Amino acid dipepetide frequency for Thermosulfidibacter takaii (strain DSM 17441 / JCM 13301 / NBRC 103674 / ABI70S6)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.237AlaAla: 5.237 ± 0.139
0.981AlaCys: 0.981 ± 0.044
3.076AlaAsp: 3.076 ± 0.067
4.779AlaGlu: 4.779 ± 0.091
3.653AlaPhe: 3.653 ± 0.08
4.981AlaGly: 4.981 ± 0.109
1.276AlaHis: 1.276 ± 0.045
5.392AlaIle: 5.392 ± 0.107
5.796AlaLys: 5.796 ± 0.115
8.136AlaLeu: 8.136 ± 0.148
1.801AlaMet: 1.801 ± 0.06
2.184AlaAsn: 2.184 ± 0.059
2.161AlaPro: 2.161 ± 0.063
2.058AlaGln: 2.058 ± 0.062
3.46AlaArg: 3.46 ± 0.083
3.836AlaSer: 3.836 ± 0.094
3.202AlaThr: 3.202 ± 0.092
5.912AlaVal: 5.912 ± 0.116
0.661AlaTrp: 0.661 ± 0.041
2.574AlaTyr: 2.574 ± 0.071
0.0AlaXaa: 0.0 ± 0.0
Cys
0.797CysAla: 0.797 ± 0.042
0.192CysCys: 0.192 ± 0.018
0.615CysAsp: 0.615 ± 0.033
0.794CysGlu: 0.794 ± 0.042
0.582CysPhe: 0.582 ± 0.039
1.22CysGly: 1.22 ± 0.047
0.572CysHis: 0.572 ± 0.084
0.699CysIle: 0.699 ± 0.036
0.78CysLys: 0.78 ± 0.039
1.002CysLeu: 1.002 ± 0.041
0.283CysMet: 0.283 ± 0.023
0.427CysAsn: 0.427 ± 0.026
0.757CysPro: 0.757 ± 0.045
0.301CysGln: 0.301 ± 0.025
0.509CysArg: 0.509 ± 0.031
0.794CysSer: 0.794 ± 0.041
0.53CysThr: 0.53 ± 0.029
0.869CysVal: 0.869 ± 0.049
0.143CysTrp: 0.143 ± 0.015
0.486CysTyr: 0.486 ± 0.034
0.0CysXaa: 0.0 ± 0.0
Asp
3.406AspAla: 3.406 ± 0.08
0.546AspCys: 0.546 ± 0.039
2.109AspAsp: 2.109 ± 0.072
4.001AspGlu: 4.001 ± 0.096
2.565AspPhe: 2.565 ± 0.078
3.013AspGly: 3.013 ± 0.08
0.705AspHis: 0.705 ± 0.036
4.111AspIle: 4.111 ± 0.096
3.425AspLys: 3.425 ± 0.073
5.078AspLeu: 5.078 ± 0.105
1.198AspMet: 1.198 ± 0.045
1.579AspAsn: 1.579 ± 0.056
2.658AspPro: 2.658 ± 0.074
0.963AspGln: 0.963 ± 0.038
2.611AspArg: 2.611 ± 0.071
2.112AspSer: 2.112 ± 0.077
2.149AspThr: 2.149 ± 0.069
4.434AspVal: 4.434 ± 0.091
0.568AspTrp: 0.568 ± 0.036
2.016AspTyr: 2.016 ± 0.057
0.0AspXaa: 0.0 ± 0.0
Glu
6.354GluAla: 6.354 ± 0.109
0.678GluCys: 0.678 ± 0.041
4.1GluAsp: 4.1 ± 0.114
8.152GluGlu: 8.152 ± 0.172
2.892GluPhe: 2.892 ± 0.073
5.392GluGly: 5.392 ± 0.121
1.238GluHis: 1.238 ± 0.053
6.356GluIle: 6.356 ± 0.104
7.748GluLys: 7.748 ± 0.127
7.636GluLeu: 7.636 ± 0.134
1.88GluMet: 1.88 ± 0.065
2.773GluAsn: 2.773 ± 0.076
2.32GluPro: 2.32 ± 0.063
1.728GluGln: 1.728 ± 0.061
4.81GluArg: 4.81 ± 0.101
3.006GluSer: 3.006 ± 0.076
3.123GluThr: 3.123 ± 0.086
6.859GluVal: 6.859 ± 0.137
0.659GluTrp: 0.659 ± 0.033
2.294GluTyr: 2.294 ± 0.066
0.0GluXaa: 0.0 ± 0.0
Phe
3.105PheAla: 3.105 ± 0.08
0.617PheCys: 0.617 ± 0.034
2.329PheAsp: 2.329 ± 0.06
3.065PheGlu: 3.065 ± 0.077
2.427PhePhe: 2.427 ± 0.083
3.109PheGly: 3.109 ± 0.069
0.768PheHis: 0.768 ± 0.041
3.002PheIle: 3.002 ± 0.077
3.14PheLys: 3.14 ± 0.072
5.092PheLeu: 5.092 ± 0.116
1.077PheMet: 1.077 ± 0.043
1.584PheAsn: 1.584 ± 0.055
1.932PhePro: 1.932 ± 0.058
1.005PheGln: 1.005 ± 0.045
1.995PheArg: 1.995 ± 0.058
2.988PheSer: 2.988 ± 0.081
2.219PheThr: 2.219 ± 0.056
3.983PheVal: 3.983 ± 0.079
0.608PheTrp: 0.608 ± 0.035
1.754PheTyr: 1.754 ± 0.056
0.0PheXaa: 0.0 ± 0.0
Gly
4.857GlyAla: 4.857 ± 0.117
1.096GlyCys: 1.096 ± 0.051
3.362GlyAsp: 3.362 ± 0.088
4.749GlyGlu: 4.749 ± 0.103
3.628GlyPhe: 3.628 ± 0.082
4.868GlyGly: 4.868 ± 0.135
1.234GlyHis: 1.234 ± 0.054
6.001GlyIle: 6.001 ± 0.101
6.067GlyLys: 6.067 ± 0.104
6.49GlyLeu: 6.49 ± 0.114
1.764GlyMet: 1.764 ± 0.062
2.404GlyAsn: 2.404 ± 0.073
1.96GlyPro: 1.96 ± 0.066
1.472GlyGln: 1.472 ± 0.053
3.735GlyArg: 3.735 ± 0.093
3.581GlySer: 3.581 ± 0.074
3.509GlyThr: 3.509 ± 0.087
5.994GlyVal: 5.994 ± 0.107
0.857GlyTrp: 0.857 ± 0.042
3.116GlyTyr: 3.116 ± 0.084
0.0GlyXaa: 0.0 ± 0.0
His
1.025HisAla: 1.025 ± 0.045
0.264HisCys: 0.264 ± 0.022
0.696HisAsp: 0.696 ± 0.035
0.956HisGlu: 0.956 ± 0.041
0.913HisPhe: 0.913 ± 0.045
1.376HisGly: 1.376 ± 0.059
0.46HisHis: 0.46 ± 0.031
1.252HisIle: 1.252 ± 0.044
1.079HisLys: 1.079 ± 0.043
1.74HisLeu: 1.74 ± 0.055
0.39HisMet: 0.39 ± 0.026
0.621HisAsn: 0.621 ± 0.036
1.254HisPro: 1.254 ± 0.045
0.456HisGln: 0.456 ± 0.028
0.913HisArg: 0.913 ± 0.04
0.883HisSer: 0.883 ± 0.045
0.886HisThr: 0.886 ± 0.044
1.203HisVal: 1.203 ± 0.043
0.201HisTrp: 0.201 ± 0.018
0.663HisTyr: 0.663 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
5.76IleAla: 5.76 ± 0.11
0.817IleCys: 0.817 ± 0.036
3.917IleAsp: 3.917 ± 0.075
5.959IleGlu: 5.959 ± 0.104
3.095IlePhe: 3.095 ± 0.082
4.843IleGly: 4.843 ± 0.104
1.165IleHis: 1.165 ± 0.046
4.635IleIle: 4.635 ± 0.1
5.641IleLys: 5.641 ± 0.103
7.132IleLeu: 7.132 ± 0.117
1.43IleMet: 1.43 ± 0.046
2.694IleAsn: 2.694 ± 0.071
3.654IlePro: 3.654 ± 0.083
1.612IleGln: 1.612 ± 0.05
3.392IleArg: 3.392 ± 0.088
4.111IleSer: 4.111 ± 0.09
3.728IleThr: 3.728 ± 0.091
5.651IleVal: 5.651 ± 0.115
0.587IleTrp: 0.587 ± 0.036
2.46IleTyr: 2.46 ± 0.063
0.0IleXaa: 0.0 ± 0.0
Lys
6.156LysAla: 6.156 ± 0.111
0.745LysCys: 0.745 ± 0.049
4.35LysAsp: 4.35 ± 0.085
8.379LysGlu: 8.379 ± 0.14
2.577LysPhe: 2.577 ± 0.075
6.064LysGly: 6.064 ± 0.125
1.137LysHis: 1.137 ± 0.047
5.735LysIle: 5.735 ± 0.108
6.688LysLys: 6.688 ± 0.133
7.151LysLeu: 7.151 ± 0.122
1.638LysMet: 1.638 ± 0.054
2.927LysAsn: 2.927 ± 0.074
3.023LysPro: 3.023 ± 0.085
1.769LysGln: 1.769 ± 0.06
4.838LysArg: 4.838 ± 0.105
3.562LysSer: 3.562 ± 0.076
3.139LysThr: 3.139 ± 0.074
6.957LysVal: 6.957 ± 0.112
0.799LysTrp: 0.799 ± 0.038
2.49LysTyr: 2.49 ± 0.083
0.0LysXaa: 0.0 ± 0.0
Leu
7.421LeuAla: 7.421 ± 0.13
1.187LeuCys: 1.187 ± 0.053
4.744LeuAsp: 4.744 ± 0.102
8.038LeuGlu: 8.038 ± 0.132
4.466LeuPhe: 4.466 ± 0.101
7.027LeuGly: 7.027 ± 0.104
1.535LeuHis: 1.535 ± 0.046
6.464LeuIle: 6.464 ± 0.131
9.32LeuLys: 9.32 ± 0.149
9.69LeuLeu: 9.69 ± 0.17
2.229LeuMet: 2.229 ± 0.055
3.411LeuAsn: 3.411 ± 0.075
4.303LeuPro: 4.303 ± 0.09
2.443LeuGln: 2.443 ± 0.075
5.266LeuArg: 5.266 ± 0.103
6.384LeuSer: 6.384 ± 0.126
4.404LeuThr: 4.404 ± 0.097
7.433LeuVal: 7.433 ± 0.139
1.007LeuTrp: 1.007 ± 0.043
3.182LeuTyr: 3.182 ± 0.085
0.0LeuXaa: 0.0 ± 0.0
Met
1.948MetAla: 1.948 ± 0.064
0.254MetCys: 0.254 ± 0.021
1.346MetAsp: 1.346 ± 0.04
1.92MetGlu: 1.92 ± 0.063
0.773MetPhe: 0.773 ± 0.038
1.944MetGly: 1.944 ± 0.056
0.362MetHis: 0.362 ± 0.024
1.395MetIle: 1.395 ± 0.052
1.995MetLys: 1.995 ± 0.059
2.187MetLeu: 2.187 ± 0.066
0.481MetMet: 0.481 ± 0.031
0.811MetAsn: 0.811 ± 0.034
0.983MetPro: 0.983 ± 0.047
0.56MetGln: 0.56 ± 0.033
1.268MetArg: 1.268 ± 0.045
1.089MetSer: 1.089 ± 0.041
0.782MetThr: 0.782 ± 0.038
1.824MetVal: 1.824 ± 0.058
0.219MetTrp: 0.219 ± 0.022
0.579MetTyr: 0.579 ± 0.035
0.0MetXaa: 0.0 ± 0.0
Asn
2.378AsnAla: 2.378 ± 0.067
0.518AsnCys: 0.518 ± 0.037
1.273AsnAsp: 1.273 ± 0.046
1.972AsnGlu: 1.972 ± 0.059
1.616AsnPhe: 1.616 ± 0.054
2.292AsnGly: 2.292 ± 0.086
0.532AsnHis: 0.532 ± 0.027
2.854AsnIle: 2.854 ± 0.073
2.31AsnLys: 2.31 ± 0.068
3.721AsnLeu: 3.721 ± 0.089
0.817AsnMet: 0.817 ± 0.037
1.266AsnAsn: 1.266 ± 0.056
2.177AsnPro: 2.177 ± 0.06
0.836AsnGln: 0.836 ± 0.045
1.997AsnArg: 1.997 ± 0.06
1.768AsnSer: 1.768 ± 0.063
1.628AsnThr: 1.628 ± 0.061
2.696AsnVal: 2.696 ± 0.069
0.446AsnTrp: 0.446 ± 0.027
1.425AsnTyr: 1.425 ± 0.053
0.0AsnXaa: 0.0 ± 0.0
Pro
2.315ProAla: 2.315 ± 0.069
0.451ProCys: 0.451 ± 0.03
2.385ProAsp: 2.385 ± 0.075
4.153ProGlu: 4.153 ± 0.099
2.144ProPhe: 2.144 ± 0.064
2.841ProGly: 2.841 ± 0.078
0.895ProHis: 0.895 ± 0.044
2.694ProIle: 2.694 ± 0.066
2.985ProLys: 2.985 ± 0.073
3.934ProLeu: 3.934 ± 0.077
0.834ProMet: 0.834 ± 0.043
1.432ProAsn: 1.432 ± 0.049
1.745ProPro: 1.745 ± 0.06
1.178ProGln: 1.178 ± 0.047
1.588ProArg: 1.588 ± 0.05
2.231ProSer: 2.231 ± 0.057
2.006ProThr: 2.006 ± 0.06
3.813ProVal: 3.813 ± 0.074
0.493ProTrp: 0.493 ± 0.029
1.698ProTyr: 1.698 ± 0.058
0.0ProXaa: 0.0 ± 0.0
Gln
1.719GlnAla: 1.719 ± 0.06
0.29GlnCys: 0.29 ± 0.026
1.121GlnAsp: 1.121 ± 0.044
2.193GlnGlu: 2.193 ± 0.061
1.0GlnPhe: 1.0 ± 0.038
1.535GlnGly: 1.535 ± 0.054
0.467GlnHis: 0.467 ± 0.031
1.82GlnIle: 1.82 ± 0.069
2.345GlnLys: 2.345 ± 0.062
2.483GlnLeu: 2.483 ± 0.071
0.633GlnMet: 0.633 ± 0.032
0.808GlnAsn: 0.808 ± 0.04
0.808GlnPro: 0.808 ± 0.034
0.801GlnGln: 0.801 ± 0.043
1.472GlnArg: 1.472 ± 0.054
0.976GlnSer: 0.976 ± 0.047
0.941GlnThr: 0.941 ± 0.044
1.815GlnVal: 1.815 ± 0.063
0.32GlnTrp: 0.32 ± 0.026
0.736GlnTyr: 0.736 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
3.298ArgAla: 3.298 ± 0.074
0.647ArgCys: 0.647 ± 0.04
2.546ArgAsp: 2.546 ± 0.072
4.588ArgGlu: 4.588 ± 0.092
2.583ArgPhe: 2.583 ± 0.076
3.331ArgGly: 3.331 ± 0.086
0.811ArgHis: 0.811 ± 0.038
4.425ArgIle: 4.425 ± 0.091
4.247ArgLys: 4.247 ± 0.09
5.433ArgLeu: 5.433 ± 0.107
1.346ArgMet: 1.346 ± 0.052
1.731ArgAsn: 1.731 ± 0.056
1.703ArgPro: 1.703 ± 0.056
1.24ArgGln: 1.24 ± 0.049
3.121ArgArg: 3.121 ± 0.085
2.117ArgSer: 2.117 ± 0.065
1.878ArgThr: 1.878 ± 0.059
4.174ArgVal: 4.174 ± 0.091
0.65ArgTrp: 0.65 ± 0.037
1.985ArgTyr: 1.985 ± 0.057
0.0ArgXaa: 0.0 ± 0.0
Ser
3.025SerAla: 3.025 ± 0.07
0.773SerCys: 0.773 ± 0.04
2.324SerAsp: 2.324 ± 0.08
3.331SerGlu: 3.331 ± 0.072
3.044SerPhe: 3.044 ± 0.077
3.999SerGly: 3.999 ± 0.093
0.981SerHis: 0.981 ± 0.045
3.731SerIle: 3.731 ± 0.092
3.59SerLys: 3.59 ± 0.068
5.728SerLeu: 5.728 ± 0.116
1.329SerMet: 1.329 ± 0.048
1.775SerAsn: 1.775 ± 0.067
2.395SerPro: 2.395 ± 0.066
1.49SerGln: 1.49 ± 0.046
2.408SerArg: 2.408 ± 0.069
3.065SerSer: 3.065 ± 0.102
2.402SerThr: 2.402 ± 0.054
3.95SerVal: 3.95 ± 0.081
0.594SerTrp: 0.594 ± 0.034
2.215SerTyr: 2.215 ± 0.075
0.0SerXaa: 0.0 ± 0.0
Thr
3.086ThrAla: 3.086 ± 0.082
0.629ThrCys: 0.629 ± 0.036
2.042ThrAsp: 2.042 ± 0.067
2.868ThrGlu: 2.868 ± 0.066
2.089ThrPhe: 2.089 ± 0.068
4.065ThrGly: 4.065 ± 0.089
0.813ThrHis: 0.813 ± 0.037
2.901ThrIle: 2.901 ± 0.08
3.034ThrLys: 3.034 ± 0.073
4.565ThrLeu: 4.565 ± 0.105
0.85ThrMet: 0.85 ± 0.039
1.556ThrAsn: 1.556 ± 0.057
2.376ThrPro: 2.376 ± 0.07
1.145ThrGln: 1.145 ± 0.049
1.955ThrArg: 1.955 ± 0.06
2.425ThrSer: 2.425 ± 0.064
2.298ThrThr: 2.298 ± 0.073
3.838ThrVal: 3.838 ± 0.083
0.414ThrTrp: 0.414 ± 0.027
1.598ThrTyr: 1.598 ± 0.063
0.0ThrXaa: 0.0 ± 0.0
Val
6.303ValAla: 6.303 ± 0.135
1.035ValCys: 1.035 ± 0.051
4.639ValAsp: 4.639 ± 0.097
6.646ValGlu: 6.646 ± 0.127
3.612ValPhe: 3.612 ± 0.085
5.436ValGly: 5.436 ± 0.102
1.329ValHis: 1.329 ± 0.049
5.863ValIle: 5.863 ± 0.096
6.569ValLys: 6.569 ± 0.112
7.943ValLeu: 7.943 ± 0.141
1.672ValMet: 1.672 ± 0.061
2.796ValAsn: 2.796 ± 0.072
3.378ValPro: 3.378 ± 0.084
1.801ValGln: 1.801 ± 0.053
3.92ValArg: 3.92 ± 0.091
4.695ValSer: 4.695 ± 0.091
3.626ValThr: 3.626 ± 0.088
7.765ValVal: 7.765 ± 0.126
0.747ValTrp: 0.747 ± 0.035
2.864ValTyr: 2.864 ± 0.071
0.0ValXaa: 0.0 ± 0.0
Trp
0.705TrpAla: 0.705 ± 0.041
0.147TrpCys: 0.147 ± 0.015
0.675TrpAsp: 0.675 ± 0.038
0.995TrpGlu: 0.995 ± 0.045
0.486TrpPhe: 0.486 ± 0.035
0.82TrpGly: 0.82 ± 0.044
0.217TrpHis: 0.217 ± 0.022
0.713TrpIle: 0.713 ± 0.037
0.78TrpLys: 0.78 ± 0.034
1.005TrpLeu: 1.005 ± 0.047
0.278TrpMet: 0.278 ± 0.025
0.393TrpAsn: 0.393 ± 0.024
0.316TrpPro: 0.316 ± 0.023
0.32TrpGln: 0.32 ± 0.022
0.546TrpArg: 0.546 ± 0.031
0.449TrpSer: 0.449 ± 0.026
0.357TrpThr: 0.357 ± 0.025
0.888TrpVal: 0.888 ± 0.042
0.149TrpTrp: 0.149 ± 0.016
0.344TrpTyr: 0.344 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.261TyrAla: 2.261 ± 0.067
0.486TyrCys: 0.486 ± 0.028
1.596TyrAsp: 1.596 ± 0.056
2.462TyrGlu: 2.462 ± 0.07
1.656TyrPhe: 1.656 ± 0.054
2.588TyrGly: 2.588 ± 0.072
0.734TyrHis: 0.734 ± 0.043
2.238TyrIle: 2.238 ± 0.071
2.588TyrLys: 2.588 ± 0.065
3.808TyrLeu: 3.808 ± 0.09
0.787TyrMet: 0.787 ± 0.04
1.346TyrAsn: 1.346 ± 0.055
1.911TyrPro: 1.911 ± 0.064
1.105TyrGln: 1.105 ± 0.044
2.051TyrArg: 2.051 ± 0.068
2.077TyrSer: 2.077 ± 0.064
1.743TyrThr: 1.743 ± 0.06
2.581TyrVal: 2.581 ± 0.072
0.46TyrTrp: 0.46 ± 0.032
1.525TyrTyr: 1.525 ± 0.057
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1756 proteins (571920 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski