Amino acid dipepetide frequency for J-virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.239AlaAla: 4.239 ± 0.753
1.187AlaCys: 1.187 ± 0.586
2.882AlaAsp: 2.882 ± 1.089
3.9AlaGlu: 3.9 ± 1.199
1.526AlaPhe: 1.526 ± 0.613
2.882AlaGly: 2.882 ± 1.238
1.017AlaHis: 1.017 ± 0.46
6.273AlaIle: 6.273 ± 1.164
1.865AlaLys: 1.865 ± 0.714
6.443AlaLeu: 6.443 ± 1.32
3.052AlaMet: 3.052 ± 0.775
3.391AlaAsn: 3.391 ± 0.631
1.695AlaPro: 1.695 ± 0.63
1.695AlaGln: 1.695 ± 0.519
2.713AlaArg: 2.713 ± 1.097
3.391AlaSer: 3.391 ± 1.215
2.543AlaThr: 2.543 ± 0.894
3.052AlaVal: 3.052 ± 1.056
1.187AlaTrp: 1.187 ± 0.416
1.356AlaTyr: 1.356 ± 0.537
0.0AlaXaa: 0.0 ± 0.0
Cys
1.187CysAla: 1.187 ± 0.662
0.509CysCys: 0.509 ± 0.342
0.509CysAsp: 0.509 ± 0.342
0.509CysGlu: 0.509 ± 0.23
0.678CysPhe: 0.678 ± 0.314
0.678CysGly: 0.678 ± 0.305
0.509CysHis: 0.509 ± 0.25
0.678CysIle: 0.678 ± 0.487
1.356CysLys: 1.356 ± 0.514
1.356CysLeu: 1.356 ± 0.652
0.17CysMet: 0.17 ± 0.114
0.848CysAsn: 0.848 ± 0.308
0.848CysPro: 0.848 ± 0.402
1.187CysGln: 1.187 ± 0.359
0.848CysArg: 0.848 ± 0.367
1.526CysSer: 1.526 ± 0.44
1.526CysThr: 1.526 ± 0.541
2.035CysVal: 2.035 ± 0.502
0.17CysTrp: 0.17 ± 0.114
1.356CysTyr: 1.356 ± 0.477
0.0CysXaa: 0.0 ± 0.0
Asp
2.374AspAla: 2.374 ± 0.869
1.356AspCys: 1.356 ± 0.385
2.713AspAsp: 2.713 ± 0.717
3.9AspGlu: 3.9 ± 1.061
1.695AspPhe: 1.695 ± 0.47
2.882AspGly: 2.882 ± 1.267
1.526AspHis: 1.526 ± 0.409
3.73AspIle: 3.73 ± 1.091
2.374AspLys: 2.374 ± 0.582
7.291AspLeu: 7.291 ± 0.723
1.356AspMet: 1.356 ± 0.456
2.713AspAsn: 2.713 ± 0.609
3.221AspPro: 3.221 ± 0.347
2.374AspGln: 2.374 ± 0.509
2.204AspArg: 2.204 ± 0.512
3.391AspSer: 3.391 ± 0.879
4.069AspThr: 4.069 ± 0.593
3.221AspVal: 3.221 ± 0.825
0.509AspTrp: 0.509 ± 0.23
2.204AspTyr: 2.204 ± 0.512
0.0AspXaa: 0.0 ± 0.0
Glu
3.052GluAla: 3.052 ± 0.691
1.187GluCys: 1.187 ± 0.537
4.917GluAsp: 4.917 ± 1.225
4.747GluGlu: 4.747 ± 1.313
2.035GluPhe: 2.035 ± 0.656
3.73GluGly: 3.73 ± 1.309
0.678GluHis: 0.678 ± 0.366
3.73GluIle: 3.73 ± 0.666
4.408GluLys: 4.408 ± 1.233
4.578GluLeu: 4.578 ± 1.206
1.356GluMet: 1.356 ± 0.472
2.882GluAsn: 2.882 ± 0.795
1.356GluPro: 1.356 ± 0.758
2.713GluGln: 2.713 ± 1.129
1.526GluArg: 1.526 ± 0.535
4.408GluSer: 4.408 ± 1.138
4.069GluThr: 4.069 ± 0.76
3.73GluVal: 3.73 ± 1.083
0.848GluTrp: 0.848 ± 0.424
2.204GluTyr: 2.204 ± 0.561
0.0GluXaa: 0.0 ± 0.0
Phe
2.374PheAla: 2.374 ± 0.545
1.017PheCys: 1.017 ± 0.422
1.526PheAsp: 1.526 ± 0.475
0.848PheGlu: 0.848 ± 0.4
2.035PhePhe: 2.035 ± 0.38
1.695PheGly: 1.695 ± 0.524
1.187PheHis: 1.187 ± 0.607
2.035PheIle: 2.035 ± 0.531
2.204PheLys: 2.204 ± 0.916
3.9PheLeu: 3.9 ± 1.07
0.678PheMet: 0.678 ± 0.415
2.204PheAsn: 2.204 ± 0.682
1.356PhePro: 1.356 ± 0.464
1.017PheGln: 1.017 ± 0.372
2.374PheArg: 2.374 ± 0.893
2.374PheSer: 2.374 ± 0.549
1.187PheThr: 1.187 ± 0.313
1.695PheVal: 1.695 ± 0.504
0.848PheTrp: 0.848 ± 0.379
1.017PheTyr: 1.017 ± 0.282
0.0PheXaa: 0.0 ± 0.0
Gly
4.239GlyAla: 4.239 ± 0.838
0.848GlyCys: 0.848 ± 0.808
3.391GlyAsp: 3.391 ± 0.768
4.578GlyGlu: 4.578 ± 2.128
2.713GlyPhe: 2.713 ± 1.115
7.46GlyGly: 7.46 ± 3.314
2.204GlyHis: 2.204 ± 0.842
3.391GlyIle: 3.391 ± 1.086
3.561GlyLys: 3.561 ± 0.808
5.934GlyLeu: 5.934 ± 0.731
2.204GlyMet: 2.204 ± 0.511
3.561GlyAsn: 3.561 ± 1.32
3.391GlyPro: 3.391 ± 1.317
1.187GlyGln: 1.187 ± 0.439
2.882GlyArg: 2.882 ± 1.024
6.782GlySer: 6.782 ± 1.981
2.543GlyThr: 2.543 ± 1.186
3.391GlyVal: 3.391 ± 1.207
0.509GlyTrp: 0.509 ± 0.601
1.526GlyTyr: 1.526 ± 0.549
0.0GlyXaa: 0.0 ± 0.0
His
1.017HisAla: 1.017 ± 0.528
0.509HisCys: 0.509 ± 0.281
0.678HisAsp: 0.678 ± 0.264
1.695HisGlu: 1.695 ± 0.394
0.848HisPhe: 0.848 ± 0.348
2.713HisGly: 2.713 ± 1.031
0.339HisHis: 0.339 ± 0.231
0.678HisIle: 0.678 ± 0.403
0.848HisLys: 0.848 ± 0.349
1.865HisLeu: 1.865 ± 0.756
0.509HisMet: 0.509 ± 0.253
1.695HisAsn: 1.695 ± 0.668
1.695HisPro: 1.695 ± 0.529
0.678HisGln: 0.678 ± 0.396
0.848HisArg: 0.848 ± 0.377
0.678HisSer: 0.678 ± 0.239
1.356HisThr: 1.356 ± 0.53
1.017HisVal: 1.017 ± 0.303
0.0HisTrp: 0.0 ± 0.0
0.339HisTyr: 0.339 ± 0.199
0.0HisXaa: 0.0 ± 0.0
Ile
4.069IleAla: 4.069 ± 1.054
1.187IleCys: 1.187 ± 0.42
3.561IleAsp: 3.561 ± 1.045
4.069IleGlu: 4.069 ± 0.567
1.865IlePhe: 1.865 ± 0.29
3.221IleGly: 3.221 ± 0.507
1.526IleHis: 1.526 ± 0.483
4.578IleIle: 4.578 ± 1.022
5.256IleLys: 5.256 ± 0.945
4.917IleLeu: 4.917 ± 1.014
1.695IleMet: 1.695 ± 0.723
5.934IleAsn: 5.934 ± 1.184
3.73IlePro: 3.73 ± 0.745
2.374IleGln: 2.374 ± 1.056
3.73IleArg: 3.73 ± 0.702
5.934IleSer: 5.934 ± 1.149
4.578IleThr: 4.578 ± 0.768
3.73IleVal: 3.73 ± 0.69
0.678IleTrp: 0.678 ± 0.295
3.052IleTyr: 3.052 ± 0.885
0.0IleXaa: 0.0 ± 0.0
Lys
3.221LysAla: 3.221 ± 0.916
1.187LysCys: 1.187 ± 0.632
2.713LysAsp: 2.713 ± 0.712
3.561LysGlu: 3.561 ± 0.245
2.204LysPhe: 2.204 ± 1.108
2.882LysGly: 2.882 ± 0.484
1.017LysHis: 1.017 ± 0.38
4.239LysIle: 4.239 ± 0.924
3.391LysLys: 3.391 ± 0.651
4.408LysLeu: 4.408 ± 1.356
2.882LysMet: 2.882 ± 0.846
3.73LysAsn: 3.73 ± 0.854
3.221LysPro: 3.221 ± 0.596
1.356LysGln: 1.356 ± 0.557
3.052LysArg: 3.052 ± 0.734
4.578LysSer: 4.578 ± 1.304
4.408LysThr: 4.408 ± 0.698
4.069LysVal: 4.069 ± 0.983
0.339LysTrp: 0.339 ± 0.247
2.374LysTyr: 2.374 ± 0.915
0.0LysXaa: 0.0 ± 0.0
Leu
4.239LeuAla: 4.239 ± 1.257
1.865LeuCys: 1.865 ± 0.687
6.782LeuAsp: 6.782 ± 1.068
5.426LeuGlu: 5.426 ± 0.567
2.713LeuPhe: 2.713 ± 1.096
6.104LeuGly: 6.104 ± 0.992
1.526LeuHis: 1.526 ± 0.512
6.104LeuIle: 6.104 ± 1.749
6.273LeuLys: 6.273 ± 1.784
7.121LeuLeu: 7.121 ± 1.195
2.713LeuMet: 2.713 ± 0.806
6.273LeuAsn: 6.273 ± 1.332
3.9LeuPro: 3.9 ± 0.926
4.069LeuGln: 4.069 ± 0.99
4.747LeuArg: 4.747 ± 0.86
6.782LeuSer: 6.782 ± 1.248
6.612LeuThr: 6.612 ± 0.97
5.426LeuVal: 5.426 ± 0.781
0.848LeuTrp: 0.848 ± 0.444
2.204LeuTyr: 2.204 ± 0.68
0.0LeuXaa: 0.0 ± 0.0
Met
0.848MetAla: 0.848 ± 0.546
0.509MetCys: 0.509 ± 0.438
2.204MetAsp: 2.204 ± 0.648
1.187MetGlu: 1.187 ± 0.699
0.678MetPhe: 0.678 ± 0.243
1.187MetGly: 1.187 ± 0.389
0.339MetHis: 0.339 ± 0.199
2.713MetIle: 2.713 ± 0.48
2.543MetLys: 2.543 ± 0.499
2.882MetLeu: 2.882 ± 0.745
1.356MetMet: 1.356 ± 0.548
2.374MetAsn: 2.374 ± 0.682
0.848MetPro: 0.848 ± 0.428
0.0MetGln: 0.0 ± 0.0
2.374MetArg: 2.374 ± 0.67
3.221MetSer: 3.221 ± 1.025
1.526MetThr: 1.526 ± 0.495
2.204MetVal: 2.204 ± 0.647
0.509MetTrp: 0.509 ± 0.273
1.187MetTyr: 1.187 ± 0.516
0.0MetXaa: 0.0 ± 0.0
Asn
2.882AsnAla: 2.882 ± 0.819
0.678AsnCys: 0.678 ± 0.399
3.052AsnAsp: 3.052 ± 1.032
2.035AsnGlu: 2.035 ± 0.605
1.695AsnPhe: 1.695 ± 0.444
2.713AsnGly: 2.713 ± 0.377
1.187AsnHis: 1.187 ± 0.387
4.747AsnIle: 4.747 ± 1.358
3.391AsnLys: 3.391 ± 0.855
4.069AsnLeu: 4.069 ± 0.793
2.035AsnMet: 2.035 ± 0.584
3.391AsnAsn: 3.391 ± 0.582
3.73AsnPro: 3.73 ± 0.92
4.239AsnGln: 4.239 ± 1.559
2.713AsnArg: 2.713 ± 0.655
4.578AsnSer: 4.578 ± 1.135
3.9AsnThr: 3.9 ± 0.822
3.052AsnVal: 3.052 ± 1.027
1.017AsnTrp: 1.017 ± 0.517
1.865AsnTyr: 1.865 ± 0.534
0.0AsnXaa: 0.0 ± 0.0
Pro
1.695ProAla: 1.695 ± 0.751
0.17ProCys: 0.17 ± 0.2
1.695ProAsp: 1.695 ± 0.458
2.882ProGlu: 2.882 ± 0.613
0.509ProPhe: 0.509 ± 0.23
3.9ProGly: 3.9 ± 1.54
1.017ProHis: 1.017 ± 0.415
3.221ProIle: 3.221 ± 0.782
3.561ProLys: 3.561 ± 1.356
3.052ProLeu: 3.052 ± 0.591
0.848ProMet: 0.848 ± 0.314
2.204ProAsn: 2.204 ± 0.951
1.695ProPro: 1.695 ± 0.673
1.356ProGln: 1.356 ± 0.663
2.543ProArg: 2.543 ± 0.666
3.73ProSer: 3.73 ± 1.103
3.052ProThr: 3.052 ± 1.017
3.561ProVal: 3.561 ± 1.021
0.17ProTrp: 0.17 ± 0.201
2.713ProTyr: 2.713 ± 0.886
0.0ProXaa: 0.0 ± 0.0
Gln
2.374GlnAla: 2.374 ± 0.881
1.017GlnCys: 1.017 ± 0.385
2.374GlnAsp: 2.374 ± 1.242
2.543GlnGlu: 2.543 ± 0.312
1.017GlnPhe: 1.017 ± 0.518
1.526GlnGly: 1.526 ± 0.368
0.678GlnHis: 0.678 ± 0.449
2.882GlnIle: 2.882 ± 0.572
2.713GlnLys: 2.713 ± 0.784
4.239GlnLeu: 4.239 ± 1.466
1.017GlnMet: 1.017 ± 0.372
1.017GlnAsn: 1.017 ± 0.418
1.187GlnPro: 1.187 ± 0.721
1.187GlnGln: 1.187 ± 0.338
1.526GlnArg: 1.526 ± 0.491
4.239GlnSer: 4.239 ± 1.177
1.017GlnThr: 1.017 ± 0.41
2.035GlnVal: 2.035 ± 0.299
0.17GlnTrp: 0.17 ± 0.2
0.848GlnTyr: 0.848 ± 0.441
0.0GlnXaa: 0.0 ± 0.0
Arg
3.391ArgAla: 3.391 ± 0.65
1.187ArgCys: 1.187 ± 0.411
2.543ArgAsp: 2.543 ± 0.534
2.713ArgGlu: 2.713 ± 0.413
1.526ArgPhe: 1.526 ± 0.416
3.052ArgGly: 3.052 ± 0.764
0.678ArgHis: 0.678 ± 0.355
3.052ArgIle: 3.052 ± 0.753
2.035ArgLys: 2.035 ± 0.773
5.934ArgLeu: 5.934 ± 1.091
1.356ArgMet: 1.356 ± 0.581
2.374ArgAsn: 2.374 ± 0.426
1.356ArgPro: 1.356 ± 0.26
1.865ArgGln: 1.865 ± 0.58
4.239ArgArg: 4.239 ± 1.23
4.239ArgSer: 4.239 ± 0.418
2.543ArgThr: 2.543 ± 1.162
3.73ArgVal: 3.73 ± 1.067
1.017ArgTrp: 1.017 ± 0.401
1.526ArgTyr: 1.526 ± 0.606
0.0ArgXaa: 0.0 ± 0.0
Ser
5.426SerAla: 5.426 ± 1.997
1.356SerCys: 1.356 ± 0.454
4.239SerAsp: 4.239 ± 1.133
4.408SerGlu: 4.408 ± 1.123
2.713SerPhe: 2.713 ± 0.709
4.747SerGly: 4.747 ± 1.528
1.695SerHis: 1.695 ± 0.588
5.765SerIle: 5.765 ± 1.535
4.239SerLys: 4.239 ± 1.392
7.799SerLeu: 7.799 ± 1.81
2.204SerMet: 2.204 ± 0.816
4.239SerAsn: 4.239 ± 0.847
1.865SerPro: 1.865 ± 0.823
2.543SerGln: 2.543 ± 0.751
3.561SerArg: 3.561 ± 0.671
5.256SerSer: 5.256 ± 0.503
6.443SerThr: 6.443 ± 0.758
7.121SerVal: 7.121 ± 1.398
0.848SerTrp: 0.848 ± 0.328
4.239SerTyr: 4.239 ± 0.725
0.0SerXaa: 0.0 ± 0.0
Thr
2.882ThrAla: 2.882 ± 0.823
0.848ThrCys: 0.848 ± 0.365
3.391ThrAsp: 3.391 ± 0.96
3.052ThrGlu: 3.052 ± 0.637
2.204ThrPhe: 2.204 ± 0.551
5.934ThrGly: 5.934 ± 1.472
0.678ThrHis: 0.678 ± 0.361
5.426ThrIle: 5.426 ± 0.772
3.73ThrLys: 3.73 ± 1.063
4.917ThrLeu: 4.917 ± 1.004
2.035ThrMet: 2.035 ± 0.497
2.204ThrAsn: 2.204 ± 0.821
2.204ThrPro: 2.204 ± 0.63
1.865ThrGln: 1.865 ± 0.52
3.561ThrArg: 3.561 ± 0.79
5.595ThrSer: 5.595 ± 1.256
4.747ThrThr: 4.747 ± 0.411
3.391ThrVal: 3.391 ± 0.889
0.678ThrTrp: 0.678 ± 0.239
3.73ThrTyr: 3.73 ± 1.476
0.0ThrXaa: 0.0 ± 0.0
Val
5.595ValAla: 5.595 ± 1.375
0.848ValCys: 0.848 ± 0.39
3.73ValAsp: 3.73 ± 0.755
2.713ValGlu: 2.713 ± 0.86
2.374ValPhe: 2.374 ± 0.584
5.426ValGly: 5.426 ± 1.25
1.356ValHis: 1.356 ± 0.42
3.391ValIle: 3.391 ± 0.67
2.713ValLys: 2.713 ± 0.751
5.595ValLeu: 5.595 ± 1.159
1.356ValMet: 1.356 ± 0.576
3.9ValAsn: 3.9 ± 0.731
3.052ValPro: 3.052 ± 0.748
2.543ValGln: 2.543 ± 0.63
3.052ValArg: 3.052 ± 0.765
3.73ValSer: 3.73 ± 1.03
3.9ValThr: 3.9 ± 1.157
2.374ValVal: 2.374 ± 0.601
1.187ValTrp: 1.187 ± 0.57
2.374ValTyr: 2.374 ± 0.645
0.0ValXaa: 0.0 ± 0.0
Trp
0.509TrpAla: 0.509 ± 0.253
0.339TrpCys: 0.339 ± 0.302
1.017TrpAsp: 1.017 ± 0.372
1.356TrpGlu: 1.356 ± 0.373
0.678TrpPhe: 0.678 ± 0.239
1.017TrpGly: 1.017 ± 0.529
0.339TrpHis: 0.339 ± 0.183
0.509TrpIle: 0.509 ± 0.316
0.678TrpLys: 0.678 ± 0.422
1.526TrpLeu: 1.526 ± 0.557
0.339TrpMet: 0.339 ± 0.183
0.339TrpAsn: 0.339 ± 0.247
0.339TrpPro: 0.339 ± 0.183
0.0TrpGln: 0.0 ± 0.0
0.339TrpArg: 0.339 ± 0.228
0.848TrpSer: 0.848 ± 0.353
0.17TrpThr: 0.17 ± 0.114
0.678TrpVal: 0.678 ± 0.302
0.17TrpTrp: 0.17 ± 0.114
0.509TrpTyr: 0.509 ± 0.342
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.678TyrAla: 0.678 ± 0.423
0.678TyrCys: 0.678 ± 0.362
1.187TyrAsp: 1.187 ± 0.625
2.035TyrGlu: 2.035 ± 0.47
1.865TyrPhe: 1.865 ± 0.828
2.543TyrGly: 2.543 ± 0.592
0.509TyrHis: 0.509 ± 0.23
2.543TyrIle: 2.543 ± 0.896
1.695TyrLys: 1.695 ± 0.555
3.9TyrLeu: 3.9 ± 1.123
1.356TyrMet: 1.356 ± 0.514
1.695TyrAsn: 1.695 ± 0.486
2.882TyrPro: 2.882 ± 0.768
1.356TyrGln: 1.356 ± 0.486
1.526TyrArg: 1.526 ± 0.535
5.426TyrSer: 5.426 ± 0.99
2.882TyrThr: 2.882 ± 1.1
1.695TyrVal: 1.695 ± 0.502
0.0TyrTrp: 0.0 ± 0.0
1.526TyrTyr: 1.526 ± 0.699
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (5899 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski