Amino acid dipepetide frequency for Pristionchus pacificus (Parasitic nematode)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.847AlaAla: 7.847 ± 0.092	1.378AlaCys: 1.378 ± 0.017	3.51AlaAsp: 3.51 ± 0.03	4.397AlaGlu: 4.397 ± 0.088	2.848AlaPhe: 2.848 ± 0.022	3.882AlaGly: 3.882 ± 0.034	1.737AlaHis: 1.737 ± 0.021	4.053AlaIle: 4.053 ± 0.024	3.891AlaLys: 3.891 ± 0.087	6.5AlaLeu: 6.5 ± 0.07	1.921AlaMet: 1.921 ± 0.03	2.684AlaAsn: 2.684 ± 0.021	4.231AlaPro: 4.231 ± 0.07	2.384AlaGln: 2.384 ± 0.021	4.106AlaArg: 4.106 ± 0.032	5.539AlaSer: 5.539 ± 0.037	4.253AlaThr: 4.253 ± 0.037	5.051AlaVal: 5.051 ± 0.063	0.686AlaTrp: 0.686 ± 0.009	1.899AlaTyr: 1.899 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	1.524CysAla: 1.524 ± 0.019	0.601CysCys: 0.601 ± 0.012	1.19CysAsp: 1.19 ± 0.017	1.191CysGlu: 1.191 ± 0.016	0.884CysPhe: 0.884 ± 0.011	1.425CysGly: 1.425 ± 0.023	0.455CysHis: 0.455 ± 0.007	1.158CysIle: 1.158 ± 0.016	1.026CysLys: 1.026 ± 0.016	1.722CysLeu: 1.722 ± 0.016	0.472CysMet: 0.472 ± 0.007	0.933CysAsn: 0.933 ± 0.029	1.236CysPro: 1.236 ± 0.019	0.624CysGln: 0.624 ± 0.014	1.15CysArg: 1.15 ± 0.015	1.794CysSer: 1.794 ± 0.024	1.263CysThr: 1.263 ± 0.016	1.292CysVal: 1.292 ± 0.017	0.221CysTrp: 0.221 ± 0.005	0.595CysTyr: 0.595 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	3.813AspAla: 3.813 ± 0.058	1.064AspCys: 1.064 ± 0.014	4.111AspAsp: 4.111 ± 0.039	4.952AspGlu: 4.952 ± 0.042	2.133AspPhe: 2.133 ± 0.018	3.88AspGly: 3.88 ± 0.052	1.241AspHis: 1.241 ± 0.018	2.687AspIle: 2.687 ± 0.019	2.837AspLys: 2.837 ± 0.028	4.239AspLeu: 4.239 ± 0.031	1.215AspMet: 1.215 ± 0.013	1.97AspAsn: 1.97 ± 0.017	2.448AspPro: 2.448 ± 0.018	1.73AspGln: 1.73 ± 0.015	3.189AspArg: 3.189 ± 0.033	3.912AspSer: 3.912 ± 0.032	2.472AspThr: 2.472 ± 0.019	3.386AspVal: 3.386 ± 0.028	0.694AspTrp: 0.694 ± 0.009	1.65AspTyr: 1.65 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	4.399GluAla: 4.399 ± 0.082	1.291GluCys: 1.291 ± 0.022	4.038GluAsp: 4.038 ± 0.037	7.933GluGlu: 7.933 ± 0.138	2.213GluPhe: 2.213 ± 0.04	3.807GluGly: 3.807 ± 0.069	1.358GluHis: 1.358 ± 0.017	3.549GluIle: 3.549 ± 0.025	5.445GluLys: 5.445 ± 0.062	4.986GluLeu: 4.986 ± 0.037	2.197GluMet: 2.197 ± 0.018	2.763GluAsn: 2.763 ± 0.028	2.395GluPro: 2.395 ± 0.062	2.434GluGln: 2.434 ± 0.036	4.636GluArg: 4.636 ± 0.041	4.352GluSer: 4.352 ± 0.035	3.322GluThr: 3.322 ± 0.03	3.691GluVal: 3.691 ± 0.053	0.94GluTrp: 0.94 ± 0.013	1.886GluTyr: 1.886 ± 0.015	0.0GluXaa: 0.0 ± 0.0
Phe	2.974PheAla: 2.974 ± 0.023	0.975PheCys: 0.975 ± 0.013	2.522PheAsp: 2.522 ± 0.032	2.316PheGlu: 2.316 ± 0.024	2.245PhePhe: 2.245 ± 0.052	2.664PheGly: 2.664 ± 0.031	1.099PheHis: 1.099 ± 0.011	2.616PheIle: 2.616 ± 0.024	1.76PheLys: 1.76 ± 0.017	3.96PheLeu: 3.96 ± 0.036	0.936PheMet: 0.936 ± 0.012	1.757PheAsn: 1.757 ± 0.019	2.015PhePro: 2.015 ± 0.017	1.079PheGln: 1.079 ± 0.011	2.089PheArg: 2.089 ± 0.018	3.474PheSer: 3.474 ± 0.043	2.466PheThr: 2.466 ± 0.021	2.945PheVal: 2.945 ± 0.024	0.5PheTrp: 0.5 ± 0.007	1.414PheTyr: 1.414 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	4.174GlyAla: 4.174 ± 0.042	1.169GlyCys: 1.169 ± 0.016	3.103GlyAsp: 3.103 ± 0.022	3.821GlyGlu: 3.821 ± 0.033	2.346GlyPhe: 2.346 ± 0.021	5.294GlyGly: 5.294 ± 0.063	1.275GlyHis: 1.275 ± 0.013	3.225GlyIle: 3.225 ± 0.043	3.375GlyLys: 3.375 ± 0.029	4.268GlyLeu: 4.268 ± 0.05	1.643GlyMet: 1.643 ± 0.017	2.288GlyAsn: 2.288 ± 0.028	2.436GlyPro: 2.436 ± 0.041	1.952GlyGln: 1.952 ± 0.026	3.81GlyArg: 3.81 ± 0.033	4.561GlySer: 4.561 ± 0.113	3.165GlyThr: 3.165 ± 0.033	3.701GlyVal: 3.701 ± 0.027	0.787GlyTrp: 0.787 ± 0.01	1.857GlyTyr: 1.857 ± 0.017	0.0GlyXaa: 0.0 ± 0.0
His	1.525HisAla: 1.525 ± 0.015	0.547HisCys: 0.547 ± 0.008	1.14HisAsp: 1.14 ± 0.013	1.313HisGlu: 1.313 ± 0.031	1.225HisPhe: 1.225 ± 0.012	1.322HisGly: 1.322 ± 0.015	0.882HisHis: 0.882 ± 0.02	1.256HisIle: 1.256 ± 0.014	1.05HisLys: 1.05 ± 0.013	2.245HisLeu: 2.245 ± 0.017	0.547HisMet: 0.547 ± 0.008	0.914HisAsn: 0.914 ± 0.011	1.393HisPro: 1.393 ± 0.017	0.853HisGln: 0.853 ± 0.011	1.504HisArg: 1.504 ± 0.016	2.291HisSer: 2.291 ± 0.025	1.186HisThr: 1.186 ± 0.013	1.378HisVal: 1.378 ± 0.02	0.299HisTrp: 0.299 ± 0.005	0.79HisTyr: 0.79 ± 0.009	0.0HisXaa: 0.0 ± 0.0
Ile	4.296IleAla: 4.296 ± 0.038	1.188IleCys: 1.188 ± 0.013	3.519IleAsp: 3.519 ± 0.023	3.71IleGlu: 3.71 ± 0.04	2.65IlePhe: 2.65 ± 0.025	3.291IleGly: 3.291 ± 0.032	1.432IleHis: 1.432 ± 0.017	3.46IleIle: 3.46 ± 0.03	2.597IleLys: 2.597 ± 0.018	5.087IleLeu: 5.087 ± 0.043	1.31IleMet: 1.31 ± 0.016	2.156IleAsn: 2.156 ± 0.018	3.034IlePro: 3.034 ± 0.022	1.767IleGln: 1.767 ± 0.017	3.297IleArg: 3.297 ± 0.036	4.533IleSer: 4.533 ± 0.024	3.147IleThr: 3.147 ± 0.025	4.324IleVal: 4.324 ± 0.035	0.572IleTrp: 0.572 ± 0.009	1.657IleTyr: 1.657 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	3.682LysAla: 3.682 ± 0.088	1.187LysCys: 1.187 ± 0.017	3.029LysAsp: 3.029 ± 0.034	5.05LysGlu: 5.05 ± 0.047	1.791LysPhe: 1.791 ± 0.015	2.958LysGly: 2.958 ± 0.024	1.14LysHis: 1.14 ± 0.014	3.037LysIle: 3.037 ± 0.028	5.43LysLys: 5.43 ± 0.097	4.32LysLeu: 4.32 ± 0.039	1.821LysMet: 1.821 ± 0.016	2.4LysAsn: 2.4 ± 0.02	3.269LysPro: 3.269 ± 0.315	1.833LysGln: 1.833 ± 0.015	4.004LysArg: 4.004 ± 0.03	3.771LysSer: 3.771 ± 0.036	3.118LysThr: 3.118 ± 0.036	2.919LysVal: 2.919 ± 0.02	0.718LysTrp: 0.718 ± 0.009	1.568LysTyr: 1.568 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	6.345LeuAla: 6.345 ± 0.052	1.803LeuCys: 1.803 ± 0.017	4.156LeuAsp: 4.156 ± 0.024	4.908LeuGlu: 4.908 ± 0.042	4.286LeuPhe: 4.286 ± 0.05	4.15LeuGly: 4.15 ± 0.056	2.29LeuHis: 2.29 ± 0.019	5.398LeuIle: 5.398 ± 0.043	4.466LeuLys: 4.466 ± 0.043	9.494LeuLeu: 9.494 ± 0.074	2.164LeuMet: 2.164 ± 0.019	3.558LeuAsn: 3.558 ± 0.036	5.081LeuPro: 5.081 ± 0.039	3.132LeuGln: 3.132 ± 0.071	5.354LeuArg: 5.354 ± 0.042	7.484LeuSer: 7.484 ± 0.042	4.874LeuThr: 4.874 ± 0.031	5.342LeuVal: 5.342 ± 0.071	0.904LeuTrp: 0.904 ± 0.011	2.387LeuTyr: 2.387 ± 0.022	0.0LeuXaa: 0.0 ± 0.0
Met	1.924MetAla: 1.924 ± 0.016	0.496MetCys: 0.496 ± 0.008	1.549MetAsp: 1.549 ± 0.013	1.982MetGlu: 1.982 ± 0.019	0.941MetPhe: 0.941 ± 0.011	1.552MetGly: 1.552 ± 0.014	0.639MetHis: 0.639 ± 0.009	1.534MetIle: 1.534 ± 0.014	1.717MetLys: 1.717 ± 0.015	2.128MetLeu: 2.128 ± 0.017	0.9MetMet: 0.9 ± 0.01	1.249MetAsn: 1.249 ± 0.013	1.172MetPro: 1.172 ± 0.013	0.961MetGln: 0.961 ± 0.014	1.809MetArg: 1.809 ± 0.015	2.014MetSer: 2.014 ± 0.035	1.523MetThr: 1.523 ± 0.015	1.461MetVal: 1.461 ± 0.026	0.27MetTrp: 0.27 ± 0.005	0.667MetTyr: 0.667 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.797AsnAla: 2.797 ± 0.031	0.908AsnCys: 0.908 ± 0.013	2.305AsnAsp: 2.305 ± 0.017	2.948AsnGlu: 2.948 ± 0.03	1.575AsnPhe: 1.575 ± 0.014	3.208AsnGly: 3.208 ± 0.024	0.91AsnHis: 0.91 ± 0.01	2.174AsnIle: 2.174 ± 0.017	2.032AsnLys: 2.032 ± 0.018	3.265AsnLeu: 3.265 ± 0.02	0.985AsnMet: 0.985 ± 0.011	1.801AsnAsn: 1.801 ± 0.016	1.969AsnPro: 1.969 ± 0.016	1.351AsnGln: 1.351 ± 0.015	2.339AsnArg: 2.339 ± 0.018	3.051AsnSer: 3.051 ± 0.03	2.043AsnThr: 2.043 ± 0.017	2.578AsnVal: 2.578 ± 0.034	0.458AsnTrp: 0.458 ± 0.006	1.242AsnTyr: 1.242 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	3.816ProAla: 3.816 ± 0.054	0.899ProCys: 0.899 ± 0.019	2.305ProAsp: 2.305 ± 0.034	2.758ProGlu: 2.758 ± 0.022	2.2ProPhe: 2.2 ± 0.022	2.747ProGly: 2.747 ± 0.045	1.209ProHis: 1.209 ± 0.013	2.978ProIle: 2.978 ± 0.025	3.478ProLys: 3.478 ± 0.313	4.664ProLeu: 4.664 ± 0.035	1.172ProMet: 1.172 ± 0.012	1.85ProAsn: 1.85 ± 0.017	4.684ProPro: 4.684 ± 0.053	1.77ProGln: 1.77 ± 0.019	2.661ProArg: 2.661 ± 0.021	5.882ProSer: 5.882 ± 0.083	3.492ProThr: 3.492 ± 0.064	3.256ProVal: 3.256 ± 0.041	0.477ProTrp: 0.477 ± 0.008	1.417ProTyr: 1.417 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	2.186GlnAla: 2.186 ± 0.033	0.837GlnCys: 0.837 ± 0.017	1.208GlnAsp: 1.208 ± 0.014	1.951GlnGlu: 1.951 ± 0.028	1.454GlnPhe: 1.454 ± 0.012	1.545GlnGly: 1.545 ± 0.017	0.822GlnHis: 0.822 ± 0.009	1.845GlnIle: 1.845 ± 0.015	1.871GlnLys: 1.871 ± 0.016	3.477GlnLeu: 3.477 ± 0.029	1.124GlnMet: 1.124 ± 0.013	1.249GlnAsn: 1.249 ± 0.012	2.086GlnPro: 2.086 ± 0.099	2.084GlnGln: 2.084 ± 0.034	2.196GlnArg: 2.196 ± 0.018	2.848GlnSer: 2.848 ± 0.064	1.785GlnThr: 1.785 ± 0.015	1.749GlnVal: 1.749 ± 0.014	0.498GlnTrp: 0.498 ± 0.007	1.069GlnTyr: 1.069 ± 0.011	0.0GlnXaa: 0.0 ± 0.0
Arg	4.158ArgAla: 4.158 ± 0.042	1.169ArgCys: 1.169 ± 0.016	3.061ArgAsp: 3.061 ± 0.022	4.195ArgGlu: 4.195 ± 0.032	2.427ArgPhe: 2.427 ± 0.023	3.361ArgGly: 3.361 ± 0.028	1.375ArgHis: 1.375 ± 0.012	3.396ArgIle: 3.396 ± 0.026	4.001ArgLys: 4.001 ± 0.028	5.408ArgLeu: 5.408 ± 0.054	1.834ArgMet: 1.834 ± 0.023	2.543ArgAsn: 2.543 ± 0.017	2.981ArgPro: 2.981 ± 0.026	2.057ArgGln: 2.057 ± 0.018	5.349ArgArg: 5.349 ± 0.071	4.903ArgSer: 4.903 ± 0.049	3.137ArgThr: 3.137 ± 0.021	3.639ArgVal: 3.639 ± 0.021	0.703ArgTrp: 0.703 ± 0.01	1.632ArgTyr: 1.632 ± 0.016	0.0ArgXaa: 0.0 ± 0.0
Ser	5.494SerAla: 5.494 ± 0.034	1.64SerCys: 1.64 ± 0.034	4.073SerAsp: 4.073 ± 0.034	4.236SerGlu: 4.236 ± 0.035	3.681SerPhe: 3.681 ± 0.031	4.417SerGly: 4.417 ± 0.039	1.912SerHis: 1.912 ± 0.016	5.209SerIle: 5.209 ± 0.035	3.768SerLys: 3.768 ± 0.03	7.774SerLeu: 7.774 ± 0.051	2.058SerMet: 2.058 ± 0.026	3.167SerAsn: 3.167 ± 0.02	4.699SerPro: 4.699 ± 0.036	2.469SerGln: 2.469 ± 0.019	4.571SerArg: 4.571 ± 0.032	9.716SerSer: 9.716 ± 0.093	6.233SerThr: 6.233 ± 0.163	4.932SerVal: 4.932 ± 0.106	0.793SerTrp: 0.793 ± 0.011	2.08SerTyr: 2.08 ± 0.018	0.0SerXaa: 0.0 ± 0.0
Thr	4.424ThrAla: 4.424 ± 0.044	1.248ThrCys: 1.248 ± 0.02	2.723ThrAsp: 2.723 ± 0.042	3.306ThrGlu: 3.306 ± 0.059	2.282ThrPhe: 2.282 ± 0.02	3.149ThrGly: 3.149 ± 0.039	1.273ThrHis: 1.273 ± 0.02	3.549ThrIle: 3.549 ± 0.03	2.834ThrLys: 2.834 ± 0.025	5.031ThrLeu: 5.031 ± 0.075	1.538ThrMet: 1.538 ± 0.024	2.198ThrAsn: 2.198 ± 0.017	3.539ThrPro: 3.539 ± 0.034	1.85ThrGln: 1.85 ± 0.088	3.174ThrArg: 3.174 ± 0.023	4.888ThrSer: 4.888 ± 0.061	5.292ThrThr: 5.292 ± 0.199	4.249ThrVal: 4.249 ± 0.028	0.629ThrTrp: 0.629 ± 0.018	1.392ThrTyr: 1.392 ± 0.014	0.0ThrXaa: 0.0 ± 0.0
Val	4.692ValAla: 4.692 ± 0.031	1.357ValCys: 1.357 ± 0.014	3.89ValAsp: 3.89 ± 0.057	4.294ValGlu: 4.294 ± 0.153	2.757ValPhe: 2.757 ± 0.021	3.188ValGly: 3.188 ± 0.034	1.625ValHis: 1.625 ± 0.016	3.715ValIle: 3.715 ± 0.027	3.317ValLys: 3.317 ± 0.022	5.492ValLeu: 5.492 ± 0.059	1.557ValMet: 1.557 ± 0.015	2.644ValAsn: 2.644 ± 0.036	3.255ValPro: 3.255 ± 0.039	2.178ValGln: 2.178 ± 0.019	3.413ValArg: 3.413 ± 0.037	4.66ValSer: 4.66 ± 0.029	3.467ValThr: 3.467 ± 0.03	4.752ValVal: 4.752 ± 0.122	0.704ValTrp: 0.704 ± 0.017	1.978ValTyr: 1.978 ± 0.023	0.0ValXaa: 0.0 ± 0.0
Trp	0.718TrpAla: 0.718 ± 0.009	0.242TrpCys: 0.242 ± 0.008	0.543TrpAsp: 0.543 ± 0.008	0.659TrpGlu: 0.659 ± 0.016	0.462TrpPhe: 0.462 ± 0.009	0.496TrpGly: 0.496 ± 0.008	0.251TrpHis: 0.251 ± 0.006	0.744TrpIle: 0.744 ± 0.01	0.824TrpLys: 0.824 ± 0.011	1.007TrpLeu: 1.007 ± 0.011	0.428TrpMet: 0.428 ± 0.006	0.658TrpAsn: 0.658 ± 0.009	0.447TrpPro: 0.447 ± 0.007	0.394TrpGln: 0.394 ± 0.007	0.825TrpArg: 0.825 ± 0.015	0.901TrpSer: 0.901 ± 0.01	0.757TrpThr: 0.757 ± 0.01	0.542TrpVal: 0.542 ± 0.008	0.176TrpTrp: 0.176 ± 0.005	0.336TrpTyr: 0.336 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.009TyrAla: 2.009 ± 0.019	0.758TyrCys: 0.758 ± 0.012	1.65TyrAsp: 1.65 ± 0.016	1.714TyrGlu: 1.714 ± 0.016	1.405TyrPhe: 1.405 ± 0.014	1.916TyrGly: 1.916 ± 0.02	0.734TyrHis: 0.734 ± 0.015	1.445TyrIle: 1.445 ± 0.015	1.327TyrLys: 1.327 ± 0.013	2.512TyrLeu: 2.512 ± 0.024	0.662TyrMet: 0.662 ± 0.009	1.159TyrAsn: 1.159 ± 0.013	1.345TyrPro: 1.345 ± 0.023	0.981TyrGln: 0.981 ± 0.011	1.854TyrArg: 1.854 ± 0.021	2.347TyrSer: 2.347 ± 0.018	1.572TyrThr: 1.572 ± 0.014	1.748TyrVal: 1.748 ± 0.02	0.379TyrTrp: 0.379 ± 0.007	1.122TyrTyr: 1.122 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 25205 proteins (11382119 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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