Amino acid dipepetide frequency for Candidatus Methanomethylophilus sp. 1R26

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.857AlaAla: 11.857 ± 0.321
1.438AlaCys: 1.438 ± 0.076
7.153AlaAsp: 7.153 ± 0.152
7.543AlaGlu: 7.543 ± 0.199
3.73AlaPhe: 3.73 ± 0.183
8.06AlaGly: 8.06 ± 0.168
1.324AlaHis: 1.324 ± 0.064
4.77AlaIle: 4.77 ± 0.134
4.489AlaLys: 4.489 ± 0.135
7.829AlaLeu: 7.829 ± 0.166
3.168AlaMet: 3.168 ± 0.099
1.993AlaAsn: 1.993 ± 0.069
3.171AlaPro: 3.171 ± 0.109
2.08AlaGln: 2.08 ± 0.086
4.484AlaArg: 4.484 ± 0.128
5.964AlaSer: 5.964 ± 0.126
3.359AlaThr: 3.359 ± 0.11
9.294AlaVal: 9.294 ± 0.193
0.815AlaTrp: 0.815 ± 0.045
2.964AlaTyr: 2.964 ± 0.092
0.0AlaXaa: 0.0 ± 0.0
Cys
1.451CysAla: 1.451 ± 0.071
0.435CysCys: 0.435 ± 0.043
1.029CysAsp: 1.029 ± 0.059
0.743CysGlu: 0.743 ± 0.037
0.616CysPhe: 0.616 ± 0.046
1.939CysGly: 1.939 ± 0.082
0.247CysHis: 0.247 ± 0.026
1.25CysIle: 1.25 ± 0.064
0.573CysLys: 0.573 ± 0.038
1.281CysLeu: 1.281 ± 0.055
0.523CysMet: 0.523 ± 0.04
0.409CysAsn: 0.409 ± 0.036
1.04CysPro: 1.04 ± 0.068
0.374CysGln: 0.374 ± 0.031
1.488CysArg: 1.488 ± 0.066
1.274CysSer: 1.274 ± 0.053
1.08CysThr: 1.08 ± 0.121
1.024CysVal: 1.024 ± 0.053
0.191CysTrp: 0.191 ± 0.02
0.478CysTyr: 0.478 ± 0.035
0.0CysXaa: 0.0 ± 0.0
Asp
6.498AspAla: 6.498 ± 0.133
0.984AspCys: 0.984 ± 0.053
4.035AspAsp: 4.035 ± 0.134
4.232AspGlu: 4.232 ± 0.111
2.452AspPhe: 2.452 ± 0.076
6.301AspGly: 6.301 ± 0.161
0.873AspHis: 0.873 ± 0.055
4.739AspIle: 4.739 ± 0.126
2.298AspLys: 2.298 ± 0.087
5.537AspLeu: 5.537 ± 0.133
2.184AspMet: 2.184 ± 0.078
1.711AspAsn: 1.711 ± 0.077
3.441AspPro: 3.441 ± 0.102
1.09AspGln: 1.09 ± 0.055
4.486AspArg: 4.486 ± 0.128
4.497AspSer: 4.497 ± 0.143
3.308AspThr: 3.308 ± 0.1
4.425AspVal: 4.425 ± 0.11
0.695AspTrp: 0.695 ± 0.046
2.404AspTyr: 2.404 ± 0.081
0.0AspXaa: 0.0 ± 0.0
Glu
6.198GluAla: 6.198 ± 0.155
0.979GluCys: 0.979 ± 0.051
4.298GluAsp: 4.298 ± 0.099
4.677GluGlu: 4.677 ± 0.165
2.173GluPhe: 2.173 ± 0.079
5.16GluGly: 5.16 ± 0.118
1.157GluHis: 1.157 ± 0.061
4.479GluIle: 4.479 ± 0.13
4.447GluLys: 4.447 ± 0.131
4.876GluLeu: 4.876 ± 0.121
2.3GluMet: 2.3 ± 0.087
2.348GluAsn: 2.348 ± 0.11
2.04GluPro: 2.04 ± 0.087
1.449GluGln: 1.449 ± 0.081
3.752GluArg: 3.752 ± 0.11
3.805GluSer: 3.805 ± 0.103
3.33GluThr: 3.33 ± 0.091
3.982GluVal: 3.982 ± 0.107
