Amino acid dipepetide frequency for Tibetan frog hepatitis B virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.189AlaAla: 5.189 ± 1.174
0.0AlaCys: 0.0 ± 0.0
2.076AlaAsp: 2.076 ± 0.863
4.152AlaGlu: 4.152 ± 0.372
2.595AlaPhe: 2.595 ± 0.238
4.67AlaGly: 4.67 ± 0.771
1.038AlaHis: 1.038 ± 0.524
4.67AlaIle: 4.67 ± 0.615
2.076AlaLys: 2.076 ± 0.441
7.784AlaLeu: 7.784 ± 1.938
1.038AlaMet: 1.038 ± 0.425
4.152AlaAsn: 4.152 ± 1.386
5.189AlaPro: 5.189 ± 1.962
2.595AlaGln: 2.595 ± 0.587
4.152AlaArg: 4.152 ± 0.936
1.557AlaSer: 1.557 ± 0.583
7.265AlaThr: 7.265 ± 1.868
3.114AlaVal: 3.114 ± 0.98
0.519AlaTrp: 0.519 ± 0.514
2.076AlaTyr: 2.076 ± 0.352
0.0AlaXaa: 0.0 ± 0.0
Cys
0.519CysAla: 0.519 ± 0.351
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
2.595CysPhe: 2.595 ± 1.181
2.076CysGly: 2.076 ± 1.3
1.557CysHis: 1.557 ± 1.053
1.557CysIle: 1.557 ± 0.761
0.519CysLys: 0.519 ± 0.351
1.038CysLeu: 1.038 ± 0.65
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
1.557CysPro: 1.557 ± 1.017
0.519CysGln: 0.519 ± 0.351
0.519CysArg: 0.519 ± 0.519
0.0CysSer: 0.0 ± 0.0
0.519CysThr: 0.519 ± 0.351
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.076AspAla: 2.076 ± 0.441
0.0AspCys: 0.0 ± 0.0
1.038AspAsp: 1.038 ± 0.524
0.0AspGlu: 0.0 ± 0.0
1.557AspPhe: 1.557 ± 1.053
2.595AspGly: 2.595 ± 0.958
0.0AspHis: 0.0 ± 0.0
1.557AspIle: 1.557 ± 0.388
1.557AspLys: 1.557 ± 1.053
3.114AspLeu: 3.114 ± 2.106
0.0AspMet: 0.0 ± 0.0
3.114AspAsn: 3.114 ± 0.98
2.595AspPro: 2.595 ± 0.876
1.038AspGln: 1.038 ± 1.028
3.114AspArg: 3.114 ± 0.719
1.038AspSer: 1.038 ± 0.702
1.557AspThr: 1.557 ± 0.388
1.557AspVal: 1.557 ± 0.73
1.557AspTrp: 1.557 ± 0.388
1.557AspTyr: 1.557 ± 0.73
0.0AspXaa: 0.0 ± 0.0
Glu
2.595GluAla: 2.595 ± 1.337
1.038GluCys: 1.038 ± 0.65
3.114GluAsp: 3.114 ± 0.406
5.708GluGlu: 5.708 ± 1.923
0.519GluPhe: 0.519 ± 0.514
2.076GluGly: 2.076 ± 0.863
4.67GluHis: 4.67 ± 1.891
4.152GluIle: 4.152 ± 0.372
4.152GluLys: 4.152 ± 1.386
5.189GluLeu: 5.189 ± 1.072
0.0GluMet: 0.0 ± 0.0
1.557GluAsn: 1.557 ± 1.542
2.076GluPro: 2.076 ± 0.441
2.076GluGln: 2.076 ± 0.352
2.595GluArg: 2.595 ± 0.767
2.076GluSer: 2.076 ± 0.544
0.0GluThr: 0.0 ± 0.0
2.595GluVal: 2.595 ± 0.238
0.0GluTrp: 0.0 ± 0.0
2.076GluTyr: 2.076 ± 0.441
0.0GluXaa: 0.0 ± 0.0
Phe
3.114PheAla: 3.114 ± 0.775
1.557PheCys: 1.557 ± 0.388
1.038PheAsp: 1.038 ± 0.524
0.0PheGlu: 0.0 ± 0.0
1.038PhePhe: 1.038 ± 0.65
1.038PheGly: 1.038 ± 0.425
0.0PheHis: 0.0 ± 0.0
0.519PheIle: 0.519 ± 0.351
1.557PheLys: 1.557 ± 0.881
7.265PheLeu: 7.265 ± 3.023
0.519PheMet: 0.519 ± 0.351
2.595PheAsn: 2.595 ± 1.221
4.152PhePro: 4.152 ± 1.05
3.114PheGln: 3.114 ± 0.98
3.633PheArg: 3.633 ± 1.655
4.152PheSer: 4.152 ± 2.348
4.152PheThr: 4.152 ± 0.936
1.038PheVal: 1.038 ± 0.702
0.519PheTrp: 0.519 ± 0.351
1.557PheTyr: 1.557 ± 0.583
0.0PheXaa: 0.0 ± 0.0
Gly
3.633GlyAla: 3.633 ± 1.273
0.519GlyCys: 0.519 ± 0.351
1.557GlyAsp: 1.557 ± 0.5
3.114GlyGlu: 3.114 ± 0.98
5.189GlyPhe: 5.189 ± 2.856
5.708GlyGly: 5.708 ± 0.566
1.557GlyHis: 1.557 ± 1.053
3.114GlyIle: 3.114 ± 1.668
2.076GlyLys: 2.076 ± 1.404
4.67GlyLeu: 4.67 ± 0.771
1.038GlyMet: 1.038 ± 0.917
4.67GlyAsn: 4.67 ± 1.366
2.595GlyPro: 2.595 ± 0.587
2.595GlyGln: 2.595 ± 0.883
5.189GlyArg: 5.189 ± 1.109
7.265GlySer: 7.265 ± 2.051
2.076GlyThr: 2.076 ± 0.352
2.595GlyVal: 2.595 ± 1.755
0.0GlyTrp: 0.0 ± 0.0
2.076GlyTyr: 2.076 ± 0.743
0.0GlyXaa: 0.0 ± 0.0
His
2.595HisAla: 2.595 ± 1.319
1.038HisCys: 1.038 ± 0.702
0.519HisAsp: 0.519 ± 0.351
2.595HisGlu: 2.595 ± 1.011
2.076HisPhe: 2.076 ± 0.352
0.519HisGly: 0.519 ± 0.351
0.0HisHis: 0.0 ± 0.0
2.595HisIle: 2.595 ± 0.767
1.038HisLys: 1.038 ± 0.702
2.595HisLeu: 2.595 ± 0.238
0.519HisMet: 0.519 ± 0.351
1.038HisAsn: 1.038 ± 0.524
1.038HisPro: 1.038 ± 0.524
1.557HisGln: 1.557 ± 0.388
2.595HisArg: 2.595 ± 1.308
3.633HisSer: 3.633 ± 0.653
3.633HisThr: 3.633 ± 2.457
4.67HisVal: 4.67 ± 1.116
0.519HisTrp: 0.519 ± 0.514
2.076HisTyr: 2.076 ± 0.743
0.0HisXaa: 0.0 ± 0.0
Ile
4.67IleAla: 4.67 ± 0.313
1.557IleCys: 1.557 ± 0.388
0.0IleAsp: 0.0 ± 0.0
0.519IleGlu: 0.519 ± 0.514
2.076IlePhe: 2.076 ± 1.3
1.557IleGly: 1.557 ± 1.017
1.038IleHis: 1.038 ± 0.702
4.67IleIle: 4.67 ± 1.268
1.038IleLys: 1.038 ± 0.671
9.341IleLeu: 9.341 ± 0.487
0.519IleMet: 0.519 ± 0.514
3.114IleAsn: 3.114 ± 0.405
6.746IlePro: 6.746 ± 1.789
1.557IleGln: 1.557 ± 0.583
3.633IleArg: 3.633 ± 1.383
1.557IleSer: 1.557 ± 1.053
3.633IleThr: 3.633 ± 0.246
3.633IleVal: 3.633 ± 1.736
0.0IleTrp: 0.0 ± 0.0
3.114IleTyr: 3.114 ± 0.405
0.0IleXaa: 0.0 ± 0.0
Lys
4.152LysAla: 4.152 ± 0.865
0.0LysCys: 0.0 ± 0.0
0.0LysAsp: 0.0 ± 0.0
2.076LysGlu: 2.076 ± 0.863
1.038LysPhe: 1.038 ± 0.702
4.152LysGly: 4.152 ± 1.485
3.114LysHis: 3.114 ± 0.775
1.038LysIle: 1.038 ± 0.425
1.038LysLys: 1.038 ± 1.037
3.633LysLeu: 3.633 ± 1.655
0.0LysMet: 0.0 ± 0.0
0.0LysAsn: 0.0 ± 0.0
3.114LysPro: 3.114 ± 0.775
1.557LysGln: 1.557 ± 1.053
3.633LysArg: 3.633 ± 0.721
4.152LysSer: 4.152 ± 1.04
0.519LysThr: 0.519 ± 0.514
1.557LysVal: 1.557 ± 0.73
0.0LysTrp: 0.0 ± 0.0
1.557LysTyr: 1.557 ± 1.053
0.0LysXaa: 0.0 ± 0.0
Leu
7.784LeuAla: 7.784 ± 1.975
0.519LeuCys: 0.519 ± 0.351
4.67LeuAsp: 4.67 ± 1.163
2.595LeuGlu: 2.595 ± 0.238
4.152LeuPhe: 4.152 ± 0.705
6.227LeuGly: 6.227 ± 0.809
1.038LeuHis: 1.038 ± 0.702
4.67LeuIle: 4.67 ± 1.058
2.595LeuLys: 2.595 ± 1.011
18.682LeuLeu: 18.682 ± 3.558
1.038LeuMet: 1.038 ± 0.65
3.114LeuAsn: 3.114 ± 0.569
8.822LeuPro: 8.822 ± 0.4
5.189LeuGln: 5.189 ± 1.75
7.784LeuArg: 7.784 ± 1.882
9.86LeuSer: 9.86 ± 0.992
11.417LeuThr: 11.417 ± 2.355
4.152LeuVal: 4.152 ± 1.059
5.708LeuTrp: 5.708 ± 2.297
4.67LeuTyr: 4.67 ± 1.116
0.0LeuXaa: 0.0 ± 0.0
Met
0.0MetAla: 0.0 ± 0.0
0.519MetCys: 0.519 ± 0.519
1.557MetAsp: 1.557 ± 0.73
2.076MetGlu: 2.076 ± 1.3
0.0MetPhe: 0.0 ± 0.0
2.595MetGly: 2.595 ± 0.561
0.0MetHis: 0.0 ± 0.0
0.519MetIle: 0.519 ± 0.519
0.519MetLys: 0.519 ± 0.351
1.038MetLeu: 1.038 ± 1.028
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
0.0MetPro: 0.0 ± 0.0
0.0MetGln: 0.0 ± 0.0
1.038MetArg: 1.038 ± 0.65
1.038MetSer: 1.038 ± 0.65
1.557MetThr: 1.557 ± 1.017
0.0MetVal: 0.0 ± 0.0
0.519MetTrp: 0.519 ± 0.351
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.557AsnAla: 1.557 ± 0.761
1.038AsnCys: 1.038 ± 0.524
1.557AsnAsp: 1.557 ± 0.73
1.038AsnGlu: 1.038 ± 0.702
0.519AsnPhe: 0.519 ± 0.351
2.076AsnGly: 2.076 ± 0.352
3.633AsnHis: 3.633 ± 0.653
1.557AsnIle: 1.557 ± 1.017
3.114AsnLys: 3.114 ± 0.405
2.076AsnLeu: 2.076 ± 1.018
2.595AsnMet: 2.595 ± 1.011
2.076AsnAsn: 2.076 ± 0.352
4.152AsnPro: 4.152 ± 1.04
1.038AsnGln: 1.038 ± 0.524
3.114AsnArg: 3.114 ± 0.98
3.114AsnSer: 3.114 ± 1.573
2.076AsnThr: 2.076 ± 0.851
1.038AsnVal: 1.038 ± 0.524
0.519AsnTrp: 0.519 ± 0.514
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
6.227ProAla: 6.227 ± 0.232
0.519ProCys: 0.519 ± 0.351
3.114ProAsp: 3.114 ± 0.719
3.633ProGlu: 3.633 ± 0.246
1.038ProPhe: 1.038 ± 0.425
4.152ProGly: 4.152 ± 1.68
4.152ProHis: 4.152 ± 1.603
4.67ProIle: 4.67 ± 0.615
3.633ProLys: 3.633 ± 0.652
7.265ProLeu: 7.265 ± 1.433
0.519ProMet: 0.519 ± 0.318
3.114ProAsn: 3.114 ± 0.98
7.265ProPro: 7.265 ± 1.227
3.114ProGln: 3.114 ± 0.98
6.746ProArg: 6.746 ± 1.548
7.784ProSer: 7.784 ± 1.141
2.595ProThr: 2.595 ± 0.587
5.708ProVal: 5.708 ± 1.923
1.038ProTrp: 1.038 ± 0.702
3.633ProTyr: 3.633 ± 0.717
0.0ProXaa: 0.0 ± 0.0
Gln
3.114GlnAla: 3.114 ± 0.406
0.519GlnCys: 0.519 ± 0.351
2.076GlnAsp: 2.076 ± 0.352
3.114GlnGlu: 3.114 ± 0.406
1.557GlnPhe: 1.557 ± 0.977
3.114GlnGly: 3.114 ± 0.901
1.557GlnHis: 1.557 ± 0.388
4.67GlnIle: 4.67 ± 0.78
2.595GlnLys: 2.595 ± 0.561
4.152GlnLeu: 4.152 ± 0.571
0.0GlnMet: 0.0 ± 0.0
1.038GlnAsn: 1.038 ± 0.524
3.114GlnPro: 3.114 ± 0.406
2.076GlnGln: 2.076 ± 0.352
3.114GlnArg: 3.114 ± 1.573
1.038GlnSer: 1.038 ± 0.702
4.152GlnThr: 4.152 ± 1.203
0.0GlnVal: 0.0 ± 0.0
0.0GlnTrp: 0.0 ± 0.0
1.557GlnTyr: 1.557 ± 0.388
0.0GlnXaa: 0.0 ± 0.0
Arg
6.746ArgAla: 6.746 ± 0.71
0.519ArgCys: 0.519 ± 0.351
2.076ArgAsp: 2.076 ± 1.124
5.189ArgGlu: 5.189 ± 1.677
6.227ArgPhe: 6.227 ± 1.561
6.746ArgGly: 6.746 ± 2.277
2.595ArgHis: 2.595 ± 0.883
2.595ArgIle: 2.595 ± 1.755
2.076ArgLys: 2.076 ± 0.352
8.303ArgLeu: 8.303 ± 0.839
1.038ArgMet: 1.038 ± 0.65
2.076ArgAsn: 2.076 ± 0.352
5.708ArgPro: 5.708 ± 2.098
4.152ArgGln: 4.152 ± 0.869
5.189ArgArg: 5.189 ± 2.443
3.633ArgSer: 3.633 ± 1.178
5.189ArgThr: 5.189 ± 2.2
3.114ArgVal: 3.114 ± 0.901
1.038ArgTrp: 1.038 ± 0.702
1.557ArgTyr: 1.557 ± 1.053
0.0ArgXaa: 0.0 ± 0.0
Ser
2.595SerAla: 2.595 ± 1.011
0.0SerCys: 0.0 ± 0.0
2.076SerAsp: 2.076 ± 0.352
2.595SerGlu: 2.595 ± 0.773
1.557SerPhe: 1.557 ± 0.761
5.708SerGly: 5.708 ± 0.974
3.114SerHis: 3.114 ± 0.405
6.227SerIle: 6.227 ± 0.232
0.519SerLys: 0.519 ± 0.351
11.417SerLeu: 11.417 ± 2.355
0.519SerMet: 0.519 ± 0.519
2.076SerAsn: 2.076 ± 1.404
7.784SerPro: 7.784 ± 0.891
3.633SerGln: 3.633 ± 0.246
8.822SerArg: 8.822 ± 4.383
9.86SerSer: 9.86 ± 1.656
4.67SerThr: 4.67 ± 0.78
2.076SerVal: 2.076 ± 1.404
2.076SerTrp: 2.076 ± 0.352
3.114SerTyr: 3.114 ± 0.405
0.0SerXaa: 0.0 ± 0.0
Thr
2.595ThrAla: 2.595 ± 1.969
2.076ThrCys: 2.076 ± 0.743
2.595ThrAsp: 2.595 ± 1.337
2.076ThrGlu: 2.076 ± 0.352
3.633ThrPhe: 3.633 ± 1.52
2.076ThrGly: 2.076 ± 0.352
1.557ThrHis: 1.557 ± 0.73
1.557ThrIle: 1.557 ± 0.388
3.633ThrLys: 3.633 ± 1.065
6.746ThrLeu: 6.746 ± 1.238
1.038ThrMet: 1.038 ± 0.616
0.519ThrAsn: 0.519 ± 0.351
5.189ThrPro: 5.189 ± 0.732
2.595ThrGln: 2.595 ± 0.716
4.67ThrArg: 4.67 ± 1.549
11.417ThrSer: 11.417 ± 2.595
2.595ThrThr: 2.595 ± 0.561
1.557ThrVal: 1.557 ± 1.542
2.595ThrTrp: 2.595 ± 1.319
3.114ThrTyr: 3.114 ± 0.406
0.0ThrXaa: 0.0 ± 0.0
Val
3.633ValAla: 3.633 ± 0.717
1.038ValCys: 1.038 ± 0.65
0.519ValAsp: 0.519 ± 0.351
2.595ValGlu: 2.595 ± 0.876
1.557ValPhe: 1.557 ± 1.053
3.114ValGly: 3.114 ± 0.406
3.633ValHis: 3.633 ± 2.006
0.519ValIle: 0.519 ± 0.514
1.557ValLys: 1.557 ± 1.053
3.114ValLeu: 3.114 ± 0.901
0.0ValMet: 0.0 ± 0.0
1.038ValAsn: 1.038 ± 0.524
3.633ValPro: 3.633 ± 0.721
1.557ValGln: 1.557 ± 0.73
3.114ValArg: 3.114 ± 1.573
4.152ValSer: 4.152 ± 0.372
2.076ValThr: 2.076 ± 1.404
4.152ValVal: 4.152 ± 0.705
1.038ValTrp: 1.038 ± 0.65
2.076ValTyr: 2.076 ± 0.352
0.0ValXaa: 0.0 ± 0.0
Trp
1.557TrpAla: 1.557 ± 0.388
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
4.152TrpGlu: 4.152 ± 0.883
1.038TrpPhe: 1.038 ± 0.65
1.038TrpGly: 1.038 ± 1.028
0.0TrpHis: 0.0 ± 0.0
1.038TrpIle: 1.038 ± 0.65
0.519TrpLys: 0.519 ± 0.351
0.519TrpLeu: 0.519 ± 0.514
1.557TrpMet: 1.557 ± 0.761
0.519TrpAsn: 0.519 ± 0.351
1.038TrpPro: 1.038 ± 0.702
0.0TrpGln: 0.0 ± 0.0
0.519TrpArg: 0.519 ± 0.351
2.076TrpSer: 2.076 ± 0.352
3.114TrpThr: 3.114 ± 1.95
0.0TrpVal: 0.0 ± 0.0
2.076TrpTrp: 2.076 ± 1.3
0.519TrpTyr: 0.519 ± 0.514
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.557TyrAla: 1.557 ± 0.388
0.519TyrCys: 0.519 ± 0.519
1.038TyrAsp: 1.038 ± 0.702
1.038TyrGlu: 1.038 ± 0.524
2.595TyrPhe: 2.595 ± 0.238
0.519TyrGly: 0.519 ± 0.351
2.595TyrHis: 2.595 ± 1.221
2.076TyrIle: 2.076 ± 0.863
0.519TyrLys: 0.519 ± 0.351
6.746TyrLeu: 6.746 ± 0.622
0.519TyrMet: 0.519 ± 0.351
2.076TyrAsn: 2.076 ± 0.352
4.152TyrPro: 4.152 ± 0.372
2.595TyrGln: 2.595 ± 0.238
2.595TyrArg: 2.595 ± 0.876
1.038TyrSer: 1.038 ± 0.425
1.038TyrThr: 1.038 ± 1.037
1.557TyrVal: 1.557 ± 1.053
1.557TyrTrp: 1.557 ± 0.761
1.557TyrTyr: 1.557 ± 0.761
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (1928 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski