Amino acid dipepetide frequency for Thamnocephalis sphaerospora

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.517AlaAla: 13.517 ± 0.136	1.537AlaCys: 1.537 ± 0.027	5.867AlaAsp: 5.867 ± 0.052	5.893AlaGlu: 5.893 ± 0.063	3.261AlaPhe: 3.261 ± 0.043	6.658AlaGly: 6.658 ± 0.054	2.666AlaHis: 2.666 ± 0.034	4.354AlaIle: 4.354 ± 0.047	3.873AlaLys: 3.873 ± 0.048	9.571AlaLeu: 9.571 ± 0.079	2.51AlaMet: 2.51 ± 0.03	3.29AlaAsn: 3.29 ± 0.037	5.343AlaPro: 5.343 ± 0.071	4.075AlaGln: 4.075 ± 0.054	6.611AlaArg: 6.611 ± 0.061	8.67AlaSer: 8.67 ± 0.078	6.7AlaThr: 6.7 ± 0.066	7.03AlaVal: 7.03 ± 0.062	1.259AlaTrp: 1.259 ± 0.024	2.706AlaTyr: 2.706 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	1.506CysAla: 1.506 ± 0.026	0.338CysCys: 0.338 ± 0.012	0.785CysAsp: 0.785 ± 0.018	0.705CysGlu: 0.705 ± 0.016	0.578CysPhe: 0.578 ± 0.016	1.069CysGly: 1.069 ± 0.024	0.404CysHis: 0.404 ± 0.012	0.817CysIle: 0.817 ± 0.019	0.527CysLys: 0.527 ± 0.015	1.457CysLeu: 1.457 ± 0.024	0.406CysMet: 0.406 ± 0.013	0.519CysAsn: 0.519 ± 0.015	0.698CysPro: 0.698 ± 0.017	0.533CysGln: 0.533 ± 0.015	1.087CysArg: 1.087 ± 0.022	1.024CysSer: 1.024 ± 0.021	0.976CysThr: 0.976 ± 0.021	1.133CysVal: 1.133 ± 0.021	0.259CysTrp: 0.259 ± 0.011	0.452CysTyr: 0.452 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.756AspAla: 6.756 ± 0.061	0.723AspCys: 0.723 ± 0.019	4.655AspAsp: 4.655 ± 0.073	4.331AspGlu: 4.331 ± 0.048	1.71AspPhe: 1.71 ± 0.03	4.3AspGly: 4.3 ± 0.051	1.259AspHis: 1.259 ± 0.024	2.528AspIle: 2.528 ± 0.034	1.937AspLys: 1.937 ± 0.028	4.506AspLeu: 4.506 ± 0.043	1.527AspMet: 1.527 ± 0.027	1.761AspAsn: 1.761 ± 0.026	2.6AspPro: 2.6 ± 0.035	1.926AspGln: 1.926 ± 0.028	3.383AspArg: 3.383 ± 0.041	3.553AspSer: 3.553 ± 0.042	3.394AspThr: 3.394 ± 0.039	4.007AspVal: 4.007 ± 0.041	0.825AspTrp: 0.825 ± 0.017	1.661AspTyr: 1.661 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	5.566GluAla: 5.566 ± 0.069	0.789GluCys: 0.789 ± 0.016	3.568GluAsp: 3.568 ± 0.052	4.883GluGlu: 4.883 ± 0.088	1.738GluPhe: 1.738 ± 0.03	2.633GluGly: 2.633 ± 0.032	1.746GluHis: 1.746 ± 0.028	2.316GluIle: 2.316 ± 0.036	2.732GluLys: 2.732 ± 0.033	5.705GluLeu: 5.705 ± 0.057	1.58GluMet: 1.58 ± 0.022	1.882GluAsn: 1.882 ± 0.029	2.364GluPro: 2.364 ± 0.037	2.963GluGln: 2.963 ± 0.043	4.804GluArg: 4.804 ± 0.051	3.53GluSer: 3.53 ± 0.045	3.139GluThr: 3.139 ± 0.037	3.177GluVal: 3.177 ± 0.044	0.657GluTrp: 0.657 ± 0.017	1.628GluTyr: 1.628 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	3.327PheAla: 3.327 ± 0.04	0.605PheCys: 0.605 ± 0.015	2.041PheAsp: 2.041 ± 0.033	1.746PheGlu: 1.746 ± 0.032	1.448PhePhe: 1.448 ± 0.023	2.689PheGly: 2.689 ± 0.036	0.785PheHis: 0.785 ± 0.018	1.531PheIle: 1.531 ± 0.026	1.102PheLys: 1.102 ± 0.021	2.989PheLeu: 2.989 ± 0.033	0.759PheMet: 0.759 ± 0.018	1.071PheAsn: 1.071 ± 0.021	1.417PhePro: 1.417 ± 0.027	1.086PheGln: 1.086 ± 0.019	1.985PheArg: 1.985 ± 0.028	2.691PheSer: 2.691 ± 0.029	1.934PheThr: 1.934 ± 0.024	2.434PheVal: 2.434 ± 0.034	0.502PheTrp: 0.502 ± 0.015	1.075PheTyr: 1.075 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	5.949GlyAla: 5.949 ± 0.053	0.991GlyCys: 0.991 ± 0.022	3.71GlyAsp: 3.71 ± 0.037	3.34GlyGlu: 3.34 ± 0.04	2.144GlyPhe: 2.144 ± 0.03	5.065GlyGly: 5.065 ± 0.071	1.838GlyHis: 1.838 ± 0.033	3.01GlyIle: 3.01 ± 0.046	2.851GlyLys: 2.851 ± 0.04	5.171GlyLeu: 5.171 ± 0.053	1.582GlyMet: 1.582 ± 0.028	2.316GlyAsn: 2.316 ± 0.032	2.482GlyPro: 2.482 ± 0.048	2.612GlyGln: 2.612 ± 0.037	4.574GlyArg: 4.574 ± 0.054	4.907GlySer: 4.907 ± 0.053	3.806GlyThr: 3.806 ± 0.038	4.39GlyVal: 4.39 ± 0.048	0.935GlyTrp: 0.935 ± 0.022	1.963GlyTyr: 1.963 ± 0.033	0.0GlyXaa: 0.0 ± 0.0
His	2.907HisAla: 2.907 ± 0.037	0.478HisCys: 0.478 ± 0.013	1.407HisAsp: 1.407 ± 0.026	1.302HisGlu: 1.302 ± 0.024	0.858HisPhe: 0.858 ± 0.019	2.06HisGly: 2.06 ± 0.031	0.918HisHis: 0.918 ± 0.026	1.177HisIle: 1.177 ± 0.023	0.801HisLys: 0.801 ± 0.019	2.445HisLeu: 2.445 ± 0.035	0.63HisMet: 0.63 ± 0.015	0.733HisAsn: 0.733 ± 0.019	1.521HisPro: 1.521 ± 0.026	1.179HisGln: 1.179 ± 0.023	2.065HisArg: 2.065 ± 0.028	1.749HisSer: 1.749 ± 0.027	1.62HisThr: 1.62 ± 0.026	1.781HisVal: 1.781 ± 0.026	0.382HisTrp: 0.382 ± 0.012	0.798HisTyr: 0.798 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	4.341IleAla: 4.341 ± 0.044	0.797IleCys: 0.797 ± 0.02	2.53IleAsp: 2.53 ± 0.032	2.282IleGlu: 2.282 ± 0.03	1.531IlePhe: 1.531 ± 0.028	2.948IleGly: 2.948 ± 0.039	0.993IleHis: 0.993 ± 0.018	2.103IleIle: 2.103 ± 0.033	1.685IleLys: 1.685 ± 0.03	3.718IleLeu: 3.718 ± 0.044	1.04IleMet: 1.04 ± 0.022	1.477IleAsn: 1.477 ± 0.024	2.052IlePro: 2.052 ± 0.03	1.491IleGln: 1.491 ± 0.024	2.842IleArg: 2.842 ± 0.032	3.041IleSer: 3.041 ± 0.036	2.564IleThr: 2.564 ± 0.033	3.178IleVal: 3.178 ± 0.036	0.674IleTrp: 0.674 ± 0.017	1.338IleTyr: 1.338 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	3.315LysAla: 3.315 ± 0.043	0.542LysCys: 0.542 ± 0.016	2.094LysAsp: 2.094 ± 0.033	2.523LysGlu: 2.523 ± 0.035	1.048LysPhe: 1.048 ± 0.021	1.949LysGly: 1.949 ± 0.03	1.117LysHis: 1.117 ± 0.028	1.509LysIle: 1.509 ± 0.026	2.25LysLys: 2.25 ± 0.046	3.579LysLeu: 3.579 ± 0.041	0.896LysMet: 0.896 ± 0.022	1.276LysAsn: 1.276 ± 0.023	1.995LysPro: 1.995 ± 0.036	1.907LysGln: 1.907 ± 0.025	3.333LysArg: 3.333 ± 0.042	2.408LysSer: 2.408 ± 0.035	2.105LysThr: 2.105 ± 0.037	2.253LysVal: 2.253 ± 0.031	0.435LysTrp: 0.435 ± 0.012	1.094LysTyr: 1.094 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	9.992LeuAla: 9.992 ± 0.069	1.642LeuCys: 1.642 ± 0.026	5.509LeuAsp: 5.509 ± 0.05	5.302LeuGlu: 5.302 ± 0.057	3.41LeuPhe: 3.41 ± 0.045	5.606LeuGly: 5.606 ± 0.048	2.549LeuHis: 2.549 ± 0.033	3.488LeuIle: 3.488 ± 0.04	3.219LeuLys: 3.219 ± 0.04	10.098LeuLeu: 10.098 ± 0.092	2.115LeuMet: 2.115 ± 0.028	2.798LeuAsn: 2.798 ± 0.032	5.58LeuPro: 5.58 ± 0.05	4.052LeuGln: 4.052 ± 0.048	7.18LeuArg: 7.18 ± 0.055	6.745LeuSer: 6.745 ± 0.06	4.767LeuThr: 4.767 ± 0.041	6.543LeuVal: 6.543 ± 0.053	1.198LeuTrp: 1.198 ± 0.022	2.567LeuTyr: 2.567 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	2.642MetAla: 2.642 ± 0.03	0.312MetCys: 0.312 ± 0.011	1.416MetAsp: 1.416 ± 0.022	1.362MetGlu: 1.362 ± 0.024	0.797MetPhe: 0.797 ± 0.02	1.183MetGly: 1.183 ± 0.021	0.77MetHis: 0.77 ± 0.017	0.916MetIle: 0.916 ± 0.02	0.724MetLys: 0.724 ± 0.017	2.823MetLeu: 2.823 ± 0.037	0.648MetMet: 0.648 ± 0.017	0.738MetAsn: 0.738 ± 0.018	1.599MetPro: 1.599 ± 0.028	1.138MetGln: 1.138 ± 0.021	1.958MetArg: 1.958 ± 0.03	1.897MetSer: 1.897 ± 0.029	1.417MetThr: 1.417 ± 0.023	1.565MetVal: 1.565 ± 0.027	0.242MetTrp: 0.242 ± 0.009	0.597MetTyr: 0.597 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.706AsnAla: 3.706 ± 0.041	0.433AsnCys: 0.433 ± 0.013	1.901AsnAsp: 1.901 ± 0.028	1.79AsnGlu: 1.79 ± 0.026	0.974AsnPhe: 0.974 ± 0.021	2.556AsnGly: 2.556 ± 0.036	0.685AsnHis: 0.685 ± 0.016	1.58AsnIle: 1.58 ± 0.029	1.158AsnLys: 1.158 ± 0.024	2.597AsnLeu: 2.597 ± 0.03	0.825AsnMet: 0.825 ± 0.017	1.089AsnAsn: 1.089 ± 0.025	1.571AsnPro: 1.571 ± 0.027	1.106AsnGln: 1.106 ± 0.022	1.914AsnArg: 1.914 ± 0.025	2.046AsnSer: 2.046 ± 0.032	2.0AsnThr: 2.0 ± 0.03	2.419AsnVal: 2.419 ± 0.031	0.472AsnTrp: 0.472 ± 0.014	0.886AsnTyr: 0.886 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	5.929ProAla: 5.929 ± 0.079	0.627ProCys: 0.627 ± 0.019	2.84ProAsp: 2.84 ± 0.039	3.134ProGlu: 3.134 ± 0.043	1.695ProPhe: 1.695 ± 0.03	3.26ProGly: 3.26 ± 0.059	1.285ProHis: 1.285 ± 0.028	2.059ProIle: 2.059 ± 0.029	1.812ProLys: 1.812 ± 0.029	4.7ProLeu: 4.7 ± 0.051	1.25ProMet: 1.25 ± 0.024	1.703ProAsn: 1.703 ± 0.028	4.267ProPro: 4.267 ± 0.102	1.964ProGln: 1.964 ± 0.035	3.134ProArg: 3.134 ± 0.034	4.886ProSer: 4.886 ± 0.077	3.656ProThr: 3.656 ± 0.06	3.872ProVal: 3.872 ± 0.043	0.638ProTrp: 0.638 ± 0.016	1.365ProTyr: 1.365 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.792GlnAla: 3.792 ± 0.046	0.597GlnCys: 0.597 ± 0.015	1.823GlnAsp: 1.823 ± 0.028	2.344GlnGlu: 2.344 ± 0.037	1.258GlnPhe: 1.258 ± 0.022	1.886GlnGly: 1.886 ± 0.029	1.435GlnHis: 1.435 ± 0.025	1.513GlnIle: 1.513 ± 0.025	1.516GlnLys: 1.516 ± 0.023	4.789GlnLeu: 4.789 ± 0.058	1.062GlnMet: 1.062 ± 0.021	1.106GlnAsn: 1.106 ± 0.021	2.654GlnPro: 2.654 ± 0.037	3.25GlnGln: 3.25 ± 0.103	3.669GlnArg: 3.669 ± 0.044	2.756GlnSer: 2.756 ± 0.036	2.234GlnThr: 2.234 ± 0.03	2.387GlnVal: 2.387 ± 0.032	0.528GlnTrp: 0.528 ± 0.013	1.071GlnTyr: 1.071 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	6.47ArgAla: 6.47 ± 0.055	1.115ArgCys: 1.115 ± 0.021	3.641ArgAsp: 3.641 ± 0.044	3.939ArgGlu: 3.939 ± 0.043	2.459ArgPhe: 2.459 ± 0.032	3.792ArgGly: 3.792 ± 0.046	2.147ArgHis: 2.147 ± 0.031	3.215ArgIle: 3.215 ± 0.038	2.985ArgLys: 2.985 ± 0.04	6.981ArgLeu: 6.981 ± 0.056	1.81ArgMet: 1.81 ± 0.029	2.233ArgAsn: 2.233 ± 0.026	3.686ArgPro: 3.686 ± 0.048	3.354ArgGln: 3.354 ± 0.044	6.811ArgArg: 6.811 ± 0.069	4.969ArgSer: 4.969 ± 0.054	3.935ArgThr: 3.935 ± 0.043	4.644ArgVal: 4.644 ± 0.044	1.138ArgTrp: 1.138 ± 0.023	2.023ArgTyr: 2.023 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	8.165SerAla: 8.165 ± 0.078	0.88SerCys: 0.88 ± 0.018	4.113SerAsp: 4.113 ± 0.044	3.655SerGlu: 3.655 ± 0.035	2.29SerPhe: 2.29 ± 0.03	5.31SerGly: 5.31 ± 0.053	1.641SerHis: 1.641 ± 0.024	3.194SerIle: 3.194 ± 0.034	2.595SerLys: 2.595 ± 0.036	6.462SerLeu: 6.462 ± 0.056	1.901SerMet: 1.901 ± 0.031	2.386SerAsn: 2.386 ± 0.03	4.448SerPro: 4.448 ± 0.078	2.641SerGln: 2.641 ± 0.031	4.527SerArg: 4.527 ± 0.045	7.059SerSer: 7.059 ± 0.096	5.161SerThr: 5.161 ± 0.072	5.031SerVal: 5.031 ± 0.044	0.923SerTrp: 0.923 ± 0.021	1.704SerTyr: 1.704 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	6.646ThrAla: 6.646 ± 0.055	0.844ThrCys: 0.844 ± 0.021	2.895ThrAsp: 2.895 ± 0.034	3.009ThrGlu: 3.009 ± 0.038	2.034ThrPhe: 2.034 ± 0.027	4.061ThrGly: 4.061 ± 0.049	1.433ThrHis: 1.433 ± 0.023	2.549ThrIle: 2.549 ± 0.033	2.001ThrLys: 2.001 ± 0.032	5.975ThrLeu: 5.975 ± 0.045	1.426ThrMet: 1.426 ± 0.023	1.711ThrAsn: 1.711 ± 0.023	4.177ThrPro: 4.177 ± 0.082	2.022ThrGln: 2.022 ± 0.029	3.683ThrArg: 3.683 ± 0.041	4.725ThrSer: 4.725 ± 0.067	4.003ThrThr: 4.003 ± 0.056	4.372ThrVal: 4.372 ± 0.038	0.696ThrTrp: 0.696 ± 0.014	1.464ThrTyr: 1.464 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	7.064ValAla: 7.064 ± 0.051	1.248ValCys: 1.248 ± 0.021	4.236ValAsp: 4.236 ± 0.046	3.808ValGlu: 3.808 ± 0.046	2.454ValPhe: 2.454 ± 0.033	3.938ValGly: 3.938 ± 0.045	1.961ValHis: 1.961 ± 0.029	2.899ValIle: 2.899 ± 0.039	2.396ValLys: 2.396 ± 0.038	6.556ValLeu: 6.556 ± 0.059	1.576ValMet: 1.576 ± 0.023	2.207ValAsn: 2.207 ± 0.032	3.736ValPro: 3.736 ± 0.042	2.645ValGln: 2.645 ± 0.034	4.553ValArg: 4.553 ± 0.037	4.657ValSer: 4.657 ± 0.045	3.837ValThr: 3.837 ± 0.038	4.997ValVal: 4.997 ± 0.052	0.88ValTrp: 0.88 ± 0.019	2.149ValTyr: 2.149 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	0.972TrpAla: 0.972 ± 0.023	0.282TrpCys: 0.282 ± 0.011	0.724TrpAsp: 0.724 ± 0.021	0.621TrpGlu: 0.621 ± 0.015	0.469TrpPhe: 0.469 ± 0.014	0.624TrpGly: 0.624 ± 0.017	0.45TrpHis: 0.45 ± 0.012	0.607TrpIle: 0.607 ± 0.017	0.525TrpLys: 0.525 ± 0.015	1.536TrpLeu: 1.536 ± 0.028	0.437TrpMet: 0.437 ± 0.011	0.478TrpAsn: 0.478 ± 0.014	0.635TrpPro: 0.635 ± 0.017	0.639TrpGln: 0.639 ± 0.016	1.213TrpArg: 1.213 ± 0.021	1.027TrpSer: 1.027 ± 0.02	0.775TrpThr: 0.775 ± 0.018	0.675TrpVal: 0.675 ± 0.016	0.247TrpTrp: 0.247 ± 0.011	0.367TrpTyr: 0.367 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.831TyrAla: 2.831 ± 0.038	0.494TyrCys: 0.494 ± 0.014	1.585TyrAsp: 1.585 ± 0.024	1.432TyrGlu: 1.432 ± 0.025	1.061TyrPhe: 1.061 ± 0.021	2.047TyrGly: 2.047 ± 0.034	0.731TyrHis: 0.731 ± 0.018	1.264TyrIle: 1.264 ± 0.022	0.937TyrLys: 0.937 ± 0.023	2.701TyrLeu: 2.701 ± 0.036	0.766TyrMet: 0.766 ± 0.016	0.934TyrAsn: 0.934 ± 0.023	1.253TyrPro: 1.253 ± 0.022	1.085TyrGln: 1.085 ± 0.018	2.021TyrArg: 2.021 ± 0.029	1.746TyrSer: 1.746 ± 0.029	1.702TyrThr: 1.702 ± 0.029	1.908TyrVal: 1.908 ± 0.032	0.414TyrTrp: 0.414 ± 0.014	0.964TyrTyr: 0.964 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6769 proteins (2686534 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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