Amino acid dipepetide frequency for Treponema azotonutricium (strain ATCC BAA-888 / DSM 13862 / ZAS-9)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.633AlaAla: 10.633 ± 0.155	0.986AlaCys: 0.986 ± 0.028	4.795AlaAsp: 4.795 ± 0.071	6.436AlaGlu: 6.436 ± 0.097	4.06AlaPhe: 4.06 ± 0.075	7.783AlaGly: 7.783 ± 0.111	1.229AlaHis: 1.229 ± 0.033	5.733AlaIle: 5.733 ± 0.077	5.11AlaLys: 5.11 ± 0.079	9.62AlaLeu: 9.62 ± 0.136	2.243AlaMet: 2.243 ± 0.043	2.962AlaAsn: 2.962 ± 0.059	3.151AlaPro: 3.151 ± 0.06	2.674AlaGln: 2.674 ± 0.055	4.412AlaArg: 4.412 ± 0.063	5.712AlaSer: 5.712 ± 0.073	2.95AlaThr: 2.95 ± 0.07	6.479AlaVal: 6.479 ± 0.085	1.06AlaTrp: 1.06 ± 0.033	2.718AlaTyr: 2.718 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.881CysAla: 0.881 ± 0.03	0.206CysCys: 0.206 ± 0.014	0.55CysAsp: 0.55 ± 0.023	0.486CysGlu: 0.486 ± 0.02	0.516CysPhe: 0.516 ± 0.024	1.011CysGly: 1.011 ± 0.032	0.215CysHis: 0.215 ± 0.013	0.784CysIle: 0.784 ± 0.031	0.533CysLys: 0.533 ± 0.024	1.049CysLeu: 1.049 ± 0.03	0.236CysMet: 0.236 ± 0.015	0.322CysAsn: 0.322 ± 0.019	0.532CysPro: 0.532 ± 0.023	0.23CysGln: 0.23 ± 0.013	0.59CysArg: 0.59 ± 0.022	0.713CysSer: 0.713 ± 0.026	0.527CysThr: 0.527 ± 0.024	0.612CysVal: 0.612 ± 0.024	0.1CysTrp: 0.1 ± 0.01	0.346CysTyr: 0.346 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	4.627AspAla: 4.627 ± 0.07	0.515AspCys: 0.515 ± 0.024	2.752AspAsp: 2.752 ± 0.069	3.876AspGlu: 3.876 ± 0.068	2.787AspPhe: 2.787 ± 0.052	3.943AspGly: 3.943 ± 0.08	0.852AspHis: 0.852 ± 0.029	4.36AspIle: 4.36 ± 0.074	3.176AspLys: 3.176 ± 0.055	5.173AspLeu: 5.173 ± 0.072	1.333AspMet: 1.333 ± 0.035	2.019AspAsn: 2.019 ± 0.052	2.728AspPro: 2.728 ± 0.057	1.222AspGln: 1.222 ± 0.038	2.682AspArg: 2.682 ± 0.052	3.357AspSer: 3.357 ± 0.065	2.939AspThr: 2.939 ± 0.055	2.977AspVal: 2.977 ± 0.055	0.699AspTrp: 0.699 ± 0.025	2.196AspTyr: 2.196 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	6.596GluAla: 6.596 ± 0.099	0.468GluCys: 0.468 ± 0.021	3.321GluAsp: 3.321 ± 0.058	4.798GluGlu: 4.798 ± 0.091	2.653GluPhe: 2.653 ± 0.054	4.569GluGly: 4.569 ± 0.069	1.0GluHis: 1.0 ± 0.037	5.126GluIle: 5.126 ± 0.077	5.638GluLys: 5.638 ± 0.102	6.226GluLeu: 6.226 ± 0.087	1.641GluMet: 1.641 ± 0.039	3.095GluAsn: 3.095 ± 0.059	1.975GluPro: 1.975 ± 0.05	1.91GluGln: 1.91 ± 0.05	3.347GluArg: 3.347 ± 0.064	3.454GluSer: 3.454 ± 0.064	3.671GluThr: 3.671 ± 0.063	3.344GluVal: 3.344 ± 0.061	0.736GluTrp: 0.736 ± 0.021	2.358GluTyr: 2.358 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	3.734PheAla: 3.734 ± 0.063	0.667PheCys: 0.667 ± 0.025	2.647PheAsp: 2.647 ± 0.057	2.605PheGlu: 2.605 ± 0.052	2.522PhePhe: 2.522 ± 0.064	3.358PheGly: 3.358 ± 0.068	0.776PheHis: 0.776 ± 0.03	3.355PheIle: 3.355 ± 0.067	2.338PheLys: 2.338 ± 0.048	4.509PheLeu: 4.509 ± 0.086	1.109PheMet: 1.109 ± 0.031	1.905PheAsn: 1.905 ± 0.043	2.128PhePro: 2.128 ± 0.047	1.133PheGln: 1.133 ± 0.029	2.228PheArg: 2.228 ± 0.052	3.665PheSer: 3.665 ± 0.061	2.727PheThr: 2.727 ± 0.055	2.588PheVal: 2.588 ± 0.052	0.566PheTrp: 0.566 ± 0.023	1.683PheTyr: 1.683 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	6.479GlyAla: 6.479 ± 0.101	1.023GlyCys: 1.023 ± 0.038	3.96GlyAsp: 3.96 ± 0.066	4.733GlyGlu: 4.733 ± 0.071	3.774GlyPhe: 3.774 ± 0.063	6.136GlyGly: 6.136 ± 0.15	1.226GlyHis: 1.226 ± 0.038	6.352GlyIle: 6.352 ± 0.093	5.592GlyLys: 5.592 ± 0.068	7.164GlyLeu: 7.164 ± 0.089	2.045GlyMet: 2.045 ± 0.04	3.344GlyAsn: 3.344 ± 0.076	2.231GlyPro: 2.231 ± 0.046	1.919GlyGln: 1.919 ± 0.04	3.896GlyArg: 3.896 ± 0.061	5.202GlySer: 5.202 ± 0.111	4.393GlyThr: 4.393 ± 0.125	4.818GlyVal: 4.818 ± 0.077	0.924GlyTrp: 0.924 ± 0.027	2.593GlyTyr: 2.593 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	1.234HisAla: 1.234 ± 0.034	0.234HisCys: 0.234 ± 0.014	0.784HisAsp: 0.784 ± 0.024	0.987HisGlu: 0.987 ± 0.03	0.874HisPhe: 0.874 ± 0.027	1.252HisGly: 1.252 ± 0.037	0.371HisHis: 0.371 ± 0.017	1.248HisIle: 1.248 ± 0.035	0.769HisLys: 0.769 ± 0.028	1.526HisLeu: 1.526 ± 0.043	0.302HisMet: 0.302 ± 0.018	0.628HisAsn: 0.628 ± 0.025	0.937HisPro: 0.937 ± 0.039	0.45HisGln: 0.45 ± 0.025	0.83HisArg: 0.83 ± 0.029	0.949HisSer: 0.949 ± 0.029	0.789HisThr: 0.789 ± 0.023	0.817HisVal: 0.817 ± 0.024	0.22HisTrp: 0.22 ± 0.016	0.672HisTyr: 0.672 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.6IleAla: 6.6 ± 0.098	0.784IleCys: 0.784 ± 0.029	3.99IleAsp: 3.99 ± 0.067	4.515IleGlu: 4.515 ± 0.073	3.143IlePhe: 3.143 ± 0.065	4.925IleGly: 4.925 ± 0.079	1.191IleHis: 1.191 ± 0.032	5.307IleIle: 5.307 ± 0.096	4.267IleLys: 4.267 ± 0.065	6.885IleLeu: 6.885 ± 0.099	1.567IleMet: 1.567 ± 0.039	3.204IleAsn: 3.204 ± 0.062	3.989IlePro: 3.989 ± 0.063	2.091IleGln: 2.091 ± 0.042	3.777IleArg: 3.777 ± 0.061	5.026IleSer: 5.026 ± 0.087	3.955IleThr: 3.955 ± 0.078	4.193IleVal: 4.193 ± 0.073	0.667IleTrp: 0.667 ± 0.028	2.268IleTyr: 2.268 ± 0.046	0.0IleXaa: 0.0 ± 0.0
Lys	5.968LysAla: 5.968 ± 0.084	0.39LysCys: 0.39 ± 0.019	3.506LysAsp: 3.506 ± 0.059	4.573LysGlu: 4.573 ± 0.081	1.846LysPhe: 1.846 ± 0.042	4.395LysGly: 4.395 ± 0.065	0.839LysHis: 0.839 ± 0.028	4.555LysIle: 4.555 ± 0.07	4.712LysLys: 4.712 ± 0.085	5.088LysLeu: 5.088 ± 0.087	1.44LysMet: 1.44 ± 0.035	3.182LysAsn: 3.182 ± 0.066	2.681LysPro: 2.681 ± 0.05	1.747LysGln: 1.747 ± 0.044	2.931LysArg: 2.931 ± 0.053	3.301LysSer: 3.301 ± 0.058	3.733LysThr: 3.733 ± 0.057	3.44LysVal: 3.44 ± 0.054	0.567LysTrp: 0.567 ± 0.024	2.006LysTyr: 2.006 ± 0.044	0.0LysXaa: 0.0 ± 0.0
Leu	9.018LeuAla: 9.018 ± 0.105	1.082LeuCys: 1.082 ± 0.033	5.581LeuAsp: 5.581 ± 0.068	6.598LeuGlu: 6.598 ± 0.088	4.354LeuPhe: 4.354 ± 0.085	7.215LeuGly: 7.215 ± 0.09	1.455LeuHis: 1.455 ± 0.038	6.201LeuIle: 6.201 ± 0.089	6.243LeuLys: 6.243 ± 0.086	9.264LeuLeu: 9.264 ± 0.125	2.132LeuMet: 2.132 ± 0.037	3.845LeuAsn: 3.845 ± 0.062	4.674LeuPro: 4.674 ± 0.077	2.456LeuGln: 2.456 ± 0.051	4.749LeuArg: 4.749 ± 0.074	7.024LeuSer: 7.024 ± 0.102	4.76LeuThr: 4.76 ± 0.118	5.702LeuVal: 5.702 ± 0.083	0.945LeuTrp: 0.945 ± 0.029	3.146LeuTyr: 3.146 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.43MetAla: 2.43 ± 0.053	0.154MetCys: 0.154 ± 0.011	1.54MetAsp: 1.54 ± 0.038	1.776MetGlu: 1.776 ± 0.047	0.769MetPhe: 0.769 ± 0.026	2.086MetGly: 2.086 ± 0.05	0.323MetHis: 0.323 ± 0.018	1.497MetIle: 1.497 ± 0.039	1.72MetLys: 1.72 ± 0.04	2.117MetLeu: 2.117 ± 0.047	0.565MetMet: 0.565 ± 0.024	1.146MetAsn: 1.146 ± 0.034	1.186MetPro: 1.186 ± 0.034	0.638MetGln: 0.638 ± 0.023	1.033MetArg: 1.033 ± 0.031	1.373MetSer: 1.373 ± 0.035	1.158MetThr: 1.158 ± 0.029	1.58MetVal: 1.58 ± 0.035	0.131MetTrp: 0.131 ± 0.011	0.608MetTyr: 0.608 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.537AsnAla: 3.537 ± 0.065	0.39AsnCys: 0.39 ± 0.021	2.019AsnAsp: 2.019 ± 0.048	2.314AsnGlu: 2.314 ± 0.047	1.913AsnPhe: 1.913 ± 0.05	3.153AsnGly: 3.153 ± 0.08	0.713AsnHis: 0.713 ± 0.031	3.188AsnIle: 3.188 ± 0.063	2.188AsnLys: 2.188 ± 0.046	3.914AsnLeu: 3.914 ± 0.059	1.059AsnMet: 1.059 ± 0.032	1.898AsnAsn: 1.898 ± 0.058	2.456AsnPro: 2.456 ± 0.047	1.22AsnGln: 1.22 ± 0.034	2.182AsnArg: 2.182 ± 0.044	2.716AsnSer: 2.716 ± 0.055	2.387AsnThr: 2.387 ± 0.057	2.087AsnVal: 2.087 ± 0.045	0.553AsnTrp: 0.553 ± 0.022	1.578AsnTyr: 1.578 ± 0.039	0.0AsnXaa: 0.0 ± 0.0
Pro	4.033ProAla: 4.033 ± 0.074	0.429ProCys: 0.429 ± 0.02	2.814ProAsp: 2.814 ± 0.055	3.631ProGlu: 3.631 ± 0.063	2.126ProPhe: 2.126 ± 0.045	3.878ProGly: 3.878 ± 0.07	0.715ProHis: 0.715 ± 0.027	2.374ProIle: 2.374 ± 0.05	2.008ProLys: 2.008 ± 0.046	4.222ProLeu: 4.222 ± 0.07	0.923ProMet: 0.923 ± 0.031	1.528ProAsn: 1.528 ± 0.037	1.861ProPro: 1.861 ± 0.057	1.379ProGln: 1.379 ± 0.032	1.827ProArg: 1.827 ± 0.038	2.716ProSer: 2.716 ± 0.054	1.516ProThr: 1.516 ± 0.042	3.52ProVal: 3.52 ± 0.07	0.604ProTrp: 0.604 ± 0.023	1.484ProTyr: 1.484 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	2.705GlnAla: 2.705 ± 0.059	0.219GlnCys: 0.219 ± 0.013	1.536GlnAsp: 1.536 ± 0.041	1.92GlnGlu: 1.92 ± 0.048	1.182GlnPhe: 1.182 ± 0.033	2.416GlnGly: 2.416 ± 0.05	0.395GlnHis: 0.395 ± 0.018	2.026GlnIle: 2.026 ± 0.039	2.083GlnLys: 2.083 ± 0.058	2.179GlnLeu: 2.179 ± 0.044	0.702GlnMet: 0.702 ± 0.026	1.366GlnAsn: 1.366 ± 0.036	0.901GlnPro: 0.901 ± 0.037	0.912GlnGln: 0.912 ± 0.036	1.406GlnArg: 1.406 ± 0.032	1.671GlnSer: 1.671 ± 0.037	1.365GlnThr: 1.365 ± 0.041	1.772GlnVal: 1.772 ± 0.039	0.353GlnTrp: 0.353 ± 0.017	1.058GlnTyr: 1.058 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	3.776ArgAla: 3.776 ± 0.055	0.473ArgCys: 0.473 ± 0.019	2.83ArgAsp: 2.83 ± 0.062	3.788ArgGlu: 3.788 ± 0.069	2.45ArgPhe: 2.45 ± 0.052	3.336ArgGly: 3.336 ± 0.061	0.88ArgHis: 0.88 ± 0.023	4.145ArgIle: 4.145 ± 0.064	3.025ArgLys: 3.025 ± 0.06	5.007ArgLeu: 5.007 ± 0.07	1.286ArgMet: 1.286 ± 0.038	2.16ArgAsn: 2.16 ± 0.046	1.806ArgPro: 1.806 ± 0.048	1.646ArgGln: 1.646 ± 0.041	2.888ArgArg: 2.888 ± 0.066	3.001ArgSer: 3.001 ± 0.051	2.301ArgThr: 2.301 ± 0.046	2.834ArgVal: 2.834 ± 0.054	0.568ArgTrp: 0.568 ± 0.022	1.836ArgTyr: 1.836 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	5.637SerAla: 5.637 ± 0.078	0.713SerCys: 0.713 ± 0.028	3.148SerAsp: 3.148 ± 0.068	3.475SerGlu: 3.475 ± 0.054	3.43SerPhe: 3.43 ± 0.058	6.456SerGly: 6.456 ± 0.146	1.038SerHis: 1.038 ± 0.026	4.644SerIle: 4.644 ± 0.085	2.968SerLys: 2.968 ± 0.054	6.803SerLeu: 6.803 ± 0.096	1.498SerMet: 1.498 ± 0.042	2.153SerAsn: 2.153 ± 0.053	3.064SerPro: 3.064 ± 0.051	1.939SerGln: 1.939 ± 0.042	3.482SerArg: 3.482 ± 0.064	4.353SerSer: 4.353 ± 0.091	2.773SerThr: 2.773 ± 0.053	4.046SerVal: 4.046 ± 0.069	0.897SerTrp: 0.897 ± 0.032	2.198SerTyr: 2.198 ± 0.057	0.0SerXaa: 0.0 ± 0.0
Thr	5.039ThrAla: 5.039 ± 0.092	0.4ThrCys: 0.4 ± 0.02	2.633ThrAsp: 2.633 ± 0.055	2.958ThrGlu: 2.958 ± 0.055	2.073ThrPhe: 2.073 ± 0.047	4.89ThrGly: 4.89 ± 0.115	0.743ThrHis: 0.743 ± 0.031	3.901ThrIle: 3.901 ± 0.07	2.206ThrLys: 2.206 ± 0.048	5.122ThrLeu: 5.122 ± 0.123	1.165ThrMet: 1.165 ± 0.036	1.76ThrAsn: 1.76 ± 0.05	2.432ThrPro: 2.432 ± 0.053	1.36ThrGln: 1.36 ± 0.036	2.219ThrArg: 2.219 ± 0.047	2.817ThrSer: 2.817 ± 0.062	2.39ThrThr: 2.39 ± 0.071	4.155ThrVal: 4.155 ± 0.082	0.57ThrTrp: 0.57 ± 0.022	1.489ThrTyr: 1.489 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	4.171ValAla: 4.171 ± 0.072	0.726ValCys: 0.726 ± 0.027	3.119ValAsp: 3.119 ± 0.06	3.768ValGlu: 3.768 ± 0.062	3.458ValPhe: 3.458 ± 0.063	3.548ValGly: 3.548 ± 0.071	1.005ValHis: 1.005 ± 0.032	4.504ValIle: 4.504 ± 0.065	3.737ValLys: 3.737 ± 0.055	6.417ValLeu: 6.417 ± 0.07	1.58ValMet: 1.58 ± 0.043	2.678ValAsn: 2.678 ± 0.06	2.823ValPro: 2.823 ± 0.055	1.739ValGln: 1.739 ± 0.043	2.973ValArg: 2.973 ± 0.054	4.751ValSer: 4.751 ± 0.072	3.321ValThr: 3.321 ± 0.079	3.695ValVal: 3.695 ± 0.068	0.695ValTrp: 0.695 ± 0.031	2.323ValTyr: 2.323 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	0.966TrpAla: 0.966 ± 0.031	0.114TrpCys: 0.114 ± 0.011	0.759TrpAsp: 0.759 ± 0.026	0.824TrpGlu: 0.824 ± 0.026	0.551TrpPhe: 0.551 ± 0.023	0.872TrpGly: 0.872 ± 0.029	0.195TrpHis: 0.195 ± 0.016	0.792TrpIle: 0.792 ± 0.028	0.75TrpLys: 0.75 ± 0.031	0.986TrpLeu: 0.986 ± 0.031	0.292TrpMet: 0.292 ± 0.013	0.61TrpAsn: 0.61 ± 0.025	0.392TrpPro: 0.392 ± 0.019	0.412TrpGln: 0.412 ± 0.019	0.539TrpArg: 0.539 ± 0.02	0.577TrpSer: 0.577 ± 0.022	0.585TrpThr: 0.585 ± 0.025	0.68TrpVal: 0.68 ± 0.024	0.145TrpTrp: 0.145 ± 0.014	0.429TrpTyr: 0.429 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.681TyrAla: 2.681 ± 0.054	0.468TyrCys: 0.468 ± 0.023	1.931TyrAsp: 1.931 ± 0.043	1.865TyrGlu: 1.865 ± 0.047	1.76TyrPhe: 1.76 ± 0.047	2.58TyrGly: 2.58 ± 0.05	0.709TyrHis: 0.709 ± 0.028	2.25TyrIle: 2.25 ± 0.047	1.837TyrLys: 1.837 ± 0.046	3.173TyrLeu: 3.173 ± 0.058	0.712TyrMet: 0.712 ± 0.023	1.66TyrAsn: 1.66 ± 0.045	1.644TyrPro: 1.644 ± 0.039	1.091TyrGln: 1.091 ± 0.04	2.043TyrArg: 2.043 ± 0.046	2.339TyrSer: 2.339 ± 0.061	2.081TyrThr: 2.081 ± 0.047	1.694TyrVal: 1.694 ± 0.044	0.469TyrTrp: 0.469 ± 0.023	1.453TyrTyr: 1.453 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3457 proteins (1156691 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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