Amino acid dipepetide frequency for Albugo candida

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.927AlaAla: 4.927 ± 0.038	1.375AlaCys: 1.375 ± 0.015	3.082AlaAsp: 3.082 ± 0.022	4.039AlaGlu: 4.039 ± 0.03	3.153AlaPhe: 3.153 ± 0.024	3.035AlaGly: 3.035 ± 0.024	1.809AlaHis: 1.809 ± 0.017	4.591AlaIle: 4.591 ± 0.031	3.902AlaLys: 3.902 ± 0.027	7.14AlaLeu: 7.14 ± 0.035	1.729AlaMet: 1.729 ± 0.016	2.829AlaAsn: 2.829 ± 0.018	2.486AlaPro: 2.486 ± 0.025	3.02AlaGln: 3.02 ± 0.03	3.746AlaArg: 3.746 ± 0.025	6.35AlaSer: 6.35 ± 0.035	3.967AlaThr: 3.967 ± 0.026	4.078AlaVal: 4.078 ± 0.027	0.702AlaTrp: 0.702 ± 0.01	1.925AlaTyr: 1.925 ± 0.017	0.0AlaXaa: 0.0 ± 0.0
Cys	1.331CysAla: 1.331 ± 0.017	0.485CysCys: 0.485 ± 0.01	1.183CysAsp: 1.183 ± 0.012	1.178CysGlu: 1.178 ± 0.013	0.924CysPhe: 0.924 ± 0.012	1.325CysGly: 1.325 ± 0.018	0.565CysHis: 0.565 ± 0.011	1.394CysIle: 1.394 ± 0.015	1.097CysLys: 1.097 ± 0.012	1.934CysLeu: 1.934 ± 0.02	0.506CysMet: 0.506 ± 0.008	0.818CysAsn: 0.818 ± 0.012	0.787CysPro: 0.787 ± 0.021	0.817CysGln: 0.817 ± 0.012	1.186CysArg: 1.186 ± 0.015	1.718CysSer: 1.718 ± 0.017	1.186CysThr: 1.186 ± 0.015	1.477CysVal: 1.477 ± 0.017	0.253CysTrp: 0.253 ± 0.006	0.569CysTyr: 0.569 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.216AspAla: 4.216 ± 0.025	1.01AspCys: 1.01 ± 0.013	3.32AspAsp: 3.32 ± 0.027	3.967AspGlu: 3.967 ± 0.031	2.352AspPhe: 2.352 ± 0.022	2.976AspGly: 2.976 ± 0.024	1.379AspHis: 1.379 ± 0.016	3.313AspIle: 3.313 ± 0.025	2.463AspLys: 2.463 ± 0.02	4.934AspLeu: 4.934 ± 0.028	1.174AspMet: 1.174 ± 0.015	1.824AspAsn: 1.824 ± 0.017	2.345AspPro: 2.345 ± 0.022	2.276AspGln: 2.276 ± 0.017	3.054AspArg: 3.054 ± 0.024	4.417AspSer: 4.417 ± 0.028	3.532AspThr: 3.532 ± 0.025	3.484AspVal: 3.484 ± 0.027	0.621AspTrp: 0.621 ± 0.012	1.389AspTyr: 1.389 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	4.709GluAla: 4.709 ± 0.031	1.299GluCys: 1.299 ± 0.016	3.603GluAsp: 3.603 ± 0.03	5.366GluGlu: 5.366 ± 0.044	2.367GluPhe: 2.367 ± 0.016	2.592GluGly: 2.592 ± 0.022	1.658GluHis: 1.658 ± 0.018	4.104GluIle: 4.104 ± 0.028	4.992GluLys: 4.992 ± 0.038	6.165GluLeu: 6.165 ± 0.036	1.967GluMet: 1.967 ± 0.019	3.516GluAsn: 3.516 ± 0.027	1.908GluPro: 1.908 ± 0.018	2.93GluGln: 2.93 ± 0.026	4.07GluArg: 4.07 ± 0.036	5.39GluSer: 5.39 ± 0.034	3.587GluThr: 3.587 ± 0.027	3.219GluVal: 3.219 ± 0.026	0.831GluTrp: 0.831 ± 0.012	1.947GluTyr: 1.947 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	2.705PheAla: 2.705 ± 0.021	0.944PheCys: 0.944 ± 0.012	2.592PheAsp: 2.592 ± 0.019	2.601PheGlu: 2.601 ± 0.021	1.767PhePhe: 1.767 ± 0.02	2.635PheGly: 2.635 ± 0.024	1.284PheHis: 1.284 ± 0.014	2.182PheIle: 2.182 ± 0.019	1.604PheLys: 1.604 ± 0.016	4.094PheLeu: 4.094 ± 0.029	0.86PheMet: 0.86 ± 0.012	1.304PheAsn: 1.304 ± 0.016	1.657PhePro: 1.657 ± 0.017	1.951PheGln: 1.951 ± 0.018	2.438PheArg: 2.438 ± 0.019	3.429PheSer: 3.429 ± 0.024	2.171PheThr: 2.171 ± 0.022	2.743PheVal: 2.743 ± 0.022	0.516PheTrp: 0.516 ± 0.01	1.312PheTyr: 1.312 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	3.065GlyAla: 3.065 ± 0.024	0.994GlyCys: 0.994 ± 0.014	2.57GlyAsp: 2.57 ± 0.025	2.578GlyGlu: 2.578 ± 0.022	2.113GlyPhe: 2.113 ± 0.018	2.882GlyGly: 2.882 ± 0.037	1.381GlyHis: 1.381 ± 0.014	3.304GlyIle: 3.304 ± 0.026	3.055GlyLys: 3.055 ± 0.025	4.001GlyLeu: 4.001 ± 0.029	1.255GlyMet: 1.255 ± 0.015	2.404GlyAsn: 2.404 ± 0.022	1.501GlyPro: 1.501 ± 0.018	1.768GlyGln: 1.768 ± 0.018	2.794GlyArg: 2.794 ± 0.024	4.425GlySer: 4.425 ± 0.035	2.922GlyThr: 2.922 ± 0.026	2.963GlyVal: 2.963 ± 0.021	0.575GlyTrp: 0.575 ± 0.01	1.576GlyTyr: 1.576 ± 0.017	0.0GlyXaa: 0.0 ± 0.0
His	1.922HisAla: 1.922 ± 0.02	0.644HisCys: 0.644 ± 0.01	1.405HisAsp: 1.405 ± 0.017	1.747HisGlu: 1.747 ± 0.019	1.305HisPhe: 1.305 ± 0.016	1.445HisGly: 1.445 ± 0.016	0.98HisHis: 0.98 ± 0.014	1.634HisIle: 1.634 ± 0.016	1.254HisLys: 1.254 ± 0.016	2.818HisLeu: 2.818 ± 0.022	0.553HisMet: 0.553 ± 0.009	1.043HisAsn: 1.043 ± 0.012	1.427HisPro: 1.427 ± 0.016	1.408HisGln: 1.408 ± 0.014	1.826HisArg: 1.826 ± 0.017	2.562HisSer: 2.562 ± 0.025	1.591HisThr: 1.591 ± 0.015	1.78HisVal: 1.78 ± 0.02	0.316HisTrp: 0.316 ± 0.007	0.807HisTyr: 0.807 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	4.549IleAla: 4.549 ± 0.028	1.345IleCys: 1.345 ± 0.016	3.566IleAsp: 3.566 ± 0.025	3.974IleGlu: 3.974 ± 0.029	2.305IlePhe: 2.305 ± 0.022	3.006IleGly: 3.006 ± 0.022	1.712IleHis: 1.712 ± 0.018	2.918IleIle: 2.918 ± 0.028	2.953IleLys: 2.953 ± 0.021	6.015IleLeu: 6.015 ± 0.033	1.213IleMet: 1.213 ± 0.014	2.162IleAsn: 2.162 ± 0.02	2.806IlePro: 2.806 ± 0.022	3.049IleGln: 3.049 ± 0.025	3.706IleArg: 3.706 ± 0.024	5.148IleSer: 5.148 ± 0.033	3.146IleThr: 3.146 ± 0.027	3.913IleVal: 3.913 ± 0.027	0.649IleTrp: 0.649 ± 0.01	1.569IleTyr: 1.569 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	4.052LysAla: 4.052 ± 0.028	1.187LysCys: 1.187 ± 0.014	2.858LysAsp: 2.858 ± 0.024	4.255LysGlu: 4.255 ± 0.036	1.706LysPhe: 1.706 ± 0.017	2.251LysGly: 2.251 ± 0.021	1.627LysHis: 1.627 ± 0.018	3.159LysIle: 3.159 ± 0.022	4.368LysLys: 4.368 ± 0.043	5.553LysLeu: 5.553 ± 0.033	1.576LysMet: 1.576 ± 0.016	2.609LysAsn: 2.609 ± 0.02	1.947LysPro: 1.947 ± 0.018	2.799LysGln: 2.799 ± 0.023	4.081LysArg: 4.081 ± 0.031	4.983LysSer: 4.983 ± 0.032	3.196LysThr: 3.196 ± 0.024	3.326LysVal: 3.326 ± 0.024	0.715LysTrp: 0.715 ± 0.011	1.767LysTyr: 1.767 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	6.29LeuAla: 6.29 ± 0.039	2.195LeuCys: 2.195 ± 0.021	5.238LeuAsp: 5.238 ± 0.031	6.824LeuGlu: 6.824 ± 0.043	3.692LeuPhe: 3.692 ± 0.028	4.368LeuGly: 4.368 ± 0.031	3.146LeuHis: 3.146 ± 0.024	5.022LeuIle: 5.022 ± 0.028	5.305LeuLys: 5.305 ± 0.03	10.079LeuLeu: 10.079 ± 0.051	2.274LeuMet: 2.274 ± 0.02	3.799LeuAsn: 3.799 ± 0.025	4.148LeuPro: 4.148 ± 0.026	5.452LeuGln: 5.452 ± 0.037	6.123LeuArg: 6.123 ± 0.032	8.197LeuSer: 8.197 ± 0.035	4.946LeuThr: 4.946 ± 0.025	5.509LeuVal: 5.509 ± 0.031	1.112LeuTrp: 1.112 ± 0.014	3.078LeuTyr: 3.078 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	1.523MetAla: 1.523 ± 0.014	0.421MetCys: 0.421 ± 0.008	1.467MetAsp: 1.467 ± 0.013	2.14MetGlu: 2.14 ± 0.021	0.751MetPhe: 0.751 ± 0.011	1.027MetGly: 1.027 ± 0.014	0.758MetHis: 0.758 ± 0.011	1.443MetIle: 1.443 ± 0.014	1.616MetLys: 1.616 ± 0.014	2.27MetLeu: 2.27 ± 0.019	0.666MetMet: 0.666 ± 0.01	1.137MetAsn: 1.137 ± 0.014	0.795MetPro: 0.795 ± 0.011	1.319MetGln: 1.319 ± 0.014	1.475MetArg: 1.475 ± 0.015	1.891MetSer: 1.891 ± 0.016	1.417MetThr: 1.417 ± 0.016	1.214MetVal: 1.214 ± 0.014	0.249MetTrp: 0.249 ± 0.006	0.802MetTyr: 0.802 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.69AsnAla: 3.69 ± 0.024	0.886AsnCys: 0.886 ± 0.013	2.619AsnAsp: 2.619 ± 0.021	3.169AsnGlu: 3.169 ± 0.024	1.537AsnPhe: 1.537 ± 0.017	2.734AsnGly: 2.734 ± 0.024	1.123AsnHis: 1.123 ± 0.014	2.356AsnIle: 2.356 ± 0.017	1.989AsnLys: 1.989 ± 0.021	3.737AsnLeu: 3.737 ± 0.031	0.933AsnMet: 0.933 ± 0.011	1.527AsnAsn: 1.527 ± 0.016	1.81AsnPro: 1.81 ± 0.018	1.901AsnGln: 1.901 ± 0.019	2.46AsnArg: 2.46 ± 0.023	3.52AsnSer: 3.52 ± 0.026	2.545AsnThr: 2.545 ± 0.022	3.071AsnVal: 3.071 ± 0.023	0.525AsnTrp: 0.525 ± 0.009	1.074AsnTyr: 1.074 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	2.297ProAla: 2.297 ± 0.022	0.669ProCys: 0.669 ± 0.011	1.853ProAsp: 1.853 ± 0.017	2.432ProGlu: 2.432 ± 0.023	1.803ProPhe: 1.803 ± 0.018	1.775ProGly: 1.775 ± 0.021	1.112ProHis: 1.112 ± 0.013	2.514ProIle: 2.514 ± 0.022	2.237ProLys: 2.237 ± 0.02	3.639ProLeu: 3.639 ± 0.028	0.875ProMet: 0.875 ± 0.012	1.942ProAsn: 1.942 ± 0.02	2.194ProPro: 2.194 ± 0.037	1.674ProGln: 1.674 ± 0.018	2.021ProArg: 2.021 ± 0.019	4.18ProSer: 4.18 ± 0.035	2.499ProThr: 2.499 ± 0.023	2.333ProVal: 2.333 ± 0.022	0.371ProTrp: 0.371 ± 0.008	1.109ProTyr: 1.109 ± 0.015	0.0ProXaa: 0.0 ± 0.0
Gln	3.072GlnAla: 3.072 ± 0.023	0.902GlnCys: 0.902 ± 0.013	2.162GlnAsp: 2.162 ± 0.017	2.997GlnGlu: 2.997 ± 0.029	1.733GlnPhe: 1.733 ± 0.017	1.603GlnGly: 1.603 ± 0.017	1.449GlnHis: 1.449 ± 0.017	2.782GlnIle: 2.782 ± 0.02	2.89GlnLys: 2.89 ± 0.024	4.907GlnLeu: 4.907 ± 0.04	1.261GlnMet: 1.261 ± 0.015	2.336GlnAsn: 2.336 ± 0.024	1.53GlnPro: 1.53 ± 0.017	2.584GlnGln: 2.584 ± 0.03	2.906GlnArg: 2.906 ± 0.023	4.199GlnSer: 4.199 ± 0.026	2.472GlnThr: 2.472 ± 0.019	2.782GlnVal: 2.782 ± 0.02	0.532GlnTrp: 0.532 ± 0.009	1.409GlnTyr: 1.409 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	3.633ArgAla: 3.633 ± 0.027	1.162ArgCys: 1.162 ± 0.014	3.069ArgAsp: 3.069 ± 0.023	3.704ArgGlu: 3.704 ± 0.029	2.611ArgPhe: 2.611 ± 0.021	2.576ArgGly: 2.576 ± 0.023	1.772ArgHis: 1.772 ± 0.017	3.809ArgIle: 3.809 ± 0.026	4.152ArgLys: 4.152 ± 0.031	5.92ArgLeu: 5.92 ± 0.032	1.621ArgMet: 1.621 ± 0.015	2.976ArgAsn: 2.976 ± 0.021	2.075ArgPro: 2.075 ± 0.017	2.852ArgGln: 2.852 ± 0.023	4.015ArgArg: 4.015 ± 0.035	5.026ArgSer: 5.026 ± 0.033	2.99ArgThr: 2.99 ± 0.023	3.579ArgVal: 3.579 ± 0.022	0.717ArgTrp: 0.717 ± 0.011	1.92ArgTyr: 1.92 ± 0.016	0.0ArgXaa: 0.0 ± 0.0
Ser	5.404SerAla: 5.404 ± 0.031	1.715SerCys: 1.715 ± 0.02	5.005SerAsp: 5.005 ± 0.029	5.264SerGlu: 5.264 ± 0.03	3.788SerPhe: 3.788 ± 0.026	4.234SerGly: 4.234 ± 0.029	2.307SerHis: 2.307 ± 0.022	5.784SerIle: 5.784 ± 0.036	5.097SerLys: 5.097 ± 0.03	8.026SerLeu: 8.026 ± 0.04	2.166SerMet: 2.166 ± 0.019	4.169SerAsn: 4.169 ± 0.03	3.543SerPro: 3.543 ± 0.033	3.604SerGln: 3.604 ± 0.025	4.823SerArg: 4.823 ± 0.029	9.116SerSer: 9.116 ± 0.059	5.71SerThr: 5.71 ± 0.038	5.239SerVal: 5.239 ± 0.032	0.917SerTrp: 0.917 ± 0.013	2.256SerTyr: 2.256 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	3.76ThrAla: 3.76 ± 0.026	1.253ThrCys: 1.253 ± 0.016	2.734ThrAsp: 2.734 ± 0.021	3.497ThrGlu: 3.497 ± 0.025	2.526ThrPhe: 2.526 ± 0.021	2.717ThrGly: 2.717 ± 0.025	1.499ThrHis: 1.499 ± 0.017	3.578ThrIle: 3.578 ± 0.027	3.355ThrLys: 3.355 ± 0.025	5.679ThrLeu: 5.679 ± 0.028	1.29ThrMet: 1.29 ± 0.013	2.52ThrAsn: 2.52 ± 0.019	2.525ThrPro: 2.525 ± 0.028	2.536ThrGln: 2.536 ± 0.022	3.275ThrArg: 3.275 ± 0.022	5.596ThrSer: 5.596 ± 0.036	3.507ThrThr: 3.507 ± 0.026	2.901ThrVal: 2.901 ± 0.024	0.613ThrTrp: 0.613 ± 0.011	1.519ThrTyr: 1.519 ± 0.016	0.0ThrXaa: 0.0 ± 0.0
Val	4.214ValAla: 4.214 ± 0.023	1.324ValCys: 1.324 ± 0.016	3.462ValAsp: 3.462 ± 0.024	3.987ValGlu: 3.987 ± 0.027	2.542ValPhe: 2.542 ± 0.023	2.779ValGly: 2.779 ± 0.026	1.657ValHis: 1.657 ± 0.016	3.349ValIle: 3.349 ± 0.027	3.242ValLys: 3.242 ± 0.025	5.989ValLeu: 5.989 ± 0.033	1.423ValMet: 1.423 ± 0.014	2.361ValAsn: 2.361 ± 0.022	2.546ValPro: 2.546 ± 0.02	2.719ValGln: 2.719 ± 0.021	3.488ValArg: 3.488 ± 0.021	5.007ValSer: 5.007 ± 0.033	3.196ValThr: 3.196 ± 0.023	3.772ValVal: 3.772 ± 0.029	0.727ValTrp: 0.727 ± 0.011	1.894ValTyr: 1.894 ± 0.017	0.0ValXaa: 0.0 ± 0.0
Trp	0.577TrpAla: 0.577 ± 0.009	0.233TrpCys: 0.233 ± 0.006	0.637TrpAsp: 0.637 ± 0.012	0.633TrpGlu: 0.633 ± 0.012	0.437TrpPhe: 0.437 ± 0.01	0.444TrpGly: 0.444 ± 0.01	0.303TrpHis: 0.303 ± 0.008	0.865TrpIle: 0.865 ± 0.013	1.004TrpLys: 1.004 ± 0.012	1.054TrpLeu: 1.054 ± 0.014	0.385TrpMet: 0.385 ± 0.007	0.708TrpAsn: 0.708 ± 0.011	0.342TrpPro: 0.342 ± 0.007	0.451TrpGln: 0.451 ± 0.008	0.754TrpArg: 0.754 ± 0.012	0.91TrpSer: 0.91 ± 0.012	0.691TrpThr: 0.691 ± 0.011	0.523TrpVal: 0.523 ± 0.008	0.158TrpTrp: 0.158 ± 0.005	0.352TrpTyr: 0.352 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.947TyrAla: 1.947 ± 0.017	0.686TyrCys: 0.686 ± 0.011	1.621TyrAsp: 1.621 ± 0.016	1.873TyrGlu: 1.873 ± 0.021	1.378TyrPhe: 1.378 ± 0.015	1.722TyrGly: 1.722 ± 0.018	0.948TyrHis: 0.948 ± 0.014	1.604TyrIle: 1.604 ± 0.016	1.44TyrLys: 1.44 ± 0.016	2.844TyrLeu: 2.844 ± 0.022	0.654TyrMet: 0.654 ± 0.009	1.221TyrAsn: 1.221 ± 0.013	1.157TyrPro: 1.157 ± 0.015	1.394TyrGln: 1.394 ± 0.014	1.934TyrArg: 1.934 ± 0.017	2.107TyrSer: 2.107 ± 0.021	1.607TyrThr: 1.607 ± 0.017	1.774TyrVal: 1.774 ± 0.017	0.364TyrTrp: 0.364 ± 0.008	0.95TyrTyr: 0.95 ± 0.012	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 13200 proteins (6569959 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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