Amino acid dipepetide frequency for Botrytis elliptica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.141AlaAla: 7.141 ± 0.05	0.947AlaCys: 0.947 ± 0.013	3.632AlaAsp: 3.632 ± 0.03	4.736AlaGlu: 4.736 ± 0.032	2.85AlaPhe: 2.85 ± 0.023	5.105AlaGly: 5.105 ± 0.036	1.545AlaHis: 1.545 ± 0.016	4.325AlaIle: 4.325 ± 0.029	4.145AlaLys: 4.145 ± 0.028	6.771AlaLeu: 6.771 ± 0.046	1.837AlaMet: 1.837 ± 0.018	3.017AlaAsn: 3.017 ± 0.025	4.263AlaPro: 4.263 ± 0.038	3.052AlaGln: 3.052 ± 0.031	4.107AlaArg: 4.107 ± 0.028	6.821AlaSer: 6.821 ± 0.05	4.927AlaThr: 4.927 ± 0.033	4.437AlaVal: 4.437 ± 0.031	1.003AlaTrp: 1.003 ± 0.014	2.004AlaTyr: 2.004 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	0.868CysAla: 0.868 ± 0.014	0.229CysCys: 0.229 ± 0.007	0.649CysAsp: 0.649 ± 0.013	0.642CysGlu: 0.642 ± 0.012	0.521CysPhe: 0.521 ± 0.009	0.936CysGly: 0.936 ± 0.017	0.297CysHis: 0.297 ± 0.008	0.723CysIle: 0.723 ± 0.011	0.582CysLys: 0.582 ± 0.011	1.167CysLeu: 1.167 ± 0.017	0.275CysMet: 0.275 ± 0.007	0.472CysAsn: 0.472 ± 0.01	0.641CysPro: 0.641 ± 0.013	0.427CysGln: 0.427 ± 0.01	0.653CysArg: 0.653 ± 0.011	0.919CysSer: 0.919 ± 0.015	0.706CysThr: 0.706 ± 0.012	0.735CysVal: 0.735 ± 0.012	0.195CysTrp: 0.195 ± 0.006	0.363CysTyr: 0.363 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.1AspAla: 4.1 ± 0.025	0.647AspCys: 0.647 ± 0.011	4.16AspAsp: 4.16 ± 0.045	4.673AspGlu: 4.673 ± 0.04	2.254AspPhe: 2.254 ± 0.02	3.886AspGly: 3.886 ± 0.031	1.185AspHis: 1.185 ± 0.014	3.367AspIle: 3.367 ± 0.027	2.433AspLys: 2.433 ± 0.023	4.945AspLeu: 4.945 ± 0.032	1.265AspMet: 1.265 ± 0.014	2.108AspAsn: 2.108 ± 0.02	2.981AspPro: 2.981 ± 0.025	1.772AspGln: 1.772 ± 0.018	2.77AspArg: 2.77 ± 0.028	4.395AspSer: 4.395 ± 0.028	2.99AspThr: 2.99 ± 0.025	3.442AspVal: 3.442 ± 0.025	0.858AspTrp: 0.858 ± 0.013	1.623AspTyr: 1.623 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	4.92GluAla: 4.92 ± 0.032	0.652GluCys: 0.652 ± 0.011	4.473GluAsp: 4.473 ± 0.036	6.36GluGlu: 6.36 ± 0.06	2.115GluPhe: 2.115 ± 0.019	4.012GluGly: 4.012 ± 0.035	1.311GluHis: 1.311 ± 0.016	3.779GluIle: 3.779 ± 0.03	4.584GluLys: 4.584 ± 0.039	5.189GluLeu: 5.189 ± 0.035	1.691GluMet: 1.691 ± 0.017	2.95GluAsn: 2.95 ± 0.023	2.598GluPro: 2.598 ± 0.034	2.362GluGln: 2.362 ± 0.023	4.094GluArg: 4.094 ± 0.039	4.819GluSer: 4.819 ± 0.044	3.564GluThr: 3.564 ± 0.026	3.736GluVal: 3.736 ± 0.027	0.938GluTrp: 0.938 ± 0.014	1.776GluTyr: 1.776 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	2.801PheAla: 2.801 ± 0.024	0.558PheCys: 0.558 ± 0.01	2.283PheAsp: 2.283 ± 0.023	2.341PheGlu: 2.341 ± 0.022	1.567PhePhe: 1.567 ± 0.019	2.871PheGly: 2.871 ± 0.025	0.884PheHis: 0.884 ± 0.012	1.908PheIle: 1.908 ± 0.021	1.735PheLys: 1.735 ± 0.018	3.405PheLeu: 3.405 ± 0.031	0.829PheMet: 0.829 ± 0.012	1.589PheAsn: 1.589 ± 0.018	1.971PhePro: 1.971 ± 0.022	1.421PheGln: 1.421 ± 0.015	1.824PheArg: 1.824 ± 0.019	3.08PheSer: 3.08 ± 0.025	2.241PheThr: 2.241 ± 0.02	2.263PheVal: 2.263 ± 0.021	0.633PheTrp: 0.633 ± 0.012	1.106PheTyr: 1.106 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	4.703GlyAla: 4.703 ± 0.035	0.851GlyCys: 0.851 ± 0.014	3.534GlyAsp: 3.534 ± 0.029	3.936GlyGlu: 3.936 ± 0.031	2.745GlyPhe: 2.745 ± 0.024	5.794GlyGly: 5.794 ± 0.059	1.526GlyHis: 1.526 ± 0.017	3.734GlyIle: 3.734 ± 0.027	3.923GlyLys: 3.923 ± 0.033	5.688GlyLeu: 5.688 ± 0.044	1.713GlyMet: 1.713 ± 0.017	2.978GlyAsn: 2.978 ± 0.023	2.934GlyPro: 2.934 ± 0.03	2.265GlyGln: 2.265 ± 0.022	3.796GlyArg: 3.796 ± 0.029	5.748GlySer: 5.748 ± 0.036	3.975GlyThr: 3.975 ± 0.033	4.177GlyVal: 4.177 ± 0.035	1.124GlyTrp: 1.124 ± 0.016	2.148GlyTyr: 2.148 ± 0.023	0.0GlyXaa: 0.0 ± 0.0
His	1.569HisAla: 1.569 ± 0.019	0.315HisCys: 0.315 ± 0.008	1.267HisAsp: 1.267 ± 0.015	1.358HisGlu: 1.358 ± 0.017	0.888HisPhe: 0.888 ± 0.012	1.573HisGly: 1.573 ± 0.02	0.773HisHis: 0.773 ± 0.016	1.245HisIle: 1.245 ± 0.013	1.012HisLys: 1.012 ± 0.016	2.047HisLeu: 2.047 ± 0.02	0.477HisMet: 0.477 ± 0.008	0.956HisAsn: 0.956 ± 0.011	1.523HisPro: 1.523 ± 0.019	0.983HisGln: 0.983 ± 0.015	1.357HisArg: 1.357 ± 0.015	1.921HisSer: 1.921 ± 0.028	1.334HisThr: 1.334 ± 0.017	1.236HisVal: 1.236 ± 0.016	0.307HisTrp: 0.307 ± 0.006	0.693HisTyr: 0.693 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.27IleAla: 4.27 ± 0.031	0.817IleCys: 0.817 ± 0.014	3.203IleAsp: 3.203 ± 0.027	3.476IleGlu: 3.476 ± 0.032	2.213IlePhe: 2.213 ± 0.019	3.431IleGly: 3.431 ± 0.032	1.291IleHis: 1.291 ± 0.017	3.039IleIle: 3.039 ± 0.028	2.718IleLys: 2.718 ± 0.028	5.005IleLeu: 5.005 ± 0.036	1.15IleMet: 1.15 ± 0.014	2.219IleAsn: 2.219 ± 0.02	3.483IlePro: 3.483 ± 0.025	2.11IleGln: 2.11 ± 0.021	2.803IleArg: 2.803 ± 0.022	4.707IleSer: 4.707 ± 0.032	3.296IleThr: 3.296 ± 0.029	3.312IleVal: 3.312 ± 0.023	0.788IleTrp: 0.788 ± 0.012	1.588IleTyr: 1.588 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	4.296LysAla: 4.296 ± 0.034	0.581LysCys: 0.581 ± 0.01	3.15LysAsp: 3.15 ± 0.027	4.142LysGlu: 4.142 ± 0.041	1.765LysPhe: 1.765 ± 0.019	3.29LysGly: 3.29 ± 0.028	1.199LysHis: 1.199 ± 0.016	2.95LysIle: 2.95 ± 0.023	4.093LysLys: 4.093 ± 0.04	4.436LysLeu: 4.436 ± 0.034	1.209LysMet: 1.209 ± 0.015	2.301LysAsn: 2.301 ± 0.023	2.801LysPro: 2.801 ± 0.028	1.88LysGln: 1.88 ± 0.019	3.633LysArg: 3.633 ± 0.028	4.422LysSer: 4.422 ± 0.036	3.125LysThr: 3.125 ± 0.026	3.121LysVal: 3.121 ± 0.022	0.766LysTrp: 0.766 ± 0.012	1.555LysTyr: 1.555 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	6.826LeuAla: 6.826 ± 0.039	1.124LeuCys: 1.124 ± 0.015	4.812LeuAsp: 4.812 ± 0.035	5.653LeuGlu: 5.653 ± 0.04	3.18LeuPhe: 3.18 ± 0.029	5.561LeuGly: 5.561 ± 0.038	2.062LeuHis: 2.062 ± 0.024	4.218LeuIle: 4.218 ± 0.033	4.636LeuLys: 4.636 ± 0.034	7.716LeuLeu: 7.716 ± 0.057	1.794LeuMet: 1.794 ± 0.018	3.477LeuAsn: 3.477 ± 0.026	5.278LeuPro: 5.278 ± 0.033	3.65LeuGln: 3.65 ± 0.03	5.13LeuArg: 5.13 ± 0.039	7.304LeuSer: 7.304 ± 0.04	4.718LeuThr: 4.718 ± 0.03	4.799LeuVal: 4.799 ± 0.029	1.131LeuTrp: 1.131 ± 0.014	2.288LeuTyr: 2.288 ± 0.022	0.0LeuXaa: 0.0 ± 0.0
Met	2.052MetAla: 2.052 ± 0.021	0.245MetCys: 0.245 ± 0.006	1.316MetAsp: 1.316 ± 0.017	1.508MetGlu: 1.508 ± 0.019	0.773MetPhe: 0.773 ± 0.011	1.597MetGly: 1.597 ± 0.018	0.467MetHis: 0.467 ± 0.008	1.147MetIle: 1.147 ± 0.014	1.217MetLys: 1.217 ± 0.014	1.734MetLeu: 1.734 ± 0.016	0.624MetMet: 0.624 ± 0.012	0.992MetAsn: 0.992 ± 0.013	1.206MetPro: 1.206 ± 0.015	0.859MetGln: 0.859 ± 0.013	1.247MetArg: 1.247 ± 0.013	2.004MetSer: 2.004 ± 0.02	1.33MetThr: 1.33 ± 0.017	1.295MetVal: 1.295 ± 0.016	0.253MetTrp: 0.253 ± 0.006	0.545MetTyr: 0.545 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	3.228AsnAla: 3.228 ± 0.022	0.498AsnCys: 0.498 ± 0.009	2.294AsnAsp: 2.294 ± 0.02	2.499AsnGlu: 2.499 ± 0.022	1.665AsnPhe: 1.665 ± 0.017	3.422AsnGly: 3.422 ± 0.033	1.044AsnHis: 1.044 ± 0.014	2.526AsnIle: 2.526 ± 0.023	1.915AsnLys: 1.915 ± 0.02	3.664AsnLeu: 3.664 ± 0.026	0.942AsnMet: 0.942 ± 0.012	1.985AsnAsn: 1.985 ± 0.023	2.657AsnPro: 2.657 ± 0.022	1.562AsnGln: 1.562 ± 0.019	2.092AsnArg: 2.092 ± 0.02	3.601AsnSer: 3.601 ± 0.027	2.721AsnThr: 2.721 ± 0.021	2.444AsnVal: 2.444 ± 0.023	0.601AsnTrp: 0.601 ± 0.01	1.257AsnTyr: 1.257 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	4.38ProAla: 4.38 ± 0.039	0.466ProCys: 0.466 ± 0.01	2.804ProAsp: 2.804 ± 0.025	3.624ProGlu: 3.624 ± 0.032	1.958ProPhe: 1.958 ± 0.02	3.452ProGly: 3.452 ± 0.029	1.269ProHis: 1.269 ± 0.019	3.012ProIle: 3.012 ± 0.027	2.938ProLys: 2.938 ± 0.024	4.548ProLeu: 4.548 ± 0.031	1.053ProMet: 1.053 ± 0.015	2.453ProAsn: 2.453 ± 0.02	4.699ProPro: 4.699 ± 0.063	2.455ProGln: 2.455 ± 0.027	3.142ProArg: 3.142 ± 0.03	6.076ProSer: 6.076 ± 0.05	4.066ProThr: 4.066 ± 0.033	3.212ProVal: 3.212 ± 0.028	0.658ProTrp: 0.658 ± 0.011	1.506ProTyr: 1.506 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.052GlnAla: 3.052 ± 0.027	0.422GlnCys: 0.422 ± 0.009	1.994GlnAsp: 1.994 ± 0.021	2.442GlnGlu: 2.442 ± 0.019	1.303GlnPhe: 1.303 ± 0.016	2.185GlnGly: 2.185 ± 0.02	0.983GlnHis: 0.983 ± 0.015	2.129GlnIle: 2.129 ± 0.02	2.25GlnLys: 2.25 ± 0.018	3.145GlnLeu: 3.145 ± 0.029	0.895GlnMet: 0.895 ± 0.013	1.866GlnAsn: 1.866 ± 0.019	2.214GlnPro: 2.214 ± 0.029	2.187GlnGln: 2.187 ± 0.042	2.368GlnArg: 2.368 ± 0.023	3.308GlnSer: 3.308 ± 0.031	2.317GlnThr: 2.317 ± 0.019	2.021GlnVal: 2.021 ± 0.019	0.525GlnTrp: 0.525 ± 0.009	1.207GlnTyr: 1.207 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	3.952ArgAla: 3.952 ± 0.027	0.631ArgCys: 0.631 ± 0.011	3.142ArgAsp: 3.142 ± 0.029	4.007ArgGlu: 4.007 ± 0.038	1.945ArgPhe: 1.945 ± 0.019	3.641ArgGly: 3.641 ± 0.035	1.326ArgHis: 1.326 ± 0.015	2.983ArgIle: 2.983 ± 0.026	3.742ArgLys: 3.742 ± 0.027	4.704ArgLeu: 4.704 ± 0.031	1.294ArgMet: 1.294 ± 0.015	2.532ArgAsn: 2.532 ± 0.019	2.993ArgPro: 2.993 ± 0.024	2.289ArgGln: 2.289 ± 0.021	4.465ArgArg: 4.465 ± 0.041	4.658ArgSer: 4.658 ± 0.035	3.036ArgThr: 3.036 ± 0.025	2.997ArgVal: 2.997 ± 0.025	0.809ArgTrp: 0.809 ± 0.012	1.556ArgTyr: 1.556 ± 0.016	0.0ArgXaa: 0.0 ± 0.0
Ser	6.241SerAla: 6.241 ± 0.048	0.899SerCys: 0.899 ± 0.016	4.391SerAsp: 4.391 ± 0.029	4.646SerGlu: 4.646 ± 0.037	3.178SerPhe: 3.178 ± 0.023	5.596SerGly: 5.596 ± 0.037	2.06SerHis: 2.06 ± 0.025	4.859SerIle: 4.859 ± 0.035	4.481SerLys: 4.481 ± 0.033	7.222SerLeu: 7.222 ± 0.04	1.819SerMet: 1.819 ± 0.018	3.896SerAsn: 3.896 ± 0.033	5.729SerPro: 5.729 ± 0.046	3.487SerGln: 3.487 ± 0.03	4.911SerArg: 4.911 ± 0.036	10.134SerSer: 10.134 ± 0.112	6.48SerThr: 6.48 ± 0.062	4.461SerVal: 4.461 ± 0.033	1.089SerTrp: 1.089 ± 0.015	2.275SerTyr: 2.275 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	4.726ThrAla: 4.726 ± 0.033	0.754ThrCys: 0.754 ± 0.012	2.756ThrAsp: 2.756 ± 0.022	3.23ThrGlu: 3.23 ± 0.026	2.374ThrPhe: 2.374 ± 0.021	4.088ThrGly: 4.088 ± 0.031	1.317ThrHis: 1.317 ± 0.017	3.641ThrIle: 3.641 ± 0.026	3.021ThrLys: 3.021 ± 0.023	5.209ThrLeu: 5.209 ± 0.036	1.232ThrMet: 1.232 ± 0.014	2.55ThrAsn: 2.55 ± 0.019	4.526ThrPro: 4.526 ± 0.039	2.192ThrGln: 2.192 ± 0.019	3.0ThrArg: 3.0 ± 0.025	6.247ThrSer: 6.247 ± 0.056	4.693ThrThr: 4.693 ± 0.05	3.375ThrVal: 3.375 ± 0.029	0.815ThrTrp: 0.815 ± 0.013	1.705ThrTyr: 1.705 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	4.553ValAla: 4.553 ± 0.031	0.735ValCys: 0.735 ± 0.012	3.456ValAsp: 3.456 ± 0.025	4.067ValGlu: 4.067 ± 0.03	2.277ValPhe: 2.277 ± 0.019	3.815ValGly: 3.815 ± 0.032	1.233ValHis: 1.233 ± 0.016	2.99ValIle: 2.99 ± 0.025	3.119ValLys: 3.119 ± 0.026	5.003ValLeu: 5.003 ± 0.029	1.311ValMet: 1.311 ± 0.015	2.284ValAsn: 2.284 ± 0.021	3.218ValPro: 3.218 ± 0.027	2.182ValGln: 2.182 ± 0.02	2.956ValArg: 2.956 ± 0.024	4.458ValSer: 4.458 ± 0.037	3.309ValThr: 3.309 ± 0.026	3.895ValVal: 3.895 ± 0.032	0.802ValTrp: 0.802 ± 0.015	1.636ValTyr: 1.636 ± 0.017	0.0ValXaa: 0.0 ± 0.0
Trp	0.982TrpAla: 0.982 ± 0.014	0.192TrpCys: 0.192 ± 0.007	0.856TrpAsp: 0.856 ± 0.013	0.907TrpGlu: 0.907 ± 0.014	0.522TrpPhe: 0.522 ± 0.011	0.964TrpGly: 0.964 ± 0.016	0.319TrpHis: 0.319 ± 0.008	0.81TrpIle: 0.81 ± 0.012	0.887TrpLys: 0.887 ± 0.012	1.211TrpLeu: 1.211 ± 0.016	0.383TrpMet: 0.383 ± 0.008	0.692TrpAsn: 0.692 ± 0.012	0.53TrpPro: 0.53 ± 0.009	0.518TrpGln: 0.518 ± 0.011	0.842TrpArg: 0.842 ± 0.013	1.028TrpSer: 1.028 ± 0.014	0.865TrpThr: 0.865 ± 0.013	0.819TrpVal: 0.819 ± 0.012	0.268TrpTrp: 0.268 ± 0.007	0.409TrpTyr: 0.409 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.005TyrAla: 2.005 ± 0.02	0.438TyrCys: 0.438 ± 0.009	1.683TyrAsp: 1.683 ± 0.02	1.673TyrGlu: 1.673 ± 0.017	1.218TyrPhe: 1.218 ± 0.015	2.075TyrGly: 2.075 ± 0.023	0.746TyrHis: 0.746 ± 0.011	1.535TyrIle: 1.535 ± 0.016	1.282TyrLys: 1.282 ± 0.016	2.546TyrLeu: 2.546 ± 0.023	0.617TyrMet: 0.617 ± 0.012	1.298TyrAsn: 1.298 ± 0.015	1.525TyrPro: 1.525 ± 0.018	1.161TyrGln: 1.161 ± 0.016	1.514TyrArg: 1.514 ± 0.018	2.203TyrSer: 2.203 ± 0.019	1.76TyrThr: 1.76 ± 0.018	1.519TyrVal: 1.519 ± 0.017	0.441TyrTrp: 0.441 ± 0.008	0.968TyrTyr: 0.968 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 12555 proteins (5947282 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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