0.703GluTrp: 0.703 ± 0.051
2.393GluTyr: 2.393 ± 0.096
0.0GluXaa: 0.0 ± 0.0
Phe
3.041PheAla: 3.041 ± 0.109
0.722PheCys: 0.722 ± 0.046
2.64PheAsp: 2.64 ± 0.094
2.263PheGlu: 2.263 ± 0.078
1.321PhePhe: 1.321 ± 0.051
3.369PheGly: 3.369 ± 0.094
0.47PheHis: 0.47 ± 0.034
2.245PheIle: 2.245 ± 0.078
1.313PheLys: 1.313 ± 0.074
2.918PheLeu: 2.918 ± 0.104
1.162PheMet: 1.162 ± 0.057
1.104PheAsn: 1.104 ± 0.052
1.467PhePro: 1.467 ± 0.069
0.732PheGln: 0.732 ± 0.048
2.409PheArg: 2.409 ± 0.085
3.078PheSer: 3.078 ± 0.101
2.189PheThr: 2.189 ± 0.089
2.523PheVal: 2.523 ± 0.083
0.435PheTrp: 0.435 ± 0.042
1.205PheTyr: 1.205 ± 0.073
0.0PheXaa: 0.0 ± 0.0
Gly
6.994GlyAla: 6.994 ± 0.149
1.9GlyCys: 1.9 ± 0.131
5.086GlyAsp: 5.086 ± 0.124
4.526GlyGlu: 4.526 ± 0.12
3.041GlyPhe: 3.041 ± 0.096
6.291GlyGly: 6.291 ± 0.172
1.568GlyHis: 1.568 ± 0.06
6.182GlyIle: 6.182 ± 0.144
5.444GlyLys: 5.444 ± 0.126
6.429GlyLeu: 6.429 ± 0.139
3.001GlyMet: 3.001 ± 0.088
2.839GlyAsn: 2.839 ± 0.084
2.889GlyPro: 2.889 ± 0.084
1.624GlyGln: 1.624 ± 0.07
5.542GlyArg: 5.542 ± 0.153
5.975GlySer: 5.975 ± 0.155
5.736GlyThr: 5.736 ± 0.164
5.187GlyVal: 5.187 ± 0.143
1.043GlyTrp: 1.043 ± 0.059
3.171GlyTyr: 3.171 ± 0.099
0.0GlyXaa: 0.0 ± 0.0
His
1.3HisAla: 1.3 ± 0.056
0.324HisCys: 0.324 ± 0.031
1.011HisAsp: 1.011 ± 0.06
0.87HisGlu: 0.87 ± 0.047
0.533HisPhe: 0.533 ± 0.037
1.316HisGly: 1.316 ± 0.06
0.401HisHis: 0.401 ± 0.083
1.059HisIle: 1.059 ± 0.049
0.557HisLys: 0.557 ± 0.038
1.223HisLeu: 1.223 ± 0.057
0.57HisMet: 0.57 ± 0.04
0.409HisAsn: 0.409 ± 0.03
0.929HisPro: 0.929 ± 0.05
0.297HisGln: 0.297 ± 0.03
1.0HisArg: 1.0 ± 0.057
0.926HisSer: 0.926 ± 0.051
0.815HisThr: 0.815 ± 0.048
1.112HisVal: 1.112 ± 0.049
0.159HisTrp: 0.159 ± 0.018
0.544HisTyr: 0.544 ± 0.042
0.0HisXaa: 0.0 ± 0.0
Ile
6.304IleAla: 6.304 ± 0.145
1.218IleCys: 1.218 ± 0.058
4.386IleAsp: 4.386 ± 0.102
3.778IleGlu: 3.778 ± 0.099
2.112IlePhe: 2.112 ± 0.077
5.614IleGly: 5.614 ± 0.155
0.822IleHis: 0.822 ± 0.048
4.16IleIle: 4.16 ± 0.129
2.497IleLys: 2.497 ± 0.085
4.9IleLeu: 4.9 ± 0.129
1.844IleMet: 1.844 ± 0.073
1.833IleAsn: 1.833 ± 0.079
2.903IlePro: 2.903 ± 0.093
1.12IleGln: 1.12 ± 0.059
3.661IleArg: 3.661 ± 0.111
5.179IleSer: 5.179 ± 0.119
3.388IleThr: 3.388 ± 0.103
4.855IleVal: 4.855 ± 0.125
0.592IleTrp: 0.592 ± 0.047
1.921IleTyr: 1.921 ± 0.07
0.0IleXaa: 0.0 ± 0.0
Lys
5.07LysAla: 5.07 ± 0.163
0.815LysCys: 0.815 ± 0.059
3.722LysAsp: 3.722 ± 0.103
3.866LysGlu: 3.866 ± 0.125
1.43LysPhe: 1.43 ± 0.058
3.624LysGly: 3.624 ± 0.108
0.852LysHis: 0.852 ± 0.052
3.372LysIle: 3.372 ± 0.101
3.645LysLys: 3.645 ± 0.124
3.691LysLeu: 3.691 ± 0.117
1.69LysMet: 1.69 ± 0.071
1.77LysAsn: 1.77 ± 0.075
1.499LysPro: 1.499 ± 0.06
1.077LysGln: 1.077 ± 0.061
2.592LysArg: 2.592 ± 0.101
2.746LysSer: 2.746 ± 0.097
2.987LysThr: 2.987 ± 0.1
3.683LysVal: 3.683 ± 0.102
0.472LysTrp: 0.472 ± 0.041
1.889LysTyr: 1.889 ± 0.068
0.0LysXaa: 0.0 ± 0.0
Leu
7.455LeuAla: 7.455 ± 0.176
1.435LeuCys: 1.435 ± 0.064
5.028LeuAsp: 5.028 ± 0.107
4.821LeuGlu: 4.821 ± 0.121
2.995LeuPhe: 2.995 ± 0.11
6.551LeuGly: 6.551 ± 0.14
1.159LeuHis: 1.159 ± 0.058
4.953LeuIle: 4.953 ± 0.151
4.112LeuLys: 4.112 ± 0.101
6.288LeuLeu: 6.288 ± 0.162
2.722LeuMet: 2.722 ± 0.096
2.51LeuAsn: 2.51 ± 0.078
3.237LeuPro: 3.237 ± 0.1
1.584LeuGln: 1.584 ± 0.067
5.086LeuArg: 5.086 ± 0.131
6.288LeuSer: 6.288 ± 0.13
4.407LeuThr: 4.407 ± 0.158
5.155LeuVal: 5.155 ± 0.126
0.769LeuTrp: 0.769 ± 0.047
2.518LeuTyr: 2.518 ± 0.086
0.0LeuXaa: 0.0 ± 0.0
Met
3.197MetAla: 3.197 ± 0.113
0.512MetCys: 0.512 ± 0.035
2.146MetAsp: 2.146 ± 0.068
2.043MetGlu: 2.043 ± 0.096
1.266MetPhe: 1.266 ± 0.065
2.481MetGly: 2.481 ± 0.095
0.57MetHis: 0.57 ± 0.034
1.913MetIle: 1.913 ± 0.074
2.138MetLys: 2.138 ± 0.081
2.706MetLeu: 2.706 ± 0.096
1.146MetMet: 1.146 ± 0.065
1.17MetAsn: 1.17 ± 0.055
1.576MetPro: 1.576 ± 0.065
0.833MetGln: 0.833 ± 0.047
1.801MetArg: 1.801 ± 0.075
2.367MetSer: 2.367 ± 0.087
2.038MetThr: 2.038 ± 0.069
2.051MetVal: 2.051 ± 0.078
0.276MetTrp: 0.276 ± 0.029
1.032MetTyr: 1.032 ± 0.055
0.0MetXaa: 0.0 ± 0.0
Asn
2.613AsnAla: 2.613 ± 0.095
0.557AsnCys: 0.557 ± 0.047
1.717AsnAsp: 1.717 ± 0.074
1.648AsnGlu: 1.648 ± 0.079
0.849AsnPhe: 0.849 ± 0.056
3.261AsnGly: 3.261 ± 0.126
0.419AsnHis: 0.419 ± 0.037
2.154AsnIle: 2.154 ± 0.074
1.136AsnLys: 1.136 ± 0.056
2.589AsnLeu: 2.589 ± 0.086
0.992AsnMet: 0.992 ± 0.053
0.883AsnAsn: 0.883 ± 0.053
1.656AsnPro: 1.656 ± 0.079
0.578AsnGln: 0.578 ± 0.045
1.703AsnArg: 1.703 ± 0.082
1.908AsnSer: 1.908 ± 0.099
1.576AsnThr: 1.576 ± 0.066
2.258AsnVal: 2.258 ± 0.084
0.297AsnTrp: 0.297 ± 0.031
1.165AsnTyr: 1.165 ± 0.053
0.0AsnXaa: 0.0 ± 0.0
Pro
4.009ProAla: 4.009 ± 0.138
0.568ProCys: 0.568 ± 0.041
3.059ProAsp: 3.059 ± 0.099
4.096ProGlu: 4.096 ± 0.117
1.472ProPhe: 1.472 ± 0.058
3.574ProGly: 3.574 ± 0.102
0.639ProHis: 0.639 ± 0.042
1.958ProIle: 1.958 ± 0.078
2.115ProLys: 2.115 ± 0.091
2.903ProLeu: 2.903 ± 0.104
1.242ProMet: 1.242 ± 0.06
1.12ProAsn: 1.12 ± 0.057
1.467ProPro: 1.467 ± 0.081
1.006ProGln: 1.006 ± 0.055
2.253ProArg: 2.253 ± 0.091
3.117ProSer: 3.117 ± 0.098
1.748ProThr: 1.748 ± 0.073
3.308ProVal: 3.308 ± 0.105
0.432ProTrp: 0.432 ± 0.043
1.364ProTyr: 1.364 ± 0.064
0.0ProXaa: 0.0 ± 0.0
Gln
1.985GlnAla: 1.985 ± 0.093
0.369GlnCys: 0.369 ± 0.034
1.194GlnAsp: 1.194 ± 0.065
1.289GlnGlu: 1.289 ± 0.057
0.764GlnPhe: 0.764 ± 0.043
1.451GlnGly: 1.451 ± 0.06
0.403GlnHis: 0.403 ± 0.035
1.491GlnIle: 1.491 ± 0.063
1.374GlnLys: 1.374 ± 0.066
1.573GlnLeu: 1.573 ± 0.074
0.899GlnMet: 0.899 ± 0.046
0.804GlnAsn: 0.804 ± 0.041
0.57GlnPro: 0.57 ± 0.035
0.56GlnGln: 0.56 ± 0.042
1.186GlnArg: 1.186 ± 0.06
1.337GlnSer: 1.337 ± 0.062
1.242GlnThr: 1.242 ± 0.059
1.303GlnVal: 1.303 ± 0.061
0.263GlnTrp: 0.263 ± 0.032
0.873GlnTyr: 0.873 ± 0.047
0.0GlnXaa: 0.0 ± 0.0
Arg
4.89ArgAla: 4.89 ± 0.136
1.045ArgCys: 1.045 ± 0.061
3.659ArgAsp: 3.659 ± 0.125
4.065ArgGlu: 4.065 ± 0.114
2.266ArgPhe: 2.266 ± 0.089
4.25ArgGly: 4.25 ± 0.112
0.937ArgHis: 0.937 ± 0.05
4.081ArgIle: 4.081 ± 0.106
3.518ArgLys: 3.518 ± 0.123
4.367ArgLeu: 4.367 ± 0.123
2.26ArgMet: 2.26 ± 0.079
2.223ArgAsn: 2.223 ± 0.089
2.701ArgPro: 2.701 ± 0.093
1.404ArgGln: 1.404 ± 0.06
4.593ArgArg: 4.593 ± 0.161
4.075ArgSer: 4.075 ± 0.131
3.311ArgThr: 3.311 ± 0.107
3.316ArgVal: 3.316 ± 0.118
0.616ArgTrp: 0.616 ± 0.044
2.077ArgTyr: 2.077 ± 0.073
0.0ArgXaa: 0.0 ± 0.0
Ser
6.975SerAla: 6.975 ± 0.164
1.043SerCys: 1.043 ± 0.053
5.2SerAsp: 5.2 ± 0.137
4.834SerGlu: 4.834 ± 0.132
2.725SerPhe: 2.725 ± 0.094
7.055SerGly: 7.055 ± 0.172
0.878SerHis: 0.878 ± 0.047
3.99SerIle: 3.99 ± 0.129
3.263SerLys: 3.263 ± 0.094
5.524SerLeu: 5.524 ± 0.154
2.327SerMet: 2.327 ± 0.084
1.897SerAsn: 1.897 ± 0.091
2.778SerPro: 2.778 ± 0.105
1.433SerGln: 1.433 ± 0.064
3.746SerArg: 3.746 ± 0.113
5.577SerSer: 5.577 ± 0.21
3.062SerThr: 3.062 ± 0.118
5.739SerVal: 5.739 ± 0.159
0.73SerTrp: 0.73 ± 0.047
2.282SerTyr: 2.282 ± 0.086
0.0SerXaa: 0.0 ± 0.0
Thr
5.832ThrAla: 5.832 ± 0.154
0.679ThrCys: 0.679 ± 0.044
3.566ThrAsp: 3.566 ± 0.11
3.269ThrGlu: 3.269 ± 0.101
1.977ThrPhe: 1.977 ± 0.081
5.102ThrGly: 5.102 ± 0.144
0.708ThrHis: 0.708 ± 0.041
2.81ThrIle: 2.81 ± 0.116
1.998ThrLys: 1.998 ± 0.074
4.038ThrLeu: 4.038 ± 0.112
1.491ThrMet: 1.491 ± 0.068
1.327ThrAsn: 1.327 ± 0.063
2.223ThrPro: 2.223 ± 0.081
1.183ThrGln: 1.183 ± 0.053
2.101ThrArg: 2.101 ± 0.078
3.478ThrSer: 3.478 ± 0.184
2.165ThrThr: 2.165 ± 0.091
6.238ThrVal: 6.238 ± 0.179
0.584ThrTrp: 0.584 ± 0.04
1.961ThrTyr: 1.961 ± 0.105
0.0ThrXaa: 0.0 ± 0.0
Val
5.81ValAla: 5.81 ± 0.165
1.449ValCys: 1.449 ± 0.065
4.211ValAsp: 4.211 ± 0.118
3.606ValGlu: 3.606 ± 0.106
3.117ValPhe: 3.117 ± 0.09
5.264ValGly: 5.264 ± 0.134
1.191ValHis: 1.191 ± 0.058
4.723ValIle: 4.723 ± 0.126
3.667ValLys: 3.667 ± 0.109
6.598ValLeu: 6.598 ± 0.143
2.361ValMet: 2.361 ± 0.086
2.067ValAsn: 2.067 ± 0.082
4.075ValPro: 4.075 ± 0.104
1.515ValGln: 1.515 ± 0.058
4.953ValArg: 4.953 ± 0.137
6.086ValSer: 6.086 ± 0.145
4.261ValThr: 4.261 ± 0.153
4.768ValVal: 4.768 ± 0.141
0.772ValTrp: 0.772 ± 0.049
2.685ValTyr: 2.685 ± 0.089
0.0ValXaa: 0.0 ± 0.0
Trp
0.881TrpAla: 0.881 ± 0.054
0.199TrpCys: 0.199 ± 0.022
0.677TrpAsp: 0.677 ± 0.048
0.597TrpGlu: 0.597 ± 0.044
0.451TrpPhe: 0.451 ± 0.04
0.703TrpGly: 0.703 ± 0.044
0.207TrpHis: 0.207 ± 0.024
0.69TrpIle: 0.69 ± 0.042
0.629TrpLys: 0.629 ± 0.042
0.756TrpLeu: 0.756 ± 0.043
0.371TrpMet: 0.371 ± 0.034
0.499TrpAsn: 0.499 ± 0.039
0.369TrpPro: 0.369 ± 0.034
0.241TrpGln: 0.241 ± 0.022
0.541TrpArg: 0.541 ± 0.039
0.719TrpSer: 0.719 ± 0.049
0.653TrpThr: 0.653 ± 0.043
0.602TrpVal: 0.602 ± 0.048
0.138TrpTrp: 0.138 ± 0.019
0.467TrpTyr: 0.467 ± 0.04
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.125TyrAla: 3.125 ± 0.106
0.775TyrCys: 0.775 ± 0.047
2.375TyrAsp: 2.375 ± 0.084
1.783TyrGlu: 1.783 ± 0.065
1.316TyrPhe: 1.316 ± 0.068
3.099TyrGly: 3.099 ± 0.09
0.528TyrHis: 0.528 ± 0.032
2.069TyrIle: 2.069 ± 0.077
1.279TyrLys: 1.279 ± 0.07
3.046TyrLeu: 3.046 ± 0.1
1.006TyrMet: 1.006 ± 0.056
1.045TyrAsn: 1.045 ± 0.055
1.419TyrPro: 1.419 ± 0.062
0.751TyrGln: 0.751 ± 0.051
2.274TyrArg: 2.274 ± 0.08
2.661TyrSer: 2.661 ± 0.092
2.075TyrThr: 2.075 ± 0.124
2.356TyrVal: 2.356 ± 0.078
0.409TyrTrp: 0.409 ± 0.038
1.258TyrTyr: 1.258 ± 0.063
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1473 proteins (376912 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski