 ± 0.1
0.44ThrCys: 0.44 ± 0.046
1.369ThrAsp: 1.369 ± 0.075
2.048ThrGlu: 2.048 ± 0.093
2.094ThrPhe: 2.094 ± 0.103
2.667ThrGly: 2.667 ± 0.113
0.857ThrHis: 0.857 ± 0.063
3.52ThrIle: 3.52 ± 0.128
2.982ThrLys: 2.982 ± 0.1
5.774ThrLeu: 5.774 ± 0.157
0.884ThrMet: 0.884 ± 0.055
1.487ThrAsn: 1.487 ± 0.069
1.802ThrPro: 1.802 ± 0.085
0.933ThrGln: 0.933 ± 0.07
1.377ThrArg: 1.377 ± 0.072
2.614ThrSer: 2.614 ± 0.134
2.196ThrThr: 2.196 ± 0.216
2.363ThrVal: 2.363 ± 0.122
0.406ThrTrp: 0.406 ± 0.042
1.677ThrTyr: 1.677 ± 0.084
0.0ThrXaa: 0.0 ± 0.0
Val
3.884ValAla: 3.884 ± 0.129
0.63ValCys: 0.63 ± 0.053
3.088ValAsp: 3.088 ± 0.11
4.692ValGlu: 4.692 ± 0.145
2.435ValPhe: 2.435 ± 0.083
4.127ValGly: 4.127 ± 0.148
0.74ValHis: 0.74 ± 0.059
6.115ValIle: 6.115 ± 0.155
7.913ValLys: 7.913 ± 0.194
5.182ValLeu: 5.182 ± 0.123
1.275ValMet: 1.275 ± 0.067
2.989ValAsn: 2.989 ± 0.134
1.976ValPro: 1.976 ± 0.079
0.96ValGln: 0.96 ± 0.068
3.198ValArg: 3.198 ± 0.106
3.862ValSer: 3.862 ± 0.137
3.042ValThr: 3.042 ± 0.124
3.661ValVal: 3.661 ± 0.137
0.694ValTrp: 0.694 ± 0.053
2.375ValTyr: 2.375 ± 0.1
0.0ValXaa: 0.0 ± 0.0
Trp
0.535TrpAla: 0.535 ± 0.052
0.163TrpCys: 0.163 ± 0.025
0.546TrpAsp: 0.546 ± 0.049
0.744TrpGlu: 0.744 ± 0.06
0.531TrpPhe: 0.531 ± 0.044
0.671TrpGly: 0.671 ± 0.047
0.125TrpHis: 0.125 ± 0.024
1.127TrpIle: 1.127 ± 0.067
0.823TrpLys: 0.823 ± 0.056
1.081TrpLeu: 1.081 ± 0.066
0.307TrpMet: 0.307 ± 0.036
0.505TrpAsn: 0.505 ± 0.043
0.3TrpPro: 0.3 ± 0.032
0.243TrpGln: 0.243 ± 0.034
0.561TrpArg: 0.561 ± 0.051
0.493TrpSer: 0.493 ± 0.053
0.36TrpThr: 0.36 ± 0.043
0.751TrpVal: 0.751 ± 0.05
0.205TrpTrp: 0.205 ± 0.03
0.364TrpTyr: 0.364 ± 0.039
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.639TyrAla: 1.639 ± 0.097
0.493TyrCys: 0.493 ± 0.049
2.026TyrAsp: 2.026 ± 0.084
2.902TyrGlu: 2.902 ± 0.11
2.033TyrPhe: 2.033 ± 0.091
2.671TyrGly: 2.671 ± 0.105
0.725TyrHis: 0.725 ± 0.053
3.16TyrIle: 3.16 ± 0.109
3.278TyrLys: 3.278 ± 0.111
4.825TyrLeu: 4.825 ± 0.151
0.766TyrMet: 0.766 ± 0.052
1.851TyrAsn: 1.851 ± 0.086
1.961TyrPro: 1.961 ± 0.084
0.899TyrGln: 0.899 ± 0.07
1.646TyrArg: 1.646 ± 0.079
2.875TyrSer: 2.875 ± 0.125
1.631TyrThr: 1.631 ± 0.083
2.075TyrVal: 2.075 ± 0.087
0.47TyrTrp: 0.47 ± 0.051
1.813TyrTyr: 1.813 ± 0.089
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1118 proteins (263615 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski