Amino acid dipepetide frequency for Thauera linaloolentis 47Lol = DSM 12138

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.944AlaAla: 18.944 ± 0.192	1.452AlaCys: 1.452 ± 0.04	7.304AlaAsp: 7.304 ± 0.081	7.855AlaGlu: 7.855 ± 0.085	4.272AlaPhe: 4.272 ± 0.068	12.093AlaGly: 12.093 ± 0.15	2.72AlaHis: 2.72 ± 0.054	5.396AlaIle: 5.396 ± 0.078	2.968AlaLys: 2.968 ± 0.06	15.128AlaLeu: 15.128 ± 0.146	3.226AlaMet: 3.226 ± 0.05	2.778AlaAsn: 2.778 ± 0.05	5.87AlaPro: 5.87 ± 0.082	4.75AlaGln: 4.75 ± 0.072	10.283AlaArg: 10.283 ± 0.122	6.516AlaSer: 6.516 ± 0.087	5.562AlaThr: 5.562 ± 0.085	8.775AlaVal: 8.775 ± 0.101	1.96AlaTrp: 1.96 ± 0.046	2.551AlaTyr: 2.551 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	1.168CysAla: 1.168 ± 0.035	0.15CysCys: 0.15 ± 0.01	0.528CysAsp: 0.528 ± 0.023	0.538CysGlu: 0.538 ± 0.021	0.343CysPhe: 0.343 ± 0.017	0.985CysGly: 0.985 ± 0.032	0.309CysHis: 0.309 ± 0.021	0.402CysIle: 0.402 ± 0.02	0.191CysLys: 0.191 ± 0.013	0.879CysLeu: 0.879 ± 0.027	0.188CysMet: 0.188 ± 0.011	0.227CysAsn: 0.227 ± 0.014	0.507CysPro: 0.507 ± 0.026	0.221CysGln: 0.221 ± 0.014	0.697CysArg: 0.697 ± 0.026	0.505CysSer: 0.505 ± 0.021	0.456CysThr: 0.456 ± 0.023	0.656CysVal: 0.656 ± 0.024	0.12CysTrp: 0.12 ± 0.011	0.214CysTyr: 0.214 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.52AspAla: 7.52 ± 0.094	0.467AspCys: 0.467 ± 0.02	3.16AspAsp: 3.16 ± 0.058	3.722AspGlu: 3.722 ± 0.067	2.194AspPhe: 2.194 ± 0.047	5.531AspGly: 5.531 ± 0.093	1.152AspHis: 1.152 ± 0.037	2.885AspIle: 2.885 ± 0.054	1.72AspLys: 1.72 ± 0.043	5.389AspLeu: 5.389 ± 0.069	1.208AspMet: 1.208 ± 0.032	1.38AspAsn: 1.38 ± 0.066	2.913AspPro: 2.913 ± 0.057	1.425AspGln: 1.425 ± 0.036	3.622AspArg: 3.622 ± 0.061	2.389AspSer: 2.389 ± 0.043	2.889AspThr: 2.889 ± 0.063	3.902AspVal: 3.902 ± 0.055	1.085AspTrp: 1.085 ± 0.029	1.534AspTyr: 1.534 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	7.809GluAla: 7.809 ± 0.096	0.412GluCys: 0.412 ± 0.019	2.677GluAsp: 2.677 ± 0.051	2.653GluGlu: 2.653 ± 0.056	1.771GluPhe: 1.771 ± 0.043	4.201GluGly: 4.201 ± 0.07	1.566GluHis: 1.566 ± 0.035	3.079GluIle: 3.079 ± 0.053	1.746GluLys: 1.746 ± 0.047	6.327GluLeu: 6.327 ± 0.073	1.225GluMet: 1.225 ± 0.034	1.373GluAsn: 1.373 ± 0.033	2.513GluPro: 2.513 ± 0.055	2.531GluGln: 2.531 ± 0.054	5.509GluArg: 5.509 ± 0.082	2.55GluSer: 2.55 ± 0.044	2.913GluThr: 2.913 ± 0.062	4.167GluVal: 4.167 ± 0.065	0.752GluTrp: 0.752 ± 0.026	1.19GluTyr: 1.19 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.425PheAla: 4.425 ± 0.063	0.412PheCys: 0.412 ± 0.02	2.635PheAsp: 2.635 ± 0.049	2.169PheGlu: 2.169 ± 0.046	1.377PhePhe: 1.377 ± 0.044	3.527PheGly: 3.527 ± 0.067	0.814PheHis: 0.814 ± 0.025	1.65PheIle: 1.65 ± 0.037	0.957PheLys: 0.957 ± 0.031	3.065PheLeu: 3.065 ± 0.062	0.79PheMet: 0.79 ± 0.025	1.081PheAsn: 1.081 ± 0.031	1.464PhePro: 1.464 ± 0.035	0.97PheGln: 0.97 ± 0.029	2.215PheArg: 2.215 ± 0.041	2.145PheSer: 2.145 ± 0.044	1.676PheThr: 1.676 ± 0.039	2.727PheVal: 2.727 ± 0.055	0.478PheTrp: 0.478 ± 0.023	0.872PheTyr: 0.872 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	9.547GlyAla: 9.547 ± 0.101	0.962GlyCys: 0.962 ± 0.029	4.331GlyAsp: 4.331 ± 0.061	5.442GlyGlu: 5.442 ± 0.071	3.468GlyPhe: 3.468 ± 0.051	7.607GlyGly: 7.607 ± 0.11	1.985GlyHis: 1.985 ± 0.043	4.335GlyIle: 4.335 ± 0.059	3.187GlyLys: 3.187 ± 0.054	9.579GlyLeu: 9.579 ± 0.095	2.415GlyMet: 2.415 ± 0.043	2.227GlyAsn: 2.227 ± 0.05	2.929GlyPro: 2.929 ± 0.05	3.044GlyGln: 3.044 ± 0.064	6.665GlyArg: 6.665 ± 0.074	4.579GlySer: 4.579 ± 0.083	4.365GlyThr: 4.365 ± 0.095	6.433GlyVal: 6.433 ± 0.085	1.51GlyTrp: 1.51 ± 0.04	2.309GlyTyr: 2.309 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	3.11HisAla: 3.11 ± 0.048	0.278HisCys: 0.278 ± 0.017	1.315HisAsp: 1.315 ± 0.028	1.199HisGlu: 1.199 ± 0.03	0.939HisPhe: 0.939 ± 0.027	2.259HisGly: 2.259 ± 0.057	0.697HisHis: 0.697 ± 0.025	0.94HisIle: 0.94 ± 0.027	0.566HisLys: 0.566 ± 0.022	2.409HisLeu: 2.409 ± 0.048	0.443HisMet: 0.443 ± 0.018	0.522HisAsn: 0.522 ± 0.019	1.507HisPro: 1.507 ± 0.045	0.696HisGln: 0.696 ± 0.023	1.649HisArg: 1.649 ± 0.046	1.01HisSer: 1.01 ± 0.03	1.073HisThr: 1.073 ± 0.028	1.527HisVal: 1.527 ± 0.034	0.394HisTrp: 0.394 ± 0.02	0.691HisTyr: 0.691 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.399IleAla: 6.399 ± 0.072	0.408IleCys: 0.408 ± 0.018	3.535IleAsp: 3.535 ± 0.058	3.483IleGlu: 3.483 ± 0.055	1.323IlePhe: 1.323 ± 0.037	4.64IleGly: 4.64 ± 0.07	1.004IleHis: 1.004 ± 0.028	1.758IleIle: 1.758 ± 0.049	1.286IleLys: 1.286 ± 0.037	3.787IleLeu: 3.787 ± 0.06	0.778IleMet: 0.778 ± 0.028	1.388IleAsn: 1.388 ± 0.038	2.043IlePro: 2.043 ± 0.046	1.278IleGln: 1.278 ± 0.035	3.095IleArg: 3.095 ± 0.05	2.353IleSer: 2.353 ± 0.048	2.345IleThr: 2.345 ± 0.057	3.573IleVal: 3.573 ± 0.065	0.412IleTrp: 0.412 ± 0.019	1.004IleTyr: 1.004 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.556LysAla: 3.556 ± 0.072	0.171LysCys: 0.171 ± 0.013	1.466LysAsp: 1.466 ± 0.042	1.4LysGlu: 1.4 ± 0.039	0.766LysPhe: 0.766 ± 0.03	2.198LysGly: 2.198 ± 0.049	0.664LysHis: 0.664 ± 0.026	1.321LysIle: 1.321 ± 0.038	1.062LysLys: 1.062 ± 0.034	3.109LysLeu: 3.109 ± 0.051	0.648LysMet: 0.648 ± 0.022	0.822LysAsn: 0.822 ± 0.03	1.677LysPro: 1.677 ± 0.041	1.096LysGln: 1.096 ± 0.026	2.134LysArg: 2.134 ± 0.05	1.408LysSer: 1.408 ± 0.036	1.554LysThr: 1.554 ± 0.039	2.198LysVal: 2.198 ± 0.044	0.314LysTrp: 0.314 ± 0.016	0.646LysTyr: 0.646 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	15.83LeuAla: 15.83 ± 0.141	1.012LeuCys: 1.012 ± 0.028	6.815LeuAsp: 6.815 ± 0.11	5.74LeuGlu: 5.74 ± 0.09	3.607LeuPhe: 3.607 ± 0.067	9.066LeuGly: 9.066 ± 0.097	2.469LeuHis: 2.469 ± 0.054	4.628LeuIle: 4.628 ± 0.085	3.177LeuLys: 3.177 ± 0.053	11.653LeuLeu: 11.653 ± 0.14	2.268LeuMet: 2.268 ± 0.051	2.748LeuAsn: 2.748 ± 0.052	6.462LeuPro: 6.462 ± 0.091	3.717LeuGln: 3.717 ± 0.056	8.392LeuArg: 8.392 ± 0.094	6.348LeuSer: 6.348 ± 0.075	4.925LeuThr: 4.925 ± 0.085	7.275LeuVal: 7.275 ± 0.087	1.203LeuTrp: 1.203 ± 0.03	2.185LeuTyr: 2.185 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.774MetAla: 2.774 ± 0.053	0.158MetCys: 0.158 ± 0.012	1.05MetAsp: 1.05 ± 0.031	1.054MetGlu: 1.054 ± 0.031	0.682MetPhe: 0.682 ± 0.025	1.591MetGly: 1.591 ± 0.038	0.512MetHis: 0.512 ± 0.02	1.011MetIle: 1.011 ± 0.026	0.95MetLys: 0.95 ± 0.03	2.755MetLeu: 2.755 ± 0.048	0.577MetMet: 0.577 ± 0.023	0.867MetAsn: 0.867 ± 0.027	1.446MetPro: 1.446 ± 0.037	0.975MetGln: 0.975 ± 0.028	1.726MetArg: 1.726 ± 0.038	1.581MetSer: 1.581 ± 0.041	1.2MetThr: 1.2 ± 0.033	1.577MetVal: 1.577 ± 0.04	0.197MetTrp: 0.197 ± 0.013	0.339MetTyr: 0.339 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.107AsnAla: 3.107 ± 0.062	0.266AsnCys: 0.266 ± 0.016	1.324AsnAsp: 1.324 ± 0.039	1.191AsnGlu: 1.191 ± 0.032	0.893AsnPhe: 0.893 ± 0.026	2.228AsnGly: 2.228 ± 0.044	0.539AsnHis: 0.539 ± 0.021	1.223AsnIle: 1.223 ± 0.032	0.713AsnLys: 0.713 ± 0.03	2.779AsnLeu: 2.779 ± 0.045	0.565AsnMet: 0.565 ± 0.02	0.69AsnAsn: 0.69 ± 0.029	1.753AsnPro: 1.753 ± 0.039	0.774AsnGln: 0.774 ± 0.026	1.801AsnArg: 1.801 ± 0.053	1.018AsnSer: 1.018 ± 0.029	1.432AsnThr: 1.432 ± 0.054	1.785AsnVal: 1.785 ± 0.039	0.435AsnTrp: 0.435 ± 0.021	0.745AsnTyr: 0.745 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	7.356ProAla: 7.356 ± 0.098	0.386ProCys: 0.386 ± 0.019	3.249ProAsp: 3.249 ± 0.057	3.439ProGlu: 3.439 ± 0.055	1.758ProPhe: 1.758 ± 0.039	4.672ProGly: 4.672 ± 0.064	1.044ProHis: 1.044 ± 0.03	1.87ProIle: 1.87 ± 0.042	1.221ProLys: 1.221 ± 0.035	5.228ProLeu: 5.228 ± 0.072	1.134ProMet: 1.134 ± 0.032	1.129ProAsn: 1.129 ± 0.033	2.771ProPro: 2.771 ± 0.069	1.892ProGln: 1.892 ± 0.044	3.208ProArg: 3.208 ± 0.053	2.476ProSer: 2.476 ± 0.042	2.039ProThr: 2.039 ± 0.043	3.906ProVal: 3.906 ± 0.058	0.687ProTrp: 0.687 ± 0.028	1.108ProTyr: 1.108 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	5.188GlnAla: 5.188 ± 0.084	0.239GlnCys: 0.239 ± 0.015	1.601GlnAsp: 1.601 ± 0.038	1.53GlnGlu: 1.53 ± 0.038	1.078GlnPhe: 1.078 ± 0.029	2.791GlnGly: 2.791 ± 0.056	0.878GlnHis: 0.878 ± 0.029	1.749GlnIle: 1.749 ± 0.05	0.977GlnLys: 0.977 ± 0.028	3.566GlnLeu: 3.566 ± 0.062	0.779GlnMet: 0.779 ± 0.029	0.774GlnAsn: 0.774 ± 0.025	1.969GlnPro: 1.969 ± 0.04	1.594GlnGln: 1.594 ± 0.048	3.15GlnArg: 3.15 ± 0.063	1.649GlnSer: 1.649 ± 0.041	1.606GlnThr: 1.606 ± 0.046	2.513GlnVal: 2.513 ± 0.049	0.521GlnTrp: 0.521 ± 0.021	0.738GlnTyr: 0.738 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.42ArgAla: 8.42 ± 0.105	0.623ArgCys: 0.623 ± 0.022	4.097ArgAsp: 4.097 ± 0.058	4.658ArgGlu: 4.658 ± 0.075	3.185ArgPhe: 3.185 ± 0.045	5.248ArgGly: 5.248 ± 0.07	2.228ArgHis: 2.228 ± 0.054	4.264ArgIle: 4.264 ± 0.067	2.116ArgLys: 2.116 ± 0.043	9.24ArgLeu: 9.24 ± 0.104	2.057ArgMet: 2.057 ± 0.039	1.996ArgAsn: 1.996 ± 0.042	3.624ArgPro: 3.624 ± 0.056	3.022ArgGln: 3.022 ± 0.053	6.178ArgArg: 6.178 ± 0.093	3.695ArgSer: 3.695 ± 0.067	3.322ArgThr: 3.322 ± 0.054	5.168ArgVal: 5.168 ± 0.065	1.09ArgTrp: 1.09 ± 0.033	2.086ArgTyr: 2.086 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.407SerAla: 6.407 ± 0.08	0.437SerCys: 0.437 ± 0.021	2.452SerAsp: 2.452 ± 0.057	2.369SerGlu: 2.369 ± 0.041	2.005SerPhe: 2.005 ± 0.044	5.407SerGly: 5.407 ± 0.082	1.18SerHis: 1.18 ± 0.033	2.548SerIle: 2.548 ± 0.052	1.235SerLys: 1.235 ± 0.037	5.741SerLeu: 5.741 ± 0.064	1.168SerMet: 1.168 ± 0.032	1.29SerAsn: 1.29 ± 0.036	2.658SerPro: 2.658 ± 0.041	1.57SerGln: 1.57 ± 0.04	3.73SerArg: 3.73 ± 0.065	2.641SerSer: 2.641 ± 0.06	2.626SerThr: 2.626 ± 0.06	3.715SerVal: 3.715 ± 0.061	0.695SerTrp: 0.695 ± 0.025	1.263SerTyr: 1.263 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	5.756ThrAla: 5.756 ± 0.116	0.379ThrCys: 0.379 ± 0.019	2.383ThrAsp: 2.383 ± 0.049	2.467ThrGlu: 2.467 ± 0.065	1.526ThrPhe: 1.526 ± 0.043	4.451ThrGly: 4.451 ± 0.08	1.118ThrHis: 1.118 ± 0.033	2.005ThrIle: 2.005 ± 0.046	0.987ThrLys: 0.987 ± 0.033	6.242ThrLeu: 6.242 ± 0.105	0.971ThrMet: 0.971 ± 0.029	1.085ThrAsn: 1.085 ± 0.029	3.109ThrPro: 3.109 ± 0.053	1.544ThrGln: 1.544 ± 0.042	3.524ThrArg: 3.524 ± 0.051	2.233ThrSer: 2.233 ± 0.054	2.432ThrThr: 2.432 ± 0.063	3.933ThrVal: 3.933 ± 0.068	0.622ThrTrp: 0.622 ± 0.022	1.02ThrTyr: 1.02 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	9.051ValAla: 9.051 ± 0.1	0.69ValCys: 0.69 ± 0.023	4.146ValAsp: 4.146 ± 0.051	4.335ValGlu: 4.335 ± 0.059	2.852ValPhe: 2.852 ± 0.052	5.387ValGly: 5.387 ± 0.067	1.483ValHis: 1.483 ± 0.032	3.441ValIle: 3.441 ± 0.056	2.077ValLys: 2.077 ± 0.053	8.073ValLeu: 8.073 ± 0.096	1.78ValMet: 1.78 ± 0.044	1.82ValAsn: 1.82 ± 0.043	3.631ValPro: 3.631 ± 0.063	2.192ValGln: 2.192 ± 0.043	5.348ValArg: 5.348 ± 0.068	4.152ValSer: 4.152 ± 0.062	3.537ValThr: 3.537 ± 0.064	5.84ValVal: 5.84 ± 0.081	0.914ValTrp: 0.914 ± 0.028	1.435ValTyr: 1.435 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.314TrpAla: 1.314 ± 0.033	0.141TrpCys: 0.141 ± 0.012	0.624TrpAsp: 0.624 ± 0.023	0.602TrpGlu: 0.602 ± 0.021	0.519TrpPhe: 0.519 ± 0.022	0.903TrpGly: 0.903 ± 0.029	0.369TrpHis: 0.369 ± 0.016	0.61TrpIle: 0.61 ± 0.024	0.453TrpLys: 0.453 ± 0.019	2.097TrpLeu: 2.097 ± 0.05	0.385TrpMet: 0.385 ± 0.019	0.455TrpAsn: 0.455 ± 0.021	0.649TrpPro: 0.649 ± 0.02	0.751TrpGln: 0.751 ± 0.028	1.31TrpArg: 1.31 ± 0.037	0.756TrpSer: 0.756 ± 0.026	0.601TrpThr: 0.601 ± 0.023	0.917TrpVal: 0.917 ± 0.031	0.232TrpTrp: 0.232 ± 0.014	0.309TrpTyr: 0.309 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.724TyrAla: 2.724 ± 0.054	0.241TyrCys: 0.241 ± 0.015	1.398TyrAsp: 1.398 ± 0.035	1.118TyrGlu: 1.118 ± 0.038	0.888TyrPhe: 0.888 ± 0.028	2.133TyrGly: 2.133 ± 0.04	0.493TyrHis: 0.493 ± 0.022	0.774TyrIle: 0.774 ± 0.024	0.622TyrLys: 0.622 ± 0.026	2.476TyrLeu: 2.476 ± 0.047	0.416TyrMet: 0.416 ± 0.017	0.61TyrAsn: 0.61 ± 0.026	1.073TyrPro: 1.073 ± 0.025	0.847TyrGln: 0.847 ± 0.029	2.081TyrArg: 2.081 ± 0.046	1.136TyrSer: 1.136 ± 0.037	1.233TyrThr: 1.233 ± 0.038	1.597TyrVal: 1.597 ± 0.036	0.376TyrTrp: 0.376 ± 0.018	0.64TyrTyr: 0.64 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3836 proteins (1253860 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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