Amino acid dipepetide frequency for Caenorhabditis nigoni

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.873AlaAla: 4.873 ± 0.052	1.053AlaCys: 1.053 ± 0.01	3.05AlaAsp: 3.05 ± 0.023	4.161AlaGlu: 4.161 ± 0.026	2.563AlaPhe: 2.563 ± 0.014	3.109AlaGly: 3.109 ± 0.025	1.351AlaHis: 1.351 ± 0.012	3.637AlaIle: 3.637 ± 0.018	3.86AlaLys: 3.86 ± 0.04	4.963AlaLeu: 4.963 ± 0.023	1.586AlaMet: 1.586 ± 0.011	2.666AlaAsn: 2.666 ± 0.013	3.726AlaPro: 3.726 ± 0.045	2.415AlaGln: 2.415 ± 0.02	2.999AlaArg: 2.999 ± 0.018	4.615AlaSer: 4.615 ± 0.031	3.608AlaThr: 3.608 ± 0.021	3.943AlaVal: 3.943 ± 0.021	0.572AlaTrp: 0.572 ± 0.006	1.651AlaTyr: 1.651 ± 0.01	0.0AlaXaa: 0.0 ± 0.0
Cys	1.098CysAla: 1.098 ± 0.01	0.506CysCys: 0.506 ± 0.007	1.085CysAsp: 1.085 ± 0.011	1.234CysGlu: 1.234 ± 0.014	0.926CysPhe: 0.926 ± 0.009	1.225CysGly: 1.225 ± 0.012	0.494CysHis: 0.494 ± 0.006	1.072CysIle: 1.072 ± 0.009	1.024CysLys: 1.024 ± 0.01	1.688CysLeu: 1.688 ± 0.012	0.451CysMet: 0.451 ± 0.005	0.839CysAsn: 0.839 ± 0.01	1.05CysPro: 1.05 ± 0.013	0.881CysGln: 0.881 ± 0.01	1.1CysArg: 1.1 ± 0.009	1.622CysSer: 1.622 ± 0.014	1.004CysThr: 1.004 ± 0.009	1.189CysVal: 1.189 ± 0.012	0.207CysTrp: 0.207 ± 0.004	0.638CysTyr: 0.638 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	3.149AspAla: 3.149 ± 0.02	0.98AspCys: 0.98 ± 0.009	3.916AspAsp: 3.916 ± 0.024	4.564AspGlu: 4.564 ± 0.032	2.688AspPhe: 2.688 ± 0.017	3.426AspGly: 3.426 ± 0.046	1.204AspHis: 1.204 ± 0.012	3.009AspIle: 3.009 ± 0.015	2.864AspLys: 2.864 ± 0.015	4.478AspLeu: 4.478 ± 0.021	1.349AspMet: 1.349 ± 0.01	2.281AspAsn: 2.281 ± 0.014	2.648AspPro: 2.648 ± 0.028	2.028AspGln: 2.028 ± 0.011	2.651AspArg: 2.651 ± 0.015	4.254AspSer: 4.254 ± 0.029	2.512AspThr: 2.512 ± 0.014	3.828AspVal: 3.828 ± 0.03	0.684AspTrp: 0.684 ± 0.009	1.892AspTyr: 1.892 ± 0.012	0.0AspXaa: 0.0 ± 0.0
Glu	4.25GluAla: 4.25 ± 0.073	1.152GluCys: 1.152 ± 0.012	4.455GluAsp: 4.455 ± 0.032	7.102GluGlu: 7.102 ± 0.051	2.857GluPhe: 2.857 ± 0.016	2.737GluGly: 2.737 ± 0.015	1.5GluHis: 1.5 ± 0.012	4.406GluIle: 4.406 ± 0.019	6.337GluLys: 6.337 ± 0.039	5.552GluLeu: 5.552 ± 0.025	2.141GluMet: 2.141 ± 0.012	4.095GluAsn: 4.095 ± 0.02	2.682GluPro: 2.682 ± 0.031	2.816GluGln: 2.816 ± 0.022	3.517GluArg: 3.517 ± 0.023	4.768GluSer: 4.768 ± 0.025	3.934GluThr: 3.934 ± 0.036	3.898GluVal: 3.898 ± 0.022	0.771GluTrp: 0.771 ± 0.007	2.118GluTyr: 2.118 ± 0.014	0.0GluXaa: 0.0 ± 0.0
Phe	2.57PheAla: 2.57 ± 0.013	1.051PheCys: 1.051 ± 0.009	2.719PheAsp: 2.719 ± 0.016	3.08PheGlu: 3.08 ± 0.015	2.548PhePhe: 2.548 ± 0.016	2.887PheGly: 2.887 ± 0.02	1.235PheHis: 1.235 ± 0.016	2.561PheIle: 2.561 ± 0.015	2.458PheLys: 2.458 ± 0.014	4.51PheLeu: 4.51 ± 0.022	1.147PheMet: 1.147 ± 0.009	2.108PheAsn: 2.108 ± 0.013	2.0PhePro: 2.0 ± 0.012	1.979PheGln: 1.979 ± 0.013	2.306PheArg: 2.306 ± 0.012	3.613PheSer: 3.613 ± 0.018	2.26PheThr: 2.26 ± 0.018	3.015PheVal: 3.015 ± 0.016	0.626PheTrp: 0.626 ± 0.007	1.687PheTyr: 1.687 ± 0.012	0.0PheXaa: 0.0 ± 0.0
Gly	3.26GlyAla: 3.26 ± 0.028	1.05GlyCys: 1.05 ± 0.011	2.686GlyAsp: 2.686 ± 0.017	3.108GlyGlu: 3.108 ± 0.022	2.574GlyPhe: 2.574 ± 0.016	4.047GlyGly: 4.047 ± 0.054	1.208GlyHis: 1.208 ± 0.019	3.326GlyIle: 3.326 ± 0.023	3.293GlyLys: 3.293 ± 0.02	3.758GlyLeu: 3.758 ± 0.024	1.305GlyMet: 1.305 ± 0.01	2.632GlyAsn: 2.632 ± 0.019	2.391GlyPro: 2.391 ± 0.031	1.959GlyGln: 1.959 ± 0.018	2.669GlyArg: 2.669 ± 0.016	4.308GlySer: 4.308 ± 0.027	3.028GlyThr: 3.028 ± 0.026	3.117GlyVal: 3.117 ± 0.019	0.655GlyTrp: 0.655 ± 0.008	1.932GlyTyr: 1.932 ± 0.019	0.0GlyXaa: 0.0 ± 0.0
His	1.169HisAla: 1.169 ± 0.01	0.497HisCys: 0.497 ± 0.006	1.055HisAsp: 1.055 ± 0.008	1.297HisGlu: 1.297 ± 0.011	1.249HisPhe: 1.249 ± 0.011	1.277HisGly: 1.277 ± 0.011	0.924HisHis: 0.924 ± 0.013	1.336HisIle: 1.336 ± 0.015	1.126HisLys: 1.126 ± 0.009	2.324HisLeu: 2.324 ± 0.017	0.571HisMet: 0.571 ± 0.005	0.98HisAsn: 0.98 ± 0.009	1.278HisPro: 1.278 ± 0.017	1.219HisGln: 1.219 ± 0.018	1.41HisArg: 1.41 ± 0.011	1.688HisSer: 1.688 ± 0.012	1.065HisThr: 1.065 ± 0.009	1.461HisVal: 1.461 ± 0.012	0.308HisTrp: 0.308 ± 0.004	0.807HisTyr: 0.807 ± 0.007	0.0HisXaa: 0.0 ± 0.0
Ile	3.562IleAla: 3.562 ± 0.015	1.272IleCys: 1.272 ± 0.011	3.441IleAsp: 3.441 ± 0.015	4.04IleGlu: 4.04 ± 0.018	3.046IlePhe: 3.046 ± 0.017	3.388IleGly: 3.388 ± 0.02	1.441IleHis: 1.441 ± 0.011	3.345IleIle: 3.345 ± 0.017	3.157IleLys: 3.157 ± 0.016	5.605IleLeu: 5.605 ± 0.031	1.359IleMet: 1.359 ± 0.01	2.526IleAsn: 2.526 ± 0.015	3.382IlePro: 3.382 ± 0.024	2.593IleGln: 2.593 ± 0.016	3.421IleArg: 3.421 ± 0.019	4.778IleSer: 4.778 ± 0.031	3.168IleThr: 3.168 ± 0.02	3.82IleVal: 3.82 ± 0.019	0.765IleTrp: 0.765 ± 0.016	1.873IleTyr: 1.873 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	3.535LysAla: 3.535 ± 0.026	1.394LysCys: 1.394 ± 0.014	3.294LysAsp: 3.294 ± 0.021	4.968LysGlu: 4.968 ± 0.034	2.751LysPhe: 2.751 ± 0.015	2.436LysGly: 2.436 ± 0.014	1.302LysHis: 1.302 ± 0.01	4.208LysIle: 4.208 ± 0.02	6.347LysLys: 6.347 ± 0.053	5.679LysLeu: 5.679 ± 0.026	2.139LysMet: 2.139 ± 0.012	3.665LysAsn: 3.665 ± 0.018	2.803LysPro: 2.803 ± 0.032	2.388LysGln: 2.388 ± 0.013	3.773LysArg: 3.773 ± 0.021	4.853LysSer: 4.853 ± 0.024	4.025LysThr: 4.025 ± 0.022	3.506LysVal: 3.506 ± 0.02	0.846LysTrp: 0.846 ± 0.008	2.035LysTyr: 2.035 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	5.422LeuAla: 5.422 ± 0.023	1.552LeuCys: 1.552 ± 0.011	4.607LeuAsp: 4.607 ± 0.036	6.348LeuGlu: 6.348 ± 0.032	3.919LeuPhe: 3.919 ± 0.019	3.824LeuGly: 3.824 ± 0.019	2.024LeuHis: 2.024 ± 0.017	5.008LeuIle: 5.008 ± 0.022	6.125LeuLys: 6.125 ± 0.025	7.815LeuLeu: 7.815 ± 0.029	2.15LeuMet: 2.15 ± 0.013	4.175LeuAsn: 4.175 ± 0.021	4.255LeuPro: 4.255 ± 0.024	3.501LeuGln: 3.501 ± 0.019	4.809LeuArg: 4.809 ± 0.033	6.262LeuSer: 6.262 ± 0.027	4.565LeuThr: 4.565 ± 0.018	4.916LeuVal: 4.916 ± 0.023	0.872LeuTrp: 0.872 ± 0.01	2.369LeuTyr: 2.369 ± 0.014	0.0LeuXaa: 0.0 ± 0.0
Met	1.707MetAla: 1.707 ± 0.01	0.475MetCys: 0.475 ± 0.006	1.547MetAsp: 1.547 ± 0.01	2.084MetGlu: 2.084 ± 0.014	1.188MetPhe: 1.188 ± 0.009	1.237MetGly: 1.237 ± 0.014	0.526MetHis: 0.526 ± 0.006	1.638MetIle: 1.638 ± 0.01	2.024MetLys: 2.024 ± 0.012	2.015MetLeu: 2.015 ± 0.011	0.891MetMet: 0.891 ± 0.008	1.413MetAsn: 1.413 ± 0.01	1.174MetPro: 1.174 ± 0.009	0.934MetGln: 0.934 ± 0.01	1.398MetArg: 1.398 ± 0.01	2.161MetSer: 2.161 ± 0.013	1.597MetThr: 1.597 ± 0.01	1.485MetVal: 1.485 ± 0.011	0.272MetTrp: 0.272 ± 0.004	0.754MetTyr: 0.754 ± 0.006	0.0MetXaa: 0.0 ± 0.0
Asn	2.811AsnAla: 2.811 ± 0.014	0.998AsnCys: 0.998 ± 0.009	2.526AsnAsp: 2.526 ± 0.013	3.238AsnGlu: 3.238 ± 0.018	2.41AsnPhe: 2.41 ± 0.015	3.359AsnGly: 3.359 ± 0.022	1.136AsnHis: 1.136 ± 0.009	2.659AsnIle: 2.659 ± 0.014	2.476AsnLys: 2.476 ± 0.016	4.394AsnLeu: 4.394 ± 0.024	1.307AsnMet: 1.307 ± 0.009	2.367AsnAsn: 2.367 ± 0.017	2.473AsnPro: 2.473 ± 0.016	2.26AsnGln: 2.26 ± 0.018	2.671AsnArg: 2.671 ± 0.017	3.846AsnSer: 3.846 ± 0.018	2.399AsnThr: 2.399 ± 0.015	3.085AsnVal: 3.085 ± 0.014	0.625AsnTrp: 0.625 ± 0.009	1.663AsnTyr: 1.663 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	3.364ProAla: 3.364 ± 0.033	0.656ProCys: 0.656 ± 0.013	2.476ProAsp: 2.476 ± 0.032	3.665ProGlu: 3.665 ± 0.033	1.968ProPhe: 1.968 ± 0.013	2.642ProGly: 2.642 ± 0.045	0.989ProHis: 0.989 ± 0.009	3.306ProIle: 3.306 ± 0.036	3.112ProLys: 3.112 ± 0.021	3.594ProLeu: 3.594 ± 0.022	1.22ProMet: 1.22 ± 0.01	2.361ProAsn: 2.361 ± 0.015	4.371ProPro: 4.371 ± 0.06	1.99ProGln: 1.99 ± 0.016	2.484ProArg: 2.484 ± 0.022	4.385ProSer: 4.385 ± 0.031	3.521ProThr: 3.521 ± 0.037	3.181ProVal: 3.181 ± 0.05	0.44ProTrp: 0.44 ± 0.006	1.352ProTyr: 1.352 ± 0.011	0.0ProXaa: 0.0 ± 0.0
Gln	2.298GlnAla: 2.298 ± 0.016	0.806GlnCys: 0.806 ± 0.011	1.726GlnAsp: 1.726 ± 0.016	2.625GlnGlu: 2.625 ± 0.018	1.891GlnPhe: 1.891 ± 0.016	1.735GlnGly: 1.735 ± 0.022	1.0GlnHis: 1.0 ± 0.01	2.406GlnIle: 2.406 ± 0.013	3.278GlnLys: 3.278 ± 0.023	3.88GlnLeu: 3.88 ± 0.022	1.363GlnMet: 1.363 ± 0.011	2.412GlnAsn: 2.412 ± 0.021	2.019GlnPro: 2.019 ± 0.016	2.693GlnGln: 2.693 ± 0.038	2.282GlnArg: 2.282 ± 0.015	2.808GlnSer: 2.808 ± 0.017	2.125GlnThr: 2.125 ± 0.013	2.1GlnVal: 2.1 ± 0.012	0.511GlnTrp: 0.511 ± 0.005	1.305GlnTyr: 1.305 ± 0.011	0.0GlnXaa: 0.0 ± 0.0
Arg	2.927ArgAla: 2.927 ± 0.016	1.029ArgCys: 1.029 ± 0.009	2.625ArgAsp: 2.625 ± 0.015	3.463ArgGlu: 3.463 ± 0.023	2.547ArgPhe: 2.547 ± 0.019	2.471ArgGly: 2.471 ± 0.018	1.364ArgHis: 1.364 ± 0.012	3.405ArgIle: 3.405 ± 0.017	4.158ArgLys: 4.158 ± 0.02	4.448ArgLeu: 4.448 ± 0.025	1.462ArgMet: 1.462 ± 0.01	2.939ArgAsn: 2.939 ± 0.017	2.373ArgPro: 2.373 ± 0.018	2.292ArgGln: 2.292 ± 0.013	4.171ArgArg: 4.171 ± 0.025	4.037ArgSer: 4.037 ± 0.023	2.806ArgThr: 2.806 ± 0.021	2.906ArgVal: 2.906 ± 0.015	0.652ArgTrp: 0.652 ± 0.009	1.624ArgTyr: 1.624 ± 0.014	0.0ArgXaa: 0.0 ± 0.0
Ser	4.651SerAla: 4.651 ± 0.023	1.43SerCys: 1.43 ± 0.012	4.419SerAsp: 4.419 ± 0.037	5.425SerGlu: 5.425 ± 0.032	3.446SerPhe: 3.446 ± 0.015	4.47SerGly: 4.47 ± 0.033	1.626SerHis: 1.626 ± 0.012	4.759SerIle: 4.759 ± 0.024	4.735SerLys: 4.735 ± 0.021	6.261SerLeu: 6.261 ± 0.028	1.925SerMet: 1.925 ± 0.012	3.805SerAsn: 3.805 ± 0.019	3.954SerPro: 3.954 ± 0.025	3.029SerGln: 3.029 ± 0.018	3.986SerArg: 3.986 ± 0.022	8.788SerSer: 8.788 ± 0.054	5.561SerThr: 5.561 ± 0.046	4.591SerVal: 4.591 ± 0.033	0.863SerTrp: 0.863 ± 0.011	2.204SerTyr: 2.204 ± 0.016	0.0SerXaa: 0.0 ± 0.0
Thr	3.545ThrAla: 3.545 ± 0.021	1.194ThrCys: 1.194 ± 0.013	2.876ThrAsp: 2.876 ± 0.033	3.6ThrGlu: 3.6 ± 0.029	2.504ThrPhe: 2.504 ± 0.013	2.829ThrGly: 2.829 ± 0.018	1.156ThrHis: 1.156 ± 0.012	3.706ThrIle: 3.706 ± 0.024	3.191ThrLys: 3.191 ± 0.02	4.536ThrLeu: 4.536 ± 0.016	1.475ThrMet: 1.475 ± 0.014	2.557ThrAsn: 2.557 ± 0.015	3.442ThrPro: 3.442 ± 0.036	2.005ThrGln: 2.005 ± 0.021	2.635ThrArg: 2.635 ± 0.013	5.363ThrSer: 5.363 ± 0.04	5.066ThrThr: 5.066 ± 0.072	4.102ThrVal: 4.102 ± 0.026	0.641ThrTrp: 0.641 ± 0.007	1.58ThrTyr: 1.58 ± 0.01	0.0ThrXaa: 0.0 ± 0.0
Val	3.928ValAla: 3.928 ± 0.016	1.232ValCys: 1.232 ± 0.012	3.5ValAsp: 3.5 ± 0.027	4.471ValGlu: 4.471 ± 0.059	3.061ValPhe: 3.061 ± 0.015	2.835ValGly: 2.835 ± 0.017	1.429ValHis: 1.429 ± 0.01	3.611ValIle: 3.611 ± 0.021	3.692ValLys: 3.692 ± 0.021	5.351ValLeu: 5.351 ± 0.023	1.491ValMet: 1.491 ± 0.009	2.638ValAsn: 2.638 ± 0.013	3.241ValPro: 3.241 ± 0.021	2.413ValGln: 2.413 ± 0.014	2.974ValArg: 2.974 ± 0.018	4.57ValSer: 4.57 ± 0.027	3.469ValThr: 3.469 ± 0.025	4.231ValVal: 4.231 ± 0.026	0.712ValTrp: 0.712 ± 0.011	1.904ValTyr: 1.904 ± 0.011	0.0ValXaa: 0.0 ± 0.0
Trp	0.586TrpAla: 0.586 ± 0.006	0.239TrpCys: 0.239 ± 0.004	0.588TrpAsp: 0.588 ± 0.007	0.664TrpGlu: 0.664 ± 0.008	0.573TrpPhe: 0.573 ± 0.012	0.462TrpGly: 0.462 ± 0.007	0.276TrpHis: 0.276 ± 0.006	0.88TrpIle: 0.88 ± 0.009	0.999TrpLys: 0.999 ± 0.01	0.968TrpLeu: 0.968 ± 0.01	0.378TrpMet: 0.378 ± 0.004	0.797TrpAsn: 0.797 ± 0.013	0.413TrpPro: 0.413 ± 0.006	0.438TrpGln: 0.438 ± 0.006	0.702TrpArg: 0.702 ± 0.009	0.834TrpSer: 0.834 ± 0.012	0.71TrpThr: 0.71 ± 0.006	0.563TrpVal: 0.563 ± 0.007	0.199TrpTrp: 0.199 ± 0.006	0.393TrpTyr: 0.393 ± 0.005	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.696TyrAla: 1.696 ± 0.014	0.766TyrCys: 0.766 ± 0.008	1.813TyrAsp: 1.813 ± 0.011	1.951TyrGlu: 1.951 ± 0.013	1.652TyrPhe: 1.652 ± 0.011	1.909TyrGly: 1.909 ± 0.016	0.855TyrHis: 0.855 ± 0.009	1.703TyrIle: 1.703 ± 0.013	1.692TyrLys: 1.692 ± 0.011	2.698TyrLeu: 2.698 ± 0.016	0.813TyrMet: 0.813 ± 0.009	1.446TyrAsn: 1.446 ± 0.011	1.404TyrPro: 1.404 ± 0.016	1.429TyrGln: 1.429 ± 0.013	1.742TyrArg: 1.742 ± 0.014	2.377TyrSer: 2.377 ± 0.014	1.578TyrThr: 1.578 ± 0.012	1.812TyrVal: 1.812 ± 0.012	0.442TyrTrp: 0.442 ± 0.006	1.227TyrTyr: 1.227 ± 0.009	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 44209 proteins (17210255 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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