Amino acid dipepetide frequency for Nocardioides albidus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.276AlaAla: 20.276 ± 0.189	1.032AlaCys: 1.032 ± 0.031	8.971AlaAsp: 8.971 ± 0.118	8.639AlaGlu: 8.639 ± 0.102	3.551AlaPhe: 3.551 ± 0.057	12.891AlaGly: 12.891 ± 0.108	2.64AlaHis: 2.64 ± 0.05	4.762AlaIle: 4.762 ± 0.06	2.676AlaLys: 2.676 ± 0.057	13.692AlaLeu: 13.692 ± 0.129	2.754AlaMet: 2.754 ± 0.046	1.958AlaAsn: 1.958 ± 0.043	6.552AlaPro: 6.552 ± 0.086	3.663AlaGln: 3.663 ± 0.052	9.709AlaArg: 9.709 ± 0.098	6.357AlaSer: 6.357 ± 0.063	7.642AlaThr: 7.642 ± 0.08	11.784AlaVal: 11.784 ± 0.119	1.965AlaTrp: 1.965 ± 0.041	2.474AlaTyr: 2.474 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.93CysAla: 0.93 ± 0.029	0.097CysCys: 0.097 ± 0.008	0.506CysAsp: 0.506 ± 0.019	0.38CysGlu: 0.38 ± 0.018	0.234CysPhe: 0.234 ± 0.012	0.905CysGly: 0.905 ± 0.029	0.165CysHis: 0.165 ± 0.012	0.193CysIle: 0.193 ± 0.012	0.11CysLys: 0.11 ± 0.01	0.634CysLeu: 0.634 ± 0.022	0.106CysMet: 0.106 ± 0.009	0.141CysAsn: 0.141 ± 0.011	0.467CysPro: 0.467 ± 0.022	0.177CysGln: 0.177 ± 0.011	0.583CysArg: 0.583 ± 0.021	0.445CysSer: 0.445 ± 0.02	0.478CysThr: 0.478 ± 0.021	0.612CysVal: 0.612 ± 0.024	0.097CysTrp: 0.097 ± 0.009	0.151CysTyr: 0.151 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.261AspAla: 8.261 ± 0.083	0.368AspCys: 0.368 ± 0.018	4.701AspAsp: 4.701 ± 0.073	4.512AspGlu: 4.512 ± 0.059	1.636AspPhe: 1.636 ± 0.035	6.686AspGly: 6.686 ± 0.089	1.571AspHis: 1.571 ± 0.035	2.125AspIle: 2.125 ± 0.041	1.178AspLys: 1.178 ± 0.034	7.527AspLeu: 7.527 ± 0.069	0.769AspMet: 0.769 ± 0.023	0.968AspAsn: 0.968 ± 0.03	4.824AspPro: 4.824 ± 0.062	1.803AspGln: 1.803 ± 0.039	5.095AspArg: 5.095 ± 0.057	2.42AspSer: 2.42 ± 0.049	2.861AspThr: 2.861 ± 0.051	6.027AspVal: 6.027 ± 0.079	0.97AspTrp: 0.97 ± 0.026	1.235AspTyr: 1.235 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	7.261GluAla: 7.261 ± 0.087	0.349GluCys: 0.349 ± 0.017	3.065GluAsp: 3.065 ± 0.051	3.532GluGlu: 3.532 ± 0.067	1.514GluPhe: 1.514 ± 0.036	4.323GluGly: 4.323 ± 0.061	1.616GluHis: 1.616 ± 0.04	2.779GluIle: 2.779 ± 0.049	1.258GluLys: 1.258 ± 0.036	6.643GluLeu: 6.643 ± 0.081	1.022GluMet: 1.022 ± 0.03	0.938GluAsn: 0.938 ± 0.032	3.296GluPro: 3.296 ± 0.069	2.305GluGln: 2.305 ± 0.047	5.569GluArg: 5.569 ± 0.081	2.681GluSer: 2.681 ± 0.043	2.866GluThr: 2.866 ± 0.046	5.435GluVal: 5.435 ± 0.064	0.821GluTrp: 0.821 ± 0.027	1.018GluTyr: 1.018 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	3.725PheAla: 3.725 ± 0.049	0.265PheCys: 0.265 ± 0.015	2.093PheAsp: 2.093 ± 0.038	1.671PheGlu: 1.671 ± 0.037	0.806PhePhe: 0.806 ± 0.027	2.995PheGly: 2.995 ± 0.056	0.642PheHis: 0.642 ± 0.024	0.767PheIle: 0.767 ± 0.026	0.501PheLys: 0.501 ± 0.021	2.522PheLeu: 2.522 ± 0.041	0.418PheMet: 0.418 ± 0.018	0.573PheAsn: 0.573 ± 0.022	1.272PhePro: 1.272 ± 0.036	0.642PheGln: 0.642 ± 0.024	1.765PheArg: 1.765 ± 0.041	1.448PheSer: 1.448 ± 0.035	1.775PheThr: 1.775 ± 0.036	2.585PheVal: 2.585 ± 0.044	0.412PheTrp: 0.412 ± 0.018	0.535PheTyr: 0.535 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	10.919GlyAla: 10.919 ± 0.096	0.817GlyCys: 0.817 ± 0.024	5.61GlyAsp: 5.61 ± 0.08	5.251GlyGlu: 5.251 ± 0.064	2.939GlyPhe: 2.939 ± 0.049	8.427GlyGly: 8.427 ± 0.127	2.05GlyHis: 2.05 ± 0.04	3.805GlyIle: 3.805 ± 0.059	2.167GlyLys: 2.167 ± 0.052	9.57GlyLeu: 9.57 ± 0.101	1.926GlyMet: 1.926 ± 0.037	1.674GlyAsn: 1.674 ± 0.046	4.741GlyPro: 4.741 ± 0.061	2.567GlyGln: 2.567 ± 0.047	7.305GlyArg: 7.305 ± 0.082	5.335GlySer: 5.335 ± 0.07	5.778GlyThr: 5.778 ± 0.079	8.159GlyVal: 8.159 ± 0.091	1.672GlyTrp: 1.672 ± 0.036	2.155GlyTyr: 2.155 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.544HisAla: 2.544 ± 0.048	0.203HisCys: 0.203 ± 0.013	1.565HisAsp: 1.565 ± 0.035	1.21HisGlu: 1.21 ± 0.034	0.594HisPhe: 0.594 ± 0.02	2.232HisGly: 2.232 ± 0.042	0.696HisHis: 0.696 ± 0.026	0.559HisIle: 0.559 ± 0.022	0.319HisLys: 0.319 ± 0.015	2.387HisLeu: 2.387 ± 0.045	0.288HisMet: 0.288 ± 0.016	0.351HisAsn: 0.351 ± 0.02	1.65HisPro: 1.65 ± 0.035	0.661HisGln: 0.661 ± 0.022	1.903HisArg: 1.903 ± 0.036	0.841HisSer: 0.841 ± 0.025	1.064HisThr: 1.064 ± 0.025	1.937HisVal: 1.937 ± 0.042	0.297HisTrp: 0.297 ± 0.014	0.459HisTyr: 0.459 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	5.486IleAla: 5.486 ± 0.067	0.283IleCys: 0.283 ± 0.014	2.856IleAsp: 2.856 ± 0.058	2.461IleGlu: 2.461 ± 0.052	0.823IlePhe: 0.823 ± 0.026	3.939IleGly: 3.939 ± 0.057	0.672IleHis: 0.672 ± 0.025	1.003IleIle: 1.003 ± 0.031	0.813IleLys: 0.813 ± 0.026	2.792IleLeu: 2.792 ± 0.051	0.504IleMet: 0.504 ± 0.02	0.796IleAsn: 0.796 ± 0.025	1.917IlePro: 1.917 ± 0.042	0.801IleGln: 0.801 ± 0.024	2.486IleArg: 2.486 ± 0.048	1.817IleSer: 1.817 ± 0.038	2.266IleThr: 2.266 ± 0.04	3.523IleVal: 3.523 ± 0.056	0.423IleTrp: 0.423 ± 0.017	0.584IleTyr: 0.584 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	2.676LysAla: 2.676 ± 0.052	0.106LysCys: 0.106 ± 0.008	1.22LysAsp: 1.22 ± 0.033	1.13LysGlu: 1.13 ± 0.034	0.447LysPhe: 0.447 ± 0.018	1.676LysGly: 1.676 ± 0.043	0.431LysHis: 0.431 ± 0.019	0.801LysIle: 0.801 ± 0.029	0.748LysLys: 0.748 ± 0.034	1.656LysLeu: 1.656 ± 0.038	0.395LysMet: 0.395 ± 0.017	0.466LysAsn: 0.466 ± 0.021	1.174LysPro: 1.174 ± 0.03	0.658LysGln: 0.658 ± 0.025	1.39LysArg: 1.39 ± 0.032	1.014LysSer: 1.014 ± 0.033	1.072LysThr: 1.072 ± 0.037	2.145LysVal: 2.145 ± 0.044	0.228LysTrp: 0.228 ± 0.012	0.444LysTyr: 0.444 ± 0.019	0.001LysXaa: 0.001 ± 0.001
Leu	15.433LeuAla: 15.433 ± 0.121	0.749LeuCys: 0.749 ± 0.022	7.193LeuAsp: 7.193 ± 0.08	5.463LeuGlu: 5.463 ± 0.07	2.394LeuPhe: 2.394 ± 0.045	9.827LeuGly: 9.827 ± 0.11	2.118LeuHis: 2.118 ± 0.043	3.085LeuIle: 3.085 ± 0.052	1.774LeuLys: 1.774 ± 0.045	10.641LeuLeu: 10.641 ± 0.127	1.638LeuMet: 1.638 ± 0.038	1.494LeuAsn: 1.494 ± 0.037	5.785LeuPro: 5.785 ± 0.066	2.365LeuGln: 2.365 ± 0.041	7.879LeuArg: 7.879 ± 0.082	5.19LeuSer: 5.19 ± 0.06	6.271LeuThr: 6.271 ± 0.081	10.21LeuVal: 10.21 ± 0.089	1.146LeuTrp: 1.146 ± 0.033	1.527LeuTyr: 1.527 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.311MetAla: 2.311 ± 0.044	0.125MetCys: 0.125 ± 0.01	0.872MetAsp: 0.872 ± 0.024	0.725MetGlu: 0.725 ± 0.023	0.471MetPhe: 0.471 ± 0.02	1.358MetGly: 1.358 ± 0.032	0.338MetHis: 0.338 ± 0.017	0.717MetIle: 0.717 ± 0.024	0.415MetLys: 0.415 ± 0.019	1.746MetLeu: 1.746 ± 0.033	0.353MetMet: 0.353 ± 0.018	0.383MetAsn: 0.383 ± 0.018	1.026MetPro: 1.026 ± 0.031	0.447MetGln: 0.447 ± 0.019	1.445MetArg: 1.445 ± 0.037	1.46MetSer: 1.46 ± 0.035	1.679MetThr: 1.679 ± 0.035	1.489MetVal: 1.489 ± 0.037	0.202MetTrp: 0.202 ± 0.012	0.285MetTyr: 0.285 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.166AsnAla: 2.166 ± 0.044	0.176AsnCys: 0.176 ± 0.01	1.057AsnAsp: 1.057 ± 0.032	0.812AsnGlu: 0.812 ± 0.027	0.461AsnPhe: 0.461 ± 0.017	1.691AsnGly: 1.691 ± 0.043	0.361AsnHis: 0.361 ± 0.017	0.657AsnIle: 0.657 ± 0.022	0.386AsnLys: 0.386 ± 0.018	1.7AsnLeu: 1.7 ± 0.037	0.28AsnMet: 0.28 ± 0.015	0.419AsnAsn: 0.419 ± 0.022	1.34AsnPro: 1.34 ± 0.034	0.528AsnGln: 0.528 ± 0.021	1.222AsnArg: 1.222 ± 0.032	0.721AsnSer: 0.721 ± 0.025	0.912AsnThr: 0.912 ± 0.032	1.508AsnVal: 1.508 ± 0.035	0.253AsnTrp: 0.253 ± 0.013	0.383AsnTyr: 0.383 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	8.081ProAla: 8.081 ± 0.105	0.312ProCys: 0.312 ± 0.018	4.606ProAsp: 4.606 ± 0.061	3.996ProGlu: 3.996 ± 0.061	1.51ProPhe: 1.51 ± 0.034	5.78ProGly: 5.78 ± 0.071	1.133ProHis: 1.133 ± 0.03	1.805ProIle: 1.805 ± 0.038	1.051ProLys: 1.051 ± 0.033	4.879ProLeu: 4.879 ± 0.061	0.971ProMet: 0.971 ± 0.029	0.872ProAsn: 0.872 ± 0.031	3.043ProPro: 3.043 ± 0.066	1.425ProGln: 1.425 ± 0.028	3.688ProArg: 3.688 ± 0.064	3.04ProSer: 3.04 ± 0.044	3.553ProThr: 3.553 ± 0.054	5.317ProVal: 5.317 ± 0.062	0.893ProTrp: 0.893 ± 0.027	1.123ProTyr: 1.123 ± 0.03	0.001ProXaa: 0.001 ± 0.001
Gln	3.459GlnAla: 3.459 ± 0.049	0.139GlnCys: 0.139 ± 0.011	1.27GlnAsp: 1.27 ± 0.034	1.318GlnGlu: 1.318 ± 0.036	0.728GlnPhe: 0.728 ± 0.022	2.09GlnGly: 2.09 ± 0.041	0.665GlnHis: 0.665 ± 0.023	1.19GlnIle: 1.19 ± 0.031	0.537GlnLys: 0.537 ± 0.019	2.977GlnLeu: 2.977 ± 0.045	0.545GlnMet: 0.545 ± 0.02	0.417GlnAsn: 0.417 ± 0.018	1.655GlnPro: 1.655 ± 0.043	1.192GlnGln: 1.192 ± 0.034	2.527GlnArg: 2.527 ± 0.05	1.192GlnSer: 1.192 ± 0.028	1.355GlnThr: 1.355 ± 0.031	2.811GlnVal: 2.811 ± 0.048	0.426GlnTrp: 0.426 ± 0.018	0.509GlnTyr: 0.509 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	9.55ArgAla: 9.55 ± 0.106	0.522ArgCys: 0.522 ± 0.022	4.459ArgAsp: 4.459 ± 0.065	4.432ArgGlu: 4.432 ± 0.057	2.325ArgPhe: 2.325 ± 0.041	5.635ArgGly: 5.635 ± 0.061	1.908ArgHis: 1.908 ± 0.04	3.437ArgIle: 3.437 ± 0.047	1.52ArgLys: 1.52 ± 0.036	8.34ArgLeu: 8.34 ± 0.097	1.759ArgMet: 1.759 ± 0.035	1.25ArgAsn: 1.25 ± 0.028	4.379ArgPro: 4.379 ± 0.066	2.072ArgGln: 2.072 ± 0.043	7.516ArgArg: 7.516 ± 0.111	4.271ArgSer: 4.271 ± 0.054	4.782ArgThr: 4.782 ± 0.066	6.29ArgVal: 6.29 ± 0.074	1.388ArgTrp: 1.388 ± 0.034	1.613ArgTyr: 1.613 ± 0.036	0.001ArgXaa: 0.001 ± 0.001
Ser	6.43SerAla: 6.43 ± 0.062	0.383SerCys: 0.383 ± 0.017	2.918SerAsp: 2.918 ± 0.049	2.45SerGlu: 2.45 ± 0.045	1.655SerPhe: 1.655 ± 0.035	5.582SerGly: 5.582 ± 0.069	0.958SerHis: 0.958 ± 0.025	1.862SerIle: 1.862 ± 0.042	0.964SerLys: 0.964 ± 0.029	4.854SerLeu: 4.854 ± 0.06	1.181SerMet: 1.181 ± 0.032	0.92SerAsn: 0.92 ± 0.027	3.087SerPro: 3.087 ± 0.053	1.245SerGln: 1.245 ± 0.033	3.676SerArg: 3.676 ± 0.057	3.043SerSer: 3.043 ± 0.048	3.221SerThr: 3.221 ± 0.049	4.453SerVal: 4.453 ± 0.054	0.904SerTrp: 0.904 ± 0.03	1.38SerTyr: 1.38 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	7.599ThrAla: 7.599 ± 0.086	0.489ThrCys: 0.489 ± 0.023	3.613ThrAsp: 3.613 ± 0.055	3.001ThrGlu: 3.001 ± 0.047	1.854ThrPhe: 1.854 ± 0.043	6.135ThrGly: 6.135 ± 0.07	1.158ThrHis: 1.158 ± 0.032	2.248ThrIle: 2.248 ± 0.044	1.141ThrLys: 1.141 ± 0.032	5.644ThrLeu: 5.644 ± 0.072	0.988ThrMet: 0.988 ± 0.028	1.036ThrAsn: 1.036 ± 0.028	3.906ThrPro: 3.906 ± 0.061	1.336ThrGln: 1.336 ± 0.03	3.822ThrArg: 3.822 ± 0.056	3.37ThrSer: 3.37 ± 0.058	4.046ThrThr: 4.046 ± 0.061	5.615ThrVal: 5.615 ± 0.083	0.979ThrTrp: 0.979 ± 0.029	1.371ThrTyr: 1.371 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	12.708ValAla: 12.708 ± 0.12	0.696ValCys: 0.696 ± 0.025	6.326ValAsp: 6.326 ± 0.068	5.591ValGlu: 5.591 ± 0.074	2.373ValPhe: 2.373 ± 0.047	7.711ValGly: 7.711 ± 0.092	1.969ValHis: 1.969 ± 0.044	3.381ValIle: 3.381 ± 0.056	1.67ValLys: 1.67 ± 0.041	10.171ValLeu: 10.171 ± 0.108	1.484ValMet: 1.484 ± 0.036	1.683ValAsn: 1.683 ± 0.037	5.246ValPro: 5.246 ± 0.071	2.106ValGln: 2.106 ± 0.034	7.049ValArg: 7.049 ± 0.078	4.584ValSer: 4.584 ± 0.063	5.768ValThr: 5.768 ± 0.08	10.321ValVal: 10.321 ± 0.111	1.075ValTrp: 1.075 ± 0.03	1.432ValTyr: 1.432 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.612TrpAla: 1.612 ± 0.036	0.133TrpCys: 0.133 ± 0.011	0.836TrpAsp: 0.836 ± 0.024	0.726TrpGlu: 0.726 ± 0.024	0.48TrpPhe: 0.48 ± 0.019	1.025TrpGly: 1.025 ± 0.032	0.335TrpHis: 0.335 ± 0.016	0.602TrpIle: 0.602 ± 0.02	0.308TrpLys: 0.308 ± 0.016	1.802TrpLeu: 1.802 ± 0.037	0.294TrpMet: 0.294 ± 0.015	0.351TrpAsn: 0.351 ± 0.017	0.718TrpPro: 0.718 ± 0.024	0.48TrpGln: 0.48 ± 0.02	1.288TrpArg: 1.288 ± 0.037	1.007TrpSer: 1.007 ± 0.031	0.968TrpThr: 0.968 ± 0.031	1.191TrpVal: 1.191 ± 0.032	0.348TrpTrp: 0.348 ± 0.018	0.28TrpTyr: 0.28 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.56TyrAla: 2.56 ± 0.04	0.164TyrCys: 0.164 ± 0.011	1.8TyrAsp: 1.8 ± 0.036	0.993TyrGlu: 0.993 ± 0.03	0.618TyrPhe: 0.618 ± 0.025	1.956TyrGly: 1.956 ± 0.041	0.329TyrHis: 0.329 ± 0.017	0.469TyrIle: 0.469 ± 0.021	0.339TyrLys: 0.339 ± 0.016	2.007TyrLeu: 2.007 ± 0.041	0.175TyrMet: 0.175 ± 0.011	0.346TyrAsn: 0.346 ± 0.018	1.003TyrPro: 1.003 ± 0.026	0.527TyrGln: 0.527 ± 0.025	1.53TyrArg: 1.53 ± 0.034	0.93TyrSer: 0.93 ± 0.028	0.993TyrThr: 0.993 ± 0.027	1.933TyrVal: 1.933 ± 0.035	0.286TyrTrp: 0.286 ± 0.016	0.414TyrTyr: 0.414 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.001XaaCys: 0.001 ± 0.001	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 4085 proteins (1314685 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